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9034903 Acyl piperidine inhibitors of soluble epoxide hydrolase  
Inhibitors of the soluble epoxide hydrolase (sEH) are provided that incorporate multiple pharmacophores and are useful in the treatment of diseases. In some embodiments, the present invention...
9029401 Sorafenib derivatives as sEH inhibitors  
The present invention provides compounds for the inhibition of soluble epoxide hydrolase and associated disease conditions.
9029115 Lipase variants for pharmaceutical use  
The pharmaceutical use of lipases related to the Thermomyces lanuginosus (Humicola lanuginosa) lipase comprising amino acids 1-269 of SEQ ID NO: 2, optionally in combination with a protease and/or...
9023631 PON polypeptides, polynucleotides encoding same and compositions and methods utilizing same  
Isolated polynucleotides and polypeptides encoded therefrom are provided. These include mutated PON enzymes with increased, modified or substantially the same substrate specificity as compared to...
9017961 Recombinant bacteria comprising novel sucrose transporters  
Recombinant bacteria capable of metabolizing sucrose are described. The recombinant bacteria comprise in their genome or on at least one recombinant construct, a novel nucleotide sequence encoding...
9017960 Crystal structure of amino terminal portion of influenza virus polymerase PA subunit and use thereof  
Present invention discloses the three-dimensional crystal structure of the N-terminus polypeptide of influenza virus polymerase subunit (PA_N of SEQ ID NO:7). PA_N of SEQ ID NO: 1 is residues 1—50...
9012229 Capillary electrophoresis method for fine structural analysis of enoxaparin sodium  
A capillary electrophoresis method for quantitatively analyzing characteristic oligosaccharide present in enoxaparin sodium is provided in this invention. The method may be used for quantitatively...
9012167 Quick method for detecting enzymes and microorganisms  
The present invention concerns an in vitro method for detecting an enzyme or a microorganism in a biological sample, comprising the steps of: a1) concentrating the microorganisms present in the...
9011821 PLA2G16 as a target for antiviral compounds  
In some aspects, the invention provides compositions and methods for inhibiting viral infection. In some aspects, the invention provides compositions and methods useful for identifying antiviral...
8980605 Ketoreductases and uses thereof  
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides...
8975043 Enzymatic degradation of lipid A fatty acids of bacterial LPS  
Novel enzymes, processes and antigenic structures useful in producing vaccines and compounds useful in combating gram-negative bacteria are described. Enzymes were isolated from the slime mold...
8975055 Reduced-fat foodstuffs and cooking oils, and methods for making same  
The present invention relates to a newly identified lipase belonging to the Ustilaginaceae family of Basidomycetes and variants thereof. The invention also relates to polynucleotides encoding the...
8969061 Compositions, methods and related uses for cleaving modified DNA  
Compositions, methods and a kit are described relating to a novel family of enzymes which preferentially bind to a hydroxymethylated cytosine or a glucosylated hydroxymethylated cytosine and...
8962295 Stable, functional chimeric cellobiohydrolase class I enzymes  
The present disclosure relates to CBH I chimera fusion polypeptides, nucleic acids encoding the polypeptides, and host cells for producing the polypeptides.
8962302 Biological tissue processing substrate for fixing proteins or protein degradation products in tissue for analysis  
A biological tissue processing substrate for fixing proteins in a biological tissue or degradation products of the proteins, the substrate comprising: a porous body that forms a contact surface...
8961962 Acid ceramidase and mammalian cell survival  
The present invention relates to methods of promoting the survival of cells by treating the cells with acid ceramidase. A kit for promoting ex vivo cell survival is also disclosed, as is a method...
8951770 GH8 xylanase variants  
The present invention relates to isolated polypeptides having xylanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs,...
8951752 N-demethyase genes and uses thereof  
The invention provides isolated nucleic acid encoding one or more gene products that allow for degradation of caffeine and related structures, and for preparation of intermediates in that...
8951751 Polypeptides with xylanase activity  
Polypeptides with xylanase activity modified to increase bran solubilization and/or xylanase activity. The modification comprises at least an amino acid modification i position 110 and may have...
8940497 Enzyme regulating ether lipid signaling pathways  
A multidimensional profiling strategy that combines activity-based proteomics and metabolomics was used to determine that an active protein, which is a previously uncharacterized enzyme highly...
8932818 Screening assays for compounds that modulate programmed ribosomal frameshifting  
The present invention relates to compounds that modulate ribosomal frameshifting and nucleic acid constructs for use in methods for identifying or validation of compounds that modulate ribosomal...
8932881 Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates  
New chemiluminescent compounds, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and 1,2-dioxetanes. Among the new acridane-based compounds are...
8927244 Organophosphorus hydrolase  
The present disclosure provides methods, devices, systems and compositions for detecting and/or modifying chemical agents. In some embodiments, a biosensor may be configured to detect a chemical...
8927263 Derivatization of PNGase F released glycans on an HPLC chip  
A microfluidic device for glycan analysis includes a deglycosylation column comprising a glycosidase attached to a solid support; a tagging column comprising a reactive ester for reaction with an...
8921620 Compositions comprising a dehalogenase substrate and a contrast agent and methods of use  
A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase...
8906629 Method for screening ameliorants of dry skin caused by atopic dermatitis using bleomycin hydrolase activity as indicator  
The present invention provides a method for screening and evaluating ameliorants of dry skin caused by atopic dermatitis, comprising: evaluating a candidate drug as being an ameliorant of dry skin...
8895787 Compositions comprising a dehalogenase substrate and a radionuclide and methods of use  
A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase...
8895284 Class II human histone deacetylases, and uses related thereto  
The invention provides histone deacetylase class II nucleic acids and polypeptides, methods and reagents for their use, and related compounds including small molecule libraries containing class II...
8889371 Lipolytic enzyme: uses thereof in the food industry  
The invention encompasses the use of a lipolytic enzyme obtainable from one of the following genera: Streptomyces, Corynebacterium and Thermobifida in various methods and uses, wherein the...
8883478 Methods of preparing tissues for xenotransplantation using α-galactosidases  
This invention relates to novel α-galactosidases for the enzymatic removal of the immunodominant monosaccharides on blood products and tissues. Specifically this invention provides a novel family...
8883436 Method of analyzing cellulose decay in lignocellulosic material hydrolysis  
Enzymes and/or polypeptides and/or mixtures of interest are evaluated during hydrolysis of cellulosic material by the use of indicator constituents such as fluorescent agents, resulting in...
8883445 Protein glycosylation modification in methylotrophic yeast  
The present invention provides genetically engineered strains of methylotrophic yeast including Pichia and especially Pichia pastoris capable of producing proteins with reduced or modified...
8871458 Methods for detecting risk of fatal prostate cancer using serum calcium  
A method of screening for increased risk of fatal prostate cancer in a subject comprises providing a blood sample collected from the subject, and then detecting the presence or absence of an...
8865420 Methods and compositions for risk stratification  
The present invention provides an approach for the simultaneous determination of the activation states of a plurality of proteins in single cells. This approach permits the rapid detection of...
8865708 Methods and compositions for inhibition of the transitional endoplasmic reticulum ATPase  
Compounds of Formulas I-XLIII are identified as direct inhibitors of p97 ATPase or of the degradation of a p97-dependent ubiquitin-proteasome system (UPS) substrate. Methods and compositions are...
8852907 Conversion system for biomass  
The efficient production of ethanol from low-cost biomass (e.g., corn, sugar beets, sugar cane, switchgrass and/or paper) has become increasingly important in making ethanol competitive with...
8852880 Test for predicting neutralization of asparaginase activity  
Method of in vitro measurement of the presence of factors that are able to neutralize asparaginase activity in a sample of blood, plasma, serum or derived medium that may contain asparaginase...
8841085 Nanoparticle sensor for measuring protease activity and method for manufacturing the same  
Disclosed are a nanoparticle sensor for measuring protease activity, for protease imaging, and a method for preparing the same. More specifically, the present invention relates to a nanoparticle...
8834867 Method for producing lipase, transformed yarrowia lipolytica cell capable of producing said lipase and their uses  
Method for producing Yarrowia lipolytica acid-resistant recombinant lipase utilizing a culture medium without any products of animal origin or non-characterized mixtures such as tryptone, peptone...
8835467 SIR2 regulation  
Compounds are disclosed which inhibit SIR2 base exchange more than deacetylation, thus enhancing SIR2 deacetylation activity. Methods of using the compounds for enhancing SIR2 deacetylation...
8822172 Method of detecting isolevuglandin phospholipid adducts  
A method of measuring isolevuglandin and/or levuglandin adducts associated with oxidative injury in a subject includes obtaining a bodily sample from a subject suspected of including...
8822173 Wound dressing or swab for detecting infection  
The present invention relates to a wound dressing or a wound swab, which allows the detection of at least three enzymes selected from the group consisting of lysosyme, elastase, cathepsin G and...
8815531 Dry test strip and method for measuring creatinine  
A dry test strip for measuring creatinine comprises: a support; a reagent layer that is disposed on the support; a reagent holding layer that is disposed on the reagent layer; and a connection...
8809010 Method for prophylactic treatment of alzheimer's disease using inhibitors of glutaminyl cyclase and glutamate cyclases  
Provided herein are methods for treating and preventing neurodegenerative disease in a mammal by administering an inhibitor of glutaminyl cyclase (QC). Neurodegenerative diseases treatable or...
8809011 HIFα hydroxylation assay  
The present invention provides methods of identifying compounds that decrease proline hydroxylation of the alpha subunit of hypoxia inducible factor (HIFα).
8809009 Methods of diagnosing a disease and methods of monitoring treatment of a disease by quantifying a non-reducing end glycan residual compound and comparing to a second biomarker  
Provided herein are methods of diagnosing or monitoring the treatment of abnormal glycan accumulation or a disorder associated with abnormal glycan accumulation.
8802387 Methods and compounds for detecting beta-lactamase activity  
The present invention relates to compounds for and a method of detecting beta-lactamase activity in a sample. The sample is contacted with a nanoparticulate tag. The nanoparticulate tag comprises...
8802388 Detergent compositions containing Bacillus agaradhaerens mannanase and methods of use thereof  
The present compositions and methods relate to an endo-β-mannanase cloned from Bacillus agaradhaerens, polynucleotides encoding the endo-β-mannanase, and methods of use thereof. Formulations...
8796004 Method for treating systemic DNA mutation disease  
The invention is directed to treatment of systemic DNA mutation diseases accompanied with development of somatic mosaicism and elevation of blood extracellular DNA. The inventive method comprises...
8795979 Hydrolase enzyme substrates and uses thereof  
The present invention provides novel methods for determining the presence or amount of a hydrolytic enzyme in a sample, based on novel substrates for the enzymes, and also provides compositions...