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US20120204276 METHODS RELATED TO A MUTATION IN COMPLEMENT FACTOR H-RELATED PROTEIN 5 IN PATIENTS WITH GLOMERULONEPHRITIS  
The invention relates to methods of regulating complement. In particular, the inventors have identified a relationship between a particular gene, CFHR5, and irregularities in complement...
US20140047569 Methods of Treating Disorders Associated with Protein Aggregation  
The present invention relates to methods of treatment of clinical disorders associated with protein aggregation comprising administering, to a subject, an effective amount of an anti-protein...
US20130024953 Methods of Treating Disorders Associated with Protein Aggregation  
The present invention relates to methods of treatment of clinical disorders associated with protein aggregation comprising administering, to a subject, an effective amount of an anti-protein...
US20110047633 Control of Exocrine Pancreatic Function Using Bone Morphogenetic Proteins  
Methods are described for controlling exocrine pancreatic function, for reducing the level of amylase in the blood, and for treating pancreatitis in an individual comprising administering to the...
US20140237630 SCREENING METHOD  
The present invention provides a method of screening a mammal for the onset or predisposition to the onset of a neuropsychiatric disorder. More particularly, the present invention provides a...
US20140143897 EPHA4 IS A DISEASE MODIFIER IN MOTOR NEURON DISEASE  
The present application relates to the field of motor neuron diseases, most particularly to amyotrophic lateral sclerosis and spinomuscular atrophy. Provided herein are strategies to improve...
US20130219530 Leishmania Challenge Model  
The present invention provides a method for effectively and reproducibly infecting canines with Leishmania infantum using sand flies to vector the parasite. The inventive method comprises several...
US20120311729 Immunomodulatory Methods and Systems for Treatment and/or Prevention of Atherosclerosis  
Immunostimulatory methods and systems for treating or preventing atherosclerosis and/or a condition associated thereto in an individual.
US20140150124 In Vivo Reporter System  
A construct system for expressing a reporter protein, as well as a transgenic animal and a screening method employing the same, are provided. In certain embodiments, the construct system is a...
US20120180145 Tool for Studying Endothelial Haematopoietic Transition (EHT) and Epithelial-Mesenchymal Transition (EMT) Associated Events  
The present invention relates to the field of endothelial haematopoietic transition (EHT) and epithelial-mesenchymal transition (EMT) and more particularly relates to the use of fish embryo or...
US20110047631 HEAT SHOCK PROTEIN DEFICIENCIES AS MODEL SYSTEMS FOR BRAIN PATHOLOGY AND CANCER  
The invention provides non-human transgenic animals as models of neurodegenerative brain pathology, including, but not limited to, Alzheimer's disease (AD), and cancer. The non-human transgenic...
US20150082468 INVERSE PATTERNING PROCESS FOR THREE-DIMENSIONAL MULTI-COMPARTMENTAL MICRO-ORGANIZATION OF MULTIPLE CELL TYPES  
The invention features an “inverse patterning” or “Intaglio-Void/Embed-Relief Topographic (In VERT) molding” manufacturing process for generating high-resolution three-dimensional (3D)...
US20120122144 METHODS EMPLOYING INSECT MODELS FOR DETERMINING INTESTINAL ABSORPTION OF CHEMICAL COMPOUNDS  
There is provided insect screening models to determine gastrointestinal absorption of different chemical compounds in vertebrates, and in particular humans, in order to improve the compound...
US20110088103 ALLERGIC DISEASE MODEL ANIMALS  
The object of the present invention is to provide a mouse model for allergic diseases such as atopic dermatitis, and a dermatitis mouse model with impaired skin-barrier function. The present...
US20130347136 Compositions and Methods for Characterizing and Treating Muscular Dystrophy  
Compositions and methods for identifying new treatments for Facioscapulohumeral muscular dystrophy (FSHD), and uses thereof.
US20130347135 ANIMAL MODEL FOR PARKINSON'S DISEASE  
An animal model for Parkinson's disease has a disrupted Mfn2 gene in dopaminergic neurons.
US20150106961 Humanized IL-15 Animals  
Genetically modified non-human animals comprising a humanized interleukin-15 (IL-15) gene. Cells, embryos, and non-human animals comprising a human IL-15 gene. Rodents that express humanized or...
US20120159658 EXTRACELLULAR VESICLES DERIVED FROM GRAM-POSITIVE BACTERIA, AND USE THEREOF  
The present application relates to extracellular vesicles (EVs) derived from gram-positive bacteria. In detail, the present application provides animal models of disease using extracellular...
US20150026833 Mito-Ob: A Transgenic Mouse Model for Obesity  
An obese mouse model was developed by overexpressing the mitochondrial protein prohibitin (PHB) in white adipose tissue (WAT) specific manner driven by adipocyte protein 2 (aP2) promoter. These...
US20110030070 DIAGNOSIS AND TREATMENT OF AUTISM USING CD38  
The invention relates to a method for screening a pharmaceutical for treating or preventing a neurodevelopmental disorder or a psychiatric disorder accompanied by an abnormality of oxytocin system...
US20110263691 METHODS CONCERNING PPAR DELTA AND ANTAGONISTS THEREOF  
Non-human animals which overexpress PPARd or which express transgenic PPARd are useful as models for inflammatory skin conditions such as psoriasis. Test substances can be screened to assess their...
US20120252878 USE OF CATHEPSIN H  
Present invention concerns the use of Cathepsin H. Other aspects of the invention concern methods for screening pharmaceuticals, for diagnosing pain susceptibility and for the treatment of pain.
US20150250815 INDUCTION OF CHRONIC ELEVATION OF INTRAOCULAR PRESSURE WITH INTRACAMERAL CROSS-LINKING HYDROGEL  
The present invention provides a method for inducing chronic elevation of intraocular pressure in the eyes of an animal by introducing into the eyes a cross-linking hydrogel, an animal produced by...
US20130347137 Stabilized Step Function Opsin Proteins and Methods of Using the Same  
Provided herein are compositions comprising non-human animals comprising neurons expressing stabilized step function opsin proteins on neural plasma membranes and methods of using the same to...
US20140068794 R2R1/2 In Diagnosis and Therapy  
The present invention stems from the finding that two genes designated R2R1 and R2R2, play important roles in tissue development and cancer biology. In particular, the inventors have discovered...
US20120182520 Methods for Diagnosing and Treating Eye-Length Related Disorders  
The invention provides to methods for diagnosing eye-length related disorders, including myopia. The invention also provides methods for treating and limiting eye-length related disorders,...
US20140283149 In Vivo Cellular Screening Methods and Compositions for Modeling and Treating Nervous System Dysfunction  
Described herein are methods and composition for identifying agents that modulate nerve regeneration in vivo in extended third instar (ETI) Drosophila larvae. The methods include the use of ETI...
US20110289605 Animal Model for Osteoarthritis and Intervertebral Disc Disease  
Provided herein is a transgenic animal whose genome comprises a first nucleic acid sequence encoding a fusion polypeptide, wherein the fusion polypeptide comprises a Cre recombinase and a mutated...
US20110082093 Methods and compositions for treating trinucleotide repeat disorders  
Disclosed herein are methods and compositions for treating trinucleotide repeat disorders.
US20120255044 URATE TRANSPORTER, AS WELL AS METHOD AND KIT FOR EVALUATING URATE TRANSPORT-RELATED DISEASE FACTOR AND INFLAMMATION-RELATED DISEASE FACTOR, AND TEST SAMPLE AND DRUG  
A method and evaluation kit are provided, in which a high-capacity urate transporter is identified to assist in the early treatment and prevention of urate transport-related disease and...
US20150113673 CD81 AND OCLN DOUBLE TRANSGENIC MOUSE AND ITS CONSTRUCTION METHODS  
The present invention provides a CD81 and OCLN double transgenic mouse and its construction method and use. The double transgenic mouse can be used to constitute acute and chronic HCV infection in...
US20150203918 MUTATED ACVR1 FOR DIAGNOSIS AND TREATMENT OF FIBRODYPLASIA OSSIFICANS PROGRESSIVA (FOP)  
This invention is directed to mutated Activin A type I receptor proteins (ACVR1) and isolated nucleic acids encoding same. The invention also relates to the use of mutated ACVR1 in the diagnosis...
US20140011737 COMPOSITIONS AND METHODS FOR REGULATING METABOLISM  
The present invention features compositions and methods for treating and preventing a metabolic syndrome featuring the collagen triple helix repeat containing-1 (Cthrc1) protein.
US20130139273 Chronic Lymphocytic Leukemia Modeled in Mouse by Targeted miR-29 Expression  
A mouse model and uses there of for detecting, treating, characterizing, and diagnosing various diseases are described.
US20130184321 Model Mouse of Attention Deficit Hyperactivity Disorder, Method for Investigating Effects for Preventing and Alleviating Attention Disorder using the Model Mouse, and Method for Treating Attention Disorder by Suppressing T-Type Calcium Channel  
The present invention relates to an Attention deficit and hyperactivity disorder (ADHD) mouse model and a screening method for a composition for the prevention and treatment of attention deficit...
US20120198576 METHODS FOR MAKING EMBRYONIC CELLS, EMBRYOS, AND ANIMALS SENSITIZED TO STRESS  
Embodiments of the invention are based upon the discovery that exposure of cleavage-stage embryos to a stress inducer, e.g. heat shock or chemical, renders the exposed embryos more sensitive to a...
US20140082758 Control and Characterization of Psychotic States  
Provided herein are methods of inducing psychosis in animals using light-responsive opsins and methods of identifying or screening compounds that may be useful in treating psychosis.
US20110214189 G PROTEIN COUPLED RECEPTORS AND USES THEREOF  
The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are...
US20120222142 GUT FLORA-DERIVED EXTRACELLULAR VESICLES, AND METHOD FOR SEARCHING FOR A DISEASE MODEL, VACCINE, AND CANDIDATE DRUG AND FOR DIAGNOSIS USING THE SAME  
The present application relates to a composition including gut flora-derived extracellular vesicles, and to an animal disease model using same. In addition, the present application relates to a...
US20150143553 Methods And Compositions Comprising A Drosophila Model Of Amyotrophic Lateral Sclerosis  
In an aspect, the invention relates to a method of screening for a therapeutic for amyotrophic lateral sclerosis. In an aspect, the invention relates to transgenic Drosophila. In an aspect, the...
US20150052624 GENETICALLY MODIFIED RAT MODELS FOR PAIN  
This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of gene(s) or gene product(s) resulting in altered...
US20130283403 ZEBRAFISH SEIZURE MODEL, METHOD FOR ESTABLISHING THE SAME, AND METHOD FOR SCREENING ANTIEPILEPTIC DRUG USING THE SAME  
A zebrafish seizure model, a method for establishing the same, and a method for screening for antiepileptic drug using the same are disclosed. The method for establishing the zebrafish seizure...
US20140041063 Genetically Modified Rat Models for Obesity and Diabetes  
This invention relates to a genetically modified or chimeric rat cell whose genome comprises chromosomal alleles of an obesity-diabetes gene (especially, the Mc4r gene or Lep gene), wherein at...
US20150173330 MOUSE MODEL OF AMYOTROPHIC LATERAL SCLEROSIS AND/OR FRONTOTEMPORAL LOBAR DEGENERATION  
To generate an animal model exhibiting symptoms similar to those of human amyotrophic lateral sclerosis and/or human frontotemporal lobar degeneration. An animal model exhibiting symptoms similar...
US20110021605 MEANS AND METHODS FOR THE SPECIFIC INHIBITION OF GENES IN CELLS AND TISSUE OF THE CNS AND/OR EYE  
Described is a method for the specific modulation of the expression of target genes in cells and/or tissues of the CNS and/or eye, wherein a composition comprising one or more doubled stranded...
US20110033442 TARGETS, INCLUDING YAP1, FOR ANTIFUNGAL DRUG DISCOVERY AND THERAPY  
The present invention is based on the discovery of a two organism model system that can be used to identify virulence factors. The system is also useful in the process of drug delivery. More...
US20140033333 TRANSGENIC PIG FOR MUTANT GUCY2D AS CONE DYSTROPHY MODEL  
The present invention relates to a transgenic pig as a model for studying a cone affecting disease, in particular a cone dystrophy or cone-rod-dystrophy, wherein the pig model expresses a dominant...
US20130031646 MODEL SYSTEM OF ACANTHAMOEBA KERATITIS SYNDROME AND METHOD FOR SELECTING A TREATMENT THEREOF  
Methods for generating a feline model for ocular complications arising from amoeba infection are described. The invention further relates to screening methods for therapeutics for the treatment of...
US20120060230 METHODS AND COMPOSITIONS FOR MODIFICATION OF A HLA LOCUS  
Disclosed herein are methods and compositions for modulating the expression of a HLA locus or for selectively deleting or manipulating a HLA locus or HLA regulator.
US20130061339 METHOD OF DIAGNOSING TRICHOTILLOMANIA AND SIMILAR DISORDERS IN HUMANS AND RODENTS  
The present disclosure provides a method of diagnosing neurological disorders including for example, impulse control disorders, such as barbering and trichotillomania using biomarkers such as...