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US20110190149 NEOEPITOPE DETECTION OF DISEASE USING PROTEIN ARRAYS  
A biosensor for use in detecting the presence of diseases, the biosensor comprising a detector for detecting a presence of at least one marker indicative of a specific disease. A method of...
US20130115230 DELIVERY PROTEINS  
Disclosed herein are materials and methods related to vaccines. Materials and methods for delivery of a payload, e.g., an immunogen, to the reticuloendothelial system via non-circulating lymphoid...
US20130039912 ROBO1-FC FUSION PROTEIN AND USE THEREOF FOR TREATING TUMOURS  
The present invention relates to a Robo1-Fc recombinant protein and to the use thereof for treating diseases in which a Slit protein is overexpressed, in particular cancer. The invention also...
US20130035283 ENGINEERED OPSONIN FOR PATHOGEN DETECTION AND TREATMENT  
The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems...
US20120164140 HEMOJUVELIN FUSION PROTEINS AND USES THEREOF  
The present invention provides a hemojuvelin (HJV) fusion protein (e.g., a human HJV.Fc) protein, polynucleotides and vectors encoding such proteins, and methods for making such proteins. Also...
US20150099297 CHIMERIC PROTEINS FOR TREATMENT OF DISEASES  
A chimeric protein is made from the combination of (i) a pathogen recognition module derived from a scavenger receptor and (ii) an anchor domain from a different scavenger receptor. The chimeric...
US20140221621 SINGLE-CHAIN MULTIVALENT BINDING PROTEIN COMPOSITIONS AND METHODS  
Provided are protein, nucleic acid, and cellular libraries of single chain multivalent binding proteins (e.g., scDVD and scDVDFab molecules) and methods of using these of these libraries for the...
US20140308272 TREATMENT OF PRION PROTEIN RELATED DISEASES  
According to the present invention, treatment of prion protein related diseases, and in particular cancer tumours, is effected by providing to a subject in need thereof a therapeutically effective...
US20110044975 TREATMENT OF PRION PROTEIN RELATED DISEASES  
According to the present invention, treatment of prion protein related diseases, and in particular cancer tumours, is effected by providing to a subject in need thereof a therapeutically effective...
US20140314745 METHODS TO CONTROL PROTEIN HETEROGENEITY  
The instant invention relates to the field of protein production and in particular to controlled protein heterogeneity compositions and processes for controlling the heterogeneity of proteins...
US20110112037 CRYSTAL STRUCTURE  
The invention provides a method of predicting a three dimensional structural representation of a target protein of unknown structure, or part thereof, comprising: providing the coordinates of the...
US20120059156 METHOD OF PROTEIN NANOSTRUCTURE FABRICATION  
A method of assembling a protein nanostructure on a surface including selectively patterning a surface with a fixation site, bringing a protein node into contact with the surface, and allowing the...
US20140235476 MULTIVALENT BINDING PROTEIN COMPOSITIONS AND METHODS FOR IDENTIFYING VARIANTS OF SAME  
Provided are protein, nucleic acid, and cellular libraries of multivalent binding proteins (e.g., DVD-Fab or DVD-Ig molecules) and the use of these libraries for the screening of multivalent...
US20120039908 Control of Protein Glycosylation and Compositions and Methods Relating Thereto  
The invention relates to novel methods for controlling the glycosylation of a protein and the protein produced thereby. An exemplary method of the invention comprises producing a protein...
US20130129727 METHODS AND SYSTEMS FOR INCREASING PROTEIN STABILITY  
Methods and systems for increasing stability of a target polypeptide in a serum are described. The methods and systems utilize a fusion protein comprising a single-domain antibody against a serum...
US20120021484 Recombinant FcRn and Variants Thereof for Purification of Fc-Containing Fusion Proteins  
The invention is directed to methods of purifying Fc-containing molecules using a soluble neonatal Fc receptor (sFcRn). Native FcRn binds Fc-containing proteins at or below about pH 6.5 and...
US20130115208 HETERODIMERIC PROTEINS AND METHODS FOR PRODUCING AND PURIFYING THEM  
The present invention relates to engineered heteromultimeric proteins, and more specifically, to methods for producing and purifying heterodimeric proteins, such as bispecific antibodies and other...
US20140356354 THERAPY FOR FILOVIRUS INFECTION  
The present invention addresses a need for improved treatments for filovirus infections.
US20140120091 FUSION PROTEINS FOR THERAPY OF AUTOIMMUNE AND CARDIOVASCULAR DISEASE  
The present invention provides improved fusion proteins for therapy of autoimmune and cardiovascular disease.
US20150037251 MAMMALIAN HOMOLOGUES OF FLOWER, THEIR USE IN CANCER DIAGNOSTICS, PREVENTION AND TREATMENT  
The invention relates inhibiting nucleic acids directed at mammalian homologues of the Drosophila fwe gene (Flower) and to antibodies against the respective proteins, and their use in diagnosing,...
US20150158923 Follistatin Fusion Proteins and Uses Thereof  
In certain aspects, the present invention provides methods for dosing a patient with an ActRIIb antagonist and methods for managing patients treated with an ActRIIb anatagonist. In certain...
US20140178389 IL-1 BINDING PROTEINS  
The disclosure provides binding proteins that specifically bind to IL-1α and IL-1β. These binding proteins can be organized into DVD-Igs. These proteins can be used to modulate the activity of...
US20120289684 METHODS OF TREATING INFLAMMATION USING SOLUBLE IL-17RA/RC FUSION PROTEINS  
Disclosed are antagonists of IL-17A and IL-17F. The antagonists are based on soluble IL-17RA and IL-17RC fusion proteins, including hybrid soluble receptors comprising portions of both IL-17RC and...
US20110009601 LABELED PROTEIN AND METHOD FOR OBTAINING THE SAME  
It is an object of the present invention to obtain a labeled protein, and specifically, to separate a labeled protein and the same unlabeled protein. There is provided a labeled protein including:...
US20140128577 PURIFICATION OF CHIMERIC PROTEIN  
Provided is a method for purification of TNFR:Fc fusion protein comprising hydrophobic interaction chromatography, wherein the buffer solution used in the said chromatography does not contain any...
US20110300157 METALLOPROTEINASE 9 AND METALLOPROTEINASE 2 BINDING PROTEINS  
Proteins that bind to matrix metalloproteinase 9 and to matrix metalloproteinase 2 and methods of using such proteins are described.
US20110318345 NASAL DELIVERY  
substances and the nasal administration thereof, in particular as one of a liquid, as a suspension or solution, or a powder, to the nasal airway of a subject, in particular the posterior region of...
US20130064851 INACTIVATED STAPHYLOCOCCAL WHOLE-CELL VACCINE  
The vaccine that is protective against pathogenic bacterial species, typically staphylococcal species, and including methods to prepare said vaccine and to culture pathogenic bacteria.
US20130231464 METHODS OF USE OF SOLUBLE CD24 FOR THERAPY OF RHEUMATOID ARTHRITIS  
Provided herein is a method of treating rheumatoid arthritis using a CD24 protein. The CD24 protein may include mature human or mouse CD24, as well as a N- or C-terminally fused portion of a...
US20120149875 AFFINITY CHROMATOGRAPHY MATRIX  
The present invention relates to a method of separating one or more immunoglobulin containing proteins from a liquid. The method includes first contacting the liquid with a separation matrix...
US20140107322 METHODS OF USE OF SOLUBLE CD24 FOR THERAPY OF RHEUMATOID ARTHRITIS  
Provided herein is a CD24 protein. The CD24 protein may include mature human or mouse CD24, as well as a N- or C-terminally fused portion of a mammalian immunoglobulin.
US20150239962 Protein A Crystals and Cross-Linked Crystals and Methods of Use Thereof  
Protein A crystals and Protein A cross-linked protein crystals (CLPCs) are described. Methods of preparing and using are also disclosed.
US20130053548 Protein A Crystals and Cross-Linked Crystals and Methods of Use Thereof  
Protein A crystals and Protein A cross-linked protein crystals (CLPCs) are described. Methods of preparing and using are also disclosed.
US20140170064 METHODS AND COMPOSITIONS FOR RADIOHALOGEN PROTEIN LABELING  
Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic...
US20130324701 COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS  
The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion...
US20120301921 COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS  
The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion...
US20110281302 COMPOSITIONS AND METHODS OF TREATING DISEASE WITH FGFR FUSION PROTEINS  
The invention provides FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis. The FGFR fusion...
US20150152129 Synthetic Oligosaccharides for P. Aeruginosa Vaccine  
The present invention provides synthetic Pseudomonas aeruginosa lipooligosaccharide (LOS)-based oligosaccharides and conjugates containing various P. aeruginosa serotype-specific oligosaccharide...
US20110129468 PURIFIED IMMUNOGLOBULIN FUSION PROTEINS AND METHODS OF THEIR PURIFICATION  
The invention provides methods and compositions for separating impurities during the manufacture of immunoglobulin (Ig) fusion proteins. Examples of impurities which may be removed in accordance...
US20130224191 NOTUM PROTEIN MODULATORS AND METHODS OF USE  
Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat hyperproliferative disorders are provided.
US20150030593 COMPOSITIONS OF PENETRATION-ENHANCED TARGETING PROTEINS AND METHODS OF USE  
The disclosure relates to penetration-enhanced targeted proteins and their uses for therapeutics delivery.
US20120129766 METHODS OF TREATING FGF21-ASSOCIATED DISORDERS  
The invention relates to the identification of new polypeptide and protein variants of fibroblast growth factor 21 (FGF21) that have improved pharmaceutical properties. Also disclosed are methods...
US20140227286 Annexin A2 as Immunological Target  
AnnexinA2 (ANXA2), a member of the Annexin family of calcium-dependent, phospholipid binding proteins, is one of a panel of identified antigens recognized by the post-vaccination sera of patients...
US20140363431 METHODS FOR TREATING PROGRESSIVE MULTIPLE SCLEROSIS  
The present invention concerns methods for treating progressive multiple sclerosis (MS) in a patient, and an article of manufacture with instructions for such use.
US20140187751 PURIFICATION OF FUSION PROTEINS  
The invention relates generally to methods for purifying a Fc-fusion protein produced in a eukaryotic expression system. More specifically, the invention provides a robust and scalable downstream...
US20140349371 Protein Refolding Method  
The present invention provides a method for producing a protein which has a restored native higher-order structure by bringing a protein which has lost its native higher-order structure into...
US20110077384 PROTEIN REFOLDING METHOD  
The present invention provides a method for producing a protein which has a restored native higher-order structure by bringing a protein which has lost its native higher-order structure into...
US20130243768 MULTIMERIC PROTEINS AND METHODS OF MAKING AND USING SAME  
The invention provides multimerization polypeptides capable of conferring formation of multimers when the multimerization polypeptide is linked to a molecule, such as a heterologous polypeptide...
US20150033410 METHODS AND COMPOSITIONS FOR EMERGENCY POST-INFECTION TREATMENT OF ANTHRAX  
Compositions effective for treating or preventing an anthrax infection in a subject in need thereof and recombinant proteins included in the compositions are provided. Methods for producing...
US20140079702 ANTAGONISTS OF IL-6 TO RAISE ALBUMIN AND/OR LOWER CRP  
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to improve survivability or quality of...