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US20100330079 BIOMARKDER COMBINATIONS FOR COLORECTAL CANCER  
The present invention relates to methods and kits for the detection of predetermined biomarkers for early diagnosis and management of cancer, and in particular, colorectal cancer.
US20100297121 Methods for Treating Pressure Induced Optic Neuropathy, Preventing Neuronal Degeneration and Promoting Neuronal Cell Survival Via Administration of LINGO-1 Antagonists and TrkB Agonists  
This invention relates to methods for promoting neuronal survival and regeneration using LINGO-1 antagonists and TrkB agonists. Additionally, the invention relates to methods for treating pressure...
US20130136692 MOLECULAR SIGNATURE OF CANCER  
The present invention provides compounds, compositions, and methods for detecting, diagnosing and treating cancers such as glioblastoma multiforme.
US20140315801 METHODS OF TREATMENT OF CELL PROLIFERATIVE AND/OR OPHTHALMIC DISEASES, DISORDERS AND CONDITIONS USING INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY  
This invention relates to methods for treating cell proliferative diseases and conditions and ophthalmic diseases, disorders and conditions using compounds that inhibit protein tyrosine kinase...
US20090074718 Avian derived erythropoietin  
Erythropoietin obtained from eggs laid by transgenic avians having avian N-linked and O-linked glycosylation patterns.
US20150174202 Methods and Compositions for Modulating Beta Cell Proliferation  
Methods and compositions are provided for modulating pancreatic islet β cell proliferation. Aspects of the methods include promoting β cell proliferation by providing agents that promote PDGFR...
US20060057067 Lymph-like composition and method to prevent and treat central nervous system injuries  
The existence of the cerebrospinal fluid and the intracranial pressure contribute the susceptibility of the CNS to injuries. A lymph-like composition and method for treating brain and spinal cord...
US20070280947 Tie Receptor and Tie Ligand Materials and Methods for Modulating Female Fertility  
The present invention provides materials and methods involving Tie receptors and Angiopoietin ligands for modulating female fertility in mammals, including humans. Materials and methods for...
US20080038317 Therapeutic Lacrimal Canalicular Inserts And Related Methods  
Lacrimal canalicular inserts include a polymeric component and a therapeutic component. The therapeutic component is released from the inserts for extended periods of time, such as for more than...
US20090305974 THERAPEUTIC INDICATIONS OF COLONY STIMULATING FACTORS  
The present invention relates to the use of at least one colony stimulating factor (CSF) for the production of medicinal products in the treatment or prophylaxis of coma or neurotoxicity.
US20050100887 Targets for hepatitis C virus infections  
Methods for the detection of compounds useful for prophylaxis and/or treatment of Hepatitis C virus infections and methods for detecting Hepatitis C virus infections in an individual or in cells...
US20070105773 Pharmaceutical composition comprising TrkAIg2 for use in the prevention and/or treatment of cancer  
This invention relates to the treatment of cancer and is particularly, though not exclusively concerned with the treatment of pancreatic cancer. In particular the invention related to the use of...
US20110021424 POLYPEPTIDE DERIVED FROM PROTEIN A AND ABLE TO BIND PDGF  
The invention provides a platelet derived growth factor receptor beta (PDGF-Rβ) binding polypeptide, comprising a platelet derived growth factor receptor beta binding motif, PBM, which motif...
US20130273063 METHODS AND KITS TO PREDICT THERAPEUTIC OUTCOME OF BTK INHIBITORS  
Methods of tests that assess the expression of DPC4 (SMAD4) to identify subjects with pancreatic cancer that are likely or unlikely to respond to treatment with BTK inhibitors; methods of treating...
US20100222266 A METHOD OF USING INTERFERON-LIKE PROTEIN ZCYTO21(IL-29) TO TREAT HEPATITIS B  
The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-a at the amino acid sequence level....
US20060263331 Therapeutic use of tumor necrosis factor-alpha mutein  
Improved methods for treating neoplastic diseases such as cancer are provided by using muteins of human tumor necrosis factor-alpha (TNF-α). Compared to wild-type human TNF-α these therapeutic TNF...
US20080194491 Methods of Diagnosing, Preventing, and Treating Early Onset of Pulmonary Hypertension  
Early onset of pulmonary disorders such as pulmonary hypertension are treated or prevented by administration of an apoptosis inhibitor or a survival factor. Early onset of such disorders may be...
US20070099828 BIOMARKERS FOR THE EFFICACY OF CALCITONIN AND PARATHYROID HORMONE TREATMENT  
A mufti-organ gene profiling analysis of the results of an administration to a subject of salmon calcitonin or a parathyroid hormone analogue provides biomarkers of calcitonin treatment efficacy...
US20050107298 Crystals and structures of c-Abl tyrosine kinase domain  
The present invention provides machine readable media embedded with the three-dimensional molecular structure coordinates of AblKD and variants and subsets thereof, including binding pockets,...
US20070212298 USE OF THE COMBINATION COMPRISING TEMOZOLOMIDE AND TNF-ALPHA FOR TREATING GLIOBLASTOMA  
Disclosed are methods of synergistically inhibiting growth of a glioma cell comprising contacting the cell with temozolomide and TNFα, or with temozolomide, TNFα, and radiation. Also disclosed are...
US20060194724 Methods and systems for nerve regeneration  
An exemplary method of regenerating a nerve within a patient includes implanting a system control unit within the patient and applying a stimulus to the nerve with the system control unit in...
US20150202251 MULTIMERIC TIE 2 AGONISTS AND USES THEREOF IN STIMULATING ANGIOGENESIS  
The present invention provides a multimeric form of a Tie 2 binding peptide monomer, wherein the multimeric form has Tie 2 agonist activity. The multimeric form, preferably a tetramer, stimulates...
US20130172234 MULTIMERIC TIE 2 AGONISTS AND USES THEREOF IN STIMULATING ANGIOGENESIS  
The present invention provides a multimeric form of a Tie 2 binding peptide monomer, wherein the multimeric form has Tie 2 agonist activity. The multimeric form, preferably a tetramer, stimulates...
US20110097300 MULTIMERIC TIE 2 AGONISTS AND USES THEREOF IN STIMULATING ANGIOGENESIS  
The present invention provides a multimeric form of a Tie 2 binding peptide monomer, wherein the multimeric form has Tie 2 agonist activity. The multimeric form, preferably a tetramer, stimulates...
US20090214424 Human glycoprotein hormone superagonists and uses thereof  
The present invention provides improved methods of imaging, targeted therapy and detection and diagnostics using modified glycoprotein hormones having increased activity over wild-type hormones.
US20060014684 Novel uses of EGF  
This invention relates to treating or preventing pathogenic infections with an epidermal growth factor (EGF). EGF is capable of inhibiting pathogenic colonization of pathogens in a variety of...
US20090203607 Method And Compositions For Simultaneously Regulating Memory And Mood  
The present invention is concerned with methods and compositions for simultaneously treating or modulating memory and mood within the same individual.
US20100227814 INHIBITORS OF GSK-3 AND CRYSTAL STRUCTURES OF GSK-3BETA PROTEIN AND PROTEIN COMPLEXES  
The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of...
US20060212008 Method for treating or preventing steroid-induced glaucoma  
An integrin antagonist reduces the occurrence of cross-linked actin network (CLAN) structures in cells of the trabecular meshwork. CLAN structures are associated with steroid-induced glaucoma....
US20060135435 Agent that retards transformation of hormone-dependent cancer to non-hormone-dependent cancer  
The present invention relates to a composition that retards the transformation of a hormone-dependent cancer to a non-hormone-dependent cancer, which contains a hormonal agent. The composition of...
US20100055146 CYCLIC ANGIOTENSIN ANALOGS  
The invention relates to analogs of angiotensins, in particular to cyclised analogs having Ang(1-8) agonistic or antagonistic activity and to cyclised Ang(1-7) analogs with agonistic or...
US20060160761 Regulation of vascular endothelium using BMX tyrosine kinase  
Vascular endothelia are subject to atherosclerotic and arteriostenotic effects transduced by molecules, such as thrombin, IL-3 and VEGF which can lead to vessel occlusion or stenosis. An...
US20060148694 Inhibition of stress-induced ligand-dependent egfr activation  
The present invention relates to the inhibition of stress-induced receptor tyrosine kinase activity by inhibiting a ligand of said receptor tyrosine kinase, particularly an extracellular ligand.
US20060234931 Treatment of diseases with kinase inhibitors  
The invention is directed to the identification and use of additional targets of BIRB 796, imatinib mesylate, and BAY 43-9006. The new targets of BIRB 796, imatinib mesylate, and BAY 43-9006 can...
US20060116319 Method for identifying and treating photodamaged skin  
The present invention relates to modulation of MAP2K2 and DUSP-1 genes and proteins encoded thereby. More specifically, the present invention relates to modulation of MAP2K2 and DUSP-1 genes to...
US20070122395 Genetic and pharmacological regulation of antidepressant-sensitive biogenic amine transporters through PKG/p38 map kinase  
The invention relates to the observation that the p38 mitogen-activated protein kinase pathway is an important regulator of biogenic amine transporter (BAT) function. By using modulator of p38...
US20050272644 Method for increasing therapeutic gain in radiotherapy and chemotherapy  
The present invention provides compositions and methods for increasing therapeutic gain in radiotherapy and chemotherapy for proliferating malignant or nonmalignant disease to produce high...
US20060216339 Neuronal pain pathway  
The present invention relates to the discovery of a novel molecular pathway involved in long-term hyperexcitability of sensory neurons, which, in higher animals, is associated with persistent...
US20080139480 Combination Of (A) N--4-(3- Pyridyl)-2-Pyrimidine-Amine And (B) At Least One Hypusination Inhibitor And The UseThereof  
The invention relates to a method of treating a warm-blooded animal, especially a human, having a proliferative disease comprising administering to the animal a combination which comprises (a)...
US20070042437 Diagnosis and treatment of Alzheimer's Disease  
This invention relates to methods for diagnosing Alzheimer's Disease (AD) by determining the level or function of insulin, insulin-like growth factors, their receptors and/or their downstream...
US20070027067 Transition-state Inhibitors of Pin1, alpha-Ketoamide-containing peptidomimetics, and synthesis thereof  
Novel α-ketoamide-containing peptidomimetics are provided, such as peptidomimetics containing an α-ketoamide Ser-Pro dipeptide analogue. The α-ketoamide is preferably incorporated into another...
US20050025765 Trans-capsular administration of high specificity cytokine inhibitors into orthopedic joints  
The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory...
US20080145346 Methods And Compounds For Altering The Load Of Hepatitis Virus  
The present invention relates to a method for altering the load of a Hepatitis virus present in an infected host organism. The method involves modulation of the complex formation of a...
US20080254023 Treating Gliosis, Glial Scarring, Inflammation or Inhibition of Axonal Growth in the Nervous System by Modulating Eph Receptor  
The present invention relates to a method of treating disorders of the nervous system and more particularly disorders associated with a gliotic response and/or an inflammatory response within the...
US20070026512 Atomic structure of the catalytic domain for use in designing and identifying inhibitors of zap-70 kinase  
The present invention relates to the three dimensional structure of ZAP-70 protein tyrosine kinase and describes methods of making a crystal of ZAP-70 and purification of the catalytic domain of...
US20120289463 Compositions and Methods for Promoting Epithelialization and Wound Closure  
Compositions for antagonizing phosphorylation and subsequent degradation of glycogen synthase kinase 3 beta (GSK3β) in epidermal cells are disclosed. GSK3β phosphorylation antagonists include...
US20080317809 Use of K -252a and Kinase Inhibitors for the Prevention or Treatment of Hmgb1-Associated Pathologies  
The present invention relates to the use of K-252a, a physiologically active substance produced by microorganisms, and of its salts or synthetic and/or chemically modified derivatives for the...
US20080025962 Remedy for Alzheimer's Disease  
The present invention provides a prophylactic/therapeutic agent for Alzheimer's disease comprising a substance that inhibits the action of β-amyloid 1-40 to suppress vascular endothelial precursor...
US20070059320 Method for ameliorating pain by modification of NMDA receptors through inhibition of Src  
The present invention provides a method for ameliorating inflammatory and/or neuropathic pain in a subject by modifying the activity of N-methyl-D-aspartate (NMDA) receptors in cells of the...
US20060275308 Combination of gallium compounds with nonchemotherapeutic anticancer agents in the treatment of neoplasia  
The present invention relates to a combination of a pharmaceutical composition comprising a gallium compound, especially gallium nitrate, and one or more nonchemotherapeutic anticancer agents...

Matches 1 - 50 out of 144 1 2 3 >