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US20140245468 NON-HUMAN ANIMALS WITH MODIFIED IMMUNOGLOBULIN HEAVY CHAIN SEQUENCES  
Non-human animals, e.g., mammals, e.g., mice or rats, are provided comprising an immunoglobulin heavy chain locus that comprises a rearranged human immunoglobulin heavy chain variable region...
US20130243759 Transgenic Animals  
The present invention relates inter alia to fertile non-human vertebrates such as mice and rats useful for producing antibodies bearing human variable regions, in which endogenous antibody chain...
US20130212719 Humanized Rodents that Express Heavy Chain Containing VL Domains  
Non-human animals, tissues, cells, and genetic material are provided that comprise a modification of an endogenous non-human heavy chain immunoglobulin sequence and that comprise an ADAM6 activity...
US20120204278 ANIMAL MODELS AND THERAPEUTIC MOLECULES  
The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof...
US20150322122 Transgenic Silkworms Capable of Producing Chimeric Spider Silk Polypeptides and Fibers  
Transgenic silkworms comprising at least one nucleic acid encoding a chimeric silk polypeptide comprising one or more spider silk elasticity and strength motifs are disclosed. Expression cassettes...
US20150047064 INHIBITING GENE EXPRESSION WITH dsRNA  
The present invention relates to the specific inhibition of gene expression in mammals by bringing the target gene into contact with double stranded RNA (dsRNA).
US20140359796 GENETICALLY STERILE ANIMALS  
A genetically modified livestock animal, and methods of making and using the same, the animal comprising a genetic modification to disrupt a target gene selectively involved in gametogenesis,...
US20140123330 CONTROL OF SEXUAL MATURATION IN ANIMALS  
A genetically modified livestock animal comprising a genome that comprises inactivation of a neuroendocrine gene selective for sexual maturation, with the inactivation of the gene preventing the...
US20130232588 Chimeric Retinoid X Receptors and Their Use in a Novel Ecdysone Receptor-Based Inducible Gene Expression System  
This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a...
US20130212718 CHIMERIC SPIDER SILK AND USES THEREOF  
Transgenic silkworms comprising at least one nucleic acid encoding a chimeric silk polypeptide comprising one or more spider silk elasticity and strength motifs are disclosed. Expression cassettes...
US20120331574 USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF  
A monomer of an I-CreI meganuclease variant wherein said monomer when in dimeric form binds and cleaves DNA.
US20120304321 USE OF MEGANUCLEASES FOR INDUCING HOMOLOGOUS RECOMBINATION EX VIVO AND IN TOTO IN VERTEBRATE SOMATIC TISSUES AND APPLICATION THEREOF  
A monomer of an I-CreI meganuclease variant wherein said monomer when in dimeric form binds and cleaves DNA.
US20120214737 METHODS FOR PROTECTING DOPAMINERGIC NEURONS FROM STRESS AND PROMOTING PROLIFERATION AND DIFFERENTIATION OF OLIGODENDROCYTE PROGENITORS BY NRG-2  
The invention features methods of treatment and diagnosis using NRG-2 polypeptides, nucleic acid molecules, and antibodies. The invention also provides novel NRG-2 polypeptides and nucleic acid...
US20120096569 ANTI-IL-6 ANTIBODIES,COMPOSITIONS, METHODS AND USES  
The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at...
US20110041195 Organisms homozygous for targeted modification  
Disclosed herein are homozygously modified organisms and methods of making and using these organisms.
US20100099111 ANTIBODIES AGAINST A PROTEIN ENTITLED 161P2F10B  
Antibodies and methods of using same against products of the gene designated 161P2F10B and its encoded protein are described wherein 161P2F10B exhibits tissue specific expression in normal adult...
US20090328244 METHODS AND REAGENTS FOR MOLECULAR CLONING  
The present invention provides compositions, methods, and kits for covalently linking nucleic acid molecules. The methods include a strand invasion step, and the compositions and kits are useful...
US20090252747 NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 282P1G3 USEFUL IN TREATMENT AND DETECTION OF CANCER  
A novel gene 282P1G3 and its encoded protein, and variants thereof, are described wherein 282P1G3 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the...
US20090252737 T Cell Regulatory Genes And Methods Of Use Thereof  
A genetic locus and corresponding family of proteins associated with regulation of immune function and cell survival are provided. These genes encode cell surface molecules with conserved IgV and...
US20090094708 Vitamin K Epoxide Recycling Polypeptide VKORC1, a Therapeutic Target of Coumarin and Their Derivatives  
The invention relates to a novel polypeptide vitamin K epoxide recycling polypeptide (VKORC1) as a target for coumarin and its derivatives. The invention further provides methods for identifying...
US20080221054 Inhibiting Gene Expression with dsRNA  
The present invention relates to the specific inhibition of gene expression in mammals by bringing the target gene into contact with double stranded RNA (dsRNA).
US20080209581 Induction of exon skipping in eukaryotic cells  
Described is a method for at least in part decreasing the production of an aberrant protein in a cell, the cell comprising pre-mRNA comprising exons coding for the protein, by inducing so-called...
US20080050342 Genetic inhibition by double-stranded RNA  
A process is provided of introducing an RNA into a living cell to inhibit gene expression of a target gene in that cell. The process may be practiced ex vivo or in vivo. The RNA has a region with...
US20150307613 NOVEL ANTI-cMET ANTIBODY  
The invention relates to a novel antibody capable of binding specifically to the human c-Met receptor and/or capable of specifically inhibiting the tyrosine kinase activity of said receptor both...
US20140359795 GENETIC TECHNIQUES FOR MAKING ANIMALS WITH SORTABLE SPERM  
Livestock with sperm labeled to indicate an X and/or Y chromosome. Male livestock that produce progeny of only one gender. Sperm that have a marker.
US20140325691 REGULATION OF ENDOGENOUS GENE EXPRESSION IN CELLS USING ZINC FINGER PROTEINS  
The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
US20140115727 NOVEL ANTI-cMET ANTIBODY  
The invention relates to a novel antibody capable of binding specifically to the human c-Met receptor and/or capable of specifically inhibiting the tyrosine kinase activity of said receptor both...
US20130209437 I-CREI HOMING ENDONUCLEASE VARIANTS HAVING NOVEL CLEAVAGE SPECIFICITY AND USE THEREOF  
A method for engineering I-CreI homing endonuclease variants able to cleave mutant I-CreI sites having variation in positions ±8 to ±10. A I-CreI homing endonuclease variant obtainable by said...
US20130198878 ORGANISMS HOMOZYGOUS FOR TARGETED MODIFICATION  
Disclosed herein are homozygously modified organisms and methods of making and using these organisms.
US20120246747 RNA-INTERFERENCE BY SINGLE-STRANDED RNA MOLECULES  
The present invention relates to sequence and structural features of single-stranded (ss)RNA molecules required to mediate target-specific nucleic acid modifications by RNA-interference (RNAi),...
US20120225034 AGENTS USEFUL IN TREATING FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY  
The invention teaches antisense agents and RNA interference agents useful for treating diseases and conditions the treatment of which can benefit from reducing the expression of double homeobox 4...
US20120159659 CUSTOM-MADE MEGANUCLEASE AND USE THEREOF  
New rare-cutting endonucleases, also called custom-made meganucleases, which recognize and cleave a specific nucleotide sequence, derived polynucleotide sequences, recombinant vector cell, animal,...
US20120144512 TRANSGENIC ANIMALS EXPRESSING HUMAN IGE-M1'  
The present application relates to apoptotic anti-IgE antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use in the treatment of IgE-mediated disorders.
US20120124683 Delivery method  
The present invention relates, in general, to siRNA and, in particular, to a method of effecting targeted delivery of siRNAs and to compounds suitable for use in such a method.
US20110247089 Organisms homozygous for targeted modification  
Disclosed herein are homozygously modified organisms and methods of making and using these organisms.
US20110247087 Regulation of endogenous gene expression in cells using zinc finger proteins  
The present invention provides methods for modulating expression of endogenous cellular genes using recombinant zinc finger proteins.
US20110239317 POLYNUCLEOTIDES ENCODING PROMYOSTATIN POLYPEPTIDES  
The present invention provides isolated polynucleotides encoding promyostatin polypeptides or a peptide portion thereof, polynucleotides complementary thereto, and oligonucleotides that can...
US20110197292 Delivery method  
The present invention relates, in general, to RNA silencing and, in particular, to a method of effecting targeted delivery of an RNA silencing moiety using a targeting moiety that binds to a cell...
US20100275279 Selecting animals for parentally imprinted traits  
Described are methods for selecting a domestic animal having desired genotypic properties, the methods comprising testing the animal for the presence of a parentally imprinted quantitative trait...
US20100080809 GITR LIGAND AND GITR LIGAND-RELATED MOLECULES AND ANTIBODIES AND USES THEREOF  
The present invention provides novel isolated and purified polynucleotides and polypeptides related to a novel ligand for glucocorticoid-induced TNF receptor (GITR). The invention also provides...
US20100021612 METHOD FOR THE PRODUCTION OF FUSION PROTEINS IN TRANSGENIC MAMMAL MILK  
Desirable fusion proteins can be produced in and purified from the milk of transgenic animals. The peptides are made as fusion proteins with a suitable fusion partner such as human...
US20090165153 Modified gene-silencing RNA and uses thereof  
Methods and means for efficiently downregulating the expression of any gene of interest in eukaryotic cells and organisms are provided. To this end, the invention provides modified antisense and...
US20080235816 MULTIPLE INDUCIBLE GENE REGULATION SYSTEM  
The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions...
US20080220002 MODIFIED TRANSFERIN-ANTIBODY FUSION PROTEINS  
Modified fission proteins of transferrin and therapeutic proteins or peptides, preferably antibody variable regions, with increased serum half-life or serum stability are disclosed. Preferred...
US20120077860 Adeno-Associated Viral Vector for Exon Skipping in a Gene Encoding a Dispensable Domain Protein  
The invention concerns an adeno-associated viral vector comprising: a U7 type modified snRNA sequence;the native U7 promoter;at least one antisense sequence directed against at least one splice...
US20120070456 POLYPEPTIDE CARRIER PROTEIN  
The invention relates to polypeptide carrier proteins that comprise at least five CD4+ T cell epitopes, for conjugation to capsular polysaccharides. The carrier proteins are useful as components...
US20110179507 LAGLIDADG HOMING ENDONUCLEASE VARIANTS HAVING MUTATIONS IN TWO FUNCTIONAL SUBDOMAINS AND USE THEREOF  
A LAGLIDADG homing endonuclease variant, having mutations in two separate subdomains, each binding a distinct part of a modified DNA target half-site, said LAGLIDADG homing endonuclease variant...
US20100313283 USES OF GDNF AND GDNF RECEPTOR  
GDNFRα, GDNFRα extracellular domain (ECD), GDNFRα variants, chimeric GDNFRα (e.g., GDNFRα immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are...
US20100154070 PiggyBac as a Tool for Genetic Manipulation and Analysis in Vertebrates  
The present invention relates to transgenic vertebrate, including mammalian, cells, whose genomes comprise one or more elements of the piggyBac family transposon system. Transgenic non-human...
US20080312158 Semaphorin Gene Family  
A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin...