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US20150190475 STABILIZED PHARMACEUTICAL FORMULATIONS OF INSULIN ASPART  
Stabilized pharmaceutical formulations of insulin aspart are disclosed.
US20120329709 PRODUCTION OF GLYCOPROTEINS  
The present invention provides methods and materials by which glycosylation of glycoproteins can be regulated. Methods include the monitoring and regulation of parameters such that a glycoprotein...
US20120178675 Compositions And Methods For Modulating The Pharmacokinetics and Pharmacodynamics of Insulin  
Compositions and methods for modulating the pharmacokinetics and pharmacodynamics of rapid acting injectable insulin formulations are described herein. In the preferred embodiment, the...
US20110020471 ERYTHROCYTE ATP-RELEASE MODULATORS  
Erythrocyte ATP-release modulators and composition and methods for their use to potentiate serum glucose clearance and vasodilation; methods for prophylactic or palliative therapy of glucose...
US20150216935 Autologous Cell-Based Therapy for Treating Obesity  
Compositions and methods for producing autologous brown adipose cells in vitro or in vivo are provided. In particular, a drug delivery device is described that recruits adipose stem cells (ASCs)...
US20140357554 Magnesium Compositions for Modulating the Pharmacokinetics and Injection Site Pain of Insulin  
Compositions and methods for modulating injection site pain associated with rapid acting injectable insulin formulations have been developed for subcutaneous injection. The formulations contain...
US20140024582 STABLE INSULIN FORMULATIONS AND METHODS OF MAKING AND USING THEREOF  
The invention provides methods for improving the physical and chemical stabilities of therapeutic proteins in solutions by reducing or eliminating protein degradation, aggregation and...
US20150174209 INSULIN-PRAMLINTIDE COMPOSITIONS AND METHODS FOR MAKING AND USING THEM  
In alternative embodiments, the invention provides formulations, pharmaceutical compositions, devices and other products of manufacture comprising a therapeutically effective mixture of an insulin...
US20060217290 Insulin analogs having protracted time action  
The present invention provides the insulin analog A0Arg A21Gly B31Arg B32Arg, which provides a protracted, even basal duration of action. The present invention also provides a method of treating...
US20060258561 Novel NPH insulin preparations  
This invention relates to NPH-insulin (crystalline preparations) that are prepared in the presence of certain high-affinity ligands for the HisB10 Zn2+-sites of the R-state insulin hexamer....
US20110046052 Excipients for Protein Stabilization  
This invention is a method of using a class of excipients for protein formulation to reduce and/or eliminate protein aggregation in solutions or solids. This class of compounds contains carbonyl...
US20150216941 Stabilized Pharmaceutical Formulations of Insulin Analogues and/or Insulin Derivatives  
Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives are disclosed.
US20140221285 STABILIZED PHARMACEUTICAL FORMULATIONS OF INSULIN ANALOGUES AND/OR INSULIN DERIVATIVES  
Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives are disclosed.
US20070093411 Zinc-free and low-zinc insulin preparations having improved stability  
The invention relates to a formulation comprising a polypeptide selected from at least one of insulin, an insulin analog, and an insulin derivative; at least one surfactant; optionally at least...
US20130280319 Compositions, methods and kits for therapeutic treatment with wet spun microstructures  
Methods, compositions, systems, devices and kits are provided for preparing and using a multi-layer polymeric microstructure composition for delivering a therapeutic agent to a subject. In various...
US20140113856 Magnesium Compositions for Modulating the Pharmacokinetics and Pharmacodynamics of Insulin and Insulin Analogs, and Injection Site Pain  
Compositions and methods for modulating injection site pain associated with rapid acting injectable insulin formulations have been developed for subcutaneous injection. The formulations contain...
US20130137632 Method of Treating a Subject According to Biomarkers for Insulin Resistance  
The invention provides compositions and methods for determining insulin resistance and/or pancreatic β-cell dysfunction in a subject. The invention also provides compositions and methods for...
US20120316108 PHOSPHOLIPID DEPOT  
The present invention is directed to compositions and methods of preparation of phospholipid depots that are injectable through a fine needle.
US20060019874 Cation complexes of insulin compund conjugates, formulation and uses thereof  
The invention provides a complex including a cation and an insulin compound conjugate. The insulin compound conjugate includes insulin compound, such as human insulin or an analog thereof,...
US20120241356 HEAT- AND VIBRATION-STABLE INSULIN PREPARATIONS  
The invention relates to a method for producing an aqueous, pharmaceutical formulation comprising an insulin, an insulin analog, or an insulin derivative, wherein the ready-made formulation takes...
US20080090753 Rapid Acting Injectable Insulin Compositions  
Injectable insulin formulations with improved stability and rapid onset of action are described herein. The formulations may be for subcutaneous, intradermal or intramuscular administration, In...
US20060148676 Polyamino acid-based particle insulin formulation  
This invention relates to dual-release formulations of insulin comprising polyamino acid particles and insulin, and a method of preparing such formulations
US20080026068 PULMONARY DELIVERY OF SPHERICAL INSULIN MICROPARTICLES  
Compositions of spherical insulin particles having improved pulmonary application potentials and methods of forming and using these compositions are disclosed in the present application. In one...
US20080171694 Pharmaceutical Formulation Comprising Crystalline Insulin and Dissolved Insulin  
The invention provides a pharmaceutical formulation and a method for preparing the formulation.
US20070155654 Novel formulations  
Stable, soluble insulin formulations having both a fast and a long action.
US20120064006 SYSTEMS AND METHODS FOR USING PHYSIOLOGICAL INFORMATION  
Systems and methods using a database of physiological information for the design, development, testing and use of therapeutics. In one aspect, the physiological information can include at least...
US20120183616 LONG ACTING INSULIN COMPOSITION  
The present invention relates to a pharmaceutical composition comprising an insulin compound in a concentration that is sufficient to maintain a therapeutically effective level of the insulin...
US20150005230 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY  
Provided are methods relating to the use of CDP-therapeutic agent conjugates for the treatment of a disease or disorder, e.g., autoimmune disease, inflammatory disease, central nervous system...
US20130196906 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY  
Provided are methods relating to the use of CDP-therapeutic agent conjugates for the treatment of a disease or disorder, e.g., autoimmune disease, inflammatory disease, central nervous system...
US20060019873 Cation complexes of insulin compound conjugates, formulations and uses thereof  
An insulin compound coupled to a modifying moiety having a formula: —X—R1—Y-PAG-Z-R (Formula VI) where, X, Y and Z are independently selected linking groups and each is optionally present, and X,...
US20060069013 Pharmaceutical preparations comprising acid-stabilised insulin  
Novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer that are capable of prolonging the action of insulin preparations are disclosed.
US20080206342 Compositions and Methods For Increasing the Bioavailability of Pulmonarily Administered Insulin  
A pharmaceutical composition suitable for pulmonary delivery includes insulin and EDTA. The presence of EDTA is effective to increase the relative pulmonary bioavailability of the insulin compared...
US20050065066 Stabilised insulin compositions  
The present invention provides pharmaceutical compositions comprising insulin and novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer. The resulting preparations have improved...
US20150250858 INJECTABLE SOLUTION AT PH 7 COMPRISING AT LEAST ONE BASAL INSULIN WHOSE PI IS BETWEEN 5.8 AND 8.5  
A composition in the form of an injectable aqueous solution, the pH of which is between 6.0 and 8.0, includes at least a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5;...
US20130065826 Injectable solution at pH 7 Comprising at least one basal insulin whose PI is between 5.8 and 8.5  
A composition in the form of an injectable aqueous solution, the pH of which is between 6.0 and 8.0, includes at least a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5;...
US20100227795 INSULIN FORMULATIONS FOR RAPID UPTAKE  
Injectable insulin formulations with improved stability and rapid onset of action are described herein. The formulations may be for subcutaneous, intradermal or intramuscular administration. In...
US20080255054 STERILE SUSPENSIONS OF SLIGHTLY SOLUBLE BASIC PEPTIDE COMPLEXES AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM  
The invention provides sterile suspensions and sterile lyophilizates of slightly soluble basic peptide complexes, and pharmaceutical formulations comprising them. The provided sterile suspensions,...
US20090220607 POLYMERIC COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF  
Described herein are polymeric compositions having a polymer residue and a crosslinker residue, wherein the polymer residue is bonded to the crosslinker residue with a moiety formed from a...
US20110124553 INSULIN-OLIGOMER CONJUGATES, FORMULATIONS AND USES THEREOF  
An insulin compound coupled to a modifying moiety having a formula: —X—R1—Y—PAG-Z—R2 (Formula VI) where,X, Y and Z are independently selected linking groups and each is optionally present, and X,...
US20110118179 CATION COMPLEXES OF INSULIN COMPOUND CONJUGATES, FORMULATIONS AND USES THEREOF  
An insulin compound coupled to a modifying moiety having a formula: —X—R1—Y-PAG-Z—R2 (Formula VI) where,X, Y and Z are independently selected linking groups and each is optionally present, and X,...
US20100178331 PREPARATION FOR TRANSNASAL APPLICATION  
Disclosed is a preparation for transnasal application, which has improved fluidability. Specifically disclosed is a preparation for transnasal application, which comprises at least a complex...
US20120135920 Preparation Comprising Insulin, Nicotinamide and an Amino Acid  
Insulin preparations comprising an insulin compound or a mixture of two or more insulin compounds, a nicotinic compound and an amino acid.
US20110077197 NOVEL INSULIN DERIVATIVES HAVING AN EXTREMELY DELAYED TIME-ACTION PROFILE  
The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end consists of an amidated basic amino acid...
US20070259047 Protein Sustained-Release Microparticle Preparation for Injection and Process for Producing the Same  
To provide protein drug sustained-release microparticle preparations for injection that in the production thereof, minimize the use of organic solvents and avoid the simultaneous use of an organic...
US20170056478 RAPID-ACTING INSULIN COMPOSITIONS  
The invention is a pharmaceutical composition of human insulin or insulin analog that includes citrate, treprostinil and stabilizing agents, that has faster pharmacokinetic and/or pharmacodynamic...
US20170028031 NOVEL FAST ACTING INSULIN PREPARATIONS  
The invention relates to a soluble preparation for injection in humans, characterized in that the preparation (1) contains human insulin or a monomeric insulin analog, (2) has a lower...
US20160129088 PRESERVATIVE FREE INSULIN FORMULATIONS AND SYSTEMS AND METHODS FOR AEROSOLIZING  
One embodiment describes an insulin formulation that is specifically adapted for aerosolization. The formulation comprises a major amount of water and a minor amount of insulin. Further, the...
US20160058874 CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTIC DELIVERY  
Provided are methods relating to the use of CDP-therapeutic agent conjugates for the treatment of a disease or disorder, e.g., autoimmune disease, inflammatory disease, central nervous system...
US20150328314 PHOTOCLEAVABLE DRUG CONJUGATES  
Novel photocleavable drug conjugates for forming drug depots comprise drugs attached to photocleavable groups. In one embodiment, the drug is linked via photocleavable group(s) to a polymer chain...
US20150297681 Pegylated Insulin Lispro Compounds  
The present invention relates to the field of diabetes. More particularly, the invention relates to PEGylated insulin lispro compounds that are PEGylated with high molecular weight poly(ethylene...

Matches 1 - 50 out of 51 1 2 >