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US20070232557 |
Methods and compositions for inhibiting the function of polynucleotide sequences
A therapeutic composition for inhibiting the function of a target polynucleotide sequence in a mammalian cell includes an agent that provides to a mammalian cell an at least partially... |
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US20140220636 |
PHAGE &phgr MRU POLYNUCLEOTIDES AND POLYPEPTIDES AND USES THEREOF
The invention encompasses phage φmru including phage induction, phage particles, and the phage genome. Also encompassed are phage polypeptides, as well as polynucleotides which encode these... |
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US20140193482 |
MODIFIED POLYNUCLEOTIDES ENCODING V-MYC AVIAN MYELOCYTOMATOSIS VIRAL ONCOGENE HOMOLOG
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules. |
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US20120141529 |
NOROVIRUS AND SAPOVIRUS ANTIGENS
Immunogenic compositions that elicit immune responses against Norovirus and Sapovirus antigens are described. In particular, the invention relates to polynucleotides encoding one or more capsid... |
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US20110064763 |
LENTIVIRAL VECTORS PSEUDOTYPED WITH A SINDBIS VIRUS ENVELOPE GLYCOPROTEIN
Lentiviral vector particles comprising a Sindbis virus E2 glycoprotein variant and a lentiviral vector genome comprising a sequence of interest are provided. A lentiviral vector particle... |
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US20100278791 |
ADENO-ASSOCIATED VIRUS SEROTYPE I NUCLEIC ACID SEQUENCES, VECTORS AND HOST CELLS CONTAINING SAME
The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are... |
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US20100239608 |
PHARMACEUTICAL COMPOSITION CONTAINING A STABILISED mRNA OPTIMISED FOR TRANSLATION IN ITS CODING REGIONS
The present invention relates to a pharmaceutical composition containing an mRNA that is stabilised by sequence modifications in the translated region and is optimised for the translation. The... |
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US20080050345 |
Adeno-associated virus serotype I nucleic acid sequences, vectors and host cells containing same
The nucleic acid sequences of adeno-associated virus (AAV) serotype 1 are provided, as are vectors and host cells containing these sequences and functional fragments thereof. Also provided are... |
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US20070292947 |
NOVGEL METHODS FOR DISPLAYING (POLY)PEPTIDES/PROTEINS ON BACTERIOPHAGE PARTICLES VIA DISULFIDE BONDS
The present invention relates to methods for displaying (poly)peptides/proteins on the surface of bacteriophage particles by attaching the (poly)peptide/proteins via disulfide bonds. |
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US20070264627 |
Retrovirus from the HIV group and its use
A novel immunodeficiency virus is disclosed which has the designation MVP-5180/91 and which has been deposited with the European Collection of Animal Cell Cultures (ECACC) under No. V 920 52 318.... |
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US20070087341 |
Compositions for use in identification of influenza viruses
The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the influenza virus family by... |
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US20070087340 |
Compositions for use in identification of influenza viruses
The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the influenza virus family by... |
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US20070087339 |
Compositions for use in identification of influenza viruses
The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the influenza virus family by... |
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US20070087337 |
Compositions for use in identification of influenza viruses
The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the influenza virus family by... |
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US20070087336 |
Compositions for use in identification of influenza viruses
The present invention provides oligonucleotide primers, compositions, and kits containing the same for rapid identification of viruses which are members of the influenza virus family by... |
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US20160130567 |
MESSENGER UNA MOLECULES AND USES THEREOF
This invention provides a range of translatable messenger UNA (mUNA) molecules. The mUNA molecules can be translated in vitro and in vivo to provide an active polypeptide or protein, or to provide... |
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US20130017253 |
Inducing Cellular Immune Responses to Human Papillomavirus Using Peptide and Nucleic Acid Compositions
This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare human papillomavirus (HPV) epitopes, and to develop epitope-based vaccines... |
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US20110020352 |
ENDOGENOUS RETROVIRUSES UP-REGULATED IN PROSTATE CANCER
Human endogenous retroviruses of the HML-2 family show up-regulated expression in prostate tumors. This finding can be used in prostate cancer screening, diagnosis and therapy. |
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US20110020282 |
RECOMBINANT NEWCASTLE DISEASE VIRUS
The goal of the invention is to increase the therapeutical activity of oncolytic NDV. This issue is solved by a Newcastle Disease Virus comprising a recombinant nucleic acid, wherein the nucleic... |
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US20100189743 |
CIRCOVIRUS SEQUENCES ASSOCIATED WITH PIGLET WEIGHT LOSS DISEASE (PWD)
The genome sequences and the nucleotide sequences coding for the PWD circovirus polypeptides, such as the circovirus structural and non-structural polypeptides, vectors including the sequences,... |
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US20090214632 |
Inducing cellular immune responses to human papillomavirus using peptide and nucleic acid compositions
This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare human papillomavirus (HPV) epitopes, and to develop epitope-based vaccines... |
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US20090191234 |
VACCINE
This invention relates to three newly-identified, distinct groups of antigenic peptides [LB1(f) peptides] from the same region of the P5-like fimbrin protein discovered using sequence data from... |
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US20090017052 |
Methods of determining lethality of pathogens and malignancies involving replikin peak genes
The present invention provides methods of identifying lethal, virulent and rapidly replicating viruses, organisms, and malignancies comprising comparing Replikin concentrations among different... |
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US20070071770 |
Recombinant MVA virus, and the use thereof
The present invention relates to recombinant vaccinia viruses derived from the modified vaccinia virus Ankara (MVA) and containing and capable of expressing foreign genes which are inserted at the... |
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US20070071769 |
Recombinant MVA virus, and the use thereof
The present invention relates to recombinant vaccinia viruses derived from the modified vaccinia virus Ankara (MVA) and containing and capable of expressing foreign genes which are inserted at the... |
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US20060127361 |
Compositions and methods for inducing gene expression
The present invention provides recombinant nucleic acid molecules encoding a chimeric transactivator protein including a DNA binding domain of a DNA binding protein and a protein domain capable of... |
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US20150374781 |
METHODS AND COMPOSITIONS FOR TREATING BRAIN DISEASES
The present disclosure provides targeting peptides and vectors containing a sequence that encodes targeting peptides that deliver agents to the brain. |
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US20140010885 |
SELF-ASSEMBLING NANOPARTICLE DRUG DELIVERY SYSTEM
A self-assembling nanoparticle drug delivery system for the delivery of various bioactive agents including peptides, proteins, nucleic acids or synthetic chemical drugs is provided. The... |
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US20120269840 |
EXPRESSION OF HIV POLYPEPTIDES AND PRODUCTION OF VIRUS-LIKE PARTICLES
The present invention relates to the efficient expression of HIV polypeptides in a variety of cell types, including, but not limited to, mammalian, insect, and plant cells. Synthetic expression... |
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US20120082693 |
USE OF PROTEINS AND PEPTIDES ENCODED BY THE GENOME OF A NOVEL SARS-ASSOCIATED CORONAVIRUS STRAIN
The invention relates to the use of proteins and peptides coded by the genome of the isolated or purified strain of severe acute respiratory syndrome (SARS)-associated coronavirus, resulting from... |
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US20110305727 |
RSV F PROTEIN COMPOSITIONS AND METHODS FOR MAKING SAME
The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain... |
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US20110014229 |
Chimeric flavivirus vectors
The invention provides chimeric flavivirus vectors including foreign peptides inserted into the envelope proteins of the vectors and methods of using these vectors. |
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US20080311154 |
COLD-ADAPTED EQUINE INFLUENZA VIRUSES
The present invention provides experimentally-generated cold-adapted equine influenza viruses, and reassortant influenza A viruses comprising at least one genome segment of such an equine... |
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US20080248044 |
POLYEPITOPIC PROTEIN FRAGMENTS OF THE E6 AND E7 PROTEINS OF HPV, THEIR PRODUCTION AND THEIR USE PARTICULARLY IN VACCINATION
Polyepitopic peptides of E6 and E7 proteins of Human Papillomavirus, their production, and methods of treating pathologies in which a polyepitopic peptide of the E6 and E7 protein of Human... |
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US20070042002 |
Influenza recombinant subunit vaccine
The invention provides influenza proteins, including subunit proteins and immunogenic compositions that can be utilized, with or without adjuvants, as vaccines to protect against influenza... |
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US20060159704 |
Use of flavivirus for the expression of protein epitopes and development of new live attenuated vaccine virus to immunize against flavivirus and other infectious agents
The present invention relates to a vaccine against infections caused by flavivirus. More particularly to the use of the YF vaccine virus (17D) to express at the level of its envelope, protein... |
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US20060024670 |
Influenza virus vaccine composition and methods of use
The present invention is directed to enhancing the immune response of a human in need of protection against IV infection by administering in vivo, into a tissue of the human, at least one... |
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US20150306210 |
VACCINE AGAINST BETA-HERPESVIRUS INFECTION AND USE THEREOF
The present invention is related to a beta-herpesvirus, wherein the beta-herpesvirus is spread-deficient. |
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US20150086636 |
MYOSTATIN INHIBITION FOR ENHANCING MUSCLE AND/OR IMPROVING MUSCLE FUNCTION
The present invention relates to methods for inhibiting myostatin, a regulator of muscle mass, for muscle enhancement (including inducing hypertrophy and/or hyperplasia) as well as improving... |
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US20130216613 |
CYTOMEGALOVIRUS GB ANTIGEN
The invention relates to a cytomegalovirus (CMV) gB polypeptide comprising at least a portion of a gB protein extracellular domain comprising a fusion loop 1 (FL1) domain and a fusion loop 2 (FL2)... |
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US20130189294 |
RAPID, EFFICIENT PURIFICATION OF HSV-SPECIFIC T-LYMPHOCYTES AND HSV ANTIGENS IDENTIFIED VIA SAME
Described is a method of identifying an immunologically active antigen of a virus that attacks skin, as well as a method of enriching a population of lymphocytes for T lymphocytes that are... |
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US20120156241 |
RESCUE OF INFLUENZA VIRUS
The invention relates to the field of influenza vaccine production. Influenza vaccines have been produced in embryonated hens' eggs for over 50 years, but recently there have been considerable... |
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US20110305725 |
METHODS AND COMPOSITIONS FOR IMMUNIZING PIGS AGAINST PORCINE CIRCOVIRUS
The present invention relates to the isolation and identification of two new strains of type 2B porcine circovirus. These two new strains of porcine circovirus may be used for the preparation of... |
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US20110052617 |
AAV SCLEROPROTEIN, PRODUCTION AND USE THEREOF
The invention relates to a structural protein of adeno-associated virus (AAV) which comprises at least one mutation which brings about an increase in the infectivity of the virus. |
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US20090175910 |
Modifications of HIV Env, Gag, and Pol enhance immunogenicity for genetic immunization
Modified HIV Env, Gag, Pol, or Nef DNA with improved ability to elicit antibody and CTL responses to HIV antigens have been identified as prototype immunogens for the treatment and prevention of... |
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US20090162398 |
Methods and Compositions for Immunizing Pigs Against Porcine Circovirus
The present invention relates to the isolation and identification of two new strains of type 2B porcine circovirus. These two new strains of porcine circovirus may be used for the preparation of... |
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US20090041725 |
Replication-Deficient RNA Viruses as Vaccines
The present invention relates to a genome-replication-deficient and transcription-competent negative-strand RNA virus, which can be used for the expression of transgenes and in particular for the... |
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US20070042001 |
Influenza recombinant subunit vaccine
The invention provides influenza proteins, including subunit proteins and immunogenic compositions that can be utilized, with or without adjuvants, as vaccines to protect against influenza... |
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US20060286124 |
Vaccine compositions and methods of treating coronavirus infection
The present disclosure relates to compositions and methods for treating or preventing coronavirus infections. For example, compositions are provided that comprise a coronavirus S protein or N... |
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US20110300164 |
IMMUNOSTIMULATORY DNA:RNA OLIGONUCLEOTIDES
Immunostimulatory sequence-specific RNA oligonucleotides corresponding to 3′ terminal sequences of single-stranded minus-sense RNA genomic RNAs are provided. Also provided are compositions and... |