|
Match
|
Document |
Document Title |
|
|
US20160029604 |
MULTIPLEX GENE EDITING
Materials and methods for making multiplex gene edits in cells or embryos are presented. Further methods include animals and methods of making the same. Methods of making chimeric animals are... |
|
|
US20120222143 |
GENETICALLY MODIFIED ANIMALS AND METHODS FOR MAKING THE SAME
Compositions and methods for use of TALENs to make genetically modified livestock are set forth. The methods may include reporters for selecting cells or embryos that have been modified by TALENs... |
|
|
US20160096894 |
ANTIBODIES TO INSULIN-LIKE GROWTH FACTOR I RECEPTOR
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The... |
|
|
US20150291975 |
ENHANCED NUCLEIC ACID CONSTRUCTS FOR EUKARYOTIC GENE EXPRESSION
The present invention provides polynucleotide vectors for high expression of heterologous genes, and methods for constructing such vectors. Some vectors further comprise novel transposons and... |
|
|
US20140359796 |
GENETICALLY STERILE ANIMALS
A genetically modified livestock animal, and methods of making and using the same, the animal comprising a genetic modification to disrupt a target gene selectively involved in gametogenesis,... |
|
|
US20140123330 |
CONTROL OF SEXUAL MATURATION IN ANIMALS
A genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the... |
|
|
US20060130157 |
Ungulates with genetically modified immune systems
The present invention provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional endogenous... |
|
|
US20110239317 |
POLYNUCLEOTIDES ENCODING PROMYOSTATIN POLYPEPTIDES
The present invention provides isolated polynucleotides encoding promyostatin polypeptides or a peptide portion thereof, polynucleotides complementary thereto, and oligonucleotides that can... |
|
|
US20090165153 |
Modified gene-silencing RNA and uses thereof
Methods and means for efficiently downregulating the expression of any gene of interest in eukaryotic cells and organisms are provided. To this end, the invention provides modified antisense and... |
|
|
US20070033664 |
Quiescent cell populations for nuclear transfer
A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit... |
|
|
US20070028312 |
Unactivated oocytes as cytoplast recipients for nuclear transfer
A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at... |
|
|
US20060212952 |
Methods for cloning mammals using reprogrammed donor chromatin or donor cells
The invention provides methods for cloning mammals that allow the donor chromosomes or donor cells to be reprogrammed prior to insertion into an enucleated oocyte. The invention also features... |
|
|
US20150067899 |
Multiple Inducible Gene Regulation System
The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions... |
|
|
US20140201857 |
HORNLESS LIVESTOCK
Compositions and methods for making livestock with a polled allele are presented, including migrating a polled allele into a bovine species without changing other genes or chromosomal portions. |
|
|
US20110231943 |
TRANSGENIC ANIMALS AND USES THEREOF
In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic... |
|
|
US20060117398 |
Suppression of endogenous immunoglobulin expression
The invention provides a novel approach for the suppression of endogenous antibody expression in non-human transgenic animals genetically engineered to express one or several human or humanized... |
|
|
US20060117395 |
Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates
The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and... |
|
|
US20050216963 |
Prion-free transgenic ungulates
Transgenic and cloned ungulates and particularly cloned cattle are disclosed, wherein such cattle contain a deletion or disruption of the prion gene locus and do not express functional prion... |
|
|
US20160143256 |
MRAP2 KNOCKOUTS
As described herein, Mrap2 negatively regulates weight gain in animals. Accordingly, provided herein are cells, animals, and methods relating to the inhibition of Mrap2 to increase the rate of... |
|
|
US20070209083 |
Cell and transgenic animal modelling human antigenic presentation and their uses
The invention concerns an isolated animal cell comprising at least a transgene including at least a nucleotide sequence coding for at least a human polypeptide involved in the recognition and/or... |
|
|
US20070011754 |
Lysosomal proteins produced in the milk of transgenic animals
The invention provides transgenic nonhuman mammals producing phosphorylated lysosomal proteins in their milk, and methods of generating the same. Phosphorylation occurs at the 6′ position of a... |
|
|
US20120233715 |
HUMAN ARTIFICIAL CHROMOSOME VECTOR
A human artificial chromosome vector comprising a human antibody heavy chain gene, a human antibody light chain gene, and a human antibody surrogate light chain gene. |
|
|
US20050198698 |
Production of recombinant polypeptides by bovine species and transgenic methods
Transgenes for producing recombinant polypeptides transgenic bovine species. A transgene for producing recombinant polypeptides in the milk of transgenic bovine species comprises at least one... |
|
|
US20050183145 |
Production of ungulates, preferably bovines that produce human immunoglobulins
The present invention relates to a method of producing an ungulate having both copies of the IgM heavy chain (mu) rag-1 and/or rag-2 gene eliminated from its genome. Animals which have IgM, rag-1... |
|
|
US20170079251 |
GENETICALLY MODIFIED ANIMALS HAVING INCREASED HEAT TOLERANCE
Disclosed herein are genomically modified livestock animals and methods to provide them that express the SLICK phenotype. The animals disclosed herein express a truncated allele for the prolactin... |
|
|
US20120185954 |
Mutant Receptors and Their Use in a Nuclear Receptor-Based Inducible Gene Expression
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to... |
|
|
US20110016540 |
GENOME EDITING OF GENES ASSOCIATED WITH TRINUCLEOTIDE REPEAT EXPANSION DISORDERS IN ANIMALS
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with trinucleotide repeat expansion disorders.... |
|
|
US20160137705 |
COLON DISEASE TARGETS AND USES THEREOF
The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic... |
|
|
US20110296544 |
COLON CANCER TARGETS AND USES THEREOF
The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic... |
|
|
US20110016543 |
GENOMIC EDITING OF GENES INVOLVED IN INFLAMMATION
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding inflammation-related proteins. In particular, the animals or cells are... |
|
|
US20120128682 |
APOLIPOPROTEIN L- I VARIANTS AND THEIR USE
An isolated human Apolipoprotein L-I corresponding to a wild type human Apolipoprotein sequence is modified by a deletion at its C-terminal end. |
|
|
US20110023158 |
BOVINE GENOME EDITING WITH ZINC FINGER NUCLEASES
The present invention provides a genetically modified bovine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger... |
|
|
US20050223416 |
C1 inhibitor produced in the milk of transgenic mammals
The invention provides transgenic nonhuman mammals expressing C1 inhibitor in their milk. The C1 inhibitor is useful in treating patients with hereditary angioedema or patients requiring... |
|
|
US20150368357 |
HIGHLY GALACTOSYLATED ANTI-HER2 ANTIBODIES AND USES THEREOF
In one aspect, the disclosure relates to highly galactosylated anti-HER2 antibodies and compositions thereof. In one aspect, the disclosure relates to populations of anti-HER2 antibodies with a... |
|
|
US20130212722 |
TRANSGENIC ANIMALS WITH CUSTOMIZABLE TRAITS
Disclosed are materials and methods for creating customizable traits in animals. In the demonstration of the principle of the subject invention, a keratin-14 specific promoter is used with, red... |
|
|
US20100024047 |
Prion-free transgenic ungulates
Transgenic and cloned ungulates and particularly cloned cattle are disclosed, wherein such cattle contain a deletion or disruption of the prion gene locus and do not express functional prion... |
|
|
US20050210537 |
Pluripotent mammalian cells
The invention relates to a method of making pluripotent stem cells that does not involve the formation of early preimplantation embryos or fetal tissue. The method has general utility in the... |
|
|
US20050172342 |
Production of collagen in the milk of transgenic mammals
The invention provides transgenic nonhuman mammals capable secreting exogenous procollagen or collagen into their milk. The mammals are healthy and capable of producing procollagen or collagen at... |
|
|
US20110030072 |
GENOME EDITING OF IMMUNODEFICIENCY GENES IN ANIMALS
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding immunodeficiency proteins. In particular, the animals or cells are generated... |
|
|
US20090221492 |
EXPRESSION OF ACTIVE HUMAN FACTOR IX IN MAMMARY TISSUE OF TRANSGENIC ANIMALS
Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present... |
|
|
US20160177336 |
Expression Tools for Multiprotein Applications
Polynucleotides for multigene applications comprising a novel functional arrangement, as well as vectors, host cells, and recombinant animals comprising the polynucleotides are described. Methods... |
|
|
US20090133137 |
Method of cloning animals
The present invention relates to cloning technologies. The invention relates in part to immortalized and totipotent cells useful for cloning animals, the embryos produced from these cells using... |
|
|
US20060294610 |
Alpha1-3 galactosyltransferase gene and promoter
The present invention provides a recombinant expression cassette comprising an α1-3 galactosyltransferase promoter operably linked to a polynucleotide for expression. The invention also provides a... |
|
|
US20080213426 |
Growth Differentiation Factor-8
A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity... |
|
|
US20110016541 |
GENOME EDITING OF SENSORY-RELATED GENES IN ANIMALS
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with nociception or taste disorders. In... |
|
|
US20130131317 |
EXPRESSION OF SECRETED HUMAN ALPHA-FETOPROTEIN IN TRANSGENIC ANIMALS
The invention features a process of expressing secreted recombinant human alpha-fetoprotein (rHuAFP) in the milk or urine of transgenic mammals. |
|
|
US20120259093 |
EXPRESSION OF SECRETED HUMAN ALPHA-FETOPROTEIN IN TRANSGENIC ANIMALS
The invention features a process of expressing secreted recombinant human alpha-fetoprotein (rHuAFP) in the milk or urine of transgenic mammals. |
|
|
US20110077208 |
EXPRESSION OF SECRETED HUMAN ALPHA-FETOPROTEIN IN TRANSGENIC ANIMALS
The invention features a process of expressing secreted recombinant human alpha-fetoprotein (rHuAFP) in the milk or urine of transgenic mammals. |
|
|
US20110023143 |
GENOMIC EDITING OF NEURODEVELOPMENTAL GENES IN ANIMALS
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with neurodevelopmental disorders. In... |
|
|
US20100333218 |
TRANSGENIC PROTEINS FROM MULTI-GENE SYSTEMS, METHODS, COMPOSITIONS, USES AND THE LIKE RELATING THERETO
A non-human transgenic mammalian animal, as described above, contains one or more exogenous double stranded DNA sequence(s) stably integrated into the genome of the animal, which comprises... |