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US20080027141 1,3-Dihydroxyl-9,10-anthraquinone and 3-[(3-amino)-propoxy]- 9,10-anthraquinone derivatives and pharmaceutical compositions comprising the same  
Disclosed herein are 1,3-dihydroxyl-9,10-anthraquinone and 3-[(3-amino)-propoxy]-9,10-anthraquinone derivatives, in particular 1,3-dihydroxy-4-prenyl-9,10-anthraquinone and...
US20130267717 PROCESS FOR THE PREPARATION OF ATOVAQUONE  
Disclosed herein is novel process for preparation of atovaquone, which process includes reacting 1H-2-benzopyran-1,4(3H)-dione with 4-(4-chlorophenyl)cyclohexanecarbaldehyde. The invention further...
US20100120735 COMPOUND SHOWING ANTI-INFLAMMATORY ACTIVITY AND ANTIVIRAL ACTIVITY, PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME, A PROCESS FOR OBTAINING THE SAME AND USE OF THE SAME IN THE TREATMENT OF EPIDEMIC KERATOCONJUNCTIVITES AND HERPETIC STROMAL KERATIS  
The present invention refers to a compound having anti-inflammatory and antiviral activity according to the following structural formula: wherein, R1 and R3 are selected from H, HO—, R5—O—, HCOO—,...
US20090215044 Receptor in Dendritic Cells  
GPBAR1 for use as a target for selective inhibition of Th1 mediated immune responses.
US20070203103 Preparation of pharmaceutical salts of 3-O-(3',3'-dimethylsuccinyl)betulinic acid  
This invention relates to a novel process for making 3-O-(3′,3′-dimethylsuccinyl)betulinic acid (“DSB”). This invention also relates to methods of treating HIV and related diseases using...
US20110184199 Methods For Producing Paricalcitol  
The present invention is directed to novel processes for the preparation of paricalcitol to novel intermediates used in these processes, and to processes for preparation of the novel intermediates.
US20130131359 PROCESSES AND INTERMEDIATES FOR PREPARING STERIC COMPOUNDS  
This invention relates to processes and intermediates for the preparation of an alpha-amino beta-hydroxy acid of Formula 1 wherein the variables R1, R′1 and R2 are defined herein and the compound...
US20090062230 NOVEL CATIONIC 17 ALPHA-SUBSTITUTED-ESTRADIOL DERIVATIVES USEFUL AS ANTI-CANCER AGENT  
The present invention provides a novel series of cationic, lipid-based, 17α-substituted-estradiol derivatives. The present invention further provides a process for the preparation of a novel...
US20050090476 Process for the preparation of 7alpha-methylsteroids  
The invention relates to a process for the preparation of 7α-methyl hydroxy steroids of the formula I wherein R1 is hydrogen, methyl or C≡CH; R2 is (CH2)nOH, wherein n is 0, 1 or 2; by a copper...
US20140107358 PROCESS FOR THE PRODUCTION OF ESTETROL INTERMEDIATES  
The present invention relates to a process for the preparation of a compound of formula (I) said process comprising the steps of: a) reacting a compound of formula (II), with an acylating or a...
US20140107091 PROCESS FOR THE PRODUCTION OF ESTETROL INTERMEDIATES  
The present invention relates to a process for the preparation of a compound of formula (I) comprising the steps of a) reacting a compound of formula (II) with a silylating or an acylating agent...
US20100196290 COMPOSITIONS COMPRISING BETULONIC ACID  
The invention relates to compositions of cosmetic and pharmaceutical industries comprising betulonic acid for humans and animals, and further, to the use of betulonic acid in compositions of...
US20100063018 BILE ACID DERIVATIVES AS FXR LIGANDS FOR THE PREVENTION OR TREATMENT OF FXR-MEDIATED DISEASES OR CONDITIONS  
The present invention relates to compounds of formula (I) wherein: R1 is hydrogen or an alkyl group; R2 is hydrogen or a halogen, nitro, alkyloxy, amino or carboxy group; Y is CH2, oxygen or...
US20120142655 NOVEL CRYSTAL FORM OF AN ORGANIC COMPOUND AND PROCESS FOR THE PREPARATION THEREOF  
The present invention relates to novel crystalline Form II of 17α-acetoxy-21-methoxy-11β-[4-N,N-dimethylaminophenyl]-19-no rpregna-4,9-diene-3,20-dione, (also known as CDB-4124), processes for the...
US20110269725 NOVEL ESTROGENIC COMPOUNDS  
Novel estrogenic compounds of Formula I are provided. wherein the bond represented by the wavy line may be a single or double bond such that when the wavy line is a single bond, R1 is selected...
US20100152142 CRYSTALLINE FORM II OF TIGECYCLINE AND PROCESSES FOR PREPARATION THEREOF  
The present invention provides processes for the preparation of crystalline forms of Tigecycline.
US20090312564 METHOD FOR THE PURIFICATION OF RADIOLABELLED COMPOUNDS  
The invention relates to methods and apparatus for purifying a radiolabelled compound. The method comprises (i) passing a crude reaction mixture comprising the desired radiolabelled compound and...
US20070104781 HYPOCHOLESTEREMIC PREPARATIONS CONTAINING MIXTURES OF PHYTOSTENOL(ESTER)S AND CONJUGATED FATTY ACIDS, AND METHODS OF USING THE SAME  
A hypocholesteremic preparation containing at least one component (a) selected from the group consisting of phytostenols and phytostenol esters and at least one component (b) selected from...
US20150025222 Substituted Anthraquinone Dyes for Cellular Stains and Enzyme Detection  
The invention discloses new substituted anthraquinone dyes that may be useful as cellular stains. In some aspect of the invention, the nuclear stains are useful for staining the nuclei of dead or...
US20120252063 SUBSTITUTED ANTHRAQUINONE DYES FOR CELLULAR STAINS AND ENZYME DETECTION  
The invention discloses new substituted anthraquinone dyes that may be useful as cellular stains. In some aspect of the invention, the nuclear stains are useful for staining the nuclei of dead or...
US20100099654 FATTY ACID ESTERS OF GLUCOCORTICOIDS AS ANTI-INFLAMMATORY AND ANTI-CANCER AGENTS  
The present invention relates to certain unsaturated fatty acid derivatives of therapeutically active glucocorticoides-fatty acid esters of glucocorticoids as anti-inflammatory and anti-cancer...
US20130072691 MEMBRANE ENHANCED POLYMER SYNTHESIS  
This invention relates to the synthesis of polymers. More specifically, the present invention relates to the synthesis of heterobifunctional polymers and polymers with narrow and mono-disperse...
US20120029167 AUTO MAGNETIC METAL SALEN COMPLEX COMPOUND  
A drug using the magnetic properties of a metal salen complex as represented by the following general formula in order to magnetize the intended drug by chemically binding the drug to a metal...
US20100292084 NOVEL DIARYLPHOSPHINE- AND DIALKYLPHOSPHINE-CONTAINING COMPOUNDS, PROCESSES OF PREPARING SAME AND USES THEREOF AS TRIDENTATE LIGANDS  
A novel process of preparing tridentate ligands containing one or more of a diarylphosphine and/or dialkylphosphine electron donating groups are disclosed. Use of this process for preparing a...
US20100047688 PHENANTHRENEQUINONE COMPOUND, ELECTRODE ACTIVE MATERIAL, AND POWER STORAGE DEVICE  
Disclosed is a novel organic compound synthesized by oligomerizing or polymerizing a specific quinone compound having two quinone groups at the ortho position and having a property such that the...
US20080061287 Polyacene Compound And Organic Semiconductor Thin Film  
The present invention provides an organic semiconductor material which exhibits a high mobility, and excellent solubility in solvents and oxidation resistance. The present invention also provides...
US20050085452 Process for the synthesis of pharmacologically active (z/e)-guggulsterones  
The invention relates to an improved process for producing pharmacologically active synthetic stereoisomeric mixture of guggulsterones (4) in the three steps. The mixture of gugguisterones...
US20090275767 PROCESS FOR SYNTHESIS OF ANDROSTANE 17-BETA CARBOTHIOIC ACID AND RELATIVE COMPOUNDS THEREOF  
A process for synthesis of androstane 17-β carbothioic acid is provided. The process includes mixing an androstane 17-β carboxylic acid and a coupling reagent, and adding an alkanethioic acid to...
US20090004402 Radiation Crosslinker  
There is provided a class of crosslinking compound, said compound comprising (i) one or more fluorinated aromatic group; and (ii) one or more ionisable group, wherein the crosslinking compound is...
US20080234505 Exemestane and Its Intermediates and Methods of Making the Same  
A method is provided for preparing an aromatase inhibitor of formula (I) wherein each of R1, R2, R3, R4, independently, is hydrogen, halogen or C1-C6 alkyl. In one form, the aromatase inhibitor is...
US20080108122 Microchemical nanofactories  
Embodiments of an apparatus, system, and method for chemical synthesis and/or analysis are disclosed. One embodiment of a disclosed apparatus comprises a laminated, microfluidic structure defining...
US20060035872 Process for the preparation of 3-oximino steroids  
The present invention provides a method of preparing norelgestromin or norgestimate by reacting the corresponding 3-oxosteroid precursor with hydroxylamine HCl and a base to obtain a reaction...
US20050143365 Structural modification of 19-norprogesterone I: 17-alpha-substituted-11-beta-substituted-4-aryl and 21-substituted 19-norpregnadienedione as new antiprogestational agents  
The present invention relates, inter alia, to compounds having the general formula: in which: R1 is a member selected from the group consisting of —OCH3, —SCH3, —N(CH3)2, —NHCH3, —NC4H8, —NC5H10,...
US20120142653 C-28 AMIDES OF MODIFIED C-3 BETULINIC ACID DERIVATIVES AS HIV MATURATION INHIBITORS  
Compounds having drug and bio-affecting properties, their pharmaceutical compositions and methods of use are set forth. In particular, modified C-3 and C-28 betulinic acid derivatives that possess...
US20100217020 PROCESS FOR PRODUCING VITAMIN D DERIVATIVE USING CONVERGENT METHOD  
There are provided a novel process for producing [{(5Z,7E)-(1S,3R,20S)-1,3-dihydroxy-9,10-secopregna-5,7,10(1 9),16-tetraen-20-yl}oxy]-N-(2,2,3,3,3-pentafluoropropyl)acet amide, which process is...
US20130041106 CHEMOSELECTIVE ENRICHMENT FOR COMPOUND ISOLATION  
Chemoselective isolation of hydroxyl group-containing and carboxyl group-containing compounds is accomplished via formation of polymeric silyl ethers and polymeric siloxyl esters, respectively....
US20100249083 16,17-CARBOCYCLIC CONDENSED STEROID COMPOUNDS HAVING SELECTIVE ESTROGENIC ACTIVITY  
The invention discloses a steroid compound having the formula (1): wherein dotted bonds represent optional double bonds; R6 is H, ═CH2, or —CH3, or —CH2—CH3; R7 is H, C1-4-alkyl, C2-5 alkenyl or...
US20100130455 BISMETHYLENE-17A CARBOLACTONES AND RELATED USES  
Described herein are bismethylene-17α carbolactone derivatives having progestational and/or antimineralocorticoid and/or aldosterone antagonistic activity. Also described herein are methods of...
US20070249014 LABELING AND DETECTION OF POST TRANSLATIONALLY MODIFIED PROTEINS  
Provided in certain embodiments are new methods for forming azido modified biomolecule conjugates of reporter molecules, carrier molecules or solid support. In other embodiments are provided...
US20150056367 COMPOSITION FOR FORMING LIQUID CRYSTAL ALIGNMENT FILM AND LIQUID CRYSTAL DISPLAY ELEMENT  
The present invention, which enables to align a liquid crystal molecule, when no voltage is applied thereto, and also to control pretilt angle of the liquid crystal molecule, relates to a...
US20100261917 PROCESS FOR PRODUCING VITAMIN D DERIVATIVE USING PHOTOREACTION  
There are provided a novel process for producing [{(5Z,7E)-(1S,3R,20S)-1,3-dihydroxy-9,10-secopregna-5,7,10(1 9),16-tetraen-20-yl}oxy]-N-(2,2,3,3,3-pentafluoropropyl)acet amide, which process is...
US20070021394 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic ester derivative  
A drug effective for the treatment and prevention of psychiatric disorders such as schizophrenia, anxiety and related ailments thereof, depression, bipolar disorder and epilepsy. The drug...
US20060281719 Oestrogen-17-sulphamates as inhibitors of steroid sulphatase  
There is provided a compound of Formula I wherein X is a ring system; R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group;...
US20060247220 Preventing the crystallization of cholesterol using oxysterols  
A therapeutic agent in the treatment of humans or animals wherein the agent is oxysterol, and a method of treatment wherein the agent is administered orally, parenterally, transdermally, buccally,...
US20060234956 Dicarboxylic acid ester derivatives of ginsenoside, pharmaceutical preparations containing the same, and preparation thereof  
The present invention relates to a series of dicarboxylic acid ester derivatives of ginsenosides such as succinate and glutarate derivatives of 20-O-β-D-glucopyranosyl-protopanaxadiol (compound K,...
US20050113349 2-Alpha vitamin D derivatives having substituents  
An object of the present invention is to synthesize a novel vitamin D3 derivative having a substituent at the 2α-position. The present invention provides vitamin D derivatives represented...
US20120248389 STABLE, WATER-SOLUBLE NEAR INFRARED DYES  
The synthesis of stable, water-soluble tris and tetrakis aminium dyes. More particularly, carboxylic-acid modified tris and tetrakis dye intermediates, as well as salts and near-infrared dyes...
US20120035369 METHOD FOR PRODUCING OPTICALLY ACTIVE DIAMINE DERIVATIVE  
The problem to be solved is to provide an important intermediate for production of an FXa inhibitor. The solution thereto is a method for industrially producing a compound (1) or a compound (4),...
US20100183517 Peptidomimetic Inhibitors Of PSMA, Compounds Comprising Them, And Methods Of Use  
Compounds of the formula, A-L-B, wherein A is glutamate or a glutamate analog; L is a phosphoramidate or a phosphoramidate analog; and B is serine or a serine analog are described which are potent...
US20100143830 SULFONIUM SALT, ACID GENERATOR, RESIST COMPOSITION, PHOTOMASK BLANK, AND PATTERNING PROCESS  
A sulfonium salt has formula (1) wherein R1 is a monovalent hydrocarbon group except vinyl and isopropenyl, R2, R3, and R4 are alkyl, alkenyl, oxoalkyl, aryl, aralkyl or aryloxoalkyl or may bond...