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9040018 Monoclonal antibodies against alpha-actinin-4 antigens, and uses therefor  
Monoclonal antibodies (MoAbs or mAbs) specific for ALPHA-ACTININ-4 antigens, hybridoma lines that secrete these ALPHA-ACTININ-4 mAbs, and the use of such mAbs to detect ALPHA-ACTININ-4 antigens,...
9034254 Titanium oxide immobilized with bioreceptors and antibacterial method using the same  
Disclosed is an antibacterial composition comprising titanium oxide particles immobilized with an antibody having affinity and cognitive power to a microorganism of interest, and a method for...
9034334 Protofibril selective antibodies and the use thereof  
The invention relates to an isolated antibody, or fragment thereof, having high affinity for human Aβ protofibrils. The invention further relates to compositions that include the antibody, or a...
9028798 Modulation of the immune response  
Methods for identifying compounds that modulate the generation of regulatory T cells (Treg) in vivo and in vitro, i.e., compounds that act on the transcription factors that increase or decrease...
9012372 Method and means for identifying substances which inhibit IgE production  
The invention relates to the field of biomedical and pharmacological research, in particular to the area of immunology, allergies and autoimmune diseases. The inventors have shown that SWAP-70 is...
9005574 Proteins with high immunoreactivity and method for their production  
The invention relates to (glyco-) proteins, in particular monoclonal antibodies, which have an immunoreactivity of >81%, preferably >90%. The inventive monoclonal antibodies are produced using a...
8999289 Treatment of protein degradation disorders  
The invention relates to methods of treating protein degradation disorders, such cellular proliferative disorders (e.g., cancer) and protein deposition disorders (e.g., neurodegenerative...
8961968 Human monoclonal antibodies against CD25  
Isolated human monoclonal antibodies which bind to and inhibit human CD25, and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced by a...
8951499 Trifunctional reagent for conjugation to a biomolecule  
A reagent for conjugation to a biomolecule, wherein the reagent is a single molecule with at least three functional parts and has schematic structure (I): a) wherein a trifunctional cross-linking...
8940272 Human anti-tau antibodies  
Provided are novel human tau-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies...
8932593 Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses  
The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular...
8920776 Compositions and methods for the detection diagnosis and therapy of hematological malignancies  
Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas....
8911732 Anti-mesothelin antibodies and immunoconjugates  
The invention provides anti-mesothelin antibodies and immunoconjugates and methods of using the same.
8906342 Compositions against cancer antigen LIV-1 and uses thereof  
Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.
8865122 Methods and compositions for protein labelling  
A modular platform is provided for rapid preparation of various water-soluble prosthetic groups capable to efficiently introduce 18F into proteins with 18F labelling reagents.
8852551 Methods to impair hematologic cancer progenitor cells and compounds related thereto  
Primitive or progenitor hematologic cancer cells have been implicated in the early stages and development of leukemia and malignant lymphoproliferative disorders, including acute myelogenous...
8852552 Agents and methods for visualizing analytes  
Provided herein are novel compounds based on xanthene, for example biarsenical compounds, which are useful as molecular probes. The compounds contain at least one isotope atom, such as a...
8846005 APCDD1 inhibitors for treating, diagnosing or detecting cancer  
The invention provides, inter alia, methods for methods for treating cancer, compositions for treating cancer, and methods and compositions for diagnosing and/or detecting cancer. In particular,...
8808665 In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents  
The present application discloses compositions and methods of synthesis and use involving click chemistry reactions for in vivo or in vitro formation of therapeutic and/or diagnostic complexes....
8784772 Urothelial differentiation of urothelial carcinoma: a bladder cancer stem cell model  
The present invention provides a method of treating cancer in a patient (e.g., a human patient) in need thereof, the method comprising administering a therapeutically effective regimen, the...
8784819 Influenza hemagglutinin antibodies, compositions and related methods  
Antibodies against influenza hemagglutinin, compositions containing the antibodies, and methods of using the antibodies are provided herein.
8784776 Use of FSH receptor ligands for diagnosis and therapy of cancer  
The present invention relates to diagnostic imaging and in particular to the diagnostic imaging and therapy of cancer by means of compositions which specifically target the FSH Receptor expressed...
8758723 Compositions and methods for cellular imaging and therapy  
The present invention relates generally to the fields of chemistry and radionuclide imaging. More particularly, it concerns compositions, kits and methods for imaging and therapy involving N4...
8759297 Genetically encoded multifunctional compositions bidirectionally transported between peripheral blood and the cns  
Provided herein are compositions for increasing transport of agents across the blood-brain barrier, in some embodiments in both directions, while allowing their activity once across the barrier to...
8753610 Methods for diagnosing CNS disorders with fusion antibodies that cross the blood-brain barrier in both directions  
The invention provides diagnostic and therapeutic macromolecular compositions that cross the blood-brain barrier, in some embodiments in both directions, while allowing their activity to remain...
8728477 Nucleotide and protein sequences of an antibody directed against an epitope common to human acidic and basic ferritins, monoclonal antibodies or antibody-like molecules comprising these sequences and uses thereof  
The present invention is directed to monoclonal, chimeric or humanized, antibodies or antibody-like molecules that recognize an epitope common to human acidic and basic isoferritins. The...
8715619 Compositions and methods for treating haematological proliferative disorders of myeloid origin  
The disclosure relates to methods and compositions effective in the diagnosis, prognosis and treatment of human hematopoietic cancers. In particular, the disclosure provides tumor-associated genes...
8663598 Anti-human transferrin receptor antibody and uses thereof  
One embodiment of the disclosure provides an amino sequence of an anti-human transferrin receptor antibody, including: an amino sequence of a heavy chain variable region which is represented by...
8647636 Low antigen-dose immunization utilizing overlapping peptides for maximizing T-helper cell 1 (Th1) immunity against a pathogen  
Disclosed are compositions, kits, and methods for inducing an immune response against disease. The dosage of antigen contained or utilized in the presently disclosed compositions, kits, and...
8636981 Detection of amyloid deposits using anti-amyloid antibodies  
Methods useful for effecting prophylaxis or treatment of amyloidosis, including AA Amyloidosis and AL amyloidosis, by administering peptides comprising neoepitopes, such as AA fragments from a...
8628749 Radioimmunoconjugates and uses thereof  
The present invention relates to a radioimmunoconjugate that binds human CD37. Pharmaceutical compositions and uses thereof for the treatment of cancer—and in particular B-cell malignancies—are...
8623349 Systems, methods and microrganisms for antibody production with type III secretion system  
Exemplary embodiments disclosed herein include a microorganism that produces, secretes and injects recombinant antibodies into eukaryote cells said the described microorganisms can be used to...
8623328 Use of DKK-1 protein in the cancer diagnosis  
Use of DKK-1 protein or the nucleic acid sequence in preparation of cancer diagnostic agents or kits, method to detect liver cancer with the monoclonal antibody thereof, the kit comprising...
8613929 Methods and compositions for targeting agents into and across the blood-brain barrier and other endothelial cell microvascular barriers  
The present invention relates to nucleic acids and polypeptides encoded thereby, whose expression is modulated in brain microvascular endothelial cells undergoing early dynamic...
8591863 Compositions against cancer antigen LIV-1 and uses thereof  
Described herein are methods and compositions that can be used for diagnosis and treatment of cancer.
8568723 Method of reducing pruritis using IL-31 monoclonal antibodies  
The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced delayed type cutaneous allergic reactions,...
8545850 Anti-CD79B antibodies and immunoconjugates and methods of use  
The present invention is directed to compositions of matter comprising immunoconjugates comprising an anti-CD79b antibody comprising: (i) an HVR-L1 sequence of KASQSVDYEGDSFLN (SEQ ID NO: 194),...
8512675 N and/or Nα derivatized, metal and organic protected L-histidine for coupling to biomolecules for highly efficient labeling with [M(OH2)3 (CO)3]+ by fac coordination  
The present invention relates to novel histidine derivates that can be used for the labeling of biomolecules with radioactive metal tricarbonyls. The new derivatives have a histidine that is...
8512754 Stabilized products, processes and devices for preparing the same  
A composition comprising a glassified, stabilized particle preparation having a low water activity (between about 0.1 and 0.9) is provided. The preparations provide improved products with enhanced...
8512704 Tmem27 antibody  
The present invention relates to an antibody directed to a beta cell marker protein, in particular to an antibody directed to the protein TMEM27.
8496912 In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents  
The present application discloses compositions and methods of synthesis and use involving click chemistry reactions for in vivo or in vitro formation of therapeutic and/or diagnostic complexes....
8486409 Alpha-emitting constructs and uses thereof  
The present invention discloses alpha particle emitting, radioactive constructs capable of killing large tumors (>1 mm in diameter), or other cells involved in human or animal diseases such as...
8475763 Method of determining the course of treatment for a patient having adenocarcinoma  
A method for detecting antigen associated with adenocarcinoma commences by forming a 124I conjugate of a preferential locator, such as an antibody, and introducing the conjugate into a patient...
8463365 Method for imaging and treating organs and tissues  
The present invention provides methods and compositions for detecting and treating malignant tissue, organs or cells in a mammal. The method includes parenterally injecting a mammalian subject, at...
8440167 Multimodal imaging of atherosclerotic plaque targeted to LOX-1  
The present invention provides multiple modalities for detecting LOX-1. More particularly, an imaging composition is provided that allows for the in vivo imaging of atherosclerotic plaque.
8435488 Methods and compositions for protein labelling  
A modular platform is provided for rapid preparation of various water-soluble prosthetic groups capable to efficiently introduce 18F into proteins with 18F labelling reagents.
8425876 Gene encoding a multidrug resistance human P-glycoprotein homologue on chromosome 7P15-21 and uses thereof  
The invention relates to an MDR family P-glycoprotein located on human chromosome 7p15-21, polynucleotide sequences encoding this P-glycoprotein and fragments thereof. This gene is utilized in...
8398956 In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents  
The present application discloses compositions and methods of synthesis and use involving click chemistry reactions for in vivo or in vitro formation of therapeutic and/or diagnostic complexes....
8383081 Anti-CD74 immunoconjugates and methods of use  
Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more...
8383083 Polymer precursors of radiolabeled compounds, and methods of making and using the same  
One aspect of the present invention relates to novel compounds that can be used to prepare radiolabeled compounds in an effective manner. A second aspect of the present invention relates to a...