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US20150141251 SPONTANEOUS SELF-FORMING MIXED SURFACTANT NANO-EMULSIONS FROM WATER INSOLUBLE PESTICIDES IN MIXED WATER MISCIBLE SOLVENTS  
The present disclosure relates to a pesticidal formulation including i) at least one pesticide, typically an organophosphate compound in an amount between 5.0% w/w and 40.0% w/w, preferably...
US20150005260 METHODS FOR THE DETECTION AND THE TREATMENT OF DIASTOLIC DYSFUNCTION  
The present invention relates to methods and kits for detecting diastolic dysfunction in subjects without clinical signs of heart failure.
US20120070513 Method and Composition for Treating Diabetic Ketoacidosis  
Methods of treating diabetic ketoacidosis are disclosed. The methods utilize an endothelin antagonist to treat diabetic ketoacidosis in mammals, including humans.
US20060135482 Use of fosinopril to reduce cardiovascular events in disalysis patients  
The invention relates to the use of fosinopril or a pharmaceutically acceptable salt thereof, to reduce the risk of occurrence of a cardiovascular event in dialysis patients, in particular blood...
US20110237525 METHOD OF AMELIORATING OXIDATIVE STRESS AND SUPPLEMENTING THE DIET  
A method of supplementing a diet and ameliorating oxidative stress in a mammal includes administering a pharmaceutically effective amount of lipid soluble, hydrophobic active compounds having a...
US20110257130 Compositions and Methods for Treatment of Renin-Angiotensin Aldosterone System (RAAS)- Related Disorders  
Compounds are provided which can be useful in reducing the activity of an angiotensin-converting enzyme and thus be used to treat or prevent a renin-angiotensin aldosterone system-related...
US20110092463 COMBINATION FOR USE IN THE TREATMENT OF INFLAMMATORY DISORDERS  
There is provided combination products comprising (a) pemirolast, or a pharmaceutically-acceptable salt or solvate thereof; and (b) a compound that inhibits the formation and/or action of...
US20110269717 NEUROGENESIS BY MODULATING ANGIOTENSIN  
The instant invention describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The invention includes...
US20110092464 NEUROGENESIS BY MODULATING ANGIOTENSIN  
The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The invention includes...
US20130101514 COMPOSITIONS AND METHODS FOR TREATING NEPHROPATHY  
Activated fatty acids, pharmaceutical composition compositions including activated fatty acids, methods for using activated fatty acids to treat nephropathy, and methods for preparing activated...
US20130012444 CRYSTALLINE SOLVATES OF 6-(PIPERIDIN-4-YLOXY)-2H-ISOQUINOLIN-1-ONE HYDROCHLORIDE  
The present invention relates to crystalline solvates of 6-(Piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride, processes for their preparation and the use thereof.
US20130338110 MITOCHONDRIA TARGETED CATIONIC ANTI-OXIDANT COMPOUNDS FOR PREVENTION, THERAPY OR TREATMENT OF HYPER-PROLIFERATIVE DISEASE, NEOPLASIAS AND CANCERS  
The inventions disclosed include methods of treating cancers and related neoplasias, especially prostate cancer, with pharmaceutically acceptable salts comprising lipophilic cation moieties linked...
US20110059922 MITOCHONDRIA TARGETED CATIONIC ANTI-OXIDANT COMPOUNDS FOR PREVENTION, THERAPY OR TREATMENT OF HYPER-PROLIFERATIVE DISEASE, NEOPLASIAS AND CANCERS  
The inventions disclosed include methods of treating cancers and related neoplasias, especially prostate cancer, with pharmaceutically acceptable salts comprising lipophilic cation moieties linked...
US20130178424 THERAPY FOR COMPLICATIONS OF DIABETES  
A method for enhancing glycemic control and/or insulin sensitivity in a human subject having diabetic nephropathy and/or metabolic syndrome comprises administering to the subject a selective...
US20120142638 COMBINATION OF ORGANIC COMPOUNDS  
The present invention relates to a combination, such as a combined preparation or pharmaceutical composition, respectively, comprising a therapeutic agent acting on the renin-angiotensin system...
US20140206632 Endothelin in the Diagnosis of Cardiac Disease  
A method for determining the risk, severity or progression of cardiovascular disease, such as cardiac heart failure. A method for determining the likelihood of admission to the hospital for...
US20050176685 Method for inhibiting bone resorption with an alendronate and vitamin d formulation  
Composition and method for preventing or treating abnormal bone resorption in mammals, the composition characterized as containing, a supplementary effective amount of a non-activated metabolite...
US20140274962 METHODS OF INHIBITING PRESBYOPIA  
Described herein are methods of inhibiting or reversing the progression of presbyopia in an eye by administering a βL-crystallin electrostatic interaction inhibitor. Presbyopia is caused by...
US20110265786 Inhalable Formulations For Treating Pulmonary Hypertension And Methods Of Using Same  
The present invention is directed to an inhalable formulation for the treatment of pulmonary hypertension in a mammal (e.g., humans), wherein the formulation comprises at least one hypertension...
US20120301458 CYCLOPROPYL MODULATORS OF P2Y12 RECEPTOR  
The present invention relates to new cyclopropyl modulators of P2Y12 receptor activity, pharmaceutical compositions thereof, and methods of use thereof
US20090162420 Matrix-Controlled Transdermal System Comprising Salts of ACE Inhibitor Dicarboxylic Acids  
The invention relates to a salt of an ACE inhibitor dicarboxylic acid with an organic amine and/or an alkali compound, a transdermal therapeutic system comprising the salt, and a method of...
US20150239918 FUNCTIONALIZED CARBON MATRIX MATERIALS  
Various embodiments of the present invention provide a functionalized carbon matrix, compositions and composites including the same, and methods of making and using the same. In various...
US20130157984 PROSTAGLANDIN-BISPHOSPHONATE CONJUGATE COMPOUNDS, METHODS OF MAKING SAME, AND USES THEREOF  
The invention provides in part, conjugate compounds. The invention also provides synthesis methods for making the compounds, and uses of the compounds.
US20130012479 POLYMORPHS OF 6-(PIPERIDIN-4-YLOXY)-2H-ISOQUINOLIN-1-ONE HYDROCHLORIDE  
The present invention relates to new crystalline polymorphs of 6-(Piperidin-4-yloxy)-2H-isoquinolin-1-one hydrochloride, processes for their preparation and their use, in particular for the...
US20050130924 Antisense inhibition via RNAse H-independent reduction in mRNA  
The present invention provides compositions and methods for reducing levels of a preselected mRNA, using antisense compounds targeted to a splice site or a region up to 50 nucleobases upstream of...
US20130287688 NOVEL COMPOSITIONS AND USES OF ANTI-HYPERTENSION AGENTS FOR CANCER THERAPY  
Methods and compositions for improving the delivery and/or efficacy of a therapy (e.g., a cancer therapy) are disclosed. In one embodiment, methods and compositions for treating or preventing a...
US20070021323 Use of a nitroxide or a prodrug thereof in the prophylactic and therapeutic treatment of cancer  
The present invention provides a method for the prophylactic and therapeutic treatment of cancer. The method comprises administering to an animal, preferably a mammal, more preferably a human, at...
US20140255517 MANAGING POST-TRAUMATIC STRESS DISORDER  
In certain embodiments, the disclosure relates to methods of treating or preventing posttraumatic stress disorder comprising administering a pharmaceutical composition comprising effective amount...
US20050187194 Preventive agents for diabetes mellitus  
The present invention relates to a pharmaceutical composition containing an FBPase inhibitor as an active ingredient, which is a preventative agent for diabetes mellitus, diabetic complications,...
US20110046090 MODULATION OF NEUROGENESIS WITH GABA AGENTS AND GABA ANALOGS  
The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes...
US20110104315 TETRAHYDROQUINOLINE DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS  
The invention provides for compounds of formula I wherein the substitutents are as described herein. Further provided are methods of using such compounds for the treatment of eating disorders,...
US20090156559 2-ethyl N,N-bis(2-chloroethyl)phosphorodiamidates  
2-{[2-(Substituted amino)ethyl]sulfonyl}ethyl N,N-bis(2-chloroethyl)phosphorodiamidates and their salts, their preparation and intermediates in their preparation, pharmaceutical compositions...
US20050107309 Use of dipeptidyl peptidase IV effectors for normalizing the blood glucose level in mammals  
The present invention comprises the use of activity-reducing effectors of dipeptidyl peptidase (DP IV) and DP IV-analogous enzyme activity in the blood of a mammal to lower elevated post-prandial...
US20100119482 Treatment of Conditions Through Modulation of the Autonomic Nervous System During at Least One Predetermined Menstrual Cycle Phase  
Methods are provided for treating a subject for a condition. In accordance with the subject methods, at least a portion of a subject's autonomic nervous system is modulated during at least one...
US20060270633 Crystalline form of fosinopril calcium  
Novel crystalline form of fosinopril calcium, process for its preparation, pharmaceutical compositions and use thereof in therapy.
US20120225846 HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK  
Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human...
US20140286931 BIPHENYL-3-CARBOXYLIC ACID MODULATORS OF BETA-3-ADRENORECEPTOR  
The present invention relates to new biphenyl-3-carboxylic acid modulators of beta-3-adrenoceptor activity, pharmaceutical compositions thereof, and methods of use thereof.
US20070027067 Transition-state Inhibitors of Pin1, alpha-Ketoamide-containing peptidomimetics, and synthesis thereof  
Novel α-ketoamide-containing peptidomimetics are provided, such as peptidomimetics containing an α-ketoamide Ser-Pro dipeptide analogue. The α-ketoamide is preferably incorporated into another...
US20120178681 BIPIPERIDINYL COMPOUNDS, COMPOSITIONS, CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT  
Bipiperidinyl compounds of the formula I, are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. Pharmaceutically acceptable salts and solvates are included as...
US20110160154 SUBSTITUTED PIPERAZINES  
Disclosed herein are substituted piperazine late Na+ channel modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
US20130225530 WOGONIN FOR THE PREVENTION AND THERAPY OF CARDIAC HYPERTROPHY  
The present invention relates to a pharmaceutical composition for use as a medicament for the treatment or prophylaxis of cardiac hypertrophy, comprising at least one compound of formula (I),...
US20140093513 METHODS OF LOWERING PROPROTEIN CONVERSATE SUBTILISIN/KEXIN TYPE 9 (PCSK9)  
The invention relates to new methods of modulating cholesterol by inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9) with fatty acid derivatives; and new methods for treating or...
US20130157982 NOVEL COMPOUNDS AS RECEPTOR MODULATORS WITH THERAPEUTIC UTILITY  
The present invention relates to novel amine derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of...
US20090081158 PHOSPHADIAZINE HCV POLYMERASE INHIBITORS IV  
Provided herein are phosphadiazine polymerase inhibitor, for example, of any of Formulas IV, IV′, I″, II″, or IVa, pharmaceutical compositions comprising the compounds, and processes of...
US20100047322 Combination antihypertensive wafer  
Sheet-like dosage forms that quickly dissolve or disintegrate in an aqueous environment, for the application of active agent combinations for the treatment of hypertension. The dosage forms...
US20110318388 S1P Receptors Modulators and Their Use Thereof  
The invention relates to novel compounds that have S1P receptor modulating activity. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the...
US20150174146 ANGIOTENSIN CONVERTING ENZYME INHIBITORS FOR TREATING OPTIC NEUROPATHY OR CONGENITAL OPTIC ATROPHY  
The present invention relates to an ophthalmic composition comprising at least one angiotensin converting enzyme (ACE) inhibitor and a pharmaceutically acceptable vehicle for use as an ophthalmic...
US20110082114 Methods of Treating Aneurysmal Dilatation, Blood Vessel Wall Weakness and Specifically Abdominal Aortic and Thoracic Aneurysm Using Matrix Metalloprotease-2 Inhibitors  
The present invention provides methods of treating aneurysmal dilatation, blood vessel wall weakness, and specifically abdominal aortic aneurysm and thoracic aneurysm by inhibiting MMPs and...
US20110118212 Pestcidal active mixtures comprising isoxazoline compounds I  
The present invention relates to pesticidal mixtures comprising as active compounds 1) at least one isoaxazoline compound I of the formula (I) wherein R1, R2, R3, R4, R5 and A are defined in the...
US20120208784 SUBSTITUTED PROPANE PHOSPHINIC ACID DERIVATIVES  
The present invention relates to a series of substituted 3-aminopropane phosphinic acid derivatives of formula I: wherein R, R1, P1, P2 and P3 are as defined herein. The compounds of this...
Matches 1 - 50 out of 98 1 2 >