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US20070191599 METHODS OF MANUFACTURING CORTISCOSTEROID SOLUTIONS  
The present invention relates to methods of manufacturing compositions comprising a corticosteriod and at least one solubility enhancer, as well as compositions made by these methods.
US20080008930 Ionic Liquid  
The present invention relates to ionic liquids having low melting points, low viscosities and high electrical conductivities; and more specifically, to ionic liquids including at least one organic...
US20080234506 PROCESS FOR THE PREPARATION OF FLUOROTETRAENE  
There is provided a process for preparing 21-acetyloxy-6-alpha-fluoro-pregna-1,4,9(11),16-tetraene-3,2 0-dione compound of Formula I, which comprises reacting...
US20070149781 Process for preparing bisphospholane ligands  
The present invention is directed at a process for preparing enantiomerically enriched compounds of the general formula (I). Compounds of the type shown are employed in catalyst systems.
US20140107323 SDP-containing Heterobifunctional Agents  
The present disclosure is directed to a reactive ester agent for conjugating a click-reactive group to a carrier molecule or solid support. The reactive ester agent has the general formula IA,...
US20110008634 RUST INHIBITOR AND SURFACE TREATMENT METAL MATERIAL  
A rust inhibitor usable for metal surface coating includes, as an effective component, a compound containing a chelate group, and a long chain alkyl group and/or a cyclic alkyl group, which are...
US20060217358 Use of derivatives of cholest-4-en-3-one as medicaments, pharmaceutical compositions containing same, novel derivatives and preparation method thereof  
Compound of formula I where X=O or ═N—OH group, R represents a group chosen from A=hydrogen or together with B a carbon-carbon bond, B=hydrogen, hydroxy or together with A a carbon-carbon bond, C,...
US20150203442 Anthraquinone Analogs and Methods of Making and Using Thereof  
Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system. Such rings...
US20140357868 METHODS FOR STEREOSELECTIVE REDUCTION  
The invention is directed to a method to reduce a C—C double bond of an enone of a steroidal compound to produce a mixture of β ketone product and α ketone product, comprising treating a solution...
US20140274936 COORDINATION COMPLEXES, PHARMACEUTICAL SOLUTIONS COMPRISING COORDINATION COMPLEXES, AND METHODS OF TREATING PATIENTS  
A coordination complex having a physiologically acceptable pKa includes a metal and a biologically active agent. The pKa of the coordination complex is less than the pKa of the biologically active...
US20110077228 NOVEL C-21-KETO LUPANE DERIVATIVES PREPARATION AND USE THEREOF  
The invention relates to 21-keto triterpene compounds of formula (I): wherein R1, X and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit...
US20070287672 Macromolecular Gsh-Activiated Glyoxylase I Inhibitors  
This invention relates to macromolecular prodrugs having antitumor activity when activated by GSH, and methods for synthesizing and administering these to patients. More particularly, this...
US20150018322 PRO-DRUG FORMING COMPOUNDS  
Various prodrug compounds having the general structure: Active agent-(acid)-(linker)-SO2NR1R2 are described herein. Compounds having this general structure were shown to be more orally active than...
US20140221231 TH-17 DIFFERENTIATION MARKERS FOR ROSACEA AND USES THEREOF  
A method is described that uses ROR gamma t, or ROR alpha to diagnose rosacea and/or to screen inhibitors of Th17 differentiation, notably in inhibiting ROR gamma t or ROR alpha. Also described is...
US20090187032 INDUSTRIAL PROCESS FOR THE SYNTHESIS OF 17alpha-ACETOXY-11beta-[4-(N,N-DIMETHYL-AMINO)-PHENYL]-19-NORPREGNA-4,9-DIENE-3,20-DIONE AND NEW INTERMEDIATES OF THE PROCESS  
The present invention relates to a new industrial process for the synthesis of solvate-free 17α-acetoxy-11β-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna -4,9-diene-3,20-dione [CDB-2914] of formula...
US20100305309 NANODIAMOND PARTICLE COMPLEXES  
The present invention provides various functionalized nanodiamond particles. In particular, the present invention provides soluble complexes of nanodiamond particles and therapeutic agents, for...
US20140364405 TREATMENT OF SEBORRHOEA  
A method for the treatment of seborrhoea in a patient comprises administering to the patient an effective amount of (24RS) or (24S) scymnol, an ester thereof or a pharmaceutically acceptable salt...
US20100204497 Process For The Preparation of 7 alpha-Methylsteroids  
The invention relates to a process for the preparation of 7α-methyl hydroxy steroids of the formula I wherein R1 is hydrogen, methyl or C≡CH; R2 is (CH2)nOH, wherein n is 0, 1 or 2; by a copper...
US20140046061 Processes Employing Cyclodextrin Derivative Quaternary Salts  
Chiral salts comprising anionic cyclodextrin derivatives with particular types of non-metal cations are provided. The anionic CD derivative salts can serve as ionic liquids and can possess...
US20120029013 DERIVATIVES OF AMINOCYCLOBUTANE OR AMINOCYCLOBUTENE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICAL PRODUCTS  
The present invention concerns compounds of general formula (1), where in:—-a- is a single or double bond, Ar is an aromatic group, substituted or unsubstituted, R1 and R2 each independently or...
US20110178316 NOVEL FULLERENE CYCLOPROPANATION REACTION  
Fullerene compounds represented by the formulae Cm[C(R)CON3]n, Cm[C(R)NCO]n, Cm[C(R)NHCORd]n, and Cm[C(R)NH2]n, wherein Cm represents a fullerene moiety having m carbon atoms, m represents an even...
US20150191504 PREPARATION METHOD OF DEGLYCOSYLATED GINSENOSIDES  
The present invention provides a preparation method of deglycosylated ginsenosides, which uses the supercritical fluid technology to conduct the deglycosylation of ginsenosides extract in...
US20100222286 RECEPTOR MODULATORS EXHIBITING NEUROPROTECTIVE AND MEMORY ENHANCING ACTIVITIES  
The present invention provides therapeutically active compounds and compositions as NMDA and MC receptor antagonists, which are useful in preventing and treating central nervous system disorders...
US20070042999 Phosphate derivatives of pharmaceutical products  
According to the invention, there is provided a complex of a pharmaceutical compound selected from the group consisting of opioids, hormones, anaethetics and chemotherapeutic agents comprising the...
US20120149732 MULTIFUNCTIONAL LINKERS AND METHODS FOR THE USE THEREOF  
In accordance with the present invention, novel multifunctional compounds have been developed which have orthogonal reactive groups thereon, thereby facilitating preparation of compounds having...
US20120149653 MULTIFUNCTIONAL LINKERS AND METHODS FOR THE USE THEREOF  
In accordance with the present invention, novel multifunctional compounds have been developed which have orthogonal reactive groups thereon, thereby facilitating preparation of compounds having...
US20100144683 METHODS FOR GENERATING MAMMALIAN MODELS OF ATOPIC DISEASES, AND SCREENING FOR THEIR TREATMENT  
The present invention concerns a method for generating a human atopic disease-like phenotype, preferably an atopic dermatitis (AD)-like phenotype in a mammal comprising administering to said...
US20110082295 NOVEL CURCUMIN DERIVATIVE  
To develop a highly safe measure to treat Alzheimer's disease using a secretase-inhibiting substance, there is provided a compound represented by the following general formula (I) or a salt...
US20060110771 Proteins capable of binding to female sex hormones and process for producing the same  
The present invention provides a protein capable of binding to a female sex hormone, which protein is supplemented with useful properties for measuring, quantifying and concentrating female sex...
US20090124819 2-SUBSTITUTED VITAMIN D DERIVATIVES  
The object of the present invention is to synthesize novel vitamin D derivatives. According to the present invention, there are provided vitamin D derivatives represented by the following general...
US20130123522 PROCESS FOR PREPARATION OF LACOSAMIDE AND SOME N-BENZYL-PROPANAMIDE INTERMEDIATE DERIVATIVES  
The present invention discloses novel process for the preparation of (2R)-2-acetamido-N-benzyl-3-methoxypropanamide of Formula I involving novel intermediates of Formula-XIX and Formula-XX.
US20120141788 PROCESS AND DEVICE FOR THE PRECIPITATION OF AN ORGANIC COMPOUND  
The present invention relates a process for the precipitation of an organic compound, wherein: (a) a solution (I) of the organic compound in a first solvent is introduced via a first inlet into a...
US20090062526 NOVEL METHOD OF SYNTHESIZING ALKYLATED BILE ACID DERIVATIVES  
A novel, improved method of synthesizing alkylated bile acid derivatives is provided. Such derivatives include, but are not limited to the active, potent, and selective FXR receptor agonist such...
US20070060746 PROCESSES FOR PREPARATION OF 9,11 EPOXY STEROIDS AND INTERMEDIATES USEFUL THEREIN  
Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula I wherein: -A-A- represents the group...
US20080200533 Drug or Pharmaceutical Compounds and a Preparation Thereof  
The administration of pharmaceuticals of drugs which are having less solubility, lower bioavailability, lower bioabsorbability, less rate of absorption has become a big challenge in day to day...
US20150007851 MEANS FOR DYEING AND/OR MATTING KERATINIC FIBRES CONTAINING NOVEL 1,4 DIAMINOANTHRAQUINONE DYES  
Agents for coloring and/or matting keratinic fibers, in particular human hair, include in a cosmetic carrier at least one specific substituted 1,4-diaminoanthraquinone derivative of formula (I),...
US20110288061 Triterpenoid derivatives, benzenoid derivatives and pharmaceutical compositions containing the same  
The present invention relates to triterpenoid derivatives, benzenoid derivatives, and pharmaceutical compositions containing the same for treating cancers or inflammatory symptoms. According to...
US20050245752 Synthesis of unsymmetric anthracene compounds  
A process for forming an unsymmetric anthracene compound comprises a first step of forming a 9-perfluoroalkylsulfonate derivative of anthrone by reacting the anthrone with a perfluoroalkyl...
US20130317109 PROCESS FOR THE PREPARATION OF LACOSAMIDE  
There is provided a process for the preparation of Lacosamide (which is a useful medicament) of formula I, which comprises an enantioselective enzymatic acylation.
US20110224182 SALTS OF (3-0-(3',3'-DIMETHYLSUCCINYL) BETULINIC ACID AND SOLID STATE FORMS THEREOF  
The present invention concerns novel pharmaceutically active compounds, pharmaceutical compositions containing the same, methods of making the compounds, polymorphic forms of the compounds, the...
US20060003971 Aromatic a-ring derivatives of tetracycline compounds  
Aromatized A-ring derivatives of tetracycline compounds are described.
US20110098493 Method of separating ergosterol  
The present invention provides a method of separating ergosterol from a solution containing ergosterol in water-insoluble organic solvent, comprising supplying water to the solution and...
US20100222571 PROCESS FOR THE PREPARATION OF DROSPIRENONE  
A process for the preparation of Drospirenone (I) according to the scheme (A) wherein the substituent R is defined in the description. The process improves the product yield and purity by reducing...
US20140014882 FULLERENE DERIVATIVE AND PHOTOELECTRIC CONVERSION DEVICE USING SAME  
The present invention provides a fullerene derivative having an electron donating group adjacent to the fullerene nucleus, represented by formula (I) which exhibits a high LUMO energy and a high...
US20100256402 NOVEL SOLVATE  
The present invention relates to the novel crystalline form X of Tigecycline and to processes of preparing the same. Furthermore the present invention relates to the use of crystalline form X of...
US20150225443 NOVEL DERIVATIVES OF CHOLEST-4-EN-3-ONE OXIME, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PREPARATION METHOD  
The object of the invention is the use as a drug of a compound fitting formula I wherein X represents an oxygen atom or a ═N—OH groupand R represents a group selected from or one of its esters...
US20130012480 CRYSTALLINE SALTS OF (4S,4AS,5AR,12AS)-4-DIMETHYLAMINO-3,10,12,12A-TETRAHYDROXY-7-[(METHOXY(METHYL)AMINO)-METHYL]-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-NAPHTHACENE-2-CARBOXYLIC ACID AMIDE AND METHODS OF USING THE SAME  
A crystalline mono hydrochloride salt of (4S,4aS,5aR,12aS)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7 -[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11 ,12a-octahydro-naphthacene-2-carbo...
US20120122827 Novel derivatives of cholest-4-en-3-one oxime, pharmaceutical compositions containing them and preparation method  
The object of the invention is the use as a drug of a compound fitting formula I wherein X represents an oxygen atom or a ═N—OH group and R represents a group selected from or one of its esters...
US20110286958 HPMA POLYMER PLATINUM CHELATES  
Polymeric platinum amidomalonate complexes, where the platinum is in +2 or +4 oxidation state, and where the complexes optionally contain tumor seeking groups, are useful in the treatment of cancer.
US20100016263 9, 10-SECOPREGNANE DERIVATIVE AND PHARMACEUTICAL  
A main object of the invention is to provide a novel useful vitamin D3 derivative, which has an excellent vitamin D3 activity and, as compared with conventional vitamin D3 derivatives, has a...