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US20140115728 DOUBLE KNOCKOUT (GT/CMAH-KO) PIGS, ORGANS AND TISSUES  
The invention provides double knockout transgenic pigs (GT/CMAH-KO pigs) lacking expression of any functional αGAL and CMAH. Double knockout GT/CMAH-KO transgenic organs, tissues and cells are...
US20150135344 METHODS OF MODULATING THROMBOCYTOPENIA AND MODIFIED TRANSGENIC PIGS  
The application provides methods of modulating platelet uptake by liver sinusoidal endothelial cells and of modulating thrombocytopenia. Transgenic pigs modified to bind fewer platelets are provided.
US20130024961 Methods of Modulating Thrombocytopenia and Modified Transgenic Pigs  
The application provides methods of modulating platelet uptake by liver sinusoidal endothelial cells and of modulating thrombocytopenia. Transgenic pigs modified to bind fewer platelets are provided.
US20100333218 TRANSGENIC PROTEINS FROM MULTI-GENE SYSTEMS, METHODS, COMPOSITIONS, USES AND THE LIKE RELATING THERETO  
A non-human transgenic mammalian animal, as described above, contains one or more exogenous double stranded DNA sequence(s) stably integrated into the genome of the animal, which comprises...
US20120278910 Transgenic Pig in which HO-1 and TNFR1-Fc are Simultaneously Expressed, and Method for Producing Same  
The present invention relates to a method for producing a transgenic pig in which immune rejection response is inhibited, and in which human HO-1 genes and TNFR1-Fe fusion genes are simultaneously...
US20150106962 MINIATURE SWINE TRANSGENIC FOR ONE OR MORE COAGULATION FACTORS  
Transgenic swine that express human coagulation factors, e.g., human coagulation factor VII, and/or one or more of human coagulation factors II, X and XII, and do not express the corresponding...
US20130276156 Multiple Inducible Gene Regulation System  
The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions...
US20140096275 PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS RESISTANT ANIMALS  
The disclosure relates to genetically modified swine wherein at least one allele of a SIGLEC1 gene has been inactivated and/or at least one allele of a CD163 gene has been inactivated. Genetically...
US20110023141 GENOMIC EDITING OF GENES INVOLVED WITH PARKINSON'S DISEASE  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with Parkinson's disease. In particular, the animals or...
US20110016546 PORCINE GENOME EDITING WITH ZINC FINGER NUCLEASES  
The present invention provides a genetically modified porcine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger...
US20130024960 OPTIMISED CODING SEQUENCE AND PROMOTER  
An optimized coding sequence of human blood clotting factor eight (VIII) and a promoter may be used in vectors, such as rAAV, for introduction of factor VIII, and/or other blood clotting factors...
US20140201858 METHODS FOR SITE-SPECIFIC GENETIC MODIFICATION IN STEM CELLS USING XANTHOMONAS TAL NUCLEASES (XTN) FOR THE CREATION OF MODEL ORGANISMS  
The invention relates to organisms and compositions comprising one or more stem cells or one or more embryos, wherein the one or more stem cells or one or more embryos comprise one or more of the...
US20110283375 Transgenic Prothrombin And Related Thrombin Precursors And Transgenics, Methods, Compositions, Uses And The Like Relating Thereto  
The invention provides, among other things, activatable prothrombin, compositions comprising prothrombin, transgenic organisms for making prothrombin, methods for making the transgenic organisms,...
US20130336940 MODIFIED PIG ISLETS FOR DIABETES TREATMENT  
The present invention relates to a modified pig islet capable of producing higher levels of glucagon than a native pig islet or capable of producing a glucagon analog, and methods for obtaining...
US20120331576 Pathogen Restriction Factors  
The use of interferon induced transmembrane protein 1, 2, or 3 (IFITM1, 2, or 3) as a viral restriction factor, and methods of using the same to produce virus, transgenic animals expressing...
US20110023139 GENOMIC EDITING OF GENES INVOLVED IN CARDIOVASCULAR DISEASE  
The present invention provides genetically modified animals and cells comprising edited chromosomal involved in cardiovascular disease. In particular, the animals or cells are generated using a...
US20110023151 GENOME EDITING OF ABC TRANSPORTERS  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding ABC transporter proteins. In particular, the animals or cells are generated...
US20150017130 METHODS AND COMPOSITIONS FOR INHIBITION OF IMMUNE RESPONSES  
Methods and compositions for modulating immune responses are provided herein.
US20140351965 SWINE GENETICALLY MODIFIED WITH SPECIFICITY FOR LDL-R KNOCKOUT  
Compositions and methods for swine LDL-R gene knockouts.
US20110016543 GENOMIC EDITING OF GENES INVOLVED IN INFLAMMATION  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding inflammation-related proteins. In particular, the animals or cells are...
US20110126297 TRANSGENIC ANIMAL WITH MONOCYTE CHEMOTACTIC PROTEIN 1 PROMOTER  
The present invention relates to a transgenic animal, which comprises in its genome a recombinant polynucleotide encoding one or more reporter proteins and a monocyte chemotactic protein-1 (MCP-1)...
US20110023146 GENOMIC EDITING OF GENES INVOLVED IN SECRETASE-ASSOCIATED DISORDERS  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with a secretase disorder. In particular, the...
US20130219533 PLA2G16 AS A TARGET FOR ANTIVIRAL COMPOUNDS  
In some aspects, the invention provides compositions and methods for inhibiting viral infection. In some aspects, the invention provides compositions and methods useful for identifying antiviral...
US20150150153 ARTIFICIAL OOCYTE ACTIVATION  
The present invention provides novel methods for improving the efficiency of artificial activation of unfertilized mammalian oocytes by reducing the intracellular concentration of Zn2+ in the...
US20130191931 FUMARYLACETOACETATE HYDROLASE (FAH)-DEFICIENT PIGS AND USES THEREOF  
Described herein is the generation of Fah+/− heterozygote pigs by homologous recombination and somatic cell nuclear transfer, and a method for producing Fah−/− homozygote pigs. The Fah-deficient...
US20110023145 GENOMIC EDITING OF GENES INVOLVED IN AUTISM SPECTRUM DISORDERS  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with ASD. In particular, the animals or cells are...
US20110023153 GENOMIC EDITING OF GENES INVOLVED IN ALZHEIMER'S DISEASE  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with AD. In particular, the animals or cells are...
US20120233713 METHODS AND SYSTEMS FOR INDUCIBLE ABLATION OF NEURAL CELLS  
The present invention relates to methods and systems for inducible ablation of neural cells, in particular non-proliferating cells, such as oligodendrocytes and Schwann cells. The methods and...
US20140304846 GENE AND MUTATIONS THEREOF ASSOCIATED WITH SEIZURE AND MOVEMENT DISORDERS  
The present invention relates to the proline rich transmembrane protein 2 (PRRT2) gene, and the identification of mutations and variations in PRRT2 that give rise to seizure and movement...
US20120167239 Novel ecdysone receptor/invertebrate retinoid X receptor-based inducible gene expression system  
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a...
US20070067860 Novel culture systems for ex vivo development  
The present invention provides methods for the culture of animal pluripotent stem cells and their differentiated progeny cells, tissues, and organs, and nonhuman animal embryos and fetuses.
US20110016540 GENOME EDITING OF GENES ASSOCIATED WITH TRINUCLEOTIDE REPEAT EXPANSION DISORDERS IN ANIMALS  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with trinucleotide repeat expansion disorders....
US20100299770 TARGETED CELL DEATH  
The present invention provides compositions and methods for studying neuropathy. The compositions and methods provided herein are particularly useful for screening agents of therapeutic and/or...
US20120023599 GENOME EDITING OF CYTOCHROME P450 IN ANIMALS  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding cytochrome P450 (CYP) proteins. In particular, the animals or cells are...
US20110023148 GENOME EDITING OF ADDICTION-RELATED GENES IN ANIMALS  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with addiction disorders. In particular, the animals or...
US20140123330 CONTROL OF SEXUAL MATURATION IN ANIMALS  
A genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the...
US20100077491 Modulators of RNF5 and Uses Thereof  
Provided herein are compositions and methods relating to the involvement of RNF5 in muscle wasting.
US20090228993 Transgenic Pig With Altered Incretin Function  
The present invention relates to transgenic pigs containing a dominant-negative incretin hormone receptor, namely the dominant-negative human glucose-dependent insulinotropic polypeptide receptor....
US20120159653 GENOMIC EDITING OF GENES INVOLVED IN MACULAR DEGENERATION  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins associated with MD. In particular, the animals or cells are...
US20090133133 Transgenic Mice for Bioassay of Prions from Deer and Elk with Chronic Wasting Disease  
The invention relates to the use of transgenic constructs to produce animal models for the study of chronic wasting disease.
US20130031648 Use of Follistatin-Like Related Gene (FLRG) to Increase Muscle Mass  
The present relates to use of follistatin-like related gene (FLRG) to increase muscle mass in a subject. As such, methods of ameliorating the severity of a pathologic condition characterized, at...
US20130111614 METHODS AND MATERIALS FOR REDUCING CARDIAC XENOGRAFT REJECTION  
This document provides methods and materials involved in reducing cardiac xenograft rejection. For example, methods and materials for preparing transgenic pigs expressing reduced or no endogenous...
US20110023147 GENOMIC EDITING OF PRION DISORDER-RELATED GENES IN ANIMALS  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with cognitive disorders. In particular, the...
US20130131317 EXPRESSION OF SECRETED HUMAN ALPHA-FETOPROTEIN IN TRANSGENIC ANIMALS  
The invention features a process of expressing secreted recombinant human alpha-fetoprotein (rHuAFP) in the milk or urine of transgenic mammals.
US20120259093 EXPRESSION OF SECRETED HUMAN ALPHA-FETOPROTEIN IN TRANSGENIC ANIMALS  
The invention features a process of expressing secreted recombinant human alpha-fetoprotein (rHuAFP) in the milk or urine of transgenic mammals.
US20110077208 EXPRESSION OF SECRETED HUMAN ALPHA-FETOPROTEIN IN TRANSGENIC ANIMALS  
The invention features a process of expressing secreted recombinant human alpha-fetoprotein (rHuAFP) in the milk or urine of transgenic mammals.
US20110209229 Gene of porcine beta casein, a promoter of the same and the use thereof  
The present invention provides a porcine beta-casein gene, a porcine beta-casein gene promoter, an expression vector comprising the same promoter, and a method for the production of a target...
US20110016539 GENOME EDITING OF NEUROTRANSMISSION-RELATED GENES IN ANIMALS  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with neurotransmission disorders. In particular,...
US20120185954 Mutant Receptors and Their Use in a Nuclear Receptor-Based Inducible Gene Expression  
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to...
US20110030072 GENOME EDITING OF IMMUNODEFICIENCY GENES IN ANIMALS  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding immunodeficiency proteins. In particular, the animals or cells are generated...

Matches 1 - 50 out of 191 1 2 3 4 >