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8961949 Polymer-metal complex composite having MRI contrast ability and MRI contrasting and/or antitumor composition using the same  
The present invention provides a polymer-metal complex composite, which comprises a block copolymer capable of serving as a constituent member of a polymeric micelle and a metal complex having MRI...
8945510 Radiolabeled glutaminyl cyclase (QC) inhibitors and uses of same  
Radiolabeled glutaminylcyclase (QC) inhibitors as imaging agents, in particular, but not exclusively, as medical imaging agents for the detection of neurological disorders; and pharmaceutical...
8852550 Chelator conjugates  
The present invention relates to improved chelator conjugates with biological targeting molecules, suitable for forming metal complexes with radiometals. The radiometal complexes, especially with...
8808664 Lipidated glycoprotein particles and methods of use  
Lipidated micro- or macroparticles are prepared by covalently linking a glycoprotein, typically collagen, with at least one lipid. An amino group in the glycoprotein is joined with a primary amine...
8691280 Microsphere comprising an organic lanthanide metal complex  
The invention provides a microsphere comprising an organic lanthanide metal complex wherein the lanthanide metal is present in an amount of more than 20 wt %, based on total microsphere. The...
8668898 Low radiocarbon dietary supplements and foods and methods of making and using same  
Methods and compositions for effectively lowering the carbon-14 content, particularly of DNA and histones in vertebrates, especially humans, to significantly below normal background levels and...
8623322 Non-invasive diagnostic agents and methods of diagnosing infectious disease  
The present invention is directed to novel non-invasive diagnostic tools to diagnose numerous infectious disease states or conditions. The present invention represents a clear advance in the art...
8613904 Methods for diagnosis and intervention of hepatic disorders  
The present disclosure concerns methods of administering and detecting a distinguishable agent in a sample from and assessing the condition of an organ in a subject. In a particular embodiment,...
8551447 Bifunctional compound with monosaccharide and N2S2 ligand, and preparation and use thereof  
A bifunctional compound with a monosaccharide and a N2S2 ligand, and more particularly, a bifunctional compound with a N2S2 ligand and aminohexylacetyl galactosamine (ah-GalNAc4) is provided. A...
8535639 Trifunctional imaging agent for monoclonal antibody tumor-targeted imaging  
The present invention relates to trifunctional imaging agents that include an antibody for cell targeting, as well as a chelating moiety for sequestering radioisotopes and a fluorescing moiety for...
8440167 Multimodal imaging of atherosclerotic plaque targeted to LOX-1  
The present invention provides multiple modalities for detecting LOX-1. More particularly, an imaging composition is provided that allows for the in vivo imaging of atherosclerotic plaque.
8435539 Delivery system for cytotoxic drugs by bispecific antibody pretargeting  
The present invention relates to methods and compositions for pretargeting delivery of therapeutic agents. In preferred embodiments, the pretargeting method comprises: a) administering a...
8435489 Non-invasive diagnostic agents of cancer and methods of diagnosing cancer, especially leukemia and lymphoma  
The present invention is directed to novel non-invasive diagnostic tools to image cancers, especially, leukemia and non-Hodgkin's lymphomas (NHL) with minimal toxicity in vivo. The present...
8372379 Technetium-99m (I) tricarbonyl complexes with tridentate chelators for myocardium imaging  
Chelators of the formulae (I), (II) and (III) and tricarbonyl complexes of radioisotopes of Tc and Re bound to them, for use in myocardial imaging.
8337810 Stabilized compositions and methods for radiolabeling pharmaceuticals with alpha-particle emitters  
Oxidants (e.g., N-chlorosuccinimide) can be used to stabilize α-particle emitters (e.g., 211 At) in solution, prior to their subsequent reaction to form α-particle emitter labeled compounds (e.g.,...
8147805 Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications  
Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X1—Y—X2, wherein Y...
8092779 Post-biopsy cavity treatment implants and methods  
A post-biopsy cavity treatment implant includes a radiopaque element, a core portion and a shell portion. The core portion is coupled to the radiopaque element, and includes a first porous matrix...
RE42748 Oral DTPA for radionuclide chelation  
A composition for oral radionuclide chelation therapy comprises a DTPA chelate selected from Zn-DTPA and Ca-DTPA and a permeation enhancer that preferentially increases jejunal uptake of the DTPA...
8012455 Radioactive source materials formable into various shapes  
The present invention provides an integral source material, the integral source material has at least one nuclide that is an integral source material having at least one nuclide that is...
7863047 Intracorporeal medicaments for photodynamic treatment of disease  
New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein...
7811550 Method for making magnetic fluorescent core shell nanoparticles  
This invention comprises nanoparticles for use with biosensors. The nanoparticles have core/shell architecture. The nanoparticles can be detected by two means, magnetic and optical by virtue of...
7780948 Post biopsy cavity treatment implants and methods  
A post-biopsy cavity treatment implant includes a radiopaque element, a core portion and a shell portion. The core portion is coupled to the radiopaque element, and includes a first porous matrix...
7744852 Methods and systems for marking post biopsy cavity sites  
A method of marking a cavity in a breast for subsequent visualization may include steps of providing a device having a delivery opening, a first marker and a second marker, the first and second...
7727512 Chelating agents with lipophilic carriers  
Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the...
7668662 Patient-specific dosimetry  
A patient-specific optimally effective radiation dose for administration of a radiopharmaceutical to a patient for treatment of a disease may be established by basing the calculation of the...
7615567 Compounds and methods for promoting smoking cessation  
Compounds and methods for promoting smoking cessation. The compounds may be used to treat a variety of other conditions and disease states.
7605182 Compounds that selectively bind to membranes of apoptotic cells  
The invention relates to compounds that selectively bind to phospholipid membranes having the features of membranes of apoptotic cells, pharmaceutical compositions comprising the same and...
7601331 NIR-sensitive nanoparticle  
It is provided a Near Infrared Sensitive (NIR-sensitive) nanoparticle complex comprising a NIR-sensitive nanoparticle and surfactant(s) adsorbed on the nanoparticle, wherein the surfactant is at...
7556794 Pendant fatty acid imaging agents  
The disclosure provides pendant fatty acid compounds for use in diagnostic imaging, (particularly the cardiovascular system), as well as kits comprised of the same. The disclosure also provides...
7534452 Post-biopsy cavity treatment implants and methods  
A method of treating a cavity created by a percutaneous excisional procedure carried out through an incision includes steps of providing a post-procedure cavity implant, the post-procedure cavity...
7459145 Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring  
The present invention provides multifunctional magnetic nanoparticle probe compositions for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and...
7459142 High viscosity embolizing compositions comprising prepolymers  
Disclosed are novel high viscosity compositions for embolizing blood vessels which comprise a biocompatible prepolymer and a contrast agent, and optionally a thickening agent and/or a...
7452689 Method for rapid determination of thiopurine methyltransferase activity  
This document provides methods and materials related to rapid, quantitative determination of TPMT activity in biological samples. Also featured are compositions and kits useful for determination...
7404945 Method of evaluating pharmacological effects of medicine  
A diagnostic reagent for use in the evaluation of a pharmacological effect of a medicine containing a pharmaceutical agent including an enzyme, an enzyme inhibitor or a receptor ligand or a...
7402299 Intracorporeal medicaments for photodynamic treatment of disease  
New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein...
7396850 Pyrazole derivative as PPAR modulator  
The present invention is directed to a compound, {2-Methyl-4-[3-methyl-1-(4-trifluoromethyl-phenyl)-1H-pyrazo l-4-ylmethylsulfanyl]-phenoxy}-acetic acid and pharmaceutical uses thereof.
7396523 Radioactive transition metal-imido hetero-diphosphine complexes, their preparation and radiopharmaceutical compositions thereof  
The present invention provides radioactive metal heterocomplexes of formula (I): [(Me═N—R)L1L2]+Z (I), wherein Me, R, L1 L2 and Z− have the meanings indicated in the description. The complexes...
7384623 High energy phototherapeutic agents  
High energy phototherapeutic agents or radiosensitizer agents comprised of a halogenated xanthene, or other related agents that exhibit a preference for concentration in biologically sensitive...
7378079 Agents for imaging and diagnostic methods using them  
The present invention provides novel compounds that bind selectively to cells undergoing perturbations and alterations of the normal organization of their plasma membrane, while binding to a...
7368254 Lipid-based systems for targeting diagnostic agents  
The invention relates to targeting of diagnostic agents by use of lipid-based compositions. The invention is useful in the diagnosis of various disorders which are associated with or resulting...
7344698 Integrin targeted imaging agents  
Emulsions preferably of nanoparticles formed from high boiling liquid perfluorochemical substances, said particles coated with a lipid/surfactant coating are made specific to regions of activated...
7329400 Generator for rhenium-188  
Radioisotope generators comprising inorganic layered hydroxide composition, such as magnesium aluminates and lithium aluminates. These inorganic layered hydroxides form anion exchange materials...
7320784 Immobilized labeling compounds and methods  
The invention includes methods and compounds for labelling conjugates with metals which comprise the steps of coupling the conjugate to a support surface; introducing a complex-forming metal to...
7311655 Method for manufacturing radioactive brachytherapy source material, brachytherapy source material and encapsulated radioactive brachytherapy source  
The invention relates to a method for producing a radioactive brachytherapy source material comprising indium-114m in radioactive equilibrium with indium-114 as main radioactive isotopes. A new...
7306786 Calcium phosphate cements comprising a water-soluble contrast agent  
Methods are provided for producing flowable compositions, e.g. pastes, that set into calcium phosphate products and include a contrast agent. In the subject methods, dry reactants that include a...
7294329 Poly(vinyl acetal) coatings for implantable medical devices  
A coating for a medical device, particularly for a drug eluting stent, is described. The coating includes a polyacetal-based polymer.
7279150 Chelating agents with lipophilic carriers  
Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the...
7279149 Amino acid composition with increased blood brain barrier permeability  
An amino acid composition with improved blood brain barrier permeability comprising an amino acid polymer, wherein the amino acid comprises at least one asparagyl-4-aminobutane or...
7265199 Poly-tri-fluoro-ethoxypolyphosphazene coverings and films  
The present invention relates to an anti-thrombogenic, physically well-tolerated polymer and its use for manufacturing sheaths and films as a component of therapeutic devices for preventing...
7255850 Methods for measuring rates of reserve cholesterol transport in vivo, as an index of anti-atherogenesis  
The present invention relates to biochemical methods for determining reverse cholesterol transport. Specifically, the rates of the two arms of reverse cholesterol transport (HDL or first arm and...
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