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8962262 Method of protein extraction from cells  
Methods for producing a protein extract from cells, such as cells containing viral proteins, are provided. In general terms, the methods involve: increasing the pH of the cells to a pH of at least...
8945531 Recombinant herpes virus and pharmaceutical composition containing the same  
A recombinant herpes virus showing high antitumor activity is provided. In particular, a recombinant herpes simplex virus that expresses an ICP6 gene under control of a tumor-specific promoter or...
8927251 Targeting of herpes simplex virus to specific receptors  
The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific binding pair members, such as receptors. Also, recombinant vectors for producing...
8911747 HSV-1 and HSV-2 vaccines and methods of use thereof  
This invention provides methods of treating, suppressing, inhibiting, reducing an incidence, reducing the pathogenesis of, ameliorating the symptoms of, or ameliorating the secondary symptoms of a...
8877211 Bovine herpes virus vaccine with multiple mutations  
A BHV-1 mutant virus has been made that incorporates into a single virus two or more deletions in one or more of three genes—glycoprotein N, glycoprotein E and Us9. Specifically, a BHV-1...
8871193 Viral vectors and their use in therapeutic methods  
The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
8871223 HSV-1 and HSV-2 vaccines and methods of use thereof  
This invention provides methods of vaccinating a subject against a Herpes Simplex Virus (HSV) infection and disorders and symptoms associated with same, and impeding, inhibiting, reducing the...
8865185 Methods of use for HSV-1 and HSV-2 vaccines  
This invention provides methods of treating, suppressing, inhibiting, reducing an incidence, reducing the pathogenesis of, ameliorating the symptoms of, or ameliorating the secondary symptoms of a...
8852610 Compositions and methods for vaccinating against HSV-2  
This invention relates to therapeutic compositions and methods for systemic immune activation which are effective for eliciting both a systemic, non-antigen specific immune response and a strong...
8852602 Immunological herpes simplex virus antigens and methods for use thereof  
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by...
8852611 Compositions and methods for vaccinating against HSV-2  
This invention relates to therapeutic compositions and methods for systemic immune activation which are effective for eliciting both a systemic, non-antigen specific immune response and a strong...
8840903 Compositions and methods for vaccinating against HSV-2  
This invention relates to therapeutic polynucleotide compositions and methods for systemic immune activation which are effective for eliciting both a systemic, non-antigen specific immune response...
8840904 Compositions and methods for vaccinating against HSV-2  
This invention relates to therapeutic polynucleotide compositions and methods for systemic immune activation which are effective for eliciting both a systemic, non-antigen specific immune response...
8834894 Compositions and methods for vaccinating against HSV-2  
This invention relates to therapeutic polynucleotide compositions and methods for systemic immune activation which are effective for eliciting both a systemic, non-antigen specific immune response...
8828408 Compositions and methods for vaccinating against HSV-2  
This invention relates to therapeutic polynucleotide compositions and methods for systemic immune activation which are effective for eliciting both a systemic, non-antigen specific immune response...
8809047 Herpes simplex virus vaccines  
The present invention is directed to Herpes simplex-2 viruses that may be used in vaccines to immunize patients against genital herpes.
8802109 Herpes simplex virus mutant ICP0  
A mutant herpesvirus that has a mutated gene that encodes a mutant infected cell protein 0 (ICP0) can be used in therapeutic methods as well as in diagnostics and research experiments. The encoded...
8790659 SlpA as a tool for recombinant protein and enzyme technology  
Disclosed are a recombinant DNA molecule encoding a fusion protein comprising a SlpA chaperone and a target polypeptide wherein human FK506 binding proteins (FKBPs) are excluded as target...
8765444 Compositions and methods using herpes simplex virus  
Provided herein are methods and compositions for use in treating HSV-related conditions and diseases.
8747856 Antigen binding fragments of an antibody for use in treating or diagnosing ocular diseases  
The present invention relates to the use of a fully human antigen binding fragment of an antibody for the manufacture of a medicament for the treatment or diagnosis of an ocular disease upon...
8680068 Herpes virus strains  
The present invention provides a herpes virus with improved oncolytic properties which comprises a gene encoding an immunomodulatory cytokine and which lacks a functional ICP34.5 gene and a...
8617564 Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response  
Herpes Simplex Virus-2 (HSV-2) infection is a major health concern. The present disclosure provides, inter alia, certain highly effective vaccines and immunogenic compositions against HSV-2. The...
8541002 Vaccine for treatment and prevention of herpes simplex virus infection  
The present invention relates to methods and compositions for the prevention and treatment of herpes virus infections. The invention provides antigenic peptides, and pharmaceutical compositions...
8530484 Method and kit for treatment/prevention of hair loss  
The method includes the steps of cleansing of the scalp sufficiently to remove material which would otherwise block antiviral medication from reaching hair follicles, heating the scalp to increase...
8470577 Viral vectors and their use in therapeutic methods  
The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
8460674 HSV-1 epitopes and methods for using same  
The invention provides HSV antigens and epitopes that are useful for the prevention and treatment of HSV infection. T-cells having specificity for antigens of the invention have demonstrated...
8361978 Use of herpes vectors for tumor therapy  
Eliciting a systemic antitumor immune response, in a patient who presents with or who is at risk of developing multiple metastatic tumors of a given cell type, entails, in one embodiment,...
8293248 Compositions and methods for vaccinating against HSV-2  
This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune...
8277818 Herpes virus strains for gene therapy  
The present invention provides a herpes virus with improved oncolytic properties which comprises a gene encoding an immunomodulatory cytokine and which lacks a functional ICP34.5 gene and a...
8263086 SlpA as a tool for recombinant protein and enzyme technology  
Disclosed are a recombinant DNA molecule encoding a fusion protein comprising a SlpA chaperone and a target polypeptide wherein human FK506 binding proteins (FKBPs) are excluded as target...
8263087 Compositions and methods for vaccinating against HSV-2  
This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune...
8257712 Virus-expressing host costimulation molecules  
An antiviral vaccine that encodes costimulation molecules for increasing immune response to the particular virus at issue is provided herein. In an illustrative embodiment, in mice lacking both...
8216564 Composite oncolytic herpes virus vectors  
Pharmaceutical compositions including a herpes simplex virus derived composite oncolytic vector are provided for the treatment of solid tumors in an individual. The HSV-derived composite oncolytic...
8197824 Rapid, efficient purification of HSV-specific T-lymphocytes and HSV antigens identified via same  
Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are...
8187610 Streptococcus equi strain  
The invention provides Streptococcus vaccine strains (e.g. S. equi which is causative of ‘strangles’) comprising the following modifications in their genomes: (i) attenuation of one or more...
8067010 Immunological herpes simplex virus antigens and methods for use thereof  
The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection. Disclosed herein are antigens and/or their constituent epitopes confirmed to be recognized by...
8067012 Treatment of melanoma using HSV mutant  
Use as an anti-cancer agent of a mutant herpes simplex virus wherein the mutant virus comprises a modification in the γ34.5 gene in the long repeat region (RL) such that the γ34.5 gene is a...
8057804 Herpes simplex virus combined subunit vaccines and methods of use thereof  
This invention provides vaccines comprising two or more recombinant Herpes Simplex Virus (HSV) proteins selected from a gD protein, a gC protein and a gE protein; and methods of impeding immune...
7964186 Viruses for the treatment of cellular proliferative disorders  
Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately...
7943144 Herpes simplex virus complex  
There is provided an HSV Complex which comprises an avirulent HSV and a targeting agent which allows the HSV particle to infect and lyse a specific targeted cell. The inventors have found a way in...
7935352 Compositions and methods for vaccinating against HSV-2  
This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune...
7914791 Vaccine  
A method for stimulating the immune response to a vaccine applied to a mammalian subject includes the step of administering to the subject an effective amount of EtxB or a molecule having...
7897146 Treatment using herpes simplex virus  
The use of Herpes Simplex Virus (HSV) in the treatment of tumour by extratumoural administration of HSV, and the use of HSV in treatment of tumour by combination therapy with a pharmaceutical...
7893083 Method of treating genital herpes  
The present invention is directed to a method of increasing the time period between outbreaks of genital herpes comprising providing an imidazoquinolinamine formulation, disposing an amount of the...
7879339 Compositions and methods for vaccinating against HSV-2  
This invention relates to a method for systemic immune activation which is effective for eliciting both a systemic, non-antigen specific immune response and a strong antigen-specific immune...
7811582 Herpes viruses for immune modulation  
An attenuated herpes virus which lacks a functional vhs gene or a functional equivalent thereof, but which has a functional UL43 gene or functional equivalent thereof, stimulates an immune...
7785605 Herpes simplex virus mutant ICP0 protein  
A mutant virus of herpes simplex virus type 1 (HSV-1) can include a mutant protein involved in replication so as to impair or inhibit replication of HSV-1. The mutant HSV-1 can have a mutation in...
7749745 Viral vectors and their use in therapeutic methods  
The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
7740871 Cancer immunotherapy with a viral antigen-defined, immunomodulator-secreting cell vaccine  
A human cell line, which lacks major histocompatibility class I (MHC-I) antigens and major histocompatibility class II (MHC-II) antigens and which has been modified to comprise and express (i) a...
7674468 Treatment of cancer using HSV mutant  
Use as an anti-cancer agent of a mutant herpes simplex virus wherein the mutant virus comprises a modification in the γ34.5 gene in the long repeat region (RL) such that the γ34.5 gene is a...

Matches 1 - 50 out of 163 1 2 3 4 >