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8702942 |
Laser doppler electrophoresis using a diffusion barrier
In one general aspect, an electrophoretic measurement method is disclosed that includes providing a vessel that holds a dispersant, providing a first electrode immersed in the dispersant, and... |
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8697004 |
Sequencing system with memory
The present teachings provide a device including a memory. According to various embodiments, the memory is readable, writable, and rewritable. The present teachings further provide processing... |
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8625094 |
DNA sequencing system
An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least... |
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8597485 |
Optical detection alignment coupling apparatus
An apparatus for aligning a capillary column with one or more excitation fibers and with one or more optical lens elements for Capillary Electrophoresis. The apparatus includes two identical... |
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8537356 |
Opto-fluidic nanoparticle detection apparatus
Provided herein are new methods and apparatus for quantitative measurement and analysis of particles, including new apparatus systems to process and detect nanoparticles in suspension. By focusing... |
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8525980 |
Body fluid detection method using surface enhanced Raman spectroscopy
This invention provides a body fluid detection method by using surface enhanced Raman spectroscopy. In this method, some biological macromolecules in body fluid samples could be separated with... |
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8525991 |
Method to measure particle mobility in solution with scattered and unscattered light
A method is disclosed for measurement of the electrophoretic mobility of particles in solution. A sample is placed in a cell containing two electrodes that apply an alternating electric field. A... |
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8467055 |
Optical measuring device
An optical measuring device includes: a light applying section configured to apply laser light to a sample flowing in a channel; and a fluorescence detecting section configured to detect... |
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8441638 |
Apparatus to measure particle mobility in solution with scattered and unscattered light
A method and apparatus are disclosed for measurement of the electrophoretic mobility of particles in solution. A sample is placed in a cell containing two electrodes that apply an alternating... |
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8404092 |
Method for the reduction of cross talk in multiplex capillary electrophoresis
The invention is a high-throughput multi-capillary system utilizing a 2-dimensional mask onto which the detection windows of the capillaries are lined up in alternating columns and rows. The image... |
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8390814 |
Interactive variable pathlength device
This disclosure relates generally to a sampling device, and more particularly, a sampling device that facilitates spectroscopic measurements with a variable path length and the necessary software... |
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8384899 |
DNA sequencing system
An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least... |
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8384898 |
DNA sequencing system
An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least... |
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8368893 |
Optical assembly and method
An optical apparatus and method comprising a light source, an array detector for area imaging and an optical cell assembly. The optical cell assembly comprises a chamber which is arranged to... |
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8268249 |
Analytical device with lightguide illumination of capillary and microgroove arrays
An analytical cell including a lightguide with a plurality of conduits filled with a migration medium. The medium, the lightguide and a surrounding medium have refractive indices selected such... |
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8262888 |
Capillary electrophoresis apparatus
There is provided a capillary electrophoresis apparatus wherein coupling efficiency of exciting irradiation light to a capillary array does not decline even if any one capillary array of two... |
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8246803 |
Capillary electrophoresis apparatus and electrophoresis method
An object of the present invention is to provide a capillary electrophoresis apparatus in which simultaneity can be ensured between sensitivity and data acquisition to decrease a pull-up signal... |
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8246806 |
Multi-capillary array electrophoresis device
An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than... |
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8233735 |
Methods and apparatus for detection of fluorescently labeled materials
Fluorescently marked targets bind to a substrate 230 synthesized with polymer sequences at known locations. The targets are detected by exposing selected regions of the substrate 230 to light from... |
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8169610 |
DNA sequencing system
An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least... |
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8163151 |
Assays for detection of Von Willebrand factor (vWF) multimers and for degradation of vWF by agents such as Adamts13 and related methods
Methods of analyzing the electrophoretic mobility distribution of von Willebrand factor (vWF) multimers include providing a sample medium comprising a plurality vWF multimers. The vWF multimers... |
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8124943 |
Methods and systems for altering fluorescent intensities of a plurality of particles
A method for altering fluorescent emissions of particles includes setting the particles in motion and exposing the moving particles to light such that fluorescent intensities of the particles are... |
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8114349 |
Bio-analysis cartridge tracking and protection mechanism
A reusable bio-analysis cartridge that includes a built-in mechanism to track various parameters and usage data. The tracking mechanism includes a non-volatile rewritable memory “smart-key” that... |
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8077314 |
Measuring a characteristic of a multimode optical fiber
To measure a characteristic of a multimode optical fiber, a light pulse source produces a light pulse for transmission into the multimode optical fiber. A spatial filter passes a portion of... |
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8043493 |
Multi-capillary array electrophoresis device
An electrophoresis apparatus includes a multi-capillary array having a liquid or solid disposed between the capillaries of the array. The liquid or solid exhibits a refractive index higher than... |
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8018593 |
Integrated nucleic acid analysis
The present disclosure provides fully integrated microfluidic systems to perform nucleic acid analysis. These processes include sample collection, nucleic acid extraction and purification,... |
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8012327 |
Capillary electrophoresis apparatus and electrophoresis method
An object of the present invention is to provide a capillary electrophoresis apparatus in which simultaneity can be ensured between sensitivity and data acquisition to decrease a pull-up signal... |
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7978326 |
DNA sequencing system
An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least... |
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7929138 |
Ambient-atmosphere glow discharge for determination of elemental concentration in solutions in a high-throughput or transient fashion
An ambient atmosphere glow discharge spectrometer is disclosed having a capillary, two electrodes and a means for recording the atomic emissions. |
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7780831 |
Assays for detection of von willebrand factor (vWF) multimers and for degradation of vWF by agents such as ADAMTS13 and related methods
Methods of analyzing the electrophoretic mobility distribution of von Willebrand factor (vWF) multimers include providing a sample medium comprising a plurality vWF multimers. The vWF multimers... |
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7767468 |
Repetitive affinity separation and uses therefor
Improved methods for the separation, isolation, enrichment, or detection of target molecules, such as nucleic acids and proteins, within dilute or heterogeneous samples, such as bodily fluids,... |
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7691247 |
Optical detection alignment coupling apparatus
An apparatus for aligning a capillary column with one or more excitation fibers and with one or more optical lens elements for Capillary Electrophoresis. The apparatus includes two identical... |
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7636159 |
Time-delay integration in detection of labeled beads
An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least... |
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7636160 |
System for detecting markers
An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least... |
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7545496 |
Support with a surface structure for sensitive evanescent-field detection
A support structure, such as an optical disc, is designed having surface structures formed on one or more surfaces of the support to enable formation of evanescent fields in a medium adjacent to... |
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7528398 |
Fluorescence imaging method and apparatus utilizing a fixed excitation source
An imaging section is secured to a casing, and an object is supported on an object support section, which is located within the casing. The object support section is moved within the casing in... |
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7518727 |
Multicapillary multilaser detection system
A system for detecting electromagnetic radiation from samples comprising: a plurality of sample volumes, each of said sample volumes confined within a portion of a capillary column; a plurality of... |
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7513984 |
Capillary array electrophoresis apparatus
When irradiating laser beam from the side face of the capillary array, an optical axis of the laser beam is inclined in vertical direction with respect to a plane face formed by the capillary... |
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7486396 |
Electrophoretic system with multi-notch filter and laser excitation source
Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for... |
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7468793 |
Time-delay integration in electrophoretic detection systems
An apparatus for detecting analytes in a sample is provided. The apparatus includes: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the... |
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7449097 |
Electrophoretic mobility measuring apparatus
The present invention provides an electrophoretic mobility measuring apparatus capable of conducting measurement with high sensitivity with optical attenuation reduced by incidence of light... |
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7428047 |
Time-delay integration in a flow cytometry system
An apparatus for detecting analytes in a sample is provided. The apparatus can include: a flow cytometry system including one or more detection zones; one or more irradiation sources disposed for... |
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7384781 |
Sensors for biomolecular detection and cell classification
A sensor device is provided for detecting an analyte in a sample in which an analyte is bound to a detection reagent to form a bound complex. The device comprises (a) a sample (5) comprising an... |
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7365847 |
Method and apparatus for automated excision of samples from two-dimensional electrophoresis gels
A system for automated excision of one or more samples from a sample media, including by using a device for electronically capturing one or more traits of samples in the media, using a... |
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7329333 |
Uniform laser excitation and detection in capillary array electrophoresis system and method
A capillary electrophoresis system comprises capillaries positioned in parallel to each other forming a plane. The capillaries are configured to allow samples to migrate. A light source is... |
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7298478 |
Optical detector for a particle sorting system
An optical system for acquiring fast spectra from spatially channel arrays includes a light source for producing a light beam that passes through the microfluidic chip or the channel to be... |
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7295311 |
Methods and apparatus for electrophoretic mobility determination using phase light scattering analysis
An apparatus and method are disclosed for determining electrophoretic mobility using scattering light phase analysis comprising emitting a laser light along a path and transmitting a first portion... |
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7280207 |
Time-delay integration in a flow cytometry system
An apparatus for detecting analytes in a sample is provided. The apparatus can include: a flow cytometry system including one or more detection zones; one or more irradiation sources disposed for... |
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7265833 |
Electrophoretic system with multi-notch filter and laser excitation source
Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for... |
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7262847 |
Optical assembly and method for detection of light transmission
An optical assembly comprising a light source, at least one sample vessel and a detector. The detector comprises a plurality of detector locations and the vessel comprises a wall and core of... |