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US20100160268 Isoflavonoid Analogs and their Metal Conjugates as Anti-Cancer Agents  
A pharmacologic agent for treating and/or preventing cancer, among other diseases and conditions, and particularly breast, prostate, and pancreatic cancer, in humans and animals. The novel...
US20090203661 Betulinic acid, derivatives and analogs thereof and uses therefor  
Provided herein provided herein are novel analogs and derivatives of betulinic acid. Also provided is a method for inhibiting an activity of one or more specificity protein (Sp) transcription...
US20080255380 Process and Intermediates for the Preparation of Sulfonyl Derivatives of Cholecalciferol  
Preparation of sulfonyl derivatives of cholecalciferol of Formula 1, wherein R1 is a protective group, preferably a t-butyl(dimethyl)silyl, and R2 is a heterocyclic group, such as a 2-thiazolyl, a...
US20060094696 Oestrogen derivatives as inhibitors of steroid sulphatase  
The present invention provides a compound comprising a steroidal ring system and an optional group R1 selected from any one of —OH, a sulphamate group, a phosphonate group, a thiophosphonate...
US20050123935 Pyrenyloxysulfonic acid fluorescent agents  
The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by...
US20110112254 POLYMERIC COMPOSITIONS AND METHOD OF MAKING AND ARTICLES THEREOF  
Described herein is a mixture comprising: a non-self-crosslinking polymer; and a modifying compound comprising at least two different functional groups. The first functional group of the modifying...
US20100130463 6-SUBSTITUTED ESTRADIOL DERIVATIVES AND METHODS OF USE  
Disclosed are compounds of the formula: wherein R1, R2, R3 and R4 are independently hydrogen, C1-C6 alkyl, halo, a sulfate, a glucuronide, —OH, a bulky group, aryl, cycloalkyl, heteroaryl,...
US20090105202 Androsterone Derivatives and Method of Use thereof  
The disclosure provides androsterone derivatives. The derivatives of the disclosure are useful in the treatment of androgen- and estrogen-associated diseases and disorders, including breast cancer.
US20130157987 1-DEOXY ANALOGS OF 1,25-DIHYDROXYVITAMIN D3 COMPOUNDS  
This present disclosure is directed to novel prodrugs of activated vitamin D3 compounds. The prodrugs can be designed to have one or more beneficial properties, such as selective inhibition of the...
US20120028928 Process for Isolating Tigecycline and Tigecycline Made Therefrom  
The present invention provides a process for isolating tigecycline which process comprises the step of spray drying a solution of tigecycline in a solvent. Preferably the solvent is water or an...
US20100120031 SYNTHESIS OF TRANS-TERT-BUTYL-2-AMINOCYCLOPENTYLCARBAMATE  
The present invention concerns methods of synthesis of trans-tert-butyl-2-aminocylcopentylcarbamate comprising contacting 6-tosyl-6-azabicyclo[3.1.0]hexane with TMSN3 and TBAF to produce...
US20050009924 Synthesis and pharmaceuticals of novel bis-substituted anthraquinone derivatives  
This invention relates to novel anthraquinone compounds useful in the treatment of allergic, inflammatory conditions, antioxidant, tumor condition, stem cell application, tissue engineering,...
US20090163457 Compositions and methods for delivering a biologically active agent  
The invention relates to codrugs having improved properties, methods for preparing and administering them, and methods of formulating and administering the codrugs as pharmaceutical preparations....
US20070149794 Process for preparing optically active 3-azidocarboxylic acid derivatives and 3-aminocarboxylic acid derivatives  
A process for enantioselectively preparing 3-azidocarboxylic acid derivatives comprises reacting 3-sulfonatocarboxylic acid derivatives with an alkali metal azide in a solvent selected from the...
US20130261324 SYNTHESIS OF ALISKIREN  
The present invention provides novel process for the preparation of renin inhibitor Aliskiren or its derivatives, and its pharmaceutically acceptable salts. The present invention also provides...
US20060205697 Novel betulin derivatives, preparation thereof and use thereof  
The present invention relates to novel synthetic derivatives of betulin and the use of such derivatives as pharmaceuticals. The present invention is directed to novel compounds of Formula I: or a...
US20140005156 AMINOALKYLSTEROL COMPOUNDS WITH ANTITUMORAL AND NEUROPROTECTIVE ACTIVITY  
Sterol derivatives of formula (I) and a method for the production of the compounds, a medicament using one of the compounds and a pharmaceutical composition comprising the medicament.
US20110313170 Fluorination of Aromatic Ring Systems  
This disclosure relates to reagents and methods useful in the synthesis of aryl fluorides, for example, in the preparation of 18F labeled radiotracers. The reagents and methods provided herein may...
US20110275604 AMINOALKYLSTEROL COMPOUNDS WITH ANTITUMORAL AND NEUROPROTECTIVE ACTIVITY  
Sterol derivatives of formula (I) and a method for the production of the compounds, a medicament using one of the compounds and a pharmaceutical composition comprising the medicament.
US20100228041 CYCLOOCTENE MONOMERS  
Azidoaryl-substituted cyclooctene monomers and synthesized and used in the preparation of various copolymers. Among these copolymers are those prepared from ring-opening metathesis polymerization...
US20100069654 PROCESS FOR THE PREPARATION OF TAUROURSODESOXYCHOLIC ACID  
The present invention relates to a novel method for preparing tauroursodeoxycholic acid which comprises a step of selective precipitation of the impurities present in the suspension obtained from...
US20080312202 6-SUBSTITUTED ESTRADIOL DERIVATIVES AND METHODS OF USE  
A compound having the structure: wherein R1 and Z are as described above, X is selected from the group consisting of: C1-C6 alkyl, a substituted alkyl, a halogen, a halogenated alkyl, a...
US20070275935 Estratriene Derivatives  
Compounds and methods for modulating mesenchymal cell function, for instance smooth muscle and fibroblast proliferation or cytokine expression, and for treating conditions associated with...
US20140235882 PROCESS FOR THE PREPARATION OF ESTETROL  
The present invention relates to a process for the preparation of estra-1,3,5(10)-trien-3,15α,16α,17β-tetraol (estetrol), via a silyl enol ether derivative...
US20130023681 STABILIZED DOXERCALCIFEROL AND PROCESS FOR MANUFACTURING THE SAME  
1 a-hydroxy vitamin D2 (doxercalciferol) of exceptionally high purity and stability is prepared by a process involving chromatographically purifying 1 α-hydroxyvitamin D2 monoacetate, chemically...
US20120077948 Methods  
The invention relates to a method of making a polypeptide comprising an orthogonal functional group, said orthogonal functional group being comprised by an aliphatic amino acid or amino acid...
US20110149128 Anthraquinone dye-containing material, composition including the same, camera including the same, and associated methods  
A (meth)acrylate ester includes a (meth)acrylate moiety having an ester oxygen, an anthraquinone moiety having a transmittance spectrum producing blue light, and a linking group covalently bound...
US20070270584 Process for the Preparation of Steroidal Carbothioic Acid Derivatives and Intermediates  
A method for the conversion of steroidal 17β-carboxylic acids to c carbothioic acid and esters thereof such as fluticasone propionate.
US20130227797 ANIONIC DIRECT DYE HAVING A TETRAALKYLAMMONIUM COUNTERION, DYEING COMPOSITION COMPRISING THEM AND METHOD FOR DYEING KERATINOUS FIBRES STARTING FROM THESE DYES  
The invention relates to the dyeing of human keratinous fibres, in particular the hair, using anionic direct dyes or acid dyes having a tetraalkylammonium counterion of formula (I) with Col(−)m....
US20120077777 NGCYCLOARTANONE DERIVATIVES WITH ANTICANCER ACTIVITY  
The present invention relates to a compound of following formula (I): or to a pharmaceutically acceptable salt thereof, as well as to pharmaceutical compositions including same and to the use...
US20110152229 BETULINIC ACID DERIVATIVES AS ANTI-HIV AGENTS  
The present invention provides compounds of the general structure: which are substituted at the 3 and 28 positions, along with pharmaceutical formulations containing the same and methods of...
US20090099376 TIGECYCLINE AND METHODS OF PREPARING INTERMEDIATES  
Methods of preparing and purifying 9-nitrominocycline and 9-aminominocycline and salts thereof used in the process of making tigecycline, are disclosed. In one embodiment, the invention is...
US20050054612 Delivery by labile hydrophobic modification of drugs  
Described are drug formulations that increase regional delivery of the drugs to cells. Methods for reversibly increasing the hydrophobicity of a drug through hydrolytic ally labile attachment of a...
US20150216878 17 Alpha, 21-Dihydroxypregnene Esters as Antiandrogenic Agents  
17α,21 -Dihydroxypregna-4,9(11)-diene-3,20-dione and 17α,21-dihydroxypregna-4-ene-3,20-dione 17 and/or 21 esters having remarkable antiandrogenic activity and processes for the preparation thereof.
US20140243298 C-3 ALKYL AND ALKENYL MODIFIED BETULINIC ACID DERIVATIVES  
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, alkyl and alkenyl C-3 modified betulinic acid derivatives...
US20120283450 COMPOUNDS INCLUDING AN ANTI-INFLAMMATORY PHARMACORE AND METHODS OF USE  
This invention provides novel compounds comprising the following anti-inflammatory pharmacore: wherein X, R1 and R2 are defined herein. Also provided are pharmaceutical compositions, kits and...
US20090069584 Levonorgestrel Crystallization  
The present invention provides for a crystalline polymorph of levonorgestrel and processes for making the same.
US20070032462 Novel methods for the preparation of dhea derivatives  
The invention relates to a method for the production of DHEA derivatives, such as 7-oxo-DHEA and 7-hydroxy-DHEA, from DHEA itself.
US20050267307 Novel anthraquinones and process for the preparation and method of use thereof  
A process for the preparation of hydroxyl substituted anthraquinones is described. The process couples a phthalic anhydride (substituted or unsubstituted) to benzene ring moiety substituted with...
US20050101583 Process and intermediates for the production of 7-substituted antiestrogens  
A process for preparing an intermediate compound of formula (II) where X is as defined in the specification, R1 is haloalkyl, alkyl, alkenyl, cycloalkyl, carboxyalkyl, alkoxycarbonylalkyl, aryl or...
US20140213805 NOVEL ARYLALCOHOLS AND METAL COMPLEXES THEREOF  
Provided herein is a compound of Formula 1: or an isomer thereof, or a salt of the compound or of an isomer thereof, wherein R1 and R2 are each independently selected from the group consisting of...
US20120130098 Skin Treatments Containing Carboxylic Acid-Substituted Idebenone Derivatives and Methods of Preparation and Use Thereof  
The present invention relates to novel carboxylic acid-substituted idebenone derivatives, skin treatment compositions containing these carboxylic acid-substituted idebenone derivatives, methods of...
US20120130097 PROCESS FOR THE PREPARATION OF CYCLOPROPYL CARBOXYLIC ACID ESTERS AND DERIVATIVES  
The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of...
US20110190520 Process for the preparation of cyclopropyl carboxylic acid esters and derivatives  
The invention relates to a novel process for the preparation of certain cyclopropyl carboxylic acid esters and other cyclopropyl carboxylic acid derivatives; a novel process for the preparation of...
US20100137269 Novel C-17-Heteroaryl Steroidal Cyp17 Inhibitors/Antiandrogens: Synehesis, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity  
Described are steroidal C-17 benzoazoles, pyrimidinoazoles (azabenzoazoles) and diazines. Methods for their synthesis are also described, which include methods having a step of nucleophilic...
US20100130454 9,10-SECOPREGNANE DERIVATIVES AND MEDICINE  
A novel useful vitamin D3 derivative which is reduced in influence on systemic calcium metabolism while retaining excellent vitamin D3 activity. The derivative is a 9,10-secopregnane derivative...
US20090275768 Preparation of Paricalcitol  
This invention relates to a method for purifying Paricalcitol by reverse phase chromatography. This invention also relates to a purified Paricalcitol prepared by said method. This invention...
US20090068257 BETULONIC AND BETULINIC ACID DERIVATIVES  
The present invention relates to betulonic and betulinic acid derivatives and, in particular, to C-28 and C-3 derivatives. The present invention relates to betulonic acid esters, dihydro-betulonic...
US20050164647 Apparatus and method capable of utilizing a tunable antenna-duplexer combination  
An embodiment of the present invention provides an apparatus, an apparatus, comprising a tunable duplexer incorporating at least two separate antennas. The tunable duplexer may be a high-band...
US20140326164 SURFACE MODIFIED PIGMENTS AND NON-AQUEOUS INKS THEREWITH  
A method for preparing a surface modified organic pigment includes the steps of a) reacting the organic pigment in an aromatic hydrocarbon solvent with a surface modifying reagent to form a...