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8974792 Internalizing erbB2 antibodies  
This invention provides novel erbB2-binding internalizing antibodies. The antibodies, designated F5 and C1, specifically bind to c-erbB2 antigen and, upon binding, are readily internalized into...
8871908 Antibodies specific for Trop-2 and their uses  
The present invention provides antibodies that specifically bind to trophoblast cell-surface antigen-2 (Trop-2). The invention further provides antibody conjugates comprising such antibodies,...
8846874 IgG Fc fragment for a drug carrier and method for the preparation thereof  
Disclosed is an IgG Fc fragment useful as a drug carrier. Also, the present invention discloses a recombinant vector expressing the IgG Fc fragment, a transformant transformed with the recombinant...
8821884 Compositions and methods using MD-2 mutants and chimeric proteins  
The invention provides compositions and methods for the targeted bacteriostatic and antibacterial agents and for treatment of sepsis caused by infectious diseases, such as bacterial and fungal...
8753641 Combination of intercalating organometallic complexes and tumor seeking biomolecules for DNA cleavage and radiotherapy  
The invention relates to molecules for treatment and diagnosis of tumors and malignancies, comprising a tumor seeking biomolecule, which is coupled to an intercalating moiety, which is capable of...
8481003 Anti-CD74 immunoconjugates and methods  
Disclosed are compositions that include anti-CD74 immunoconjugates and a therapeutic and/or diagnostic agent. Also disclosed are methods for preparing the immunoconjugates and using the...
8388973 Compositions and methods for the treatment of tumor of hematopoietic origin  
The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
8343496 Anti-CD74 immunoconjugates and methods  
Disclosed are compositions that include anti-CD74 immunoconjugates and a therapeutic and/or diagnostic agent. Also disclosed are methods for preparing the immunoconjugates and using the...
8277803 Cancerous disease modifying antibodies  
The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell...
8268317 Camptothecin-binding moiety conjugates  
The invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a...
8163291 Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses  
The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular...
8119101 Anti-CD74 immunoconjugates and methods of use  
Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more...
8114417 Recombinant protective protein from Streptococcus pneumoniae  
The present invention discloses amino acid sequences and nucleic acid sequences relating to a Streptococcus pneumoniae surface associated Pneumo Protective Protein (PPP) having a molecular weight...
8084029 Alpha-fetoprotein Immu31 antibodies and fusion proteins and methods of use thereof  
The present invention provides humanized, chimeric and human anti-alpha-fetoprotein antibodies, fusion proteins, and fragments thereof. The antibodies, fusion proteins, and fragments thereof, as...
8013128 Antibodies and related molecules that bind to PSCA proteins  
Antibodies and molecules derived therefrom that bind to novel PSCA protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is...
7914784 Anti-IGF-IR antibodies and uses thereof  
The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor IGF-IR and/or capable of specifically inhibiting the tyrosine...
7851599 Combination of an anti-ED—B fibronectin domain antibody—IL-2 fusion protein and gemcitabine  
The invention refers to the use of L19IL2 for treatment of pancreatic cancer. In another embodiment, the invention relates to a combination (i) of a fusion protein, comprising an Interleukin 2...
7846445 Methods for production of unstructured recombinant polymers and uses thereof  
The present invention provides methods of using unstructured recombinant polymers (URPs) and proteins containing one or more of the URPs. The present invention also provides microproteins, toxins...
7829064 Anti-CD74 immunoconjugates and methods  
Disclosed are compositions that include anti-CD74 immunoconjugates and a therapeutic and/or diagnostic agent. Also disclosed are methods for preparing the immunoconjugates and using the...
7811564 Prostate cancer diagnosis and treatment  
The present invention relates to novel antibodies and their use for detecting, imaging, staging, treating and monitoring of prostate cancer, and/or metastasis thereof. The present invention also...
7731978 Mutant forms of streptolysin O  
Forms of GAS25 (streptolysin O) which are not toxic but which still maintain the ability to induce protection against S. pyogenes are useful in vaccine compositions to induce protection against S....
7670605 Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds  
The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments.
7666424 Methods of preparing and using single chain anti-tumor antibodies  
This invention provides a method for identifying cells expressing a target single chain antibody (scFv) directed against a target antigen from a collection of cells that includes cells that do not...
7615225 Methods for treating a subject having cancer by the administration of a conjugate between a variant staphylococcal entertoxin E superantigen and an antibody that binds to the 5T4 antigen  
The present invention relates to compositions and methods of use, wherein the composition comprises a conjugate of a bacterial superantigen and an antibody moiety. More particularly, the bacterial...
7601817 Antibody peg positional isomers, compositions comprising same, and use thereof  
The present invention relates to recombinant protein PEG positional isomers. More specifically, it relates to PEG positional isomers of an antibody having specificity for antigenic determinants of...
7498034 Imaging, diagnosis and treatment of disease  
The present invention relates to endothelial cell-specific genes and encoded polypeptides and materials and uses thereof in the imaging, diagnosis and treatment of conditions involving the vascu...
7491706 Artificial cpg single-stranded oligodeoxynucleotide and antiviral use thereof  
The present invention provides a series of artificial CpG-containing single-stranded oligodeoxynucleotides (ODNs), each of which is consisted of single-stranded oligodeoxynucleotide DNA molecule...
7435790 Dihydroxypropyl cysteine peptide and agent containing this peptide  
The invention relates to a S-(2,3-dihydroxypropyl)-cysteine peptide which has two long-chain fatty acids bonded in the form of esters at the dihydroxypropyl group, and which has the following...
7413739 Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds  
The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments.
7387772 Chimeric, human and humanized anti-CSAP monoclonal antibodies  
The present invention provides humanized, chimeric and human anti-CSAp antibodies and anti-CSAp antibody fusion proteins that are useful for the treatment and diagnosis of various cancers,...
7344703 Mycobacterial sulfation pathway proteins and methods of use thereof  
Novel mycobacterial sulfation pathway proteins and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid...
7320791 Monoclonal antibody for analysis and clearance of polyethylene glycol and polyethylene glycol-modified molecules  
A novel anti-polyethylene glycol monoclonal antibody and its preparation are disclosed. Such an antibody can be used for determining polyethylene glycol concentration in vitro or accelerating the...
7291673 Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds  
The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments.
7070778 Therapeutical combination against cancer  
The present invention relates to compositions and methods for treating humans and warm-blood animals suffering from cancer. More particularly, a therapeutical treatment in which a monoclonal...
6977075 Photosensitizer conjugates for targeting intracellular pathogens  
The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention...
6974580 Mycobacterial sulfation pathway proteins and methods of use thereof  
Novel mycobacterial sulfation pathway proteins and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptide and nucleic acid...
6806253 Immunodulatory complex and use thereof in helicobacter diseases  
A therapeutical vaccine complex having activity specific for Helicobacter bacteria as well as non-specific immunomodulation activity for regulating the natural defenses of the body. The drug is...
6756037 Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups  
The present invention is directed to polymer conjugates of biologically active agents and methods of preparing the same. In preferred aspects of the invention, the conjugates are of the formula...
6737057 Compounds, compositions and methods for the endocytic presentation of immunosuppressive factors  
Immunomodulating agents comprising at least one Fc receptor ligand and at least one immunosuppressive factor are provided as are methods for their manufacture and use. The immunomodulating agents...
6660267 Prevention and treatment of sepsis  
Compositions and methods are described for preventing and treating sepsis in humans and animals. Surgical patients, low birth weight infants, and burn and trauma victims can be treated...
6610298 Photosensitzer conjugates for targeting intracellular pathogens  
The methods of the invention can be used to treat mycobacterial infections, or any disease or disorder that is caused by (or aggravated by) an intracellular pathogen. Accordingly, the invention...
6573242 Dihydroxypropyl cysteine peptide and agent containing this peptide  
The invention relates to a S-(2,3-dihydroxypropyl)-cysteine peptide which has two long-chain fatty acids bonded in the form of esters at the dihydroxypropyl group, and which has the following...
6562801 PpGpp and pppGpp as immunomodulatory agents  
The present invention relates generally to the fields of immunopreventive therapy and vaccine development. More particularly, it concerns compositions and methods of use of the bacterial...
RE38008 Methods for improved targeting of antibody, antibody fragments, hormones and other targeting agents, and conjugates thereof  
Methods for improved targeting of antibody, antibody fragments, peptides hormones, steroid hormones and conjugates thereof are disclosed. Enhanced delivery to target cells of antibodies or...
6524823 Vasopermeability-enhancing conjugates  
Liposomal conjugates having a clinically useful delivery vehicle linked to a biologically active species which acts to increase vascular permeability and expand blood volume at or in proximity to...
6440408 Method of treatment  
A method of producing active immunity against a bacterial or protozoal disease in a subject comprises administering to the subject a vaccine conjugate comprising a live bacteria or protozoa and a...
6218371 Methods and products for stimulating the immune system using immunotherapeutic oligonucleotides and cytokines  
The present invention relates to synergistic combinations of immunostimulatory CpG oligonucleotides and immunopotentiating cytokines. In particular, the invention relates to methods of stimulating...
6099846 Enhancement of B cell lymphoma and tumor resistance using idiotype/cytokine conjugates  
B cell lymphoma tumor-associated antigen or a fragment thereof containing an epitope are linked to an immune-enhancing cytokine, such as GM-CSF, IL-2, or IL-4 to form an immuno-complex. This...
6093399 Methods and compositions for the specific coagulation of vasculature  
Disclosed are various compositions and methods for use in achieving specific blood coagulation. This is exemplified by the specific in vivo coagulation of tumor vasculature, causing tumor...
6051230 Compositions for targeting the vasculature of solid tumors  
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunological- and growth factor-based reagents. In particular aspects,...
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