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US20140310828 TARGETED MODIFICATION OF RAT GENOME  
Compositions and methods are provided for modifying a rat genomic locus of interest using a large targeting vector (LTVEC) comprising various endogenous or exogenous nucleic acid sequences as...
US20110021605 MEANS AND METHODS FOR THE SPECIFIC INHIBITION OF GENES IN CELLS AND TISSUE OF THE CNS AND/OR EYE  
Described is a method for the specific modulation of the expression of target genes in cells and/or tissues of the CNS and/or eye, wherein a composition comprising one or more doubled stranded...
US20100071079 METHODS FOR TREATING AUTOIMMUNE AND CHRONIC INFLAMMATORY CONDITIONS USING ANTAGONISTS OF CD30 OR CD30L  
The invention provides methods of treating autoimmune and chronic inflammatory conditions by administering agents that hinder the CD30/CD30L interaction, combination treatments, and methods of...
US20090035217 Truncated Fragments of Alpha-Synuclein in Lewy Body Disease  
The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of...
US20150366175 HUMANIZED IL-15 ANIMALS  
Genetically modified non-human animals comprising a humanized interleukin-15 (IL-15) gene. Cells, embryos, and non-human animals comprising a human IL-15 gene. Rodents that express humanized or...
US20130333058 Pluripotent Cells From Rat and Other Species  
Pluripotent cells are derived and maintained in a self-renewing state in serum-free culture medium comprising a MEK inhibitor, a GSK3 inhibitor and an antagonist of an FGF receptor.
US20110197290 METHODS AND MATERIALS FOR PRODUCING TRANSGENIC ARTIODACTYLS  
Swine animal models comprising a genomic disruption of an endogenous gene chosen from the group consisting of a Low-Density Lipoprotein Receptor gene LDLR, Duchene's Muscular Dystrophy (DMD) gene,...
US20080213259 Methods for Treating Autoimmune and Chronic Inflammatory Conditions Using Antagonists of CD30 or CD30L  
The invention provides methods of treating autoimmnune and chronic inflammatory conditions by administering agents that hinder the CD30/CD30L interaction, combination treatments, and methods of...
US20140182003 ANIMAL MODELS AND THERAPEUTIC MOLECULES  
The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof...
US20140072580 NOVEL TARGETS FOR TREATMENT OF HYPERCHOLESTEROLEMIA  
In certain embodiments this invention this invention pertains to the discovery that inhibition of myosin light chain interacting protein (Mylip) can mitigate one or more symptoms of...
US20120240245 Methods and compositions for detecting and treating retinal diseases  
The invention discloses multiple genes related to age-related macular degeneration (AMD) and/or phagocytosis by RPE cells of the eye, and methods and compositions for detecting and treating AMD...
US20130227717 HDAC INHIBITORS TO TREAT CHARCOT-MARIE-TOOTH DISEASE  
The present application relates to diseases in the peripheral nervous system, particularly hereditary neuropathies, most particularly, Charcot-Marie-Tooth (CMT) disease. It is shown that this...
US20110052500 TAJ in Neuronal Function  
The invention provides methods of treating diseases, disorders, injuries, or conditions involving modulating neurite outgrowth and/or survival, including CNS disorders, stroke, or spinal injury,...
US20100287630 MODELS FOR VACCINE ASSESSMENT  
The present invention is directed to methods for constructing and using in vivo and in vitro models of aspects of human immunity and, in particular, construction of a human immune system model for...
US20080260744 G PROTEIN COUPLED RECEPTORS AND USES THEREOF  
The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are...
US20150040249 Non-Human Animal Models of Depression and Methods of Use Thereof  
The disclosure provides non-human optogenetic animal models of depression. Specifically, non-human animals each expresses a light-responsive opsin in a neuron of the animal are provided. The...
US20140033334 TARGETED CELL DEATH  
The present invention provides compositions and methods for studying neuropathy. The compositions and methods provided herein are particularly useful for screening agents of therapeutic and/or...
US20120225820 PEPTIDES ASSOCIATED WITH HLA-DR MHC CLASS II MOLECULE AND INVOLVED IN RHEUMATOID ARTHRITIS  
Antigenic peptides that bind to MHC Class II molecules with the shared epitope referred to as HLA-DR molecules are disclosed. More specifically, are citrullinated antigenic peptides having an...
US20110258713 COMPOSITIONS AND METHODS FOR RE-PROGRAMMING CELLS WITHOUT GENETIC MODIFICATION  
The present inventions are directed to compositions and methods regarding the reprogramming of biological samples (such as cells) without introducing exogenous genes to the samples. In particular,...
US20110119775 HYDRAZIDE-CONTAINING CFTR INHIBITOR COMPOUNDS AND USES THEREOF  
The invention provides compositions, pharmaceutical preparations and methods for inhibition of cystic fibrosis transmembrane conductance regulator protein (CFTR) that are useful for the study and...
US20090007281 Animal Model for Assessing Copd-Related Diseases  
Methods of diagnosis, markers, and screening techniques and animal models for assessing the severity and/or progression or regression of chronic obstructive pulmonary disease (COPD) and...
US20080083041 Pre-Clinical Animal Testing Method  
Devices and methods are provided for wirelessly powering and/or communicating with implanted medical devices used for the controlled exposure and release of reservoir contents, such as drugs or...
US20130318648 DIAGNOSIS AND THERAPEUTIC EPITOPE, AND TRANSGENIC PLANT  
A method of diagnosing coeliac disease, or susceptibility to coeliac disease, in an individual comprising: (a) contacting a sample from the host with an agent selected from (i) the epitope...
US20050120398 Animal model for HCV infection  
The present invention relates to a non-transgenic, non-human animal useful as a model for protease activity and for liver damage, including steatosis.
US20090083867 Use of Antagonists of Cxcl13 or Cxcr5 for Treating Wounds of Fibrotic Diseases  
The invention provides the use of an antagonist of CXCL 13 or CXCR5 activity in the preparation of a medicament for the prevention and/or inhibition of pathological scarring; as well as the use of...
US20060053501 Method for detecting Nipah virus and method for providing immunoprotection against Henipa viruses  
The present invention provides an animal model for monitoring Nipah virus infection, a method for the quantitative detection and rapid characterization of Nipah virus RNA in a sample, a...
US20170071173 LINCRNA-DEFICIENT NON-HUMAN ANIMALS  
Genetically modified non-human animals are provided that exhibit a functional lack of one or more lncRNAs. Methods and compositions for disrupting, deleting, and/or replacing lncRNA-encoding...
US20140082758 Control and Characterization of Psychotic States  
Provided herein are methods of inducing psychosis in animals using light-responsive opsins and methods of identifying or screening compounds that may be useful in treating psychosis.
US20120073002 PREVENTION AND TREATMENT OF BLOOD COAGULATION-RELATED DISASES  
Provided herein is an animal having a persistent hypercoagulable state by implanting a cell, for example a tumor cell, in which the gene of human tissue factor is implanted to an experimental...
US20120066779 HEPATITIS C RECEPTOR PROTEIN CD81  
The present invention relates to the use of CD81 protein and polynucleic acid in the therapy and diagnosis of hepatitis C and pharmaceutical compositions, animal models and diagnostic kits for...
US20100169987 ANIMAL MODEL SIMULATING NEUROLOGIC DISEASE  
The present invention relates to the development of a pharmacological non-human animal model that associates memory loss to histopathological features found in the brain of a subject having...
US20060130161 Animal model systems for viral pathogenesis of neurodegeneration, autoimmune demyelination, and diabetes  
Provided are non-human animal model systems for viral pathogenesis of neurodegeneration, autoimmune demyelination, and autoimmune diseases such as diseases of the central nervous system, including...
US20130097717 COMPOSITIONS AND METHODS FOR RE-PROGRAMMING CELLS WITHOUT GENETIC MODIFICATION FOR TREATMENT OF CARDIOVASCULAR DISEASES  
The present inventions are directed to compositions and methods regarding the reprogramming of other cells (such as fibroblast cells) into cardiomyocytes without introducing exogenous genes to the...
US20140041063 Genetically Modified Rat Models for Obesity and Diabetes  
This invention relates to a genetically modified or chimeric rat cell whose genome comprises chromosomal alleles of an obesity-diabetes gene (especially, the Mc4r gene or Lep gene), wherein at...
US20090176773 Non-Peptidic Inhibitors of AKAP/PKA Interaction  
The invention relates to non-peptidic molecules which modulate, especially inhibit, the interaction of protein kinase A (PKA) and A kinase anchor proteins (AKAP) and to a host or target organism...
US20150052624 GENETICALLY MODIFIED RAT MODELS FOR PAIN  
This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of gene(s) or gene product(s) resulting in altered...
US20160219845 G PROTEIN COUPLED RECEPTORS AND USES THEREOF  
The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are...
US20160174532 GENETICALLY MODIFIED RAT MODELS FOR PAIN  
This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of gene(s) or gene product(s) resulting in altered...
US20140068794 R2R1/2 In Diagnosis and Therapy  
The present invention stems from the finding that two genes designated R2R1 and R2R2, play important roles in tissue development and cancer biology. In particular, the inventors have discovered...
US20110078804 Angiogenin and Amyotrophic Lateral Sclerosis  
Methods and compositions for treating neurodegenerative disorders are provided. Transgenic animal models of neurodegenerative disorders are provided. Knockout animal models of neurodegenerative...
US20090241205 METHOD FOR IDENTIFYING CRMP MODULATORS  
The present invention refers to a method for identifying a modulator of CRMP suitable for the prevention, alleviation or/and treatment of CRMP-associated diseases.
US20130227715 USE OF ENDONUCLEASES FOR INSERTING TRANSGENES INTO SAFE HARBOR LOCI  
The present invention concerns the endonucleases capable of cleaving a target sequence located in a “safe harbor loci”, i.e. a loci allowing safe expression of a transgene. The present invention...
US20100324114 Methods and kits to detect hereditary angioedema type III  
The present invention relates to a method of diagnosing hereditary angioedema type III (HAE III) or a predisposition thereto in a subject being suspected of having developed or of having a...
US20100056624 ANIMAL MODEL FOR PERIMENOPAUSE AND MENOPAUSE AND METHODS OF INDUCING OVARIAN FAILURE  
The present invention relates to an animal model for human perimenopause and menopause. Also provided by the present invention are methods of making the animal model and methods of screening using...
US20080255253 ANIMAL MODEL FOR PROSTATIC STROMAL HYPERPLASIA  
The present invention provides an animal model for prostatic stromal hyperplasia, and a method for screening for a substance effective for preventing/treating human benign prostatic hyperplasia...
US20130139273 Chronic Lymphocytic Leukemia Modeled in Mouse by Targeted miR-29 Expression  
A mouse model and uses there of for detecting, treating, characterizing, and diagnosing various diseases are described.
US20070157324 HUMAN DISEASE MODELING USING SOMATIC GENE TRANSFER  
This invention provides a system for modeling neurodegenerative and other diseases through somatic gene transfer. In addition, methods of multiple gene transfer, disease analysis and drug testing...
US20050198696 Transgenic zebra fish embryo model for hematopoiesis and lymphoproliferative disorders  
A transgenic zebrafish animal model for the study of haemopoietic cell differentiation, control, and screening of therapeutic agents.
US20160033523 PHARMACOKINETIC ANIMAL MODEL  
The present invention relates to a method of assessing pharmacokinetic properties of a variant of human serum albumin using a non-primate animal species where the native albumin of the animal...
US20100132058 Methods and materials for determining pain sensitivity and predicting and treating related disorders  
Methods of treating somatosensory disorders and modulating production of proinflammatory cytokines by administering to a subject an effective amount of a COMT modulator, ADRB2 modulator, ADRB3...

Matches 1 - 50 out of 306 1 2 3 4 5 6 7 >