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8147805 |
Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X1—Y—X2, wherein Y... |
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7862800 |
Radiopaque cyanoacrylate compositions
This invention relates to sterilized cyanoacrylate adhesive compositions with x-ray imagining capabilities, methods of making such compositions, and methods of using such compositions. |
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7666390 |
DTPA derivatives and metal complexes thereof, and radiation source and contrast agent including the metal complexes
The present invention relates to diethylenetriamine pentaacetic acid (DTPA) derivates and metal complexes thereof, and radiation sources and contrast agents including the metal complexes. More... |
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7507394 |
High viscosity embolizing compositions
Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery. |
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6962689 |
High viscosity embolizing compositions
Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter deliver. |
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6531111 |
High viscosity embolizing compositions
Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery. |
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6475466 |
Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms
Disclosed are methods for treating endoleaks arising from endovascular repair of abdominal aortic aneurysms. The disclosed methods involve the in situ sealing of endoleaks after placement of an... |
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6203779 |
Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms
Disclosed are methods for treating endoleaks arising from endovascular repair of abdominal aortic aneurysms. The disclosed methods involve the in situ sealing of endoleaks after placement of an... |
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6072069 |
Biodegradable nonionic contrast media
Novel non-ionic contrast media are provided, which fulfill the requirements for x-ray visualization media, while being biodegradable. The compounds are characterized by being... |
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6051210 |
N,N-dimethyldiatrizoic acid and its conjugates as hepatobiliary agents for X-ray CT imaging
Compounds having formulae I, II or III, or pharmaceutically acceptable salts thereof, ##STR1## wherein ##STR2## R1, R2, R3, R4, R5, R6, R7 and R8 are the same or different and are hydrogen, alkyl,... |
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RE36418 |
Contrast media comprising a non-ionic contrast agent with low levels of sodium and calcium ions
The physiological acceptability of contrast media, especially media for use in angiography, may be enhanced by inclusion of sub-plasma levels of sodium and calcium and, optionally, potassium... |
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5725840 |
Steroidal ester contrast media for x-ray and magnetic resonance imaging
The present invention relates to metabolically labile esters, and to contrast media for X-ray and magnetic resonance imaging comprising these esters. The esters have formula (I): ##STR1## in which... |
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5695742 |
Aqueous injectable formulations useful for radiodiagnosis comprising iodinated aromatic compounds used as X-ray contrast media
This invention refers to injectable aqueous formulations containing radiopaque contrast agents useful for X-ray imaging of human or animal body. This invention specially deals with injectable... |
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5693311 |
Polyiodinated compounds, process for preparing them and diagnostic compositions
A compound of the following formula II ##STR1## in which R7, R8, R'7, R'8, collectively, contain 10-24 hydroxyl groups and are selected, independently, from H, (C1 -C10)alkyl, (C1 -C10)alkyl... |
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5670136 |
2,4,6-triiodo-5-substituted-amino-isophthalate esters useful as x-ray contrast agents for medical diagnostics imaging
Compounds having the structure: ##STR1## wherein Q is ##STR2## n is an integer from 0 to 20; R1 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl; R2, R3, R4 and... |
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5587143 |
Butylene oxide-ethylene oxide block copolymer surfactants as stabilizer coatings for nanoparticle compositions
This invention provides a composition comprised of nanoparticles containing a therapeutic or diagnostic agent having a nonionic polymeric surfactant as a surface modifier adsorbed on the surface... |
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5575905 |
Iodination process
The invention provides a process for the preparation of a 2,4,6-triiodinated or 2,4,6,2',4',6'-hexaiodinated 3,5-disubstituted-aniline or 3,3'-disubstituted-5,5'-linked bisaniline, which process... |
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5550263 |
X-ray contrast agent
The present invention refers to a phospholipid-based compound, that is a phospholipid to which an X-ray contrast-giving moiety has been covalently linked, liposomes comprising said compound as... |
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5531979 |
Compositions of iodophenoxy alkanes and iodophenyl ethers and pharmaceutically acceptable clays for visualization of the gastrointestinal tract
Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodophenoxy alkanes and iodophenyl ethers as the x-ray producing agents in... |
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5451393 |
X-ray contrast compositions useful in medical imaging
An X-ray contrast composition comprising particles consisting essentially of a non-radioactive crystalline organic x-ray contrast agent having a surface modifier adsorbed on the surface thereof in... |
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5447710 |
Method of making nanoparticulate X-ray blood pool contrast agents using high molecular weight nonionic surfactants
The present invention is directed to a composition comprised of nanoparticles containing an x-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier... |
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5370861 |
Iodinated esters contrast medium and use
Water insoluble iodinated esters of formula (I), in which R1 is a substituted or unsubstituted C1-20 aliphatic, C7-20 araliphatic or C6-20 aryl group or a C1-20 heterocyclic group having one or... |
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5366722 |
Contrast media comprising a non-ionic contrast agent and sodium ions
The invention relates to improved contrast media containing non-ionic contrast agents, e.g. non-ionic iodinated X-ray contrast agents, the improvement being achieved by incorporation of sodium at... |
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5326552 |
Formulations for nanoparticulate x-ray blood pool contrast agents using high molecular weight nonionic surfactants
The present invention is directed to a composition comprised of nanoparticles containing an X-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier... |
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5312615 |
Injectable opacifying composition containing liposomes of high encapsulation capacity for X-ray examinations
Injectable aqueous composition intended for opacifying certain organs with a view to examination by X-rays. This composition is based on liposomes containing, encapsulated therein, an aqueous... |
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5312616 |
Compositions of iodobenzoic acid derivatives in film-forming materials for visualization of the gastrointestinal tract
Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal... |
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5258172 |
Iodinated aliphatic emulsions for X-ray contrast
Contrast agents comprising stable aqueous emulsions of iophendylate and their use in radiological examination of the small and large intestine after oral administration are described. |
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5242683 |
Contrast media comprising a paramagnetic agent and an iodinated agent for X-ray and MRI
There is provided a contrast medium comprising a physiologically tolerable paramagnetic metal species containing substance together with a water soluble iodinated X-ray contrast agent. The... |
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5238714 |
Efficient microcapsule preparation and method of use
The present invention relates to a method of preparing microcapsules suitable for encapsulation of therapeutic and diagnostic agents. The capsular coats are prepared from biodegradable polymers.... |
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5186922 |
Use of biodegradable microspheres labeled with imaging energy constrast materials
The invention relates to an inexpensive and easy to use method of visualizing an arterial circulation, using biodegradable microspheres which are permeated with an imaging energy absorbent... |
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4925649 |
Radioiodinated diacylglycerol analogues and methods of use
Novel iodinated and radioiodinated 1,2-diacylglycerol analogues are biological reagents for studying the effect of diacylglycerols in the activation of protein kinase C. This calcium-requiring... |
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4863714 |
Sterilization of compositions of limited stability
Methods and compositions are provided for producing sterile drug formulations, where drugs are thermolabile and pH sensitive. The method provides formulating the drug with a physiologically... |
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4735795 |
Alkylammonium complexes of diatrizoic acid as X-ray contrast agents
New X-ray contrast agents are provided which are alkylammonium complexes of diatrizoic acid having the structure ##STR1## X-ray contrast medium containing the above X-ray contrast agent and a... |
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4656224 |
Radiopaque thermoset polymer
Compositions consisting essentially of thermoset polymers prepared by copolymerizing a solution of an iodine containing, crosslinkable, unsaturated polyester resin dissolved in a vinyl monomer are... |
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4474747 |
Process for increasing the tolerance of X-ray contrast media, and contrast media obtained thereby
X-ray contrast media, for which the human body has a greater tolerance than that of contrast media comprising solely iodobenzene compounds, and an opacity of the same order of magnitude as the... |
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4328202 |
Ionic 5-C-substituted 2,4,6-triiodoisophthalic acid derivatives
Ionic compounds of the formula ##STR1## wherein X is --CONR1 R2, --CH2 NHAcyl or --CH2 OH; Y is --NR3 R4, --NHAcyl or OR5 ; R1, R2, R3 and R4 can be identical or different, and each is hydrogen,... |
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4285928 |
Contrast composition for angiography
A contrast composition for angiography comprising an emulsion containing an organic iodine compound as X-ray contrast agents and a perfluorocarbon compound having oxygen carrying ability. |
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4269819 |
2,4,6-Triiodobenzonitrile derivatives and X-ray contrast media comprising them
2,4,6-Triiodobenzonitriles of the formula ##STR1## wherein Z is a direct bond or alkylene, X is --COOH or --NR1 R2 wherein R1 is H or hydrocarbon or hydroxy-hydrocarbon and R2 is lower acyl, and Y... |
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4192859 |
Contrast media containing liposomes as carriers
X-Ray contrast media are provided containing an X-ray contrast agent such as N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-o
xopropyl)am ino]-2,4,6-triiodo-1,3-benzenedicarboxamide,... |
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4160015 |
2,4,6-Triiodobenzoic acid derivatives and their use as x-ray contrast agents
5-Gluconamido-2,4,6-triiodo-N-methylisophthalamic acid, 3-acetamido-2,4,6-triiodo-5-trishydroxymethylacetamido-benzo
ic acid, related compounds and salts and esters thereof are useful as x-ray... |
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4132731 |
Novel iodized isophthalamic acid compounds
Iodized isophthalamic acid compounds of the formula ##STR1## wherein R1 is straight-chain or branched lower hydroxyalkyl; R2 is hydroxymethyl or a lower, straight-chain or branched alkyl of at... |
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4069250 |
Substituted 2,4,6-triiodoisophthalamic acids
Certain N-[poly(hydroxyalkyl)alkyl], 2,4,6-triiodoisophthalamic acids are useful as x-ray contrast agents. A representative compound has the structure ##STR1## |
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4018783 |
Esters of metrizoic acid
The phthalide, alkyl, aralkyl, dialkylaminoalkyl and alkylcarbonyloxyalkyl esters of iothalamic acid and metrizoic acid are useful as X-ray contrast agents. |
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3953501 |
Triiodoisophthalic acid monoamino acid amides
New amino acid derivative of acylamino-5-alkylcarbamoyl-2,4,6-triiodobenzoic acids are described together with processes for their preparation and use and novel intermediates useful in preparing... |
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3953497 |
2,4,6-Triiodo-5-methoxyacetamido-N-methylisophthalamic acid and salts, acyl halides and esters thereof
2,4,6-Triiodo-5-methoxyacetamido-N-methylisophthalamic acid and salts and esters thereof are useful as x-ray contrast agents. The corresponding acyl halides are useful as intermediates. |
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3914294 |
3,5-Disubstituted-2,4,6-triiodobenzoic acids
3,5-Disubstituted-2,4,6-triiodobenzoic acids and derivatives thereof and their methods of preparation are disclosed. In addition, useful compositions containing said compounds and their methods of... |
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3912776 |
Novel hydroxy- and alkoxy-acetamidotriiodobenzoic acids
Hydroxy- and alkoxy-acetamidotriiodobenzoic acids of the formula ##EQU1## wherein R is a hydrogen atom or lower-alkyl of 1-4 carbon atoms and Ac is alkanoyl of up to 4 carbon atoms; mixtures... |
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3910989 |
N-triiodobenzyl-carbamic acid derivatives
Water-soluble salts of pharmaceutically acceptable bases with N-(2,4,6-triiodo-3-acylamino-5-carboxy-benzyl)-carbamic acid esters of the formula ##EQU1## ARE RELATIVELY NON-TOXIC, QUICKLY EXCRETED... |
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3890318 |
Derivatives of triiodo aminobenzenecarboxylic acids and the preparation thereof
Derivatives of triiodo-aminobenzene carboxylic acids having the general formula: ##SPC1## A process for their preparation and X-ray contrast agents containing them. |
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3886203 |
3-Hydroxyacyl aminomethyl-5-acylamino-2,4,6-triiodobenzoic acid salts as x-ray contrast agents
The water-soluble, physiologically tolerated sodium and alkanolamine salts of 3-hydroxyacylaminomethyl-5-acylamino-2,4,6-triiodobenzoic acids of the formula ##SPC1## Wherein R and R" are hydrogen... |