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9034391 Compositions with enhanced bioavailability and fast acting inhibitor or gastric acid secretion  
The present invention relates to the use of pharmaceutically acceptable zinc salts, preferably water soluble zinc salts alone or optionally, in combination with one or more of a protein pump...
9023344 Method of treating toxemia  
A therapeutic agent for the treatment of toxemia, preeclampsia and eclampsia and a method for preparing the therapeutic agent are disclosed. The therapeutic agent is a stable pharmaceutical...
9017665 Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same  
A therapeutic agent for the treatment of the symptoms of addiction and the method for preparing the therapeutic agent is disclosed. The therapeutic agent is a stable pharmaceutical preparation...
9017667 Dosage forms that facilitate rapid activation of barley protease zymogen  
The therapeutic efficacy of zymogen proteins for oral administration is improved by including in the formulation one or more excipients that optimize pH and other reaction conditions for rapid...
8980254 Formulation for oral administration of proteins  
Pharmaceutical formulations of orally administered proteins can be stabilized from oxidative degradation and inactivation in the stomach and GI tract by the addition of an antioxidant.
8974802 Medicament for the treatment of cancer of the pancreas  
The invention relates to a suspension of red corpuscles encapsulating asparaginase as a medicament for treating pancreatic cancer. It in particular concerns a therapeutic composition or medicament...
8951514 Statin and omega 3 fatty acids for reduction of apolipoprotein-B levels  
A composition and a method of treatment utilizing a combination of statins (or HMG-CoA reductase inhibitors), a class of drug used to lower cholesterol levels by inhibiting the enzyme HMG-CoA...
8945602 Porous photonic crystals for drug delivery to the eye  
A minimally invasive controlled drug delivery system for delivering a particular drug or drugs to a particular location of the eye, the system including a porous film template having pores...
8895047 Combined fibrinolytic and antimicrobial catheter and uses thereof  
Implantable catheters are provided which comprise an antimicrobial agent incorporated in a coating or bulk distributed, in combination with a fibrinolytic agent incorporated in a top coating.
8889128 Use of the endoglycosidase endos for treating immunoglobulin G mediated diseases  
The invention provides use of an EndoS polypeptide, or a polynucleotide encoding an EndoS polypeptide, in the manufacture of a medicament for the treatment or prevention of a disease or condition...
8883740 Peptides, compositions, and uses thereof  
Compositions for regenerating tissue and wound repair, among other applications, are described.
8883143 Treatment of traumatic-induced migraine headache  
A method for selection and treatment of externally caused migraine headache, the method includes identifying a patient group having chronic migraine headache; determining the identified patient...
8871710 Method for inducing tissue growth, differentiation and/or regeneration by delivering a GDF-5 related precursor protein  
This invention relates to the production and use of pharmaceutical growth factor compositions with novel characteristics, e.g. improved solubility and controlled release characteristics under...
8834908 Pesticidal compositions and methods of use thereof  
A pest-combating composition including sodium lauryl sulfate and one or more of C6-12 fatty acids, preferably lauric and/or capric and/or caprylic acid, soy methyl ester, and 2-undecanone, and...
8834869 Pharmacological vitreolysis  
A method of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject comprising contacting a vitreous and/or aqueous humor with a composition comprising a...
8802729 Enzyme stabilized detergent compositions  
Biodegradable detergent compositions comprising enzymes and 1,3-propanediol are provided. The 1,3-propanediol in the composition is biologically derived and enhances the stability of the enzymes...
8796201 Enzyme treatment of foodstuffs for celiac sprue  
Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects...
8778338 Combination enzyme therapy for digestion of dietary gluten  
A combination enzyme product consisting of a glutamine specific endoprotease and a prolyl endopeptidase is provided. Both enzymes are active and stable in the stomach and can therefore be...
8715648 Method for treating obesity with anti-obesity formulations and omega 3 fatty acids for the reduction of body weight in cardiovascular disease patients (CVD) and diabetics  
Combinations of one or more anti-obesity drugs with mixtures of an omega-3 fatty acid formulation containing about 90% or more omega 3 fatty acids by weight comprised of a combination of...
8697066 Botulinum toxin compositions and methods  
Disclosed herein are methods of using extracellular matrix digesting enzymes and neurotoxins, such as a Clostridial neurotoxins, to treat various medical conditions, such as overactive bladder,...
8691213 Protein free formula  
The invention relates to the use of composition comprising free amino acids as a sole source of protein, a fatty acid source comprising long chain polyunsaturated fatty acids, a carbohydrate...
8685392 Rothia species glutamine endopeptidases and use thereof  
The invention relates to glutamine endopeptidase enzymes from Rothia spp. bacteria that are naturally associated with the oral cavity, formulations comprising the glutamine endopeptidase enzymes...
8673972 Human papilloma virus as predictor of cancer prognosis  
Methods of treating a head and neck cancer are disclosed.
8673853 Method and device for repairing the larynx, trachea and other fibrocartilaginous tissues  
Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of...
8663633 Protease screening methods and proteases identified thereby  
Methods for identifying modified proteases with modified substrate specificity or other properties are provided. The methods screen candidate and modified proteases by contacting them with a...
8658163 Compositions and use thereof for treating symptoms of preeclampsia  
A therapeutic agent for the treatment of toxemia, preeclampsia and eclampsia and a method for preparing the therapeutic agent is disclosed. The therapeutic agent is a stable pharmaceutical...
8652476 Pharmaceutical composition for treating ischemic events  
Methods and pharmaceutical compositions for treating severe ischemic events including cerebral infarction, cardiac infarction, or pulmonary embolism, comprising a thrombolytic intervention...
8632770 Glycopegylated factor IX  
The present invention provides conjugates between Factor IX and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the...
8632771 High molecular weight derivatives of vitamin K-dependent polypeptides  
Modifications of vitamin K-dependent polypeptides that lead to enhanced protein function on a weight or molar basis and/or increase of protein lifetime in the circulation are described. Both...
8586319 Recombinant ACE2 polypeptide dimer  
The present invention relates to recombinant ACE2 polypeptide, where the ACE2 polypeptide is present as a dimer. The dimer is formed specifically from glycosylated monomers and is used for...
8551467 Replenishment and enrichment of ocular surface lubrication  
An ophthalmic composition, and methods of use thereof, including for treating ocular boundary deficiency, symptoms associated therewith, or undesired condition that is associated with or causes...
8540983 Debriding composition from bromelain and methods of production thereof  
The present invention relates to a debriding composition obtained from bromelain and to methods of producing same. Particularly, the present invention relates to a debriding composition obtained...
8524220 Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria  
Bacteria which co-express protease inhibitors and protease sensitive therapeutic agents, which are surface displayed, secreted and/or released and result in their localized production and...
8524225 Use of proline specific endoproteases to hydrolyse peptides and proteins  
The present invention relates to a process for the proteolytic hydrolysis of a peptide or a polypeptide, said peptide or polypeptide comprising 4 to 40, preferably 5 to 35, amino acid residues and...
8518414 Compositions and methods of topical application and transdermal delivery of botulinum toxins with reduced non-toxin proteins  
This invention relates to novel compositions of botulinum toxin that can be applied topically for various therapeutic, aesthetic and/or cosmetic purposes. The compositions may include botulinum...
8506944 Replenishment and enrichment of ocular surface lubrication  
An ophthalmic composition, and methods of use thereof, including for treating ocular boundary deficiency, symptoms associated therewith, or undesired condition that is associated with or causes...
8486390 Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same  
A therapeutic agent for the treatment of the symptoms of addiction and the method for preparing the therapeutic agent is disclosed. The therapeutic agent is a stable pharmaceutical preparation...
8440182 Methods and compositions for treating phenylketonuria  
Provided herein are methods for treating a subject suffering from phenylketonuria by administering a phenylalanine hydroxylase (“PAH”) and/or a phenylalanine ammonia lyase (“PAL”) to the subject...
8388953 Method of increasing cathepsin B-induced cleavage of amyloid-β peptides  
The present invention provides a method of increasing cathepsin B-induced cleavage of amyloid-β (Aβ) peptide in a cell or tissue, the method generally involving contacting the cell or tissue with...
8383103 Botulinum toxin compositions and methods  
Disclosed herein are methods of using extracellular matrix digesting enzymes and neurotoxins, such as a Clostridial neurotoxins, to treat various medical conditions, such as overactive bladder,...
8367060 Pharmaceutical composition containing arazyme for the prevention of liver dysfunction  
The present invention relates to a composition and a method for the treatment of liver dysfunction which contains administration of a composition containing arazyme as an active ingredient, more...
8318158 Pharmaceutical preparation for the treatment of the symptoms of addiction and method of diagnosing same  
A therapeutic agent for the treatment of the symptoms of addiction and the method for preparing the therapeutic agent is disclosed. The therapeutic agent is a stable pharmaceutical preparation...
8309341 2-mercaptocyclopentanecarboxylic acid compounds, a process for their preparation and pharmaceutical compositions containing them  
Compounds of formula (I): wherein: R1 represents a hydrogen atom or a group of formula COR4,or R1 represents a group of formula (A): R2 represents a group of formula NR5R6, or R2 represents a...
8303944 Hepatitis C virus inhibitors  
The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such...
8293230 Transport protein which is used to introduce chemical compounds into nerve cells  
The invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum. The protein binds specifically to nerve cells...
8293213 Method and apparatus for thrombus removal using magnetic particles  
A method and system for affecting a thrombus after ischemic stroke. The method may include injecting a plurality of magnetic particles into a bloodstream and moving or distorting a thrombus formed...
8269008 Oxazolopyridine and isoxazolopyridine derivatives for use in the treatment of HIF-mediated conditions  
The present invention relates to novel compounds capable of modulating the stability and/or activity of hypoxia inducible factor (HIF) by inhibiting the activity of at least one HIF hydroxylase...
8268305 Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase  
The invention relates to methods and compositions for reducing serum levels of triacylglycerides in human subjects. In particular, the invention relates to the oral administration of an effective...
8257760 Method for the prevention or reduction of haze in beverages  
The invention relates to a method for the prevention or reduction of haze in a beverage by the addition of a prolyl-specific and/or alamine specific endoprotease and the new beverages obtainable...
8246951 Collagenolytic active enzyme containing compositions, and their use in the dental field  
The invention relates to a composition comprising at least one collagenolytic active enzyme with enzymatic activity at acidic pH for drilless enzymatic caries removal. Furthermore, the present...