Matches 1 - 46 out of 46


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US20110065766 METHODS OF USE OF ANTIVIRAL COMPOUNDS  
The present invention relates, in part, to methods of treatment, prevention, and inhibition of viral disorders. In one aspect, the present invention relates to inhibition of the M2 proton channel...
US20110319398 INHIBITION OF YOPS TRANSLOCATION  
The disclosure relates to compounds and methods of inhibiting type three secretion system effector molecules, to methods of detecting compounds that inhibit Yops translocation, and to methods of...
US20120295874 COFERONS AND METHODS OF MAKING AND USING THEM  
The present invention is directed to a monomer useful in preparing therapeutic compounds. The monomer includes one or more pharmacophores which potentially binds to a target molecule with a...
US20140010773 USE OF N-(4-METHOXYPHENYL)-1-PHENYL-1H-PYRAZOL-3-AMINE AND RELATED COMPOUNDS  
This invention provides methods for treating diseases or conditions wherein the inhibition of Kit protein kinase may be beneficial, using pharmaceutical or cosmetic compositions comprising...
US20140289973 1-Hexyl-1H-Pyrazole-4,5-Diamine Hemisulfate, and Its Use in Dyeing Compositions  
1-hexyl-1H-pyrazole-4,5-diamine hemisulfate, as represented in formula (IX-a), and its use in oxidative dyeing composition. This pyrazole salt was found to combine good stability as raw material...
US20130212810 1-Hexzl-1H-Pyrazole-4,5-Diamine Hemisulfate, and Its Use in Dyeing Compositions  
1-hexyl-1H-pyrazole-4,5-diamine hemisulfate, as represented in formula (IX-a), and its use in oxidative dyeing composition. This pyrazole salt was found to combine good stability as raw material...
US20150225373 KINASE INHIBITORS  
There are provided compounds of formula (I), wherein R1 to R5, X1, X2, Ar, L, E, A, A1, G and G1 have meanings given in the description, which compounds have anti-inflammatory activity (e.g....
US20070060480 Heteroaroyl-substituted phenylalanineamides  
Pyrazolylcarbonyl-substituted phenylalanineamides of the formula I in which the variables A and R1 to R10 are as defined in the description, and their agriculturally useful salts, processes and...
US20060063938 Compounds to treat hiv infection and aids  
The present invention relates to compounds of formula I: useful HIV infection, AIDS, and other similar diseases. These compounds include inhibitors of the retroviral integrase enzyme that are...
US20100190777 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR  
Compounds of formula I active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases....
US20080280874 Phenoxy Benzamide Compounds with Utility in the Treatment of Type 2 Diabetes and Obesity  
Compounds of Formula (I): wherein: R1 is methoxymethyl; R2 is selected from —C(O)NR4R5, —SO2NR4R5, —S(O)pR4 and HET-2; HET-1 is a 5- or 6-membered, optionally substituted C-linked heteroaryl ring;...
US20140088105 Cyclohexyl Amide Derivatives and Their Use as CRF-1 Receptor Antagonists  
There are described cyclohexyl amide derivatives useful as corticotropin releasing factor (CRF1) receptor antagonists.
US20110152261 Organic compounds  
There are described cyclohexyl amide derivatives useful as corticotropin releasing (CRF1) receptor antagonists.
US20110003862 3-Animopyraolines for Treatment of Neurodegenerative and Psychiatric Diseases  
Compounds of the formula (I), inhibit D-amino acid oxidase and hence find use in treating degenerative and psychiatric diseases.
US20130123500 ETHINYL-PYRAZOLE DERIVATIVE  
Provided is a novel compound represented by formula [I] or a pharmaceutically acceptable salt thereof having antagonistic activity against group II metabolism-type glutamic acid (m-Glu) receptors....
US20100099681 SUBSTITUTED 5-AMINOPYRAZOLES AND USE THEREOF  
The present application relates to novel substituted 5-aminopyrazoles, methods of production thereof, use thereof alone or in combinations for the treatment and/or prophylaxis of diseases and use...
US20130129839 FUNGICIDAL PYRAZOLES AND THEIR MIXTURES  
Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula 1, N-oxides, and salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined...
US20140288074 FUNGICIDAL PYRAZOLES  
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, fungicides: wherein Q1, R1, R1a, R2, R3 and X are as defined in the disclosure. Also disclosed are...
US20150112073 PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS  
The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
US20070238733 Compositions useful as inhibitors of voltage-gated sodium channels  
The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of...
US20130143940 FUNGICIDAL PYRAZOLES  
Disclosed are compounds of Formula 1 and Formula 1A including all stereoisomers, N-oxides, and salts thereof, wherein Q1, Q2, R1, R2, R4, R5 and X are as defined in the disclosure. Also disclosed...
US20070037987 Preparation of 4,5-diamino-1-(substituted)-pyrazole and acid addition salts thereof  
Disclosed is an improved process for the preparation of 4,5-diamino-1-(substituted)pyrazoles and acid addition salts thereof by coupling the corresponding 5-amino-1-(substituted)pyrazole with an...
US20130317074 TOPICAL ANTIFUNGAL AGENT  
An anti-fungal agent for tinea comprising as active ingredient a compound having the skeleton of 2-(1H-pyrazol-1-yl)phenol represented by the following formula (I) or (II) or a salt thereof is...
US20150230467 FUNGICIDAL PYRAZOLES  
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein Q1 is a phenyl ring, naphthalenyl ring system, a 5- to 6-membered fully...
US20110319430 FUNGICIDAL PYRAZOLES  
Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof, wherein Q1 is a phenyl ring, naphthalenyl ring system, a 5- to 6-membered fully...
US20090239841 Diaryl Ureas as CB1 Antagonists  
Compounds of Formula I are provided. In which the variables are as described herein. Such compounds may be used to modulate CB1 activity in vivo or in vitro, and are particularly useful in the...
US20090227648 PYRAZOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CANCER  
This invention relates to novel compounds having the formula and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
US20060014815 Process for making pyrazole compounds  
This invention relates to a process for making pyrazole compounds of formula I.
US20110237783 HYDRAZONOPYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTICS  
Pharmaceutical compositions and compounds are provided. The compounds of the invention demonstrate anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell...
US20080249154 Preventive and/or Therapeutic Agent For Disease In Which Mitochondrial Benzodiazephine Receptor Participates  
A compound represented by formula (I) (wherein ring A is a nitrogen-containing ring which may have a substituent(s), E is a binding bond or a spacer of which main chain has an atom number of 1-8,...
US20080081833 Novel Pyrazole Derivatives And Their Use As Modulators Of Nicotinic Acetylcholine Receptors  
Compounds of Formula I: wherein A1, A2, D and E are as described in the specification, pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions...
US20090221838 PROCESS FOR THE PREPARATION OF SUBSTITUTED PYRAZOLES  
The invention relates to an alternative process for the preparation of substituted 5-amino-pyrazoles, in which a carbonyl compound is reacted with a hydrazine derivative and cyanogen chloride to...
US20070167490 Imino ether derivative compounds and drugs containing the compounds as the active ingredient  
The compound represented by formula (I) (wherein R1 and R2 are cyclic group which may have a substituent(s) and so on; W is a spacer of which main chain has an atom number of 1-6.; X is —O— and so...
US20100273842 AMINE DERIVATIVES HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY AND THE USES THEREOF  
This invention provides an anorectic or anti-obesity composition comprising a compound of the formula (I): a pharmaceutically acceptable salt or solvate thereof, wherein R1 is optionally...
US20100273841 AMINE-DERIVATIVES HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY AND THE USES THEREOF  
This invention provides an anorectic or anti-obesity composition comprising a compound of the formula (I): formula (I): a pharmaceutically acceptable salt or solvate thereof, wherein R1 is...
US20080015223 Pyrazole Derivatives as Modulators of the 5-Ht2a Serotonin Receptor Useful for the Treatment of Disorders Related Thereto  
The present invention relates to certain pyrazole derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the 5-HT2A serotonin receptor. Compounds and...
US20090012075 Fluorinated Arylamide Derivatives  
The present invention relates to a novel class of fluorinated arylamide derivatives. The instant compounds can be used to treat cancer. The fluorinated arylamide derivatives can also inhibit...
US20130217891 Telescoping Synthesis of 5-Amino-4-Nitroso-1-Alkyl-1H-Pyrazole Salt  
A telescoping synthesis of 5-amino-4-nitroso-1-alkyl-1H-pyrazole salt derivatives of formula (I), the compound (I) itself, and its use as an intermediate in the fabrication of...
US20110086886 INSECTICIDAL ISOXAZOLINES  
Novel isoxazolines of the formula (I) wherein A represents C or N; R represents haloalkyl; X represents halogen or haloalkyl; l represents 0, 1 or 2; Y represents halogen, alkyl, alkoxy,...
US20100249191 N-Methyl benzamide derivatives  
Novel isoxazolines of the formula (I) wherein A represents C or N; R represents haloalkyl; X represents halogen or haloalkyl; l represents 0, 1 or 2; Y represents halogen, alkyl, alkoxy,...
US20160152594 PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS  
The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.
US20160075661 SOLID FORMS OF FUNGICIDAL PYRAZOLES  
Disclosed are solid forms of 4-(2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1,3-d imethyl-1H-pyrazol-5-amine (Compound 1). Methods for the preparation of solid forms of Compound 1 and for...
US20160000763 N-HETEROARYL SUBSTITUTED ANILINE DERIVATIVES AS HCV-ANTIVIRALS  
The present invention discloses compounds of Formula (I): wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such...
US20150344436 PKM2 MODULATORS AND METHODS FOR THEIR USE  
Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs...
US20150307456 FUNGICIDAL 4-METHYLANILINO PYRAZOLES  
Disclosed are compounds of Formula 1, including all stereoisomers, N-oxides, and salts thereof, wherein R1 is F, Cl or Br;R2 is H, F, Cl or Br; andR3 is F, Cl or Br. This invention also relates to...
US20150305339 FUNGICIDAL PYRAZOLES AND THEIR MIXTURES  
Disclosed is a fungicidal composition comprising (a) at least one compound selected from the compounds of Formula 1, N-oxides, and salts thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined...

Matches 1 - 46 out of 46