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US20160029604 MULTIPLEX GENE EDITING  
Materials and methods for making multiplex gene edits in cells or embryos are presented. Further methods include animals and methods of making the same. Methods of making chimeric animals are...
US20120222143 GENETICALLY MODIFIED ANIMALS AND METHODS FOR MAKING THE SAME  
Compositions and methods for use of TALENs to make genetically modified livestock are set forth. The methods may include reporters for selecting cells or embryos that have been modified by TALENs...
US20160096894 ANTIBODIES TO INSULIN-LIKE GROWTH FACTOR I RECEPTOR  
The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), which is preferably human IGF-IR. The...
US20150291975 ENHANCED NUCLEIC ACID CONSTRUCTS FOR EUKARYOTIC GENE EXPRESSION  
The present invention provides polynucleotide vectors for high expression of heterologous genes, and methods for constructing such vectors. Some vectors further comprise novel transposons and...
US20140359796 GENETICALLY STERILE ANIMALS  
A genetically modified livestock animal, and methods of making and using the same, the animal comprising a genetic modification to disrupt a target gene selectively involved in gametogenesis,...
US20140123330 CONTROL OF SEXUAL MATURATION IN ANIMALS  
A genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the...
US20060130157 Ungulates with genetically modified immune systems  
The present invention provides ungulate animals, tissue and organs as well as cells and cell lines derived from such animals, tissue and organs, which lack expression of functional endogenous...
US20110239317 POLYNUCLEOTIDES ENCODING PROMYOSTATIN POLYPEPTIDES  
The present invention provides isolated polynucleotides encoding promyostatin polypeptides or a peptide portion thereof, polynucleotides complementary thereto, and oligonucleotides that can...
US20090165153 Modified gene-silencing RNA and uses thereof  
Methods and means for efficiently downregulating the expression of any gene of interest in eukaryotic cells and organisms are provided. To this end, the invention provides modified antisense and...
US20070033664 Quiescent cell populations for nuclear transfer  
A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit...
US20070028312 Unactivated oocytes as cytoplast recipients for nuclear transfer  
A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at...
US20060212952 Methods for cloning mammals using reprogrammed donor chromatin or donor cells  
The invention provides methods for cloning mammals that allow the donor chromosomes or donor cells to be reprogrammed prior to insertion into an enucleated oocyte. The invention also features...
US20150067899 Multiple Inducible Gene Regulation System  
The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions...
US20140201857 HORNLESS LIVESTOCK  
Compositions and methods for making livestock with a polled allele are presented, including migrating a polled allele into a bovine species without changing other genes or chromosomal portions.
US20110231943 TRANSGENIC ANIMALS AND USES THEREOF  
In general, the invention features genetically modified non-human mammals (e.g., bovines and other ungulates), and methods of making these mammals. In particular, the invention features transgenic...
US20060117398 Suppression of endogenous immunoglobulin expression  
The invention provides a novel approach for the suppression of endogenous antibody expression in non-human transgenic animals genetically engineered to express one or several human or humanized...
US20060117395 Expression of xenogenous (human) immunoglobulins in cloned, transgenic ungulates  
The present invention relates to the production of a transgenic bovine which comprises a genetic modification that results in inactivation and loss of expression of its endogenous antibodies, and...
US20050216963 Prion-free transgenic ungulates  
Transgenic and cloned ungulates and particularly cloned cattle are disclosed, wherein such cattle contain a deletion or disruption of the prion gene locus and do not express functional prion...
US20160143256 MRAP2 KNOCKOUTS  
As described herein, Mrap2 negatively regulates weight gain in animals. Accordingly, provided herein are cells, animals, and methods relating to the inhibition of Mrap2 to increase the rate of...
US20070209083 Cell and transgenic animal modelling human antigenic presentation and their uses  
The invention concerns an isolated animal cell comprising at least a transgene including at least a nucleotide sequence coding for at least a human polypeptide involved in the recognition and/or...
US20070011754 Lysosomal proteins produced in the milk of transgenic animals  
The invention provides transgenic nonhuman mammals producing phosphorylated lysosomal proteins in their milk, and methods of generating the same. Phosphorylation occurs at the 6′ position of a...
US20120233715 HUMAN ARTIFICIAL CHROMOSOME VECTOR  
A human artificial chromosome vector comprising a human antibody heavy chain gene, a human antibody light chain gene, and a human antibody surrogate light chain gene.
US20050198698 Production of recombinant polypeptides by bovine species and transgenic methods  
Transgenes for producing recombinant polypeptides transgenic bovine species. A transgene for producing recombinant polypeptides in the milk of transgenic bovine species comprises at least one...
US20050183145 Production of ungulates, preferably bovines that produce human immunoglobulins  
The present invention relates to a method of producing an ungulate having both copies of the IgM heavy chain (mu) rag-1 and/or rag-2 gene eliminated from its genome. Animals which have IgM, rag-1...
US20170079251 GENETICALLY MODIFIED ANIMALS HAVING INCREASED HEAT TOLERANCE  
Disclosed herein are genomically modified livestock animals and methods to provide them that express the SLICK phenotype. The animals disclosed herein express a truncated allele for the prolactin...
US20120185954 Mutant Receptors and Their Use in a Nuclear Receptor-Based Inducible Gene Expression  
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to...
US20110016540 GENOME EDITING OF GENES ASSOCIATED WITH TRINUCLEOTIDE REPEAT EXPANSION DISORDERS IN ANIMALS  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with trinucleotide repeat expansion disorders....
US20160137705 COLON DISEASE TARGETS AND USES THEREOF  
The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic...
US20110296544 COLON CANCER TARGETS AND USES THEREOF  
The present invention provides a method for diagnosing and detecting diseases associated with colon. The present invention provides one or more proteins or fragments thereof, peptides or nucleic...
US20110016543 GENOMIC EDITING OF GENES INVOLVED IN INFLAMMATION  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding inflammation-related proteins. In particular, the animals or cells are...
US20120128682 APOLIPOPROTEIN L- I VARIANTS AND THEIR USE  
An isolated human Apolipoprotein L-I corresponding to a wild type human Apolipoprotein sequence is modified by a deletion at its C-terminal end.
US20110023158 BOVINE GENOME EDITING WITH ZINC FINGER NUCLEASES  
The present invention provides a genetically modified bovine or cell comprising at least one edited chromosomal sequence. In particular, the chromosomal sequence is edited using a zinc finger...
US20050223416 C1 inhibitor produced in the milk of transgenic mammals  
The invention provides transgenic nonhuman mammals expressing C1 inhibitor in their milk. The C1 inhibitor is useful in treating patients with hereditary angioedema or patients requiring...
US20150368357 HIGHLY GALACTOSYLATED ANTI-HER2 ANTIBODIES AND USES THEREOF  
In one aspect, the disclosure relates to highly galactosylated anti-HER2 antibodies and compositions thereof. In one aspect, the disclosure relates to populations of anti-HER2 antibodies with a...
US20130212722 TRANSGENIC ANIMALS WITH CUSTOMIZABLE TRAITS  
Disclosed are materials and methods for creating customizable traits in animals. In the demonstration of the principle of the subject invention, a keratin-14 specific promoter is used with, red...
US20100024047 Prion-free transgenic ungulates  
Transgenic and cloned ungulates and particularly cloned cattle are disclosed, wherein such cattle contain a deletion or disruption of the prion gene locus and do not express functional prion...
US20050210537 Pluripotent mammalian cells  
The invention relates to a method of making pluripotent stem cells that does not involve the formation of early preimplantation embryos or fetal tissue. The method has general utility in the...
US20050172342 Production of collagen in the milk of transgenic mammals  
The invention provides transgenic nonhuman mammals capable secreting exogenous procollagen or collagen into their milk. The mammals are healthy and capable of producing procollagen or collagen at...
US20110030072 GENOME EDITING OF IMMUNODEFICIENCY GENES IN ANIMALS  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding immunodeficiency proteins. In particular, the animals or cells are generated...
US20090221492 EXPRESSION OF ACTIVE HUMAN FACTOR IX IN MAMMARY TISSUE OF TRANSGENIC ANIMALS  
Recombinant Factor IX characterized by a high percentage of active protein can be obtained in the milk of transgenic animals that incorporate chimeric DNA molecules according to the present...
US20160177336 Expression Tools for Multiprotein Applications  
Polynucleotides for multigene applications comprising a novel functional arrangement, as well as vectors, host cells, and recombinant animals comprising the polynucleotides are described. Methods...
US20090133137 Method of cloning animals  
The present invention relates to cloning technologies. The invention relates in part to immortalized and totipotent cells useful for cloning animals, the embryos produced from these cells using...
US20060294610 Alpha1-3 galactosyltransferase gene and promoter  
The present invention provides a recombinant expression cassette comprising an α1-3 galactosyltransferase promoter operably linked to a polynucleotide for expression. The invention also provides a...
US20080213426 Growth Differentiation Factor-8  
A transgenic non-human animal of the species selected from the group consisting of avian, bovine, ovine and porcine having a transgene which results in disrupting the production of and/or activity...
US20110016541 GENOME EDITING OF SENSORY-RELATED GENES IN ANIMALS  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with nociception or taste disorders. In...
US20130131317 EXPRESSION OF SECRETED HUMAN ALPHA-FETOPROTEIN IN TRANSGENIC ANIMALS  
The invention features a process of expressing secreted recombinant human alpha-fetoprotein (rHuAFP) in the milk or urine of transgenic mammals.
US20120259093 EXPRESSION OF SECRETED HUMAN ALPHA-FETOPROTEIN IN TRANSGENIC ANIMALS  
The invention features a process of expressing secreted recombinant human alpha-fetoprotein (rHuAFP) in the milk or urine of transgenic mammals.
US20110077208 EXPRESSION OF SECRETED HUMAN ALPHA-FETOPROTEIN IN TRANSGENIC ANIMALS  
The invention features a process of expressing secreted recombinant human alpha-fetoprotein (rHuAFP) in the milk or urine of transgenic mammals.
US20110023143 GENOMIC EDITING OF NEURODEVELOPMENTAL GENES IN ANIMALS  
The present invention provides genetically modified animals and cells comprising edited chromosomal sequences encoding proteins that are associated with neurodevelopmental disorders. In...
US20100333218 TRANSGENIC PROTEINS FROM MULTI-GENE SYSTEMS, METHODS, COMPOSITIONS, USES AND THE LIKE RELATING THERETO  
A non-human transgenic mammalian animal, as described above, contains one or more exogenous double stranded DNA sequence(s) stably integrated into the genome of the animal, which comprises...

Matches 1 - 50 out of 137 1 2 3 >