Matches 1 - 39 out of 39


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US20120071446 DOSAGE REGIMEN OF AN S1P RECEPTOR AGONIST  
S1P receptor modulators or agonists are administered following a dosage regimen whereby during the initial 3 to 6 days of treatment the daily dosage is raised so that in total the R-fold (R being...
US20110257130 Compositions and Methods for Treatment of Renin-Angiotensin Aldosterone System (RAAS)- Related Disorders  
Compounds are provided which can be useful in reducing the activity of an angiotensin-converting enzyme and thus be used to treat or prevent a renin-angiotensin aldosterone system-related...
US20150197533 AZEPANE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS  
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV...
US20140134133 HETEROAROMATIC COMPOUNDS AS PI3 KINASE MODULATORS AND METHODS OF USE  
The present invention provides heteroaromatic derivatives and pharmaceutical acceptable salts and formulations thereof useful in modulating the protein kinase activity, especially...
US20050209194 Combination therapy for glaucoma treatment  
A method is disclosed herein comprising administering a compound and a second drug to an eye of a mammal for the treatment of glaucoma or the reduction of intraocular pressure, said compound...
US20070123492 Analogs of lysophosphatidic acid and methods of making and using thereof  
Described herein are analogs of lysophosphatidic acid. Also described herein are methods of making and using analogs of lysophosphatidic acid.
US20050239751 Heterocyclic anti-viral compounds comprising metabolizable moieties and their uses  
The present invention relates to substituted prodrug and compositions thereof useful for treating or preventing Hepatitis C virus (HCV) infections. In particular, the present invention relates to...
US20150182452 LOCAL TREATMENT OF NEUROFIBROMAS  
A method for treating a neurofibroma, e.g. dermal neurofibroma, a subdermal neurofibroma, or a superficial plexiform neurofibroma, in a subject in need of such treatment is disclosed. The method...
US20120029055 MODULATORS OF APOPTOSIS AND THE USES THEREOF  
Here we demonstrate that miR-125b, a brain-enriched microRNA, is a negative regulator of p53 in animals. miR-125b-mediated downregulation of p53 is dependent on the binding of miR-125b to a...
US20110224147 METHODS AND COMPOSITIONS  
A method for inducing an analgesic response to inflammatory or neuropathic pain by administration of 1-(2-(4-chlorophenyl)-2-hydroxy)ethyl-4-(3,5-bis(1,1 dimethyl)-4-hydroxyphenyl)methyl...
US20110245204 CYCLOALKANE-CONTAINING SPHINGOSINE 1-PHOSPHATE AGONISTS  
The present invention provides sphingosine-1-phosphate analogs that are potent, and selective agonists at one or more S1P receptors, specifically the S1P1 receptor type. The compounds invention...
US20060287257 Pharmaceutical compositions to treat diseases caused by mycobacterium  
The invention teaches the synthesis of pharmaceutical composition and methods of synthesis to treat people and animals infected with a pathogenic mycobacterium. In particular the compositions of...
US20060172972 Formulation and method for administration of ophthalmologically active agents  
A method and formulation are provided for the administration of ophthalmologically active agents. In one embodiment, the method and formulation provided are for the treatment of medical conditions...
US20070082871 Antiresorptive mutual salt of raloxifene and bisphosphonic acid  
The mutual salt of raloxifene and bisphosphonic acid exhibits unexpectedly synergistic effects of two components to enhance bone mineral density (BMD), control blood-calcium density, and lower the...
US20100056478 Useful Combinations of Monobactam Antibiotics With Beta-Lactamase Inhibitors  
A pharmaceutically composition, comprising a combination of an antibiotically active compound of the formula (I): with a β-lactamase inhibitor of one of the formulae (II) to (XIII) are active...
US20070010489 Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds  
Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit 5 HIV protease...
US20070249561 Pharmacological method for treatment of neuropathic pain  
Disclosed are methods and compositions useful for treatment of neuropathic pain. In particular, the present invention provides methods of activating gamma-subtype peroxisome proliferator-activated...
US20090061024 COMPOSITIONS AND METHODS EMPLOYING NMDA ANTAGONISTS FOR ACHIEVING AN ANESTHETIC-SPARING EFFECT  
Provided herein are compositions, combinations, and methods comprising NMDA antagonists including, but not limited to, NMDA glutamate receptor antagonists such as...
US20120065169 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS  
Oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where...
US20080171724 Phosphonate Derivatives of Mycophenolic Acid  
Phosphorus substituted mycophenolate oxime derivatives with anti-cancer, anti-viral, anti-inflammatory anti-tissue/organ transplant rejection properties having use as therapeutics and for other...
US20070004679 Androgen receptor modulators and methods of treating disease using the same  
Disclosed herein are bicycloaryl compounds of Formula (I) that selectively modulate nuclear receptors, preferably the androgen receptor, or a pharmaceutically acceptable salt, ester, amide, or...
US20090176743 Methods for treating or preventing reactivation of a latent herpesvirus infection  
The invention is directed to methods and compositions for treating or preventing reactivation of a latent herpesvirus infection and the associated complications and outcomes. The methods involve...
US20060281710 17SS-HSD1 and STS inhibitors  
The present invention relates to novel substituted steroid derivatives which represent selectiv inhibitors of the 17β-hydroxysteroid dehydrogenase type I (17β-HSD1) and, in addition, which may...
US20120065168 Pharmaceutical Hypocholesterolemic Compositions  
The present invention relates to novel azetidinone-containing compounds having a novel side-chain which is attached to the aryl ring at C4 via a C—C bond and comprises a 3,3-disubstituted oxetane...
US20100112061 Monophosphates as Mutual Prodrugs of Muscarinic Receptor Antagonists and Beta-Agonists for the Treatment of COPD And Chronic Bronchitis  
A mutual prodrug of a MRA and a (β-agonist for formulation for delivery by aerosolization to inhibit pulmonary bronchoconstriction is described. The mutual prodrug is preferably formulated in a...
US20140038919 HEPATITIS C INHIBITORS AND USES THEREOF  
This disclosure relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising...
US20110038835 ANILIDES AND ANALOGS AS RHO KINASE INHIBITORS  
Compounds useful as Rho kinase inhibitors of formula (I): wherein variable are as defined herein are provided. Methods of treatment of malconditions mediated by Rho kinase, and methods of...
US20050187193 Alpha-substituted beta-aminoethyl phosphonate derivatives  
The present invention relates to novel α-substituted-β-aminoethylphosphonate and α-substituted-β-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo...
US20080039522 Composition Containing a Complex Comprising a Metal Ion and a Carboxylate Ligand Having Anti-Inflammatory Activity  
A pharmaceutical composition comprising a metal complex of a carboxylate having anti-inflammatory activity in a pharmaceutically acceptable carrier, wherein: (1) the composition has a colloidal...
US20110038952 GAMBOGIC ACID GLYCOSIDE DERIVATIVES AND ANALOGS, THEIR PREPARATION METHODS AND APPLICATIONS  
This invention relates with the gambogic acid glycoside derivatives and analogs of formula I: or stereoisomers, tautoers, prodrugs, pharmaceutically acceptable salts, complex salts or solvates...
US20060040899 Medicaments containing bisphosphonic acids and derivatives thereof for preventing and treating diseases and allergies  
Provided are compounds and methods for the prevention and treatment of autoimmune disorders and of allergies using such compositions in which autoantigens or allergens previously used for treating...
US20050124581 Alpha-substituted heteroarylalkyl phosphonate derivatives  
The present invention relates to novel α-substituted heteroarylalkylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low...
US20120107269 THIOPHENE DERIVATIVES  
Disclosed is a compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the present application.
US20100291026 PIPERIDINE INHIBITORS OF JANUS KINASE 3  
The present invention relates to new piperidine inhibitors of Janus kinase 3 activity, pharmaceutical compositions thereof, and methods of use thereof.
US20050181037 Cardiolipin compositions their methods of preparation and use  
The invention provides new synthetic routes for cardiolipin with different fatty acids and/or alkyl chains with varying chain length and also with or without unsaturation. The reaction schemes can...
US20090291049 Targeted delivery to human diseases and disorders  
The present invention provides a system presenting site-specific accumulation through a ligand that specifically targets a receptor overexpressed on the surface of specific cells within a target...
US20080286264 Modulation of Muc1 Activity  
The invention provides methods of identifying and making compounds that inhibit the interaction between MUC1 and either p53 or TBP. Also embraced by the invention are in vivo and in vitro methods...
US20160145279 STAT6 INHIBITORS  
The present disclosure provides compounds that are useful for inhibiting the STAT6 pathway. Also provided are related pharmaceutical compositions and methods of using the compounds. In some...
US20160000812 AZEPANE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS  
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV...

Matches 1 - 39 out of 39