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8147805 Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications  
Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X1—Y—X2, wherein Y...
7862800 Radiopaque cyanoacrylate compositions  
This invention relates to sterilized cyanoacrylate adhesive compositions with x-ray imagining capabilities, methods of making such compositions, and methods of using such compositions.
7666390 DTPA derivatives and metal complexes thereof, and radiation source and contrast agent including the metal complexes  
The present invention relates to diethylenetriamine pentaacetic acid (DTPA) derivates and metal complexes thereof, and radiation sources and contrast agents including the metal complexes. More...
7507394 High viscosity embolizing compositions  
Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery.
6962689 High viscosity embolizing compositions  
Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter deliver.
6531111 High viscosity embolizing compositions  
Disclosed are novel compositions for embolizing blood vessels which are particularly suited for treating vascular lesions via catheter delivery.
6475466 Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms  
Disclosed are methods for treating endoleaks arising from endovascular repair of abdominal aortic aneurysms. The disclosed methods involve the in situ sealing of endoleaks after placement of an...
6203779 Methods for treating endoleaks during endovascular repair of abdominal aortic aneurysms  
Disclosed are methods for treating endoleaks arising from endovascular repair of abdominal aortic aneurysms. The disclosed methods involve the in situ sealing of endoleaks after placement of an...
6072069 Biodegradable nonionic contrast media  
Novel non-ionic contrast media are provided, which fulfill the requirements for x-ray visualization media, while being biodegradable. The compounds are characterized by being...
6051210 N,N-dimethyldiatrizoic acid and its conjugates as hepatobiliary agents for X-ray CT imaging  
Compounds having formulae I, II or III, or pharmaceutically acceptable salts thereof, ##STR1## wherein ##STR2## R1, R2, R3, R4, R5, R6, R7 and R8 are the same or different and are hydrogen, alkyl,...
RE36418 Contrast media comprising a non-ionic contrast agent with low levels of sodium and calcium ions  
The physiological acceptability of contrast media, especially media for use in angiography, may be enhanced by inclusion of sub-plasma levels of sodium and calcium and, optionally, potassium...
5725840 Steroidal ester contrast media for x-ray and magnetic resonance imaging  
The present invention relates to metabolically labile esters, and to contrast media for X-ray and magnetic resonance imaging comprising these esters. The esters have formula (I): ##STR1## in which...
5695742 Aqueous injectable formulations useful for radiodiagnosis comprising iodinated aromatic compounds used as X-ray contrast media  
This invention refers to injectable aqueous formulations containing radiopaque contrast agents useful for X-ray imaging of human or animal body. This invention specially deals with injectable...
5693311 Polyiodinated compounds, process for preparing them and diagnostic compositions  
A compound of the following formula II ##STR1## in which R7, R8, R'7, R'8, collectively, contain 10-24 hydroxyl groups and are selected, independently, from H, (C1 -C10)alkyl, (C1 -C10)alkyl...
5670136 2,4,6-triiodo-5-substituted-amino-isophthalate esters useful as x-ray contrast agents for medical diagnostics imaging  
Compounds having the structure: ##STR1## wherein Q is ##STR2## n is an integer from 0 to 20; R1 is H, alkyl, fluoroalkyl, cycloalkyl, aryl, aralkyl, alkoxyalkyl or acetamidoalkyl; R2, R3, R4 and...
5587143 Butylene oxide-ethylene oxide block copolymer surfactants as stabilizer coatings for nanoparticle compositions  
This invention provides a composition comprised of nanoparticles containing a therapeutic or diagnostic agent having a nonionic polymeric surfactant as a surface modifier adsorbed on the surface...
5575905 Iodination process  
The invention provides a process for the preparation of a 2,4,6-triiodinated or 2,4,6,2',4',6'-hexaiodinated 3,5-disubstituted-aniline or 3,3'-disubstituted-5,5'-linked bisaniline, which process...
5550263 X-ray contrast agent  
The present invention refers to a phospholipid-based compound, that is a phospholipid to which an X-ray contrast-giving moiety has been covalently linked, liposomes comprising said compound as...
5531979 Compositions of iodophenoxy alkanes and iodophenyl ethers and pharmaceutically acceptable clays for visualization of the gastrointestinal tract  
Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising iodophenoxy alkanes and iodophenyl ethers as the x-ray producing agents in...
5451393 X-ray contrast compositions useful in medical imaging  
An X-ray contrast composition comprising particles consisting essentially of a non-radioactive crystalline organic x-ray contrast agent having a surface modifier adsorbed on the surface thereof in...
5447710 Method of making nanoparticulate X-ray blood pool contrast agents using high molecular weight nonionic surfactants  
The present invention is directed to a composition comprised of nanoparticles containing an x-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier...
5370861 Iodinated esters contrast medium and use  
Water insoluble iodinated esters of formula (I), in which R1 is a substituted or unsubstituted C1-20 aliphatic, C7-20 araliphatic or C6-20 aryl group or a C1-20 heterocyclic group having one or...
5366722 Contrast media comprising a non-ionic contrast agent and sodium ions  
The invention relates to improved contrast media containing non-ionic contrast agents, e.g. non-ionic iodinated X-ray contrast agents, the improvement being achieved by incorporation of sodium at...
5326552 Formulations for nanoparticulate x-ray blood pool contrast agents using high molecular weight nonionic surfactants  
The present invention is directed to a composition comprised of nanoparticles containing an X-ray diagnostic compound, having a high molecular weight nonionic surfactant as a surface modifier...
5312615 Injectable opacifying composition containing liposomes of high encapsulation capacity for X-ray examinations  
Injectable aqueous composition intended for opacifying certain organs with a view to examination by X-rays. This composition is based on liposomes containing, encapsulated therein, an aqueous...
5312616 Compositions of iodobenzoic acid derivatives in film-forming materials for visualization of the gastrointestinal tract  
Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material capable of forming a coating on the gastrointestinal...
5258172 Iodinated aliphatic emulsions for X-ray contrast  
Contrast agents comprising stable aqueous emulsions of iophendylate and their use in radiological examination of the small and large intestine after oral administration are described.
5242683 Contrast media comprising a paramagnetic agent and an iodinated agent for X-ray and MRI  
There is provided a contrast medium comprising a physiologically tolerable paramagnetic metal species containing substance together with a water soluble iodinated X-ray contrast agent. The...
5238714 Efficient microcapsule preparation and method of use  
The present invention relates to a method of preparing microcapsules suitable for encapsulation of therapeutic and diagnostic agents. The capsular coats are prepared from biodegradable polymers....
5186922 Use of biodegradable microspheres labeled with imaging energy constrast materials  
The invention relates to an inexpensive and easy to use method of visualizing an arterial circulation, using biodegradable microspheres which are permeated with an imaging energy absorbent...
4925649 Radioiodinated diacylglycerol analogues and methods of use  
Novel iodinated and radioiodinated 1,2-diacylglycerol analogues are biological reagents for studying the effect of diacylglycerols in the activation of protein kinase C. This calcium-requiring...
4863714 Sterilization of compositions of limited stability  
Methods and compositions are provided for producing sterile drug formulations, where drugs are thermolabile and pH sensitive. The method provides formulating the drug with a physiologically...
4735795 Alkylammonium complexes of diatrizoic acid as X-ray contrast agents  
New X-ray contrast agents are provided which are alkylammonium complexes of diatrizoic acid having the structure ##STR1## X-ray contrast medium containing the above X-ray contrast agent and a...
4656224 Radiopaque thermoset polymer  
Compositions consisting essentially of thermoset polymers prepared by copolymerizing a solution of an iodine containing, crosslinkable, unsaturated polyester resin dissolved in a vinyl monomer are...
4474747 Process for increasing the tolerance of X-ray contrast media, and contrast media obtained thereby  
X-ray contrast media, for which the human body has a greater tolerance than that of contrast media comprising solely iodobenzene compounds, and an opacity of the same order of magnitude as the...
4328202 Ionic 5-C-substituted 2,4,6-triiodoisophthalic acid derivatives  
Ionic compounds of the formula ##STR1## wherein X is --CONR1 R2, --CH2 NHAcyl or --CH2 OH; Y is --NR3 R4, --NHAcyl or OR5 ; R1, R2, R3 and R4 can be identical or different, and each is hydrogen,...
4285928 Contrast composition for angiography  
A contrast composition for angiography comprising an emulsion containing an organic iodine compound as X-ray contrast agents and a perfluorocarbon compound having oxygen carrying ability.
4269819 2,4,6-Triiodobenzonitrile derivatives and X-ray contrast media comprising them  
2,4,6-Triiodobenzonitriles of the formula ##STR1## wherein Z is a direct bond or alkylene, X is --COOH or --NR1 R2 wherein R1 is H or hydrocarbon or hydroxy-hydrocarbon and R2 is lower acyl, and Y...
4192859 Contrast media containing liposomes as carriers  
X-Ray contrast media are provided containing an X-ray contrast agent such as N,N'-bis[2-hydroxy-1-(hydroxymethyl)ethyl]-5-[(2-hydroxy-1-o xopropyl)am ino]-2,4,6-triiodo-1,3-benzenedicarboxamide,...
4160015 2,4,6-Triiodobenzoic acid derivatives and their use as x-ray contrast agents  
5-Gluconamido-2,4,6-triiodo-N-methylisophthalamic acid, 3-acetamido-2,4,6-triiodo-5-trishydroxymethylacetamido-benzo ic acid, related compounds and salts and esters thereof are useful as x-ray...
4132731 Novel iodized isophthalamic acid compounds  
Iodized isophthalamic acid compounds of the formula ##STR1## wherein R1 is straight-chain or branched lower hydroxyalkyl; R2 is hydroxymethyl or a lower, straight-chain or branched alkyl of at...
4069250 Substituted 2,4,6-triiodoisophthalamic acids  
Certain N-[poly(hydroxyalkyl)alkyl], 2,4,6-triiodoisophthalamic acids are useful as x-ray contrast agents. A representative compound has the structure ##STR1##
4018783 Esters of metrizoic acid  
The phthalide, alkyl, aralkyl, dialkylaminoalkyl and alkylcarbonyloxyalkyl esters of iothalamic acid and metrizoic acid are useful as X-ray contrast agents.
3953501 Triiodoisophthalic acid monoamino acid amides  
New amino acid derivative of acylamino-5-alkylcarbamoyl-2,4,6-triiodobenzoic acids are described together with processes for their preparation and use and novel intermediates useful in preparing...
3953497 2,4,6-Triiodo-5-methoxyacetamido-N-methylisophthalamic acid and salts, acyl halides and esters thereof  
2,4,6-Triiodo-5-methoxyacetamido-N-methylisophthalamic acid and salts and esters thereof are useful as x-ray contrast agents. The corresponding acyl halides are useful as intermediates.
3914294 3,5-Disubstituted-2,4,6-triiodobenzoic acids  
3,5-Disubstituted-2,4,6-triiodobenzoic acids and derivatives thereof and their methods of preparation are disclosed. In addition, useful compositions containing said compounds and their methods of...
3912776 Novel hydroxy- and alkoxy-acetamidotriiodobenzoic acids  
Hydroxy- and alkoxy-acetamidotriiodobenzoic acids of the formula ##EQU1## wherein R is a hydrogen atom or lower-alkyl of 1-4 carbon atoms and Ac is alkanoyl of up to 4 carbon atoms; mixtures...
3910989 N-triiodobenzyl-carbamic acid derivatives  
Water-soluble salts of pharmaceutically acceptable bases with N-(2,4,6-triiodo-3-acylamino-5-carboxy-benzyl)-carbamic acid esters of the formula ##EQU1## ARE RELATIVELY NON-TOXIC, QUICKLY EXCRETED...
3890318 Derivatives of triiodo aminobenzenecarboxylic acids and the preparation thereof  
Derivatives of triiodo-aminobenzene carboxylic acids having the general formula: ##SPC1## A process for their preparation and X-ray contrast agents containing them.
3886203 3-Hydroxyacyl aminomethyl-5-acylamino-2,4,6-triiodobenzoic acid salts as x-ray contrast agents  
The water-soluble, physiologically tolerated sodium and alkanolamine salts of 3-hydroxyacylaminomethyl-5-acylamino-2,4,6-triiodobenzoic acids of the formula ##SPC1## Wherein R and R" are hydrogen...

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