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US20160316730 STABILIZED STEP FUNCTION OPSIN PROTEINS AND METHODS OF USING THE SAME  
Provided herein are compositions comprising non-human animals comprising neurons expressing stabilized step function opsin proteins on neural plasma membranes and methods of using the same to...
US20160060297 COMPSTATIN AND ANALOGS THEREOF FOR EYE DISORDERS  
The present invention features the use of compstatin and complement inhibiting analogs thereof for treating and/or preventing age related macular degeneration and other conditions involving...
US20130318640 VITAMIN K EPOXIDE RECYCLING POLYPEPTIDE VKORC1, A THERAPEUTIC TARGET OF COUMARIN AND THEIR DERIVATIVES  
The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying...
US20100071079 METHODS FOR TREATING AUTOIMMUNE AND CHRONIC INFLAMMATORY CONDITIONS USING ANTAGONISTS OF CD30 OR CD30L  
The invention provides methods of treating autoimmune and chronic inflammatory conditions by administering agents that hinder the CD30/CD30L interaction, combination treatments, and methods of...
US20090035217 Truncated Fragments of Alpha-Synuclein in Lewy Body Disease  
The application identifies novel fragments of alpha-synuclein in patients with Lewy Body Disease (LBD) and transgenic animal models thereof. These diseases are characterized by aggregations of...
US20080248997 T1R HETERO-OLIGOMERIC TASTE RECEPTORS AND CELL LINES THAT EXPRESS SAID RECEPTORS AND USE THEREOF FOR IDENTIFICATION OF TASTE COMPOUNDS  
The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results...
US20080248996 T1R HETERO-OLIGOMERIC TASTE RECEPTORS AND CELL LINES THAT EXPRESS SAID RECEPTORS AND USE THEREOF FOR IDENTIFICATION OF TASTE COMPOUNDS  
The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results...
US20170164588 NON-HUMAN ANIMALS EXPRESSING HUMANIZED CD3 COMPLEX  
Non-human animals, expressing humanized CD3 proteins are provided. Non-human animals, e.g., rodents, genetically modified to comprise in their genome humanized CD3 proteins are also provided....
US20140325691 REGULATION OF ENDOGENOUS GENE EXPRESSION IN CELLS USING ZINC FINGER PROTEINS  
The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
US20120005766 Methods of identifying agents that modulate phenotypes related to disruptions, of a gene encoding PRO235 polypeptide  
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic...
US20110247087 Regulation of endogenous gene expression in cells using zinc finger proteins  
The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
US20110185439 G PROTEIN COUPLED RECEPTORS AND USES THEREOF  
The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are...
US20070148093 Non-terminal method of identifying anti-migraine compounds  
The present invention relates to in vivo non-terminal method of identifying anti-migraine compounds.
US20160282354 COMPOSITIONS AND METHODS FOR SELECTING A TREATMENT FOR B-CELL NEOPLASIAS  
The present invention features compositions and methods for identifying a subject having a B cell neoplasia or related condition responsive to treatment with lenalidomide and lenalidoinide-related...
US20120174239 Novel PRO1199 gene disruptions, and methods relating thereto  
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic...
US20110067121 Transgenic mice having a human major histocompatibility complex (MHC) phenotype, experimental uses and applications  
The present invention-relates to transgenic mice and isolated transgenic mouse cells, the mice and mouse cells comprising a disrupted H2 class I gene, a disrupted H2 class II gene, a functional...
US20100186097 CELL-BASED RNA INTERFERENCE AND RELATED METHODS AND COMPOSITIONS  
The invention provides, among other things, methods for performing RNA interference in stem cells and methods for using the stem cells in vivo.
US20100031377 Prevention and treatment of synucleinopathic and amyloidogenic disease  
The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including Lewy bodies of alpha-synuclein in the brain of a patient. Such...
US20090004237 B7-Like Molecules and Uses Thereof  
The present invention provides B7-Like (B7-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for...
US20080241131 SPHKS as modifiers of the p53 pathway and methods of use  
Human SPHK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53,...
US20080213259 Methods for Treating Autoimmune and Chronic Inflammatory Conditions Using Antagonists of CD30 or CD30L  
The invention provides methods of treating autoimmnune and chronic inflammatory conditions by administering agents that hinder the CD30/CD30L interaction, combination treatments, and methods of...
US20080032314 Use of VEGF and homologuest to treat neuron disorders  
The present invention relates to neurological and physiological dysfunction associated with neuron disorders. In particular, the invention relates to the involvement of vascular endothelial growth...
US20070204351 Direct differentiation of cardiomyocytes from human embryonic stem cells  
The present invention relates to the induction of differentiation in stem cells to cardiomyocytes and factors such as prostaglandin alone or in combination with other factors including essential...
US20110209227 METHODS FOR THE DIAGNOSIS AND TREATMENT OF BONE DISORDERS  
This invention pertains to chemometric methods for the analysis of chemical, biochemical, and biological data, for example, spectral data, for example, nuclear magnetic resonance (NMR) spectra,...
US20090136519 Tissue Protective Cytokine Receptor Complex, Assays for Identifying Tissue Protective Compounds and Uses Thereof  
The present invention is directed methods for identifying compounds that have a tissue protective activity using a heteromultimer receptor complex that mediates the tissue protective activities....
US20080260744 G PROTEIN COUPLED RECEPTORS AND USES THEREOF  
The present invention provides GPCR polypeptides and polynucleotides, recombinant materials, and transgenic mice, as well as methods for their production. The polypeptides and polynucleotides are...
US20080102070 SCDs As Modifiers of the p53 Pathway and Methods of Use  
Human SCD genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53,...
US20160106077 Transgenic Animal Expressing Alzheimer's Tau Protein  
The present invention provides transgenic non-human animals and non-human mammalian somatic and germ cells harbouring a human DNA sequence encoding Alzheimer's Disease (AD) derived tau protein,...
US20150040249 Non-Human Animal Models of Depression and Methods of Use Thereof  
The disclosure provides non-human optogenetic animal models of depression. Specifically, non-human animals each expresses a light-responsive opsin in a neuron of the animal are provided. The...
US20120233715 HUMAN ARTIFICIAL CHROMOSOME VECTOR  
A human artificial chromosome vector comprising a human antibody heavy chain gene, a human antibody light chain gene, and a human antibody surrogate light chain gene.
US20110288027 TARGETS, METHODS, AND REAGENTS FOR DIAGNOSIS AND TREATMENT OF SCHIZOPHRENIA  
The present invention provides targets, methods, and reagents for the diagnosis and treatment of schizophrenia and related conditions. The invention provides methods for the diagnosis of...
US20100281547 Selecting animals for desired genotypic or potential phenotypic properties  
Described are methods to select animals, such as mammals, particularly domestic animals, breeding animals or animals destined for slaughter, for having desired genotypic or potential phenotypic...
US20090186843 RNA sequence-specific mediators of RNA interference  
The present invention relates to a Drosophila in vitro system which was used to demonstrate that dsRNA is processed to RNA segments 21-23 nucleotides (nt) in length. Furthermore, when these 21-23...
US20080311107 Novel Gene Disruptions, Compositions and Methods Relating Thereto  
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic...
US20080244762 T1R HETERO-OLIGOMERIC TASTE RECEPTORS AND CELL LINES THAT EXPRESS SAID RECEPTORS AND USE THEREOF FOR IDENTIFICATION OF TASTE COMPOUNDS  
The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results...
US20080244761 T1R HETERO-OLIGOMERIC TASTE RECEPTORS AND CELL LINES THAT EXPRESS SAID RECEPTORS AND USE THEREOF FOR IDENTIFICATION OF TASTE COMPOUNDS  
The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results...
US20160302397 GENETICALLY MODIFIED RAT MODELS FOR SEVERE COMBINED IMMUNODEFICIENCY (SCID)  
This invention relates to the engineering of animal cells, preferably mammalian, more preferably rat, that are deficient due to the disruption of tumor suppressor gene(s) or gene product(s). In...
US20140033334 TARGETED CELL DEATH  
The present invention provides compositions and methods for studying neuropathy. The compositions and methods provided herein are particularly useful for screening agents of therapeutic and/or...
US20110061114 NOVEL PRO258 GENE DISRUPTIONS, AND METHODS RELATING THERETO  
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic...
US20090249500 SYSTEM FOR MONITORING BACTERIAL TUMOR TREATMENT  
A method to follow the progress of tumor treatment in subjects utilizes bacteria that have been modified to express a fluorescent protein. The method can also monitor expression of genes...
US20090007281 Animal Model for Assessing Copd-Related Diseases  
Methods of diagnosis, markers, and screening techniques and animal models for assessing the severity and/or progression or regression of chronic obstructive pulmonary disease (COPD) and...
US20060123487 Methods of screening agents for activity using teleosts  
The present invention provides methods of screening an agent for activity using teleosts. Methods of screening an agent for angiogenesis activity, toxic activity and an effect cell death activity...
US20160214958 COMPOUNDS AND USE FOR TREATING CANCER  
The present invention relates to certain 2,4-disubstituted quinoline derivatives, to their therapy, as well as to pharmaceutical compositions comprising said compounds. More specifically the...
US20160050895 TRANSGENIC NON-HUMAN ORGANISMS WITH NON-FUNCTIONAL TSPO GENES  
The present invention relates to transgenic animal models. Specifically, the present invention relates to transgenic animal models for applications associated with TSPO-related normal physiology,...
US20110016540 GENOME EDITING OF GENES ASSOCIATED WITH TRINUCLEOTIDE REPEAT EXPANSION DISORDERS IN ANIMALS  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with trinucleotide repeat expansion disorders....
US20090035279 GENETIC VARIANTS ON CHR 15Q24 AS MARKERS FOR USE IN DIAGNOSIS, PROGNOSIS AND TREATMENT OF EXFOLIATION SYNDROME AND GLAUCOMA  
The present invention relates to methods of diagnosing a susceptibility to an ocular disorder, including glaucoma and exfoliation syndrome. The invention provides methods of diagnosing an...
US20080300206 Alpha-Synuclein Kinase  
The invention provides agents and methods for treatment of diseases associated with Lewy body diseases (LBDs) in the brain of a patient. Preferred agents include inhibitors of PLK2 kinase.
US20080241114 Methods and compositions relating to modulation of hepatocyte growth, plasma cell differentiation or T cell subset activity by modulation of XBP-1 activity  
The invention demonstrates that the transcription factor XBP-1 is a regulator of hepatocyte growth, plasma cell differentiation and T cell subset activity. Methods for identifying modulators of...
US20120014975 MODIFIED SINGLE DOMAIN ANTIGEN BINDING MOLECULES AND USES THEREOF  
The invention relates to modified single domain antigen binding molecules, e.g., SDAB molecules, in particular TNF╬▒-binding SDAB molecules. Method of preparing, and using the modified single...
US20110016543 GENOMIC EDITING OF GENES INVOLVED IN INFLAMMATION  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding inflammation-related proteins. In particular, the animals or cells are...