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US20130261175 |
2-PYRONES
The present invention relates to the use of compounds of the formula (I) for the care, preservation or improvement of the general condition or appearance of the skin or hair, and to preparations... |
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US20130047887 |
NOVEL MULTIFUNCTIONAL MOLECULES FOR DENTAL BONDING APPLICATIONS HAVING IMPROVED ADHESION
The present invention describes dental adhesive compositions used for bonding dental biomaterials to hard tissue comprising a polymerizable blend of one or more newly synthesized low shrinkage,... |
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US20130245284 |
Prodrugs of Fluorinated Mevalonates to Inhibit the Mevalonate Pathway of Streptococcus pneumoniae
Fluorinated prodrug compounds as can be used for selective streptococcal mevalonate pathway inhibition. |
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US20110184056 |
USE OF STATINS AS ANTICONVULSANTS, ANTIEPILEPTICS AND NEUROPROTECTORS
The use of statins as antiepileptic, anticonvulsant, neuroprotector and antioxidant compounds, potentially useful for the prevention and/or treatment of epilepsy, epileptic seizures, convulsions,... |
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US20140356336 |
METHOD FOR INDUCING DIFFERENTIATION ENABLING TUMORIGENESIS OF IPS CELLS TO BE SUPPRESSED
The object of the invention is to provide a technique of suppressing tumorigenesis in IPS cells and inducing differentiation into target differentiated cells. In use of a statin and a... |
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US20110190307 |
Assay
The present invention provides zebrafish based methods for the identification of compounds potentially useful in the treatment of motor neuron degenerative diseases (MNDDs), compounds identified... |
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US20110054193 |
STATIN PRODUCTION
The present invention relates to a polypeptide with HMG-CoA reductase activity, to its polynucleotide congener and to a method for the production of a statin comprising over expression of said... |
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US20120172337 |
CYCLOALKYL-HYDROXYL COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES
The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and... |
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US20150258189 |
HEPATITIS C VIRUS PARTICLES FORMATION PROMOTER, AND METHOD OF PRODUCING HEPATITIS C VIRUS PARTICLES
A HCV particle formation promoter is capable of promoting formation of HCV particles in culture cells, and a method enhances production of HCV particles. A method evaluates an anti-HCV agent... |
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US20060084817 |
Synthesis of aldonolactones, aldarolactones, and aldarodilactones using gas sparging
Aldaric acids, aldonic acids, and their corresponding salts are cyclized to the corresponding lactone or dilactone using gas sparging to remove water. |
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US20060167280 |
Method for purifying simvastatin
The present invention relates to a purification method of simvastatin crystal, more particularly to a method of effectively removing impurities contained in crude simvastatin obtained by a... |
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US20140107339 |
SUBSTITUTED 3-HYDROXY-DELTA-LACTONES FROM EPOXIDES
Catalysts and methods for the carbonylation of epoxides to substituted 3-hydroxy-δ-lactones and β-lactones are disclosed. |
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US20060223882 |
Amorphous simvastatin
Amorphous simvastatin is prepared by rapidly removing solvent from a solution comprising simvastatin. The solution can also comprise a pharmaceutically acceptable carrier, to form a dispersion of... |
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US20090048335 |
PROCESS FOR PREPARING SIMVASTATIN
Preparation of simvastatin. |
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US20090156837 |
ISOLATION AND RECOVERY OF SIMVASTATIN IN LACTONE FORM OR IN THE FORM OF AN ACID SALT FROM THE HARVESTED FERMENTATION BROTH
The present invention relates to a novel process for isolation and recovery of compounds such as biosynthetically produced simvastatin in either lactone form or in the form of its acid salt in... |
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US20120095091 |
ANTIEPILEPTIC, HYPOCHOLESTEROLEMIC AND NEUROPROTECTIVE COMPOUND
The present invention describes a compound of formula (I) its hydroxy acid form, the pharmaceutically acceptable salts of said hydroxy acid and pharmaceutically acceptable prodrugs and solvates of... |
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US20060084800 |
Synthesis of aldonolactones, aldarolactones, and aldarodilactones using azeotropic distillation
Processes for making lactones and dilactones from aldaric acids, aldonic acids, and their corresponding salts by dehydrative cyclization and azeotropic distillation. The processes can be carried... |
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US20070185193 |
Huvastatin and its preparation and formulation comprising the huvastatin
The invention relates to statin compounds, and it discloses novel small molecule compounds, i.e., huvastatins, which are classified into I, II, and III. The invention also provides the preparation... |
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US20130197073 |
HYPOCHOLESTEROLEMIC, ANTI-INFLAMMATORY AND ANTIEPILEPTIC NEUROPROTECTIVE COMPOUND
The present invention describes a compound of formula (I) its hydroxy acid form, the pharmaceutically acceptable salts of said hydroxy acid and pharmaceutically acceptable prodrugs and solvates of... |
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US20070238780 |
Multifunctional enhancement systems for personal care, household, and wood products
A personal care product, a household product, an industrial formulation, or a medicinal product of at least a fluorosurfactant and/or a natural or naturally-derived or synthetic, and/or... |
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US20130281493 |
Method for Treating Cancer Harboring a p53 Mutation
A method for determining if a subject with cancer or precancerous lesions or a benign tumor, will respond to treatment with an inhibitor selected from the group comprising an inhibitor of one or... |
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US20070203334 |
Process for preparing a synthetic intermediate for preparation of branched nucleosides
A process is provided for the preparation of a key intermediate in the preparation of 2′-branched nucleoside compounds. The process includes contacting a protected precursor... |
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US20130245101 |
Liver Targeted Conjugates
Therapeutic conjugates containing a statin or a modified statin (collectively “statin”) linked to a therapeutic agent (also referred to as a drug herein) are targeted to the liver by the statin or... |
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US20120156216 |
Methods and Compositions for Treatment of Tumor Metastasis
The various embodiments of the present invention are directed to methods and compositions for treatment, inhibition or reduction of metastasis in cancers. In particular, the invention is related... |
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US20100317823 |
Production of Adipic Acid and Derivatives from Carbohydrate-Containing Materials
The present invention generally relates to processes for the chemocatalytic conversion of a glucose source to an adipic acid product. The present invention includes processes for the conversion of... |
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US20110294800 |
HYPOGLYCEMIC DIHYDROPYRIDONES
The present invention provides, inter alia, a compound of formula I: wherein the substituent designations are indicated in the Specification. The present invention also provides pharmaceutical... |
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US20110269830 |
STATIN NANOPARTICLES
The present invention relates to a complex made up of at least one molecule of statin or a derivative thereof, covalently bonded to at least one hydrocarbon radical including at least 18 carbon... |
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US20110282074 |
Process for Preparing Substantially Pure Simvastatin
This invention relates to an improved process for preparing substantially pure simvastatin (I), chemically known as... |
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US20100145046 |
Substituted 3-hydroxy-delta-lactones from epoxides
Catalysts and methods for the carbonylation of epoxides to substituted 3-hydroxy-δ-lactones and β-lactones are disclosed. |
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US20100191002 |
Method of Oxidization Using Nitric Acid
A controlled nitric acid process employing oxygen and nitric acid as co-oxidants is used to oxidize organic compounds subject to nitric acid oxidation, to their corresponding carboxylic acids.... |
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US20140206645 |
DUAL ACTION INHIBITORS AGAINST HISTONE DEACETYLASES AND 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE
Disclosed herein are novel compounds of formula (I), and uses thereof. The compounds of Formula (I) are inhibitors of histone deacetylases (HDACs) and 3-hydroxy-3-methylglutaryl coenzyme A... |
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US20110294783 |
Insecticidal Compositions Having Improved Effect
The present invention concerns boosting the activity of crop protection materials comprising inhibitors of fatty acid biosynthesis (for example phenyl-substituted cyclic ketoenols) through the... |
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US20110021592 |
ORGANIC NANOPARTICLES OBTAINED FROM MICROEMULSIONS BY SOLVENT EVAPORATION
The present invention provides a process for preparing a redispersible powder of nanoparticles of a water-insoluble organic compound, the process including the steps of: (i) preparing an... |
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US20120190870 |
ANTITUMORAL DIHYDROPYRAN-2-ONE COMPOUNDS
Antitumoral compounds obtained from a porifera, of the family Raspailiidae, genus Lithoplocamia, species lithistoides, and derivatives thereof are provided. |
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US20130309187 |
SKIN-WHITENING AGENT CONTAINING 3-HYDROXY-2-PYRONE
This invention provides a skin-whitening agent, a tyrosinase activity inhibitor, and melanin production inhibitor comprising, as an active ingredient, a compound exhibiting excellent solubility in... |
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US20110178043 |
Inhibitors of the mevalonate pathway of streptococcus pneumoniae
Compounds and related methods as can be used for selective mevalonate pathway inhibitors. |
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US20060083678 |
Radio-labeled compounds, compositions, and methods of making the same
18F radio-labeled compounds, methods of making the radio-labeled compounds, and applications of the same are disclosed. |
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US20080319211 |
PROCESS FOR THE PREPARATION OF EPOTHILONES
Intermediates in the preparation of epothilones and epothilone analogs are provided along with synthetic methods useful in the synthesis of epothilone compounds. |
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US20140256960 |
GENE EXPRESSION CASSETTE AND A TRANSFORMANT, AND A METHOD FOR MANUFACTURING 2-DEOXY-SCYLLO-INOSOSE AND A METHOD FOR PURIFYING 2-DEOXY-SCYLLO-INOSOSE USING SAID TRANSFORMANT
A transformant is prepared to insert at least a gene expression cassette comprising a gene involved in the synthesis of 2-deoxy-scyllo-inosose into E. coli as host cells. A 2-deoxy-scyllo-inosose... |
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US20120232290 |
REACTIVITY OF HYDROXYMETHYLGLUTARYL COENZYME A (HMG-COA) REDUCTASE INHIBITORS CONTAINING CONJUGATED DIENES WITH PHENOLIC ANTIOXIDANTS IN THE SOLID-STATE
The object of this invention was to probe the reactivity of lovastatin, simvastatin, pravastatin, and mevastatin in the solid-state without radical initiators in order to determine the antioxidant... |
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US20090171095 |
PRODUCTION METHOD OF HETEROCYCLIC MERCAPTO COMPOUND
A method of the invention industrially produces heterocyclic mercapto compounds useful as raw materials or intermediates in the synthesis of medicaments or pesticides, or as permanent wave agent,... |
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US20120296099 |
METHODS FOR PREPARING STATIN COMPOUNDS BY LACTONIZATION
A method for preparing a statin compound by lactonization is disclosed, which comprises the following step: lactonizing a compound of formula II into the compound of formula I in the presence of a... |
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US20100183563 |
DENTINOGENESIS PROMOTER AND DENTINOGENIC PULP-CAPPING MATERIAL
The present invention provides a dentinogenesis inducer and dentinogenesis pulp-capping material, which are effectively used for formation (regeneration) of dentin. The present invention also... |
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US20100137244 |
PREPARATION AND UTILITY OF HMG-COA REDUCTASE INHIBITORS
Chemical syntheses and medical uses of novel modulators of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and diastereomeric mixtures of isomers, individual diastereomers,... |
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US20120070511 |
MITOCHONDRIAL INHIBITORS AND USES THEREOF
Compositions which modulate mitochondrial functions treat diseases associated with cells that are hyperactively using their endoplasmic reticulum. Screening assays identify agents which modulate... |
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US20110077380 |
CARBOHYDRATE LACTONE POLYMERS
The present invention relates to a novel carbohydrate lactone, functionalized aliphatic polyesters and copolymers formed therefrom, and processes for the preparation thereof from renewable resources. |
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US20100274029 |
METHOD OF PREPARING (6R)-3-HEXYL-4-HYDROXY-6-UNDECYL-5, 6-DIHYDROPYRAN-2-ONE, AND INTERMEDIATE USED IN THE METHOD
Provided is a method of preparing a (6R)-3-hexyl-4-hydroxy-6-undecyl-5,6-dihydropyran-2-one, and a (5R)-2-hexyl-5-hydroxy-3-iminohexadecanoate derivative used in said method as an intermediate. |
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US20110251406 |
PROCESS FOR THE PREPARATION OF 2-(6-SUBSTITUTED-1,-3-DIOXANE-4-YL) ACETIC ACID DERIVATIVES
The invention relates to the preparation of 2-(6-substituted-1,3-dioxane-4-yl)acetic acid derivatives of formula (1), where X stands for a leaving group, and R1, R2, and R3 each independently... |
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US20130345429 |
PROCESS AND INTERMEDIATE COMPOUNDS USEFUL IN THE PREPARATION OF STATINS
There is provides a process for the preparation of a compound of formula (7): wherein R is an optionally substituted hydrocarbyl group or an optionally substituted heterocyclic group; provides... |
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US20120323011 |
PROCESS AND INTERMEDIATE COMPOUNDS USEFUL IN THE PREPARATION OF STATINS
There is provides a process for the preparation of a compound of formula (7): wherein R is an optionally substituted hydrocarbyl group or an optionally substituted heterocyclic group; provides... |