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US20140051687 SUBSTITUTED INDOLE COMPOUNDS HAVING NOS INHIBITORY ACTIVITY  
The present invention features inhibitors of nitric oxide synthase (NOS), particularly those that selectively inhibit neuronal nitric oxide synthase (nNOS) in preference to other NOS isoforms. The...
US20150338393 METHODS FOR TREATING NEURAL CELL SWELLING  
A composition comprising a novel Ca2+-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different...
US20150119441 Modulators of ATP-Binding Cassette Transporters  
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including...
US20150094304 Modulators of ATP-Binding Cassette Transporters  
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including...
US20140178475 Therapeutic Nanoparticles Comprising a Therapeutic Agent and Methods of Making and Using Same  
The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects...
US20130231344 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM  
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of...
US20120237449 METHODS FOR TREATING NEURAL CELL SWELLING  
A composition comprising a novel Ca2+-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different...
US20120046330 PHARMACEUTICAL COMPOSITIONS OF (R)-1-(2,2-DIFLUOROBENZO[D] [1,3]DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO-2-(1-HYDROXY-2-METHYLPROPAN-2-YL)-1H-INDOL-5-YL) CYCLOPROPANECARBOXAMIDE AND ADMINISTRATION THEREOF  
A pharmaceutical composition comprising Compound 1, (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihyd roxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-in dol-5-yl)cyclopropaneca...
US20110251253 SOLID FORMS OF (R)-1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO-2-(1-HYDROXY-2-METHYLPROPAN-2-YL)-1H-INDOL-5-YL) CYCLOPROPANECARBOXAMIDE  
The present invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihyd roxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-in dol-5-yl)cyclopropanecarbox...
US20090312390 INHIBITORS OF GLYCOGEN SYNTHASE KINASE-3 (GSK-3) FOR TREATING GLAUCOMA  
The use of inhibitors of GSK-3 useful for treating glaucoma is disclosed.
US20050032873 3-Amino chroman and 2-amino tetralin derivatives  
3-Amino chroman and 2-amino tetralin derivatives and compositions containing such compounds are disclosed. Methods of using the 3-amino chroman and 2-amino tetralin compounds and compositions...
US20140249158 Therapeutic Nanoparticles Comprising a Therapeutic Agent and Methods of Making and Using Same  
The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects...
US20140248358 Therapeutic Nanoparticles Comprising a Therapeutic Agent and Methods of Making and Using Same  
The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid, a basic therapeutic agent having a protonatable nitrogen, and a polymer. Other aspects...
US20130231311 NOVEL FORMULATIONS FOR TREATMENT OF MIGRAINE  
Systems and methods are described for treating un-met medical needs in migraine and related conditions such as cluster headache. Included are treatments that are both rapid onset and long acting,...
US20130183297 METHOD OF TREATING CANCERS AND A PHARMACEUTICAL COMPOSITION THAT MAY BE USED IN PRACTICING SAID METHOD  
The method of treating a person having a cancer selected from carcinoma, sarcoma or hematopoietic cancer by administering (a) an effective amount of at least one anti-cancer drug selected from the...
US20130004481 ANTICANCER THERAPY  
The invention describes anti-cancer therapies comprising using dual Aurora kinase/MEK inhibitors as described herein.
US20120178764 Novel Compounds  
The present invention relates to substituted indoles useful as pharmaceutical compounds for treating respiratory disorders.
US20120115922 SMAC MIMETEC  
A SMAC mimetic and pharmaceutical compositions thereof and methods of use.
US20120009142 METHODS FOR TREATING HEPATITIS C  
In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one...
US20110263614 Novel compounds  
The present invention relates to substituted indoles useful as pharmaceutical compounds for treating respiratory disorders.
US20110097321 COMBINATION OF ANGIOPOIETIN-2 ANTAGONIST AND OF VEGF-A, KDR AND/OR FLT1 ANTAGONIST FOR TREATING CANCER  
The invention relates to agents which possess anti-angiogenic activity and are accordingly useful in methods of treatment of disease states associated with angiogenesis in the animal or human...
US20100119479 THERAPEUTIC ANTIVIRAL PEPTIDES  
Disclosed herein are compounds represented by a formula: Therapeutic methods, compositions, medicaments, and dosage forms related thereto are also disclosed.
US20090118160 HETEROCYCLIC COMPOUNDS AND METHODS OF USE  
Compounds of the formula provide pharmacological agents which are potent agonists of Peroxisome Proliferator-Activated Receptors (PPARs). Accordingly, the compounds of the instant invention are...
US20070135502 HETEROCYCLIC COMPOUNDS AND METHODS OF USE  
Compounds of the formula provide pharmacological agents which are potent agonists of Peroxisome Proliferator-Activated Receptors (PPARs). Accordingly, the compounds of the instant invention are...
US20070078121 Enzyme modulators and treatments  
Novel compounds and methods of using those compounds for the treatment of inflammatory conditions, immunological disorders, hyperproliferative diseases, cancer, and diseases characterized by...
US20050171031 Method and composition for the treatment of cancer  
We have discovered that the administration of a G1 and/or S phase drug such as β-lapachone in combination with a G2/M drug such as a taxane derivative such as paclitaxel resulted in a unexpected...
US20110294827 IAP BINDING COMPOUNDS  
IAP binding molecules and compositions including these are disclosed. The IAP binding molecules interact with IAPs (inhibitor of apoptosis proteins) in cells and may be used to modify apoptosis in...
US20100063088 Raf Kinase Inhibitors  
Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
US20090291998 EPONEMYCIN AND EPOXOMICIN ANALOGS AND USES THEREOF  
The present invention provides compounds having formula (1): wherein R1-R6, A, J, D, A, G, Q, w, x, y, and z are as described generally and in classes and subclasses herein, and additionally...
US20090047246 NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION  
The embodiments provide compounds of the general Formula I, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment...
US20080175789 Modified PSMA ligands and uses related thereto  
The instant invention provides reagents and methods for diagnosis, detection and treatment of cancers (for example, prostate cancers). In particular, the invention provides methods to generate...
US20060167037 Combinational radiotherapy and chemotherapy compositions and methods  
This invention relates to combination therapies involving radiotherapy and chemotherapy. In particular the invention relates to the use of isoflavones or analogues thereof in combination with...
US20060030615 Progesterone receptor modulators comprising pyrrole-oxindole derivatives and uses thereof  
Pyrrole-oxindole derivatives useful as progesterone receptor antagonists are provided. Pharmaceutical compositions containing these derivatives are described, as is the use thereof in...
US20050203108 Glucagon antagonists/inverse agonists  
A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be...
US20050009898 New substituted indolinones, their manufacture and their use as medicaments  
The present invention relates to substituted indolinones of general formula wherein R1 to R6 and X are defined as in claim 1, the isomers and the salts thereof, in particular the physiologically...
US20120022057 BICYCLIC COMPOUNDS AS INHIBITORS OF DIACYGLYCEROL ACYLTRANSFERASE  
The present invention relates to novel heterocyclic compounds as diacylglycerol acyltransferase (“DGAT”) inhibitors, pharmaceutical compositions comprising the heterocyclic compounds and the use...
US20100029665 Methods and Compositions for Treating Migraine Pain  
The present invention provides novel methods and compositions for the treatment and prevention of headaches, vascular headaches, migraine headaches, cluster headaches, and migraine. One of the...
US20080311077 Antiviral Compounds  
The invention is related to phosphorus substituted anti-viral inhibitory compounds, compositions containing such compounds, and therapeutic methods that include the administration of such...
US20080114050 Progesterone receptor modulators comprising pyrrole-oxindole derivatives and uses thereof  
Pyrrole-oxindole derivatives useful as progesterone receptor antagonists, and methods for preparing the same, are provided. Pharmaceutical compositions containing these derivatives are described,...
US20070010570 Medical Compositions for Intravesical Treatment of Bladder Cancer  
Anti-cancer coating compositions comprising 3-hydroxymethyl-5-aziridinyl-1-1-methyl-2-[1H-indole-4,7-dio ne]propenol (E09) are disclosed. More specifically, the coating compositions comprise EO9...
US20050234030 Modulators of CRTH2, COX-2 and FAAH  
Certain substituted indoles that are modulators of one or more or of CRTH2, COX-2 AND FAAH are described. The compounds are useful for treatment of pain and/or inflammation as well as other disorders.
US20050154046 Methods of treating an inflammatory-related disease  
The invention relates to pharmaceutical compositions and methods of treating inflammatory-related diseases associated with pro-inflammatory cytokine expression and/or reduced expression of...
US20150010619 METHODS AND SYSTEMS FOR TREATMENT OF MIGRAINES AND OTHER INDICATIONS  
The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment....
US20110086877 Small Molecule Inhibitors of Botulinum Neurotoxins  
Disclosed herein are methods of inhibiting the activity of Botulinum neurotoxin A metalloprotease with the compounds disclosed herein. Also disclosed are methods of treating, inhibiting or...
US20070203079 Methods of using small molecule compounds for neuroprotection  
Methods are provided for preventing neurodegeneration and neuronal loss by administering compositions comprising small molecule compounds with the effect of preventing neurodegeneration and...
US20050215615 Medical compositions for intravesical treatment of bladder cancer  
Anti-cancer coating compositions comprising 3-hydroxymethyl-5-aziridinyl-1-1-methyl-2-[1 H-indole-4,7-dione]propenol (E09) are disclosed. More specifically, the coating compositions comprise EO9...
US20150259288 5-BROMO-INDIRUBINS  
Disclosed herein are compositions and methods for treating cancer, FLT3-AML, and CML.
US20150246025 2-PHENYL-5-HETEROCYCLYL-TETRAHYDRO-2H-PYRAN-3-AMINE COMPOUNDS FOR USE IN THE TREATMENT OF DIABETES AND ITS ASSOCIATED DISORDERS  
The present invention relates to novel compounds of the general formula (I) their tautomeric forms, their enantiomers, their diastereoisomers, their pharmaceutically accepted salts, or pro-drugs...
US20140165223 TNF SUPERFAMILY TRIMERIZATION INHIBITORS  
Described are methods and compositions for inhibiting the trimerization of ligands belonging to the TNF superfamily, in particular, inhibiting RANKL trimerization. Accordingly, the methods and...
US20140140931 ANTIOXIDANT, NEUROPROTECTIVE AND ANTINEOPLASTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT ON AN AMPHIPHILIC SPACER OR AN AMPHIPHILIC POLYMER  
This invention relates to antioxidant, neuroprotective and antineoplastic nanoparticles comprising a therapeutic agent on an amphiphilic spacer or an amphiphilic polymer. Methods of synthesizing...