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US20120201857 Transdermal delivery system for therapeutics  
The present invention provides a method and product for transdermal delivery of therapeutics, including neurotoxins and methods for use thereof. The method and system comprises pharmaceutical...
US20150071879 Stabilization of Aqueous Compositions of Proteins with Displacement Buffers  
An aqueous composition having increased protein stability is obtained by: a. determining a pH at which the protein has stability at the desired temperature; b. adding to the composition at least...
US20110190201 Method, device, and kit for maintaining physiological levels of steroid hormone in a subject  
A method, device, or kit is provided which maintain a substantially physiological cyclic pre-menopausal level of one or more steroid hormones in a mammalian subject in need thereof. The method,...
US20140024590 KRAS-Variant And Endometriosis  
The invention provides methods for predicting an increased risk or probability of developing endometriosis in a patient based upon the patient's KRAS variant status.
US20140010859 BARLEY PROTEIN MICROCAPSULES  
The invention is directed to microcapsules, pharmaceutical or nutraceutical compositions comprising same, and methods for preparing and using same for delivery of nanoparticle coated emulsions...
US20120244222 OSMOTIC MEDIATED RELEASE SYNTHETIC NANOCARRIERS  
This invention relates, at least in part, to osmotic mediated release barrier-free synthetic nanocarriers and methods of production and use.
US20130259839 GENE EXPRESSION SIGNATURE FOR CLASSIFICATION OF TISSUE OF ORIGIN OF TUMOR SAMPLES  
The present invention provides a process for classification of cancers and tissues of origin through the analysis of the expression patterns of specific microRNAs and nucleic acid molecules...
US20130136700 POLY-HAPTEN WITH TOPICAL HORMONE ALOPECIA HAIR REGROWTH SYSTEM  
A hair regrowth system consisting of sensitization, growth, and maintenance kits for alopecia areata and related alopecia balding conditions. Graduated doses of specific engineered and or...
US20140170064 METHODS AND COMPOSITIONS FOR RADIOHALOGEN PROTEIN LABELING  
Methods and compositions are provided for labeling proteins with radiohalogen-label reagents. Radiohalogen-labeled proteins may be used for imaging studies, as therapeutics and in diagnostic...
US20110171325 Systems and Methods for Treating Pain Using Brain Stimulation  
The invention comprises systems and methods for treating nociceptive pain including at least one force-regulatable device in mechanical, electrical, or chemical communication with at least one...
US20110223162 TARGETING PAX2 FOR THE TREATMENT OF BREAST CANCER  
The present application provides methods of prevention and/or treatment of breast cancer in a subject by inhibiting expression of PAX2. In the cancer treatment methods disclosed, the method of...
US20140322237 NEURODEGENERATIVE DISEASES AND METHODS OF MODELING  
Disclosed are embryonic stem cells and motor neurons derived from mice carrying transgenic alleles of the normal or mutant human SOD1 gene. Also disclosed are in vitro systems employing such SOD1...
US20140286914 PROTEIN THERAPY FOR TREATMENT OF EYE DISEASES  
The present invention encompasses methods, compositions, and devices for treating an ocular disease, disorder or condition in a mammal. The invention includes polypeptides that possess...
US20130143814 Protein Therapy for Treatment of Eye Diseases  
The present invention encompasses methods, compositions, and devices for treating an ocular disease, disorder or condition in a mammal. The invention includes polypeptides that possess...
US20140322341 NOVEL HEMOSTATIC PATCH AND USES THEREOF  
Disclosed herein is a novel hemostatic patch that may be used to control and/or arrest bleeding in patients. The patch offers an effective but also minimally invasive way to control and/or arrest...
US20110305760 TISSUE REGENERATION SYSTEM  
A system for growing tissue based upon layers of an inorganic extracellular matrix, wherein each layer of the inorganic matrix is designed to dissolve at a separate rate and result in sequential...
US20110003745 GRANULATE-MATRIX  
Composition comprising a granulate selected from the group consisting of autogenous bone material, bone/bone like material from natural sources, synthetic materials and mixtures thereof and a...
US20120114676 METHODS OF TREATING CANCER WITH PHENFORMIN  
Methods of using phenformin to treat certain types of cancers are described.
US20140148389 METHODS FOR ACCELERATING WOUND HEALING BY ADMINISTRATION OF ADIPOKINES  
The present disclosure provides a method, composition and kit for treatment of inflammatory disease and disorder using PKC isoform modulators.
US20120148658 SOLID DRESSING FOR TREATING WOUNDED TISSUE  
Disclosed are solid dressings for treated wounded tissue in mammalian patients, such as a human, comprising a haemostatic layer consisting essentially of fibrinogen and a fibrinogen activator,...
US20150087718 COMPOSITIONS AND METHODS RELATING TO DENND1A VARIANT 2 AND POLYCYSTIC OVARY SYNDROME  
Provided are compositions and methods for use in polycystic ovary syndrome diagnosis (PCOS). The method involves a sample from a subject for a DENND1A Variant 2 mRNA or DENND1 A Variant 2 protein...
US20110039775 THYROID STIMULATING HORMONE FUSION PROTEINS  
We disclose TSH fusion proteins comprising TSHα and/or TSH β and methods to treat diseases that would benefit from administration of TSH agonists and antagonists.
US20120093802 BIOACTIVE COMPOSITION INCLUDING STABILIZED PROTEIN AND PROCESS FOR PRODUCING THE SAME  
A bioactive composition includes a porous hydrogel matrix. At least one protein is immobilized in the porous hydrogel matrix forming a hydrogel protein composite that is stable in an organic...
US20110033461 Combination Therapy for the Treatment of Cancer  
Compositions which act synergistically to inhibit the growth of cancer cells and methods of use thereof are disclosed.
US20110217281 METHODS FOR DIAGNOSIS AND PROGNOSIS OF CANCER  
A method for diagnosing an early stage melanoma which includes detecting the expression level of dual specificity phosphatase 1 protein (DUSP1) and a method for determining a prognosis for a...
US20120129773 METHODS OF TREATING AUTISM AND AUTISM SPECTRUM DISORDERS  
The present invention relates to methods of treating a subject diagnosed with autism or an autism spectrum disorder, lowering the level of mercury in a subject determined to contain a high level...
US20130029910 METHOD OF TREATING PROSTATE CANCER WITH GnRH ANTAGONIST  
The invention provides methods and dosing regimens for safely and effectively treating androgen-dependent prostate cancer with a gonadotrophin releasing hormone (GnRH) antagonist without causing a...
US20110059159 NANOSCALE BOUND BILAYERS, METHODS OF USE AND PRODUCTION  
Methods for rapidly obtaining a nanoscale apolipoprotein bound phospholipid bilayer (NABB) associated with at least one membrane protein are provided. Also disclosed are methods for rapidly...
US20140243261 Method for treating diabetes and fatty liver disese by stimulating cellular metabolism  
The present invention is a method of treating various diseases and conditions through administering a substantial caloric load coupled with administration of hormone to stimulate the body to...
US20110086800 SCREENING METHOD FOR PREDICTING SUSCEPTIBILITY TO BREAST CANCER  
A method to aid in identifying a familial or sporadic pattern of risk in at least one individual for developing cancer of a mucosal epithelial tissue, the method comprising screening said at least...
US20130084241 DEVELOPMENT OF miRNA DIAGNOSTICS TOOLS IN BLADDER CANCER  
The present invention includes methods and compositions related to diagnosis of bladder cancer, including the presence of bladder cancer and/or the type or stage of bladder cancer. In specific...
US20110014153 REINFORCED TISSUE GRAFT  
A biocompatible tissue graft is provided. The tissue graft includes an extracellular matrix patch and a means for reinforcing the patch.
US20120329713 METHOD FOR DETERMINING LIKELIHOOD OF CLINICAL RECURRENCE OR CLINICALLY STABLE DISEASE OF PROSTATE CANCER AFTER RADICAL PROSTATECTOMY  
This invention describes compositions and methods for use in PSA assays having low functional sensitivity which are useful, for example, in the detection of early stage recurrence of prostate...
US20100297105 ADMINISTERING ANTISENSE OLIGONUCLEOTIDES COMPLEMENTARY TO HUMAN APOLIPOPROTEIN B  
Methods for long-term lowering of lipid levels in human subjects and for the treatment of conditions associated with elevated LDL-cholesterol and elevated ApoB are provided.
US20150164994 SYSTEMS AND METHODS FOR ANGIOGENIC TREATMENT IN WOUND HEALING  
The invention relates to systems and methods for the diagnosis, amelioration, and treatment of ischemic tissues in patients caused by and/or resulting from diminished microvascular blood flow....
US20100292791 Fully synthetic implantable multi-phased scaffold  
An implantable device is provided for soft-tissue or soft tissue-to-bone repair, fixation, augmentation, or replacement that includes a biomimetic and biodegradable nanofiber scaffold. Also...
US20120171256 ELECTROSPUN SILK MATERIAL SYSTEMS FOR WOUND HEALING  
The present invention relates to the processes of preparing silkfibroin/polyethylene oxide blended materials, and the resulting materials thereof, which are suitable for biomedical applications...
US20110110934 TREATMENT OF UVEITIS  
The present invention relates generally to the use of antagonists of G-CSF, and/or its receptor (G-CSFR) in the treatment of uveitis. The present invention contemplates, therefore, the inhibition...
US20120058940 AZINONE-SUBSTITUTED AZAPOLYCYCLE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF  
Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and...
US20110003738 AZINONE-SUBSTITUTED AZAPOLYCYCLE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF  
Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and...
US20140024588 METHOD FOR INDUCING SUSTAINED IMMUNE RESPONSE  
A method for promoting a sustained increased level of T-cell production in immunocompromised subjects in which method enkephalin peptides are administered according to an intermittent dose...
US20140073562 NASAL DELIVERY  
A nasal delivery device for and method of delivering a substance, preferably comprising oxytocin, non-peptide agonists thereof and antagonists thereof, preferably as one of a liquid, as a...
US20110135596 FUSION PROTEIN COMPRISING UBIQUITIN OR UBIQUITIN-LIKE PROTEIN, MEMBRANE TRANSLOCATION SEQUENCE AND BIOLOGICALLY ACTIVE MOLECULE AND USE THEREOF  
A transmembrane fusion protein including ubiquitin or a ubiquitin-like protein, a membrane translocation sequence linked to the C-terminus of the ubiquitin or ubiquitin-like protein, and a...
US20150045295 DRY POWDER INHALER AND SYSTEM FOR DRUG DELIVERY  
A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with...
US20120231065 METHODS OF TREATING NEUROLOGICAL CONDITIONS WITH HEMATOPOEITIC GROWTH FACTORS  
The present invention relates to a method of treating a neurological condition in a mammal by administering at least one hematopoietic growth factor.
US20120244216 COATED PHARMACEUTICAL CAPSULE DOSAGE FORM  
Pharmaceutical compositions in unit dose form comprising a hard or soft capsule containing a fill consisting of one or more inert ingredients, and one or more coatings on the capsule, wherein at...
US20140199262 METHOD FOR MANUFACTURING PROTEIN DRUG  
The present invention provides a method for manufacturing a virus-free protein drug, comprising (a) a filtration step of filtering a virus-containing protein solution through a small-pore size...
US20100310583 LET-7 MICRORNA AND MIMETICS THEREOF AS THERAPEUTICS FOR CANCER  
The present invention relates to methods to treat or prevent cancers in a subject, in particular the present invention relates to a method of treating and/or preventing cancer comprising targeting...
US20110190688 Permeant Delivery System and Methods for Use Thereof  
Disclosed are a patch, system, and method for delivery of a permeant composition into a subject via at least one formed pathway through a biological membrane of the subject. The patch comprises a...
US20120134925 Application and Uses of PRG4 and Therapeutic Modulation Thereof  
The present invention relates to the uses of the protein PRG4 and therapeutic modulation thereof. In particular, the present invention relates compositions and methods utilizing PRG4 and...