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US20090075890 Long lasting synthetic exendin-4 peptide conjugates and methods of use thereof  
Modified insulinotropic peptides are disclosed. The modified insulinotropic peptides are capable of forming a peptidase stabilized insulinotropic peptide. The modified insulinotropic peptides are...
US20080138278 CONJUGATES OF RGD PEPTIDES AND PORPHYRIN OR (BACTERIO) CHLOROHYLL PHOTOSYNTHESIZERS AND THEIR USES  
Conjugates of porphyrin, chlorophyll and bacteriochlorophyll photosensitizers with RGD-containing peptides or RGD peptidomimetics are provided that are useful for photodynamic therapy (PDT),...
US20130023646 BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES  
The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of...
US20100184641 Novel Plasma Protein Affinity Tags  
Method for increasing half-life of therapeutic agents in plasma and novel polypeptide derivatives.
US20090326192 BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES  
The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of...
US20090192093 ABUSE-RESISTANT AMPHETAMINE PRODRUGS  
The invention describes compounds, compositions, and methods of using the same comprising a chemical moiety covalently attached to amphetamine. These compounds and compositions are useful for...
US20120058154 SYNTHETIC NANOCARRIER VACCINES COMPRISING PEPTIDES OBTAINED OR DERIVED FROM HUMAN INFLUENZA A VIRUS M2E  
This invention relates to compositions and methods that can be used immunize a subject against influenza. Generally, the compositions and methods include peptides obtained or derived from human...
US20090291106 BIODEGRADABLE BLOCK COPOLYMERS WITH MODIFIABLE SURFACE  
A block copolymer containing a) a hydrophobic biodegradable polymer, b) a hydrophilic polymer and c) at least one reactive group for covalent binding of a surface-modifying substance d) to the...
US20090240030 Biomolecular coupling methods using 1,3-dipolar cycloaddition chemistry  
This invention provides methods for covalently affixing a biomolecule to either a second molecule or a solid surface using 1,3-dipolar cycloaddition chemistry. This invention also provides related...
US20130210724 Cyclodextrin-Based Polymers for Therapeutic Delivery  
Described herein are CDP-therapeutic peptide conjugates, therapeutic delivery systems comprising CDP-therapeutic peptide conjugates, compositions comprising CDP-therapeutic peptide conjugates,...
US20100324266 Photocleavable Protecting Groups  
Novel compounds are provided, which are useful as linking groups in chemical synthesis, preferably in the solid phase synthesis of oligonucleotides and polypeptides. These compounds are generally...
US20090105452 NON-FLUORESCENT QUENCHER COMPOUNDS AND BIOMOLECULAR ASSAYS  
Bis-diazo, triaryl and aryldiazo-N-arylphenazonium quencher moieties, substituted with electron-withdrawing and electron-donating substituents which induce polarity in the delocalized aryl/diazo...
US20100021881 Peptide combos and their uses  
The invention provides reagents and methods for the accurate quantification of proteins in complex biological samples. Quantification is obtained by adding to a sample a peptide combo, which is...
US20090148382 Technetium- and rhenium-bis(heteroaryl) complexes, and methods of use thereof  
One aspect of the invention relates to complexes of technetium (Tc) and rhenium (Re) with various heteroaromatic ligands, e.g., quinolinyl and isoquinolinyl ligands, and their use in fluorescence...
US20090111195 CHEMICAL REAGENTS AND METHODS FOR DETECTION AND QUANTIFICATION OF PROTEINS IN COMPLEX MIXTURES  
The invention provides a reagent comprising an affinity tag, a detectable moiety, a linker, an isotope tag and a reactive group. The invention also provides methods of using a reagent of the...
US20090083880 MODIFIED PLANT DEFENSIN  
The invention herein includes a general method for reducing or eliminating a toxic effect of transgenic defensin expression in a host plant. The invention also includes a method of modifying a...
US20080207562 Conjugates of Hydroxyalkyl Starch and Active Substance, Prepared by Chemical Ligation Via Thiazolidine  
The present invention relates to a method for preparing conjugates of an active substance and hydroxyalkyl starch and to conjugates of an active substance and hydroxyalkyl starch, preferably...
US20080096796 Peptides That Stimulate Cell Survival and Axon Regeneration  
Peptides which consist of or comprise the tetrameric peptide structural unit: Xaa-Xaa-Xaa-Xaa (SEQ.ID.NO.: 1) in which Xaa at position 1 represents Glu or Asp, Xaa at position 2 represents any...
US20140051080 Novel Ferrocene Labels for Electrochemical Assay and their Use in Analytical Methods  
Compounds of general formula I are used as labels in an electrochemical assay: (I) in which: Fc and Fc′ are substituted or unsubstituted ferrocenyl moieties, X is a C1 to C6 alkylene chain which...
US20110245462 Non-Fluorescent Quencher Compounds and Biomolecular Assays  
Bis-diazo, triaryl and aryldiazo-N-arylphenazonium quencher moieties, substituted with electron-withdrawing and electron-donating substituents which induce polarity in the delocalized aryl/diazo...
US20080177038 Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides  
Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The...
US20140371432 NOVEL OLIGONUCLEOTIDE CONJUGATES AND USE THEREOF  
The present invention provides a double-stranded RNA structure, which comprises a polymer compound covalently bonded to a double-helix oligo RNA useful for the treatment of diseases, particularly...
US20110144303 Biologically Active Peptidomimetic Macrocycles  
The present invention provides biologically active peptidomimetic macrocycles with improved properties relative to their corresponding polypeptides. The invention additionally provides methods of...
US20090239782 High-molecular weight conjugate of resorcinol derivatives  
Provided is a high-molecular weight conjugate of resorcinol derivatives which is excellent in water solubility and stability and has high antitumor activity even when used in a smaller total drug...
US20080182971 PEPTIDE DERIVATIVES, AND THEIR USE FOR THE SYNTHESIS OF SILICON-BASED COMPOSITE MATERIALS  
Methods for forming peptide derivatives using functional moieties and peptide derivatives are provided. Further, methods for using peptide derivatives to form silicon-based composite materials and...
US20100062968 Novel strategies for delivery of active agents using micelles and particles  
The present invention provides biodegradable particles (e.g., three-dimensional particles) and micelles which can be used to encapsulate active agents for delivering to a subject. The present...
US20130085188 PEPTIDE NETWORKS  
Methods of modulating interfacial characteristics in a self-assembled, force-transmitting peptide network at a fluid-fluid interface are disclosed. The methods involve exposing a peptide capable...
US20100144641 Compositions Having Antiangiogenic Activity and Uses Thereof  
The invention generally features compositions and methods that are useful for modulating blood vessel formation, as well as methods that provide for the systematic and efficient identification of...
US20090221790 METHOD FOR STABILIZATION OF PROTEINS USING NON-NATURAL AMINO ACIDS  
The present invention provides a method for producing modified stable polypeptides introducing at least one non-natural amino acid into the hydrophobic region of the polypeptide. The thermal and...
US20120283166 PEPTIDE PRODRUGS  
Provided herein are a novel class of oligopeptides and prodrugs that include amino acid sequences containing cleavage sites for fibroblast activation protein (FAP). Also provided herein are...
US20110151538 AFFINITY PURIFICATION BY COHESIN-DOCKERIN INTERACTION  
The present invention is directed to truncated dockerin polypeptides, recombinant polypeptides and affinity systems comprising the truncated dockerin polypeptide, methods of generating same, and...
US20100209352 SYNTHESIS AND CONJUGATION OF IRON OXIDE NANOPARTICLES TO ANTIBODIES FOR TARGETING SPECIFIC CELLS USING FLUORESCENCE AND MR IMAGING TECHNIQUES  
The invention provides for methods for producing water-soluble iron oxide nanoparticles comprising encapsulating the nanoparticles in phospholipids micelles. Also provided are methods for...
US20090326193 STABILIZING ALKYLGLYCOSIDE COMPOSITIONS AND METHODS THEREOF  
The present invention relates to alkylglycoside-containing compositions and methods for preventing loss of a parathyroid hormone (PTH) analog or octreotide via denaturation due to adherence upon...
US20120010124 Cell Penetrating Peptide Conjugates for Delivering of Nucleic Acids into a Cell  
The invention provides cell penetrating peptide-nucleic acid conjugates having the formula P-L-N, wherein P is a cell penetrating peptide, N is a nucleic acid, preferably an oligonucleotide and...
US20110226620 Highly Homogeneous Molecular Markers for Electrophoresis  
The invention relates to marker molecules for identifying physical properties of molecular species separated by the use of electrophoretic systems. The invention further relates to methods for...
US20080275139 Cyclodextrin-Containing Polymers and Uses Thereof  
The invention provides a cyclodextrin-containing polymer comprising one or more cyclodextrin residues. The polymer is selected from a peptide, a polypeptide, an oligonucleotide or a polynucleotide...
US20130324467 NEUROPEPTIDE ANALOGS, COMPOSITIONS, AND METHODS FOR TREATING PAIN  
Neuropeptide analogs and compositions including neuropeptide analogs are described herein. Also provided are methods of producing and using the neuropeptide analogs and compositions including one...
US20080319166 Treatment of implantable medical devices resistant to calcification  
Treatment of implantable medical devices resistant to calcification The invention relates to a method for treating an implant comprising a protein-based substrate, including the following steps in...
US20080242838 LABELING REAGENT AND METHODS OF USE  
The present invention provides compounds which are useful as multifunctional labels in proteomics studies. The labels of the present invention are both lysine specific and increase the overall...
US20150148525 METHODS OF INCORPORATING AN AMINO ACID COMPRISING A BCN GROUP INTO A POLYPEPTIDE USING AN ORTHOGONAL CODON ENCODING IT AND AN ORTHORGONAL PYLRS SYNTHASE  
The invention relates to a polypeptide comprising an amino acid having a bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN) group, particularly when said BCN group is present as: a residue of a lysine...
US20130224835 RADIOLABELLING METHODS  
The invention relates to radiodiagnostic and radiotherapeutic agents, including biologically active vectors labelled with radionuclides. It further relates to methods and reagents labelling a...
US20110301327 EPITOPE ANALOGS  
Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at...
US20090054623 Lipo-Conjugation of Peptides  
The present invention provides peptide conjugates that are formed between a modified lipid and a glycosyl residue and/or an amino acid residue on a peptide. The modified lipid includes a modifying...
US20100249375 IMMOBILIZING MOLECULES ON A SOLID SUPPORT  
A method for selectively orienting molecules on a surface of a solid support. The method includes: (a) attaching a linker molecule to the surface of the solid support, the linker molecule...
US20090321357 Affinity Particle And Affinity Separation Method  
The present invention is affinity particles that are characterized by having phosphorylcholine groups represented by the following formula (1) covalently bonded onto the surface of inorganic...
US20150057433 PREPARATION OF FUNCTIONALIZED POLYPEPTIDES, PEPTIDES, AND PROTEINS BY ALKYLATION OF THIOETHER GROUPS  
Reagents are disclosed for chemoselective tagging of methionine residues in peptides and polypeptides, subsequent bioorthogonal tag functionalization, and cleavage of the tags when desired to...
US20100092505 Method for Shielding Functional Sites or Epitopes on Proteins  
Methods of site-specifically shielding one or more binding sites within a polypeptide are disclosed, comprising attaching at least one small molecular weight, water-soluble polymer to said...
US20110003314 Hapten, Immunogens and Derivatives of Ascomycin Useful for Preparation of Antibodies and Immunoassays  
The invention teaches derivatives of ascomycin and methods of preparing immunogens and other conjugates useful in immunoassays for quantitatively measuring concentrations of tacrolimus in patient...
US20090317906 GENE SILENCING USING SENSE DNA AND ANTISENSE RNA HYBRID CONSTRUCTS COUPLED TO PEPTIDES FACILITATING THE UPTAKE INTO CELLS  
The present invention generally relates to gene silencing using sense DNA (sDNA)-antisense RNA (aRNA) hybrids wherein the sense DNA strand is coupled to a peptide which facilitates the uptake of...
US20140294902 NOVEL A4B7 PEPTIDE ANTAGONISTS  
The invention relates to disulfide-rich peptide molecules which inhibit binding of α4β7 to the mucosal addressin cell adhesion molecule (MAdCAM) in vivo, and show high selectivity against α4β1...

Matches 1 - 50 out of 157 1 2 3 4 >