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9023320 |
Method of producing a composition, composition and its use
The invention relates to a method of producing a composition comprising hyperpolarised 13C-pyruvate, the composition and its use as an imaging agent for MR imaging. |
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9017645 |
Homoglutamic acid derivatives
This invention relates to homoglutamic acid derivatives suitable for labeling or already labeled with 18F or 19F, methods of preparing such compounds, compositions comprising such compounds, kits... |
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9011913 |
Use of functionalized magnetic nanoparticles in cancer detection and treatment
The present invention provides methods of detecting a cancer cell in an individual, methods of grading a cancer, and methods of treating a cancer. The methods involve use of functionalized... |
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9005582 |
Hyperthermia therapeutic agent delivery system
A medical delivery system that enables the delivery of therapeutic agents to malignant tissue utilizing delivery agents and heating of the delivery agents thereby causing the release of the... |
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8986657 |
Methods and system for detecting soluble amyloid-β
The present invention provides methods of detecting soluble amyloid β using curcumin-derived near infrared (NIR) imaging probes. Upon interacting with soluble amyloid β, these probes undergo a... |
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8987429 |
GO-Gd-DTPA complex, preparation method thereof, and MRI contrast agent comprising the same
Disclosed herein is a GO-Gd-DTPA (gadolinium-diethylenetriamine pentaacetic-graphene oxide) complex, which is formed by an ester bond of graphene oxide (GO) and gadopentetic acid (Gd-DTPA). Since... |
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8980224 |
Method of cardiac imaging
The invention relates to a method of cardiac imaging using hyperpolarised 13C-pyruvate as MR imaging agent, which allows determination of the viability of cells in the myocardium. |
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8980225 |
Magnetic resonance imaging and/or spectroscopy contrast agents and methods of use thereof
The presently disclosed subject matter demonstrates that a spin state which has zero magnetic resonance signal, but an extremely long lifetime, can be used to store magnetization, which can then... |
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8968703 |
13C-MR detection using hyperpolarised 13C-fructose
The invention relates to a method of 13C-MR detection using an imaging medium comprising hyperpolarised 13C-fructose and to an imaging medium containing hyperpolarised 13C-fructose for use in said... |
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8969100 |
Method for detecting afferent lymph vessel inflow regions and method for identifying specific cells
Regions where metastatic cancer cells can exist are detected with high accuracy in a sentinel lymph node. Quantum dots are injected into the vicinity of a cancer in a living body, thereby... |
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8961926 |
Method of imaging localized infections
The invention relates to a method for targeting an imaging agent to cells of an animal to detect localized infections. More particularly, localized infections are detected by targeting imaging... |
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8961933 |
Process for the preparation of aqueous solutions of hyperpolarized molecules
The invention relates to a one-step process for the preparation of aqueous solutions of hyperpolarized molecules in which, in a single step, the said hyperpolarized molecules are separated from... |
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8957215 |
Heteroaryl substituted benzothiazoles
The present invention relates to novel heteroaryl substituted benzothiazole derivatives, precursors thereof, and therapeutic uses for such compounds, having the structural formula (I) below: and... |
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8951501 |
Noninvasive thermometry monitoring system
A noninvasive thermometry monitoring system for determining a temperature of tissue to which hyperthermia treatment is administered is disclosed. The monitoring system may incorporate magnetic... |
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8951500 |
13C-MR imaging or spectroscopy of cell death
The invention relates to method of 13C-MR imaging and/or 13C-MR spectroscopy of cell death using an imaging medium which comprises hyperpolarized 13C-pyruvate. |
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8936809 |
Method for treating prostate diseases based on local delivery of active substances
A method for treating prostate related diseases in a subject, the method comprising i) optionally administering to subject an initial boost dose of one or more active substances and/or prodrugs,... |
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8934959 |
Physiological pharmacokinetic analysis for combined molecular MRI and dynamic PET imaging
Magnetic resonance (MR) imaging typically has excellent spatial resolution, but relatively poor temporal resolution. In contrast, positron emission tomography (PET) typically has excellent... |
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8926947 |
Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents
Iron oxide complexes, pharmacological compositions and unit dosage thereof, and methods for their administration, of the type employing an iron oxide complex with a polyol, are disclosed. The... |
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8916132 |
Benzimidazole-derived compounds use as markers in the case of neurodegenerative diseases
Use of benzimidazole-derived compounds of formula (I) according to the following structure, wherein x is a heteroatom selected from N, S, O, P, SO, SO2 and SO3, preferably from N, S and SO3 and... |
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8911709 |
Systems and methods for assessing pulmonary gas transfer using hyperpolarized 129XE MRI
Methods and systems for assessing pulmonary gas exchange and/or alveolar-capillary barrier status include obtaining at least one MRI image and/or image data of 129Xe dissolved in the red blood... |
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8906345 |
Multimeric particles
The invention provides multimeric particle comprising metal-containing particles covalently bonded to one another by linker groups wherein at least some of said linker groups are cleavable. The... |
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8906268 |
Bimodal organ phantom and associated production method
A phantom for medical imaging instrumentation, the phantom including a first hydrogel matrix, said matrix containing additives for simulating the optical and acoustic properties of a living organ... |
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8906343 |
PAA nanoplatforms containing fluorophores and targeted moieties covalently linked and photosensitizer post-loaded
A PAA nanoparticle containing a covalently linked fluorescent dye and a post-loaded tetrapyrrolic photosensitizer. |
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8901276 |
Peptide reagents and methods for detection of colon dysplasia
The present invention is directed to peptide reagents, methods for detecting colon pre-cancer (dysplasia with non-polypoid or polypoid morphology) or cancer using the peptide reagents, and methods... |
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8894973 |
Method and system for differential diagnosis of chronic schizophrenia and chronic alcoholism
The invention is a method for the differential diagnosis of chronic schizophrenia or chronic alcoholism, by imaging the brain of a subject to detect any or all of the markers phosphocreatine... |
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8895068 |
Nanoparticle composition and associated methods thereof
A nanoparticle composition is provided, wherein the composition comprises a nanoparticulate metal oxide; and a phosphorylated polyol comprising at least two phosphate groups. The polyol comprises... |
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8894975 |
Methods of leukemia cell detection
Methods are provided for, inter alia, determining the presence of leukemia cells in a subject, determining the change or potential change in the number of leukemia cells in the subject with time,... |
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8889102 |
Neuromyelitis optica autoantibodies as a marker for neoplasia
The present invention provides for methods and materials for diagnosing and treating neuromyelitis optica (NMO). |
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8889211 |
Coating process for drug delivery balloons using heat-induced rewrap memory
A method of producing a drug coated balloon that comprises the steps of: subjecting a balloon catheter with a folded and wrapped balloon thereon to a pre-annealing step to induce a fold/wrap... |
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8889103 |
Diagnostic agent composition and associated methods thereof
A diagnostic agent composition is provided which comprises a nanoparticle composition and a pharmaceutically acceptable carrier or excipient. The nanoparticle composition comprises a... |
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8871182 |
3D nanocrystals and manufacturing methods
The invention relates to nanocrystals, containing one or more metals as defined in the specification; having a size of 2 to 200 nm; having a defined, three-dimensional polyhedral structure,... |
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8846006 |
MRI markers, delivery and extraction systems, and methods of manufacture and use thereof
Novel, non-toxic cobalt-based contrast and imaging agents for use in enhanced medical imaging modalities and processes are described, as well the manufacture of markers containing such contrast... |
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8834840 |
Magnetic resonance imaging of self-assembled biomaterial scaffolds
Compositions and/or mixtures comprising peptide amphiphile compounds comprising one or more contrast agents, as can be used in a range of magnetic resonance imaging applications. |
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8834844 |
Chemical exchange saturation transfer based MRI using reporter genes and MRI methods related thereto
Featured are a new class of reporter genes including reporter compositions as well as methods, MRI systems and MRI imaging kits related thereto. The genes according to the present invention... |
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8828357 |
Iron oxide nanoparticles as MRI contrast agents and their preparing method
Iron oxide nano contrast agents for Magnetic Resonance Imaging which have superior T2 contrast effect, and also can be used as a storage or a carrier for drugs and so on, are disclosed. The iron... |
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8815212 |
Nanocarriers for imaging and therapy applications
Nanocarriers and methods of preparation and use of nanocarriers are presented. In some embodiments, a nanocarrier composition comprises an organic liquid comprising a plurality of nanoparticles... |
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8802055 |
Use of the spin crossover complex [mx+(LY)HW]AN)Z as a magnetic resonance imaging contrast agent
A method for magnetic resonance imaging of a human or animal body includes providing a spin crossover complex having the general formula [Mx+(Ly)Hw]AN)z wherein, MX+ is a positively charged metal... |
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8795628 |
Molecular imaging of living subjects using Raman spectroscopy and labeled Raman nanoparticles
Methods of imaging a living host using Raman nanoparticles; methods of generating a true image of a living host having been administered Raman nanoparticles; methods of multiplex imaging of a... |
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8795629 |
Radio-methyl vorozole and methods for making and using the same
Radiotracer vorozole compounds for in vivo and in vitro assaying, studying and imaging cytochrome P450 aromatase enzymes in humans, animals, and tissues and methods for making and using the same... |
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8790621 |
Nanoparticles and nanoparticle compositions
The invention provides multivalent surface-crosslinked micelle (SCM) particles, crosslinked reverse micelle (CRM) particles, and methods of making and using them. The SCM particles can be used,... |
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8784772 |
Urothelial differentiation of urothelial carcinoma: a bladder cancer stem cell model
The present invention provides a method of treating cancer in a patient (e.g., a human patient) in need thereof, the method comprising administering a therapeutically effective regimen, the... |
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8785569 |
Drug carrier with chelating complex micelles and the application thereof
This invention provides Chelating Complex Micelles as a drug carrier. The Chelating Complex Micelles can load drugs without changing their structure, and therefore extend the half-life of drugs in... |
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8784800 |
Method of delivering cell therapy to a target site
A method of delivering therapy to a target site. The method includes (a) obtaining a base image of the target site, (b) injecting a dose of a mix of a therapeutic agent and a contrast agent into a... |
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8778344 |
Method of treating atopic dermatitis with antibody to zcytor17 ligand
The present invention relates to zcytor17lig polynucleotide, polypeptide and anti-zcytor17 antibody molecules. The zcytor17lig is a novel cytokine. The polypeptides may be used within methods for... |
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8778304 |
TSPO-targeting compounds and uses thereof
Translocator protein (TSPO) targeting compounds are described. Methods of making the compounds, and uses of the compounds for imaging are also described. |
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8778411 |
Heat generating nanomaterials
The present invention relates to a heat-generating composition, comprising a hetero-structure nanomaterial which comprises (a) a first material comprising at least one component selected from the... |
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8763410 |
Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media
Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer and transporting it to a receiver is provided. The methods include delivering water to a hyperpolarized... |
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8765099 |
Magnetic resonance imaging hyperpolarization of liquids or solids by light with orbital angular momentum
In magnetic resonance imaging (MRI), selected magnetic dipoles in a subject are aligned with a main magnetic field for later manipulation, and signals received after such manipulations are used to... |
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8758778 |
Polymeric nano-carriers with a linear dual response mechanism and uses thereof
The present invention features compositions in which nano-carriers are synthesized with polymers that respond to lower pH and/or ROS by being degraded. The compositions may be utilized to... |
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8758726 |
Methods and compositions for improved F-18 labeling of proteins, peptides and other molecules
The present application discloses compositions and methods of synthesis and use of 18F or 19F-labeled molecules of use in PET, SPECT and/or MR imaging. Preferably, the 18F or 19F is conjugated to... |