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US20100063272 METHOD FOR PRODUCING STEROID COMPOUND  
It is an object of the present invention to provide a novel method for producing a steroid compound. The present invention provides a method for producing 5β-3,7-dioxocholanic acid or an ester...
US20110190505 Iodonium Cyclophanes for SECURE Arene Functionalization  
This disclosure relates to compounds, reagents, and methods useful in the synthesis of aryl fluorides, for example, in the preparation of 18F labeled radiotracers. For example, this disclosure...
US20080194533 PROCESS FOR SELECTIVE SULFATION OF AROMATIC HYDROXYL GROUPS  
The present invention relates to processes for selective sulfation of an aromatic hydroxyl group over an aliphatic hydroxyl group where both are present in the same molecule. This invention also...
US20100291622 NOVEL COMPOUND, PROCESS FOR PRODUCTION THEREOF, AND USE THEREOF  
The present invention provides compounds which exhibit an inhibitory effect on undecaprenyl diphosphate synthase of microbes and thereby they are expected to be used clinically as pharmaceutical...
US20080142454 Cyclooctene monomers and polymers, and water purification articles and methods utilizing them  
Azidoaryl-substituted cyclooctene monomers and synthesized and used in the preparation of various copolymers. Among these copolymers are those prepared from ring-opening metathesis polymerization...
US20060223827 Bioreductively activated stilbene prodrugs  
A compound of formula (1), or a pharmaceutically acceptable salt thereof, wherein Ar is a substituted heteroaryl group bearing at least one nitro or azido group or is a group of formula (2) or...
US20050119241 Preparation of 24 alkyl analogs of cholecalciferol and non-racemic compounds  
Disclosed is a process for the preparation of 24-alkyl analogs of cholecalcyferol of Formula 1 having a (5E) or (5Z) configuration, wherein X represents a hydrogen atom, a hydroxy group or an OR1...
US20120004183 Unnatural reactive amino acid genetic code additions  
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include...
US20120238740 NON-POLAR AND POLAR LEAVING GROUPS  
The present invention provides novel and advantageous processes for preparing and purifying pharmaceuticals The processes comprise a nucleophilic reaction wherein a modified leaving group LM,...
US20070015740 Derivative prodrugs of ethinyl estradiol  
The present invention is a prodrug derivative of ethinyl estradiol according to Formula I:
US20140038925 Novel Vitamin D Receptor Modulators with Partial Agonist Activity  
The present invention provides a compound which functions as a selective vitamin D receptor modulator and has action-selectivity or tissue-selectivity such that it does not induce hypercalcemia...
US20100278896 SOLID COMPOSITIONS  
A solid, implantable dosage form comprising a therapeutically active agent in solid form, optionally with one or more pharmaceutically acceptable excipients, wherein the one or more excipients,...
US20050085644 Novel 3-aryl-2,5-dihydroxy-1,4-benzoquinone derivatives, their preparation method and pharmaceutical compositions containing same  
Compound of formula (I): wherein: R1 and R2, which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: R4...
US20140018538 HIGH-VALENT PALLADIUM FLUORIDE COMPLEXES AND USES THEREOF  
The present invention provides novel high-valent palladium complexes. The complexes typically include multi-dentate ligands that stabilize the octahedral coordination sphere of the palladium(IV)...
US20090118495 Process for the Preparation of 6-alpha,9-alpha-difluoro-17-alpha-((2-furanylcarbonyl)oxy)-11-beta-hydroxy-16-alpha-methyl-3-oxo-androsta-1,4-diene-17-beta- -carbothioic acid S-fluoromethyl  
A novel process for preparing a compound of formula (I) which comprises converting a compound of formula (II) to a compound of formula (I) via a compound of formula (III), or a salt thereof,...
US20090093638 Allylic Oxidations Catalyzed by Dirhodium Catalysts under Aqueous Conditions  
The present invention relates to compositions and methods for achieving the efficient allylic oxidation of organic molecules, especially olefins and steroids, under aqueous conditions. The...
US20130030195 Crystalline Minocycline Base and Processes for its Preparation  
The invention provides crystalline minocycline base. In particular, three crystalline polymorphic forms, designated Form I, Form II and Form III, of minocycline base are provided. These are...
US20080035243 Covalent modification of metal surfaces  
The present invention provides modified metal surfaces, methods of preparing the same, and intermediates thereto. These materials are useful in a variety of applications including biomaterials.
US20140106979 POLYMERS HAVING ORTHOGONAL REACTIVE GROUPS AND USES THEREOF  
Polymers having orthogonal reactive groups and solid supports comprising polymers immobilized thereto are provided. The polymers find utility in any number of applications including immobilizing...
US20150005489 PROCESS FOR THE PREPARATION OF ABIRATERONE AND INTERMEDIATES THEREOF  
The present invention provides intermediates for preparing abiraterone, and processes for preparing abiraterone and intermediates thereof. The intermediates include a compound of formula (IV):...
US20130150571 Colored Polysiloxanes  
Disclosed are compounds of the formulae wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R13 are hydrogen, alkyl, aryl, arylalkyl, or alkylaryl, R10, R11, and R12 are alkylene, arylene,...
US20120309719 (22E)-2-METHYLENE-26,27-CYCLO-22-DEHYDRO-1ALPHA-HYDROXY-19-NORVITAMIN D3 DERIVATIVES  
Cyclopropane-containing vitamin D analogs of formulas I and IV are provided. Such compounds may be used in preparing pharmaceutical compositions and are useful in treating a variety of biological...
US20100317639 Medicament Based On a Monoester of Steroids With Long Chain Fatty Acids  
A monoester of a family of steroids with a C16-C24 fatty acid for use as a medicament is disclosed. Particularly the monoester of 5α-androstan-3α,17β-diol with a C16-C24 fatty acid is disclosed,...
US20140235536 INJECTABLE SOLUTION AT PH 7 COMPRISING AT LEAST ONE BASAL INSULIN THE ISOELECTRIC POINT OF WHICH IS COMPRISED IN 5.8 AND 8.5 AND AN ANIONIC COMPOUND BEARING CARBOXYLATE CHARGES AND HYDROPHOBIC RADICALS  
A composition in the form of an injectable aqueous solution, the pH of which is from 6.6 to 7.8, comprises at least: a) a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5;...
US20120245110 VASCULAR LEAKAGE INHIBITOR  
The present disclosure relates to a novel vascular leakage inhibitor. The novel vascular leakage inhibitor of the present disclosure inhibits the apoptosis of vascular endothelial cells, inhibits...
US20080306230 Composition and Associated Method  
A composition includes a Group (VIII) transition metal, an anionic ligand bonded to the metal, a neutral electron donor ligand bonded to the metal, and an alkylidene group bonded to the metal. The...
US20070049560 Tigecycline and methods of preparing 9-nitrominocycline  
Methods of preparing and purifying tetracyclines, such as tigecycline, are disclosed. Also disclosed are tetracycline compositions, such as tigecycline compositions, prepared by these methods.
US20120264901 POLYURETHANE SYNTHESIS BY MEANS OF SELF-CONDENSATION  
The present invention relates to a compound with the following formula (I) where: R1 is particularly a straight or branched alkyl group, a is a single or double bond; R2 is particularly a hydrogen...
US20150246943 CRYSTALLINE POLYMORPHIC FORM OF ULIPRISTAL ACETATE  
A novel crystalline polymorphic form of ulipristal acetate useful as an agent for preventing and/or treating uterine leiomyoma and as a contraceptive, and a process for producing the crystalline...
US20110015269 PROCESS FOR THE PREPARATION OF DIACERIN  
The invention concerns a new process for the preparation of high purity diacerein, by oxidisation of the protected aloe-emodin in the presence of an oxidising system and radical catalyst and...
US20110245520 METHOD OF MAKING FLUORINATED ALKOXY CARBOXYLIC ACIDS AND PRECURSORS THEREOF  
A method for preparing saturated partially fluorinated alkoxy carboxylic acids or salts thereof by treating a compound: (II), where Rf represents a fluorinated, linear or branched alkyl residue...
US20110124893 ANTIBIOTIC COMPOUNDS  
The present invention relates to the new crystalline solid form XI of Tigecycline and a process of preparing the same. Form XI of Tigecycline is particularly suitable for the isolation of...
US20130158126 CANNABINOID QUINONE DERIVATIVES  
Cannabinoid quinone derivatives. The present invention refers to cannabinoid quinone derivatives to be used as medicaments, particularly as PPAR gamma (PPARg) agonists for treating diseases which...
US20070055072 Process for preparing guggulsterones and guggulsterol  
The present invention relates to a method for selective preparing 4,17 (20)-E-pregnadiene-3,16-dione (E-guggul-sterone) of the formula (III) and 4,17 (20)-Z-pregnadiene-3,16-dione...
US20140045697 ANDROSTANEDIOL DERIVATIVES AS PLANT GROWTH REGULATOR COMPOUNDS  
The present invention relates to novel androstan derivatives, methods for their production, and their use for influencing plant growth.
US20140088061 PHARMACEUTICAL COMPOSITION  
The invention relates to a solid pharmaceutical composition comprising solid amorphous fulvestrant, said composition being formulated in combination with a solubilizing composition. The invention...
US20110038847 PROCESS FOR PREPARING BIOABSORBABLE SHEET PREPARATION HOLDING THROMBIN  
A process for preparing a bioabsorbable sheet preparation holding thrombin is provided. A process for preparing a bioabsorbable sheet preparation holding thrombin which comprises immersing a...
US20080114180 Process for the Preparation of 21-Hydroxy Steroids with Control of the Epimeric Distribution at the C-21 Position  
A process is described for preparing, exclusively by chemical way, 21-hydroxy steroids having progestinic activity, said process having a high stereochemical control at C-21 position.
US20090220887 Molecular Resists Based On Functionalized Polycarbocycles  
The present invention refers to new organic molecules, derived from the class of polycarbocycle derivatives, and their application as components of photoresists, and in particular as components of...
US20050080065 Process for the production of 6α,9.alpha-difluoro-17α-(1-oxo-propoxy-11β-hydroxy-16α-methyl-3-oxo-androst-1,4-diene-17β-carbothioic acid  
A process for preparing a compound of formula (II) or a salt thereof is described.
US20070249573 17alpha-substituted 4-(3-oxoestra-4,9-dien-11beta-yl)-benzoic acid, its derivatives and process for its production  
This invention relates to 17α-substituted 4-(3-oxoestra-4,9-dien-11β-yl)-benzoic acids and derivatives thereof, a process for the production of these compounds, the use of the compounds for the...
US20120283228 2alpha-Methyl and 2beta-Methyl Analogs of 19,26-Dinor-1alpha,25-Dihydroxyvitamin D3 and Their Uses  
This invention discloses 2α-methyl and 2β-methyl analogs of 19,26-dinor-1α,25-dihydroxyvitamin D3 and pharmaceutical uses therefor. These compounds exhibit in vitro biological activities...
US20060241018 Linkers for radiopharmaceutical compounds  
A new and improved method for extending the half life of pharmaceutical compounds for use in diagnostic imaging or therapy uses a novel linker to attach a diagnostic or therapeutic moiety to a...
US20090163458 Compositions and methods for treating Parkinson's disease and related disorders  
The present disclosure relates generally to methods and compositions for treating symptoms of Parkinson's disease and/or other movement disorders. More particularly, the present disclosure...
US20150110709 METHOD FOR PRODUCING NANOPARTICLES  
A method for producing a nanoparticle to separate a diketopyrrolopyrrole pigment includes separating an α-type diketopyrrolopyrrole pigment nanoparticle having high crystallinity by carrying out...
US20100305078 METALLO-OXIDOREDUCTASE INHIBITORS USING METAL BINDING MOIETIES IN COMBINATION WITH TARGETING MOIETIES  
The presently disclosed subject matter is directed to metallo-oxidoreductase inhibitors having metal binding moities linked to a targeting moiety through a linking group or a direct bond, methods...
US20120129927 New Anthraquinone Derivatives  
The invention relates to two novel substances, namely (1R,2S,3S,4R)-3-acetoxy-1,2,4,5-tetrahydroxy-7-methoxy-2-met hyl-1,2,3,4-tetrahydroanthracene-9,10-dione (3-O-acetyl altersolanol M) and...
US20100311977 METHOD FOR PRODUCING 2-AZAADAMANTANE  
To provide a method whereby a 2-azaadamantane can easily be obtained in good yield. A method for producing a 2-azaadamantane represented by the formula (1), which comprises cyclizing a compound...
US20090318721 Process for the preparation of 7alpha-alkylated 19-norsteroids  
Processes useful in the preparation of pharmaceutical compounds such as fulvestrant and processes for the preparation of fulvestrant.
US20140221632 PHOTOCATALYTIC PREPARATION METHOD OF PARYLENE AF4  
The present invention disclosed a preparation method of parylene AF4, which provides a reactant and a reducing agent with the use of catalyst or exposure to UV light with photo-initiator, to...