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US20120184494 MULTIPLE MYELOMA PROGNOSIS AND TREATMENT  
Disclosed herein are diagnostic and prognostic methods for determining the overall survival, and therapeutic regimes, for multiple myeloma patients. The methods involve the detection of PTHR1 gene...
US20130195997 FUNGICIDAL MIXTURES  
The invention relates to a method of controlling fungi and spores and to compositions suitable for this purpose and their use. The compositions according to the invention comprise trifloxystrobin,...
US20110195934 AZOLOPYRROLONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS  
The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable faints thereof according to wherein all of the variables are defined herein.
US20120282168 METHODS OF SENSITIZING CANCER TO THERAPY-INDUCED CYTOTOXICITY  
The present application demonstrates that Salinosporamide A can be used to sensitize cancer cells to cancer therapy. Furthermore, the present application demonstrates that Salinosporamide A acts...
US20110020272 COMBINATION THERAPY FOR TREATING HEPATITIS VIRAL INFECTION  
Disclosed are methods of using proteasome inhibitors (PI) in combinations with other pharmaceutically active agents for treating viral hepatitis infections, for example, for treating...
US20120083495 COMPOUNDS FOR THE TREATMENT OF SPINAL MUSCULAR ATROPHY AND OTHER USES  
Compounds useful for the treatment of spinal muscular atrophy or other uses, as well as methods of using such compounds to increase SMN expression, increase EAAT2 expression, or increase the...
US20140178354 Salinosporamides and Methods of Use Thereof  
The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian...
US20120230972 Salinosporamides and Methods for Use Thereof  
The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian...
US20080188544 LYOPHILIZED FORMULATIONS OF SALINOSPORAMIDE A  
Lyophilized formulations comprising Salinosporamide A or analogs thereof are provided. In some aspects, lyophilized formulations comprising Salinosporamide A or analogs thereof and bulking agents...
US20110071071 PSMB10: A DIAGNOSIS MARKER AND THERAPEUTIC TARGET OF CHRONIC REJECTION  
The present invention relates to a method for diagnosing chronic graft rejection of a grafted organ in a subject from a biological sample of said subject, comprising: (a) determining in vitro an...
US20140256782 Opsin-Binding Ligands, Compositions and Methods of Use  
Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic is visual cycle products that accumulate in the eye, such as dry adult...
US20130116293 High-Throughput Methods for Determining Pharmacological Levels of Plasma D-Serine  
Described herein are high-throughput methods of monitoring D-serine levels in plasma. The assay involves the use of strong cation solid phase extraction (SPE) to isolate D-serine from plasma,...
US20090285836 USE OF SALINOSPORAMIDE A TO INHIBIT METASTASIS  
The present invention relates to methods and compositions for treating and evaluating metastatic conditions.
US20110195986 PYRROLONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS  
The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I wherein R1, R4, R5, R3, R3a, W, D,...
US20090156469 METHODS OF USING [3.2.0] HETEROCYCLIC COMPOUNDS AND ANALOGS THEREOF IN TREATING WALDENSTROM'S MACROGLOBULINEMIA  
Disclosed are methods of treating Waldenstrom's Macroglobulinemia comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound of Formula I.
US20110021543 HETEROCYCLIC COMPOUNDS AND THEIR USE AS PESTICIDES  
Novel N-aryl substituted heteroindole compounds, processes for their manufacture, veterinary compositions containing such compounds, and methods of controlling ectoparasites are provided. The...
US20110015248 SUBSTITUTED HETEROCYCLES  
The present invention relates to substituted heterocycles, processes for their preparation, and their use in medicaments, especially for the treatment of inflammatory disease, i.e. asthma, or cancer.
US20140371288 PLANT DISEASE CONTROL COMPOSITION  
To provide a plant disease control composition having excellent control effect against plant diseases. A plant disease control composition comprising an amide compound represented by formula (I):...
US20100144826 Salinosporamides and Methods for Use Thereof  
The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian...
US20120295934 New Hexahydrocyclopentapyrrolone, Hexahydropyrrolopyrrolone, Octahydropyrrolopyridinone and Octahydropyridinone Compounds  
The invention provides novel compounds having the general formula (I) wherein R1, R2, A, E, G and n are as described herein, compositions including the compounds and methods of using the...
US20120128724 SYSTEMS AND METHODS FOR TREATING HUMAN INFLAMMATORY AND PROLIFERATIVE DISEASES AND WOUNDS, WITH FATTY ACID METABOLISM INHIBITORS AND/OR GLYCOLYTIC INHIBITORS  
Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a fatty acid metabolism inhibitor, a glycolytic inhibitor, and/or an agent able to alter...
US20120264678 METHODS OF USING [3.2.0] HETEROCYCLIC COMPOUNDS AND ANALOGS THEREOF FOR TREATING INFECTIOUS DISEASES  
Disclosed are methods of treating infectious diseases comprising administering to an animal, a therapeutically effective amount of a heterocyclic compound. The animal is a mammal, preferably a...
US20150119384 ETHYNYL COMPOUNDS  
The present invention relates to ethynyl derivatives of formula I X, O, R1, R2, R3, R3′, R4, R4′, R5, R6, R6′, m, and n are as defined hereinor to a pharmaceutically acceptable acid addition salt,...
US20080058395 Fused heterocyclic inhibitors of D-amino acid oxidase  
This invention provides novel inhibitors of the enzyme D-amino acid oxidase as well as pharmaceutical compositions including the compounds of the invention. Also provided are methods for the...
US20130197011 Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament  
Substituted phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones which are glycine transporter-1 (GlyT1) inhibitors. These are useful for the treatment of schizophrenia, Alzheimer's Disease and other...
US20140275048 PRODRUGS OF FUMARATES AND THEIR USE IN TREATING VARIOUS DISEASES  
The present invention provides compounds of formula (I), and pharmaceutical compositions thereof.
US20110117015 Diagnostic Agents Selective Against Metalloproteases  
The invention relates to aryl-sulphonamido compounds endowed with affinity against metallo proteases MMP, having formula (I) below wherein R, R1, R2, R3, G and n have the meanings reported in the...
US20110009456 Compounds, Compositions and Methods for Treatment and Prevention of Orthopoxvirus Infections and Associated Diseases  
Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections...
US20090131502 Biologically active compounds  
The present invention relates to compounds of formula (I), and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions comprising compounds of...
US20150237861 INSECTICIDAL FORMULATIONS OF MICROCAPSULES  
Use of formulations consisting of suspo-emulsions comprising a microcapsule suspension, the microcapsules including at least one active ingredient selected from the pyrethroid and/or neonicotinoid...
US20120041045 USE OF PHARMACEUTICAL COMPOSITIONS CONTAINING MESEMBRENONE  
The use of mesembrenone and medicaments and dietary supplements containing mesembrenone. The applicant has surprisingly found that mesembrenone exhibits potent PDE-4 inhibition properties and, in...
US20110152210 POLYPHENOL COMPOUNDS FOR INHIBITING PROTEASOME AND USES THEREOF  
Synthetic polyphenolic compounds of formula (I), their modes of synthesis, and pharmaceutical compositions thereof are provided herein. Use of the compounds and compositions described herein for...
US20130123287 CONTROL AGENT FOR SOFT ROT AND CONTROL METHOD FOR THE SAME  
Providing a novel control agent for soft rot and a novel control method for the same. A compound having no antibacterial activity against Erwinia carotovora but having a control activity against...
US20110224274 New Therapeutic Agents  
A compound of formula (I) or a compound of formula (II) or pharmaceutically acceptable salts thereof, wherein R1-R7 and X are as defined in the description, and the use of these compounds in...
US20130317024 PYRROLOPYRROLIDINONE COMPOUNDS  
The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a...
US20140288106 CYCLOALKANE CARBOXYLIC ACID DERIVATIVES AS CXCR3 RECEPTOR ANTAGONISTS  
The present invention relates to compounds of formula 1 that are useful for the preventive or therapeutic treatment of diseases caused by abnormal activation of CXCR3 chemokines. The invention...
US20140349965 COMPOSITIONS AND METHODS FOR TREATING NEOPLASTIC DISEASES  
Disclosed herein are compositions and methods for treating neoplastic diseases. Included are compositions and methods that are effective against multiple myeloma cells resistant to conventional...
US20100179189 PYRROLINE DERIVATIVES AGAINST CELL RELEASING TUMOR NECROSIS FACTOR, PREPARATION METHODS AND USES THEREOF  
Compounds represented by Formula (I) or Formula (II) against cell releasing TNFα, their pharmaceutically acceptable salts or hydrates and preparation methods and uses thereof, in which A and B...
US20080064736 Substituted 2-Pyrrolidone Derivatives as Fungicides and Insecticides  
The use of a compound of formula (I) or a salt thereof, where the symbols have the meanings given in the description, for the control of phytopathogenic mircroorganisms of harmful animals.
US20100240581 SELECTIVE PROTEASOME INHIBITORS FOR TREATING DIABETES  
Methods of modulating chronic low-grade inflammation are provided. More particularly, methods of treating diabetes, such as for example, type-2 diabetes mellitus, in a mammal by administering an...
US20090298906 PROTEASOME INHIBITORS  
Disclosed herein are compounds of Formula (I) that include a sulfonate ester, ester or ether group. Compounds of Formula (I) can be included in pharmaceutical compositions, and can be used to...
US20130237514 PYRROLIDINONE CARBOXAMIDE DERIVATIVES  
Pyrrolidinone carboxamide compounds are provided that are useful for inhibiting the binding of ligands to the ChemR23 receptor.
US20110082172 PYRROLIDINONE CARBOXAMIDE DERIVATIVES  
Pyrrolidinone carboxamide compounds are provided that are useful for inhibiting the binding of ligands to the ChemR23 receptor.
US20100168046 METHODS OF USING [3.2.0] HETEROCYCLIC COMPOUNDS AND ANALOGS THEREOF FOR TREATING INFECTIOUS DISEASES  
Disclosed are methods of treating infectious diseases comprising administering to the animal, a therapeutically effective amount of a heterocyclic compound. The animal is a mammal, preferably a...
US20090148445 METHODS OF SENSITIZING CANCER TO THERAPY-INDUCED CYTOTOXICITY  
The present application demonstrates that Salinosporamide A can be used to sensitize cancer cells to cancer therapy. Furthermore, the present application demonstrates that Salinosporamide A acts...
US20110212969 SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF  
This invention provides compounds of formula (I): wherein ring A, X1, X2, X3, R2, R4b, R10, and G have values as described in the specification, useful as inhibitors of HDAC6. The invention also...
US20130274278 IAP INHIBITORS  
The present invention describes compounds, processes for their preparation, pharmaceutical compositions containing them, and their use in therapy.
US20120135990 IAP INHIBITORS  
The present invention describes compounds, processes for their preparation, pharmaceutical compositions containing them, and their use in therapy.
US20100227892 Compounds, Compositions and Methods for Treatment and Prevention of Orthopoxvirus Infections and Associated Diseases  
Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections...
US20140255342 THIOPHENE DERIVATIVES  
Disclosed is a compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the present application.
Matches 1 - 50 out of 58 1 2 >