Matches 1 - 38 out of 38


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US20140073682 PYRROLIDINE TRIPLE REUPTAKE INHIBITORS  
In various embodiments, the present invention provides cycloalkyl pyrrolidine compounds and methods for their use in the treatment and/or prevention of various diseases, conditions and syndromes,...
US20130137744 PYRROLIDINE TRIPLE REUPTAKE INHIBITORS  
In various embodiments, the present invention provides cycloalkyl pyrrolidine compounds and methods for their use in the treatment and/or prevention of various diseases, conditions and syndromes,...
US20120022125 PYRROLIDINE TRIPLE REUPTAKE INHIBITORS  
In various embodiments, the present invention provides cycloalkyl pyrrolidine compounds and methods for their use in the treatment and/or prevention of various diseases, conditions and syndromes,...
US20130180591 ELECTROLYTE FORMULATIONS  
The present invention relates to electrolyte formulations comprising at least one imidazolium fluorotricyanoborate or pyrrolidinium fluorotricyanoborate and their use in an electrochemical and/or...
US20110172189 Aryl-Phenyl-Sulfonamido-Cycloalkyl Compounds and Their Use  
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively...
US20090220407 PREPARATION AND FUNCTIONALIZATION OF CARBON NANO-ONIONS  
Disclosed are methods for forming carbon nano-onions. The methods include annealing a carbon nanodiamond starting material in an inert atmosphere. The method can be carried out at ambient...
US20050014700 Cbi analogues of cc-1065 and the duocarmycins  
132 CBI analogues of CC-1 065 and the duocarmycins having dimeric monocyclic, bicyclic, and tricyclic heteroaromatics substituents were synthesized by a parallel route. The resultant analogues...
US20070232586 Hydrazino-Substituted Heterocyclic Nitrile Compounds and Use Thereof  
A compound having an inhibitory activity against cysteine protease, represented by formula (I): (wherein ring X is a heterocyclic group which may contain 1 to 4 hetero atoms selected from an...
US20060052315 Cb 1/cb 2 receptor ligands and their use in the treatment of pain  
Compounds of formula (I) or pharmaceutically acceptable salts thereof wherein Ar1?, Ar2?, R1?, R2?, n and X are as defined in the specifications well as salts and pharmaceutical compositions...
US20150152045 REACTIVE IONIC LIQUIDS  
The invention relates to reactive ionic liquids containing organic cations with groups or substituents which are susceptible to electrochemical reduction and anions obtained from fluoroalkyl...
US20140187790 OLIGOMER-OPIOID AGONIST CONJUGATES  
The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of...
US20120220635 AMINOETHYLAROMATIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR  
The present invention relates to aromatic compounds of the formula (I) and the physiologically tolerated acid addition salts thereof. The invention also relates to the use of a compound of the...
US20060079719 Aminated compounds bearing at least an allyl and a difluoromethyl and method used for synthesis thereof  
The invention relates to aminated compounds bearing at least an allyl and a difluoromethyl and a method used for synthesis thereof. Said compounds comprise at least one carbon bearing: an amine...
US20050113309 Crystalline forms(2s)-n-5[amino(imino)methyl]-2-thienylmethyl-1-(2r)-2[(carboxymethyl) amino]-3,3-diphenylpropanoyl-2-pyrrolidinecarboxamide nh2o  
The present invention relates to crystalline forms of (2S)-N-5-[amino(imino)methyl]-2-thienyl-methyl-1-(2R)-2-[(ca rboxymethyl)amino]-3,3-diphenylpropanoyl-2-pyrrolidinecarbox amide nH2O.
US20100048549 Peptidomimetics selective for the somatostatin receptor subtypes 1 and/or 4  
The invention relates to (hetero)arylsulfonylamino based peptidomimetics of formula (I), wherein A, D, E, J, Q1 R1, R2, R3, p and j are defined as disclosed, or a pharmaceutically acceptable salt...
US20120215005 High Stability Diionic Liquid Salts  
The present invention relates to diionic liquid salts of dicationic or dianionic molecules, as well as solvents comprising diionic liquids and the use of diionic liquids as the stationary phase in...
US20080058528 Synthesis of (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile  
A process for making (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)p iperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile and salts thereof, and intermediates used in the process are...
US20070237818 Controlled-release formulation of HCV protease inhibitor and methods using the same  
Controlled-release dosage formulations including at least one compound of Formulae I to XXVIII herein and a controlled-release carrier and methods of treatment using the same are provided.
US20080045470 Ceramides and Apoptosis-Signaling Ligand  
The invention provides the compounds of formula ( ): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, A, X, Y, a, b and n are as defined herein. Also disclosed are methods...
US20140275569 METHOD FOR DECARBOXYLATION OF AMINO ACIDS VIA IMINE FORMATION  
The present application provides methods for decarboxylation of amino acids via imine formation with a catalyst under superheated conditions in either a microwave or oil bath.
US20070270593 Ruthenium(II) catalysts for use in stereoselective cyclopropanations  
Chiral ruthenium catalysts comprising salen and alkenyl ligands are provided for stereoselective cyclopropanation, and methods of cyclopropanation are provided. The chiral ruthenium catalyst is...
US20070117986 TRANS-3,5-DISUBSTITUTEDPYRROLIDINE: ORGANOCATALYST FOR anti-MANNICH REACTIONS  
A compound of Formula I is disclosed, in which R is a substituent containing a hydrogen bond-forming atom within three atoms from the ring carbon to which the substituent is bonded; X is CH2, O, S...
US20110082248 POLYAMINE HAVING A REDUCED BLUSHING EFFECT, AND USE THEREOF AS A CURING AGENT FOR EPOXY RESINS  
Polyamines A1 of formula (I) or (II). They can be easily synthesized from readily available raw materials and have no primary amino groups or only a low content of primary amino groups and thus...
US20100105753 Inhibitors of Fibroblast Activation Protein, and Methods of Use Thereof  
One aspect of the present invention relates to synthetic peptide derivatives that inhibit fibroblast activation protein α (FAP) activity. Another aspect of the invention relates to methods for...
US20060046967 Prodrugs containing novel bio-cleavable linkers  
The invention provides the compounds of formula (I) or pharmaceutically acceptable salts thereof. The invention also provides pharmaceutical compositions comprising one or more compounds of...
US20050085644 Novel 3-aryl-2,5-dihydroxy-1,4-benzoquinone derivatives, their preparation method and pharmaceutical compositions containing same  
Compound of formula (I): wherein: R1 and R2, which may be identical or different, each represents hydrogen, acyl or alkyl, Ar represents aryl or heteroaryl, A represents a group selected from: R4...
US20100076034 2-ARYL-2-FLUOROPROPANOIC ACIDS AND DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM  
The present invention relates to (R,S) 2-aryl-2-fluoropropanoic acids, their single enantiomers (R) and (S), their derivatives amides and acylsulfonamides and to pharmaceutical compositions...
US20070191606 2,2-Bis(4-hydroxyphenyl)-alkyl onium salt and process for the preparation thereof  
The present invention provides novel 2,2-bis(4-hydroxyphenyl)-alkyl onium salts as illustrated by 2,2-bis(4-hydroxyphenyl)-tridecyl(1,2-dimethylimidazolium)br omide and a process for preparation...
US20070112030 Processes for preparing bicyclo [3.1.0] hexane derivatives, and intermediates thereto  
Processes for the preparation of certain [3.1.0]hexane derivatives which are useful as mGluR agonists, and intermediates prepared during such processes.
US20080008930 Ionic Liquid  
The present invention relates to ionic liquids having low melting points, low viscosities and high electrical conductivities; and more specifically, to ionic liquids including at least one organic...
US20070248672 Indole and Azaindole Derivatives with Antitumor Action  
Indole and azaindole compounds useful for the treatment of solid tumours and tumours of the blood are described, they being particularly effective in the treatment of drug resistant tumours; these...
US20060142187 Methods for modulating cell-to-cell adhesion using an agonist of C1INH-type protein activity  
The present invention is based, at least in part, on the discovery that plasma C1INH contains a sialyl Lewisx related moiety on its N-glycan and is capable of binding selectin molecules. The...
US20090253671 TRICYCLIC DERIVATIVES OF AZETIDINE AND PYRROLE WITH ANTIBACTERIAL ACTIVITY  
Compounds of formula (I) and their pharmaceutically acceptable salts are described. Processes for their preparation, pharmaceutical compositions containing them, their use as medicaments and their...
US20080096903 SULFAMOYL-CONTAINING DERIVATIVES AND USES THEREOF  
Sulfamoyl-containing compounds are disclosed, having utility as inhibitors of disease-related targets, such as Heat Shock Protein 90 (HSP90), and which are useful for treating disorders, e.g.,...
US20100256391 PROCESSES FOR THE SYNTHESIS OF GAMMA NITROCARBONYL AND GAMMA DICARBONYL COMPOUNDS AND THEIR PYRROLE DERIVATIVES  
The present invention discloses processes for producing γ-nitrocarbonyl and γ-dicarbonyl compounds, which can be precursors in the synthesis of pyrrole compounds. A process for producing pyrroles...
US20100130749 METHODS  
The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren...
US20160115123 PYRROLIDINE TRIPLE REUPTAKE INHIBITORS  
In various embodiments, the present invention provides cycloalkyl pyrrolidine compounds and methods for their use in the treatment and/or prevention of various diseases, conditions and syndromes,...
US20160083387 SHIP1 MODULATORS AND METHODS RELATED THERETO  
Compounds of formula (I): where R1, R2, R3, R4a, R4b, R5, R6 and R7 are defined herein, or stereoisomers or pharmaceutically acceptable salts thereof, are described herein. Such compounds have...

Matches 1 - 38 out of 38