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US20130150422 COMPOSITIONS AND METHODS FOR TREATMENT OF CYSTIC FIBROSIS AND DISEASES ASSOCIATED WITH ABERRANT PROTEIN CELLULAR PROCESSING  
The disclosure relates to resorcylic acid lactones and indolinone-containing compounds for use in treatment of diseases associated with aberrant protein processing, such as cystic fibrosis (CF;...
US20120184560 MOLECULAR DIAGNOSTIC METHODS FOR PREDICTING BRAIN METASTASIS OF BREAST CANCER  
Disclosed are molecular diagnostic compositions and methods for predicting brain metastasis of breast cancer, as well as methods for drug repositioning to identify existing and new therapeutics...
US20110263601 METHODS OF TREATING ULCERATIVE COLITIS  
Methods are disclosed for treating ulcerative colitis and related diseases and disorders, which comprise inhibiting tryptophan hydroxylase (TPH) in patients in need thereof.
US20140336234 CHLOROPHYLL c CONTAINING DEGRANULATION SUPPRESSOR  
Degranulation suppressors are provided that are effective against allergic disease and osteoarthritis. The degranulation suppressors contain chlorophyll c.
US20110237563 FAST DISSOLVING DRUG DELIVERY SYSTEMS  
The present invention related to the administration of bioactive agents via oral fast dispersing/dissolving drug delivery systems for treating illnesses of patient with critical buccal condition,...
US20130231311 NOVEL FORMULATIONS FOR TREATMENT OF MIGRAINE  
Systems and methods are described for treating un-met medical needs in migraine and related conditions such as cluster headache. Included are treatments that are both rapid onset and long acting,...
US20110118189 NOVEL FORMULATIONS FOR TREATMENT OF MIGRAINE  
Systems and methods are described for treating un-met medical needs in migraine and related conditions such as cluster headache. Included are treatments that are both rapid onset and long acting,...
US20130131028 METHODS FOR TREATMENT OF SLEEP-RELATED BREATHING DISORDERS  
Described herein are methods for modulation of the activity of the carotid body that afford therapeutic benefit for sleep-related breathing disorders and related conditions.
US20120321615 Assay for Metastatic Colorectal Cancer  
Disclosed herein is a method for predicting the prognosis, the likelihood of metastasis in, or the desirability of administering an aggressive therapy to, a subject with colorectal cancer,...
US20120076770 Modulation of autophagy and and serotonin for treatment of multiple myeloma related diseases  
THE INVENTION RELATES TO compounds, proteins and methods of treatment therewith. Aspects of embodiments of the invention further relates to compounds and methods of treatment for bone, bone...
US20150080349 MODULATION OF BACTERIAL QUORUM SENSING WITH SYNTHETIC LIGANDS  
The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for...
US20140050694 Method of Treating Transplant Rejection and Autoimmune Diseases  
A method of treating autoimmune diseases and transplant rejection, comprising the step of treating the autoimmune or transplant patient with an effective amount of SU-5416 is disclosed.
US20130018040 Compositions And Methods For Treating Toxoplasmosis, Cryptosporidiosis, And Other Apicomplexan Protozoan Related Diseases  
Compositions and methods for the treatment of toxoplasmosis, caused by the infectious eukaryotic parasite Toxoplasma gondii (T. gondii) and for the treatment of cryptosporidiosis, caused by the...
US20110059074 Knowledge-Based Proliferation Signatures and Methods of Use  
The present invention provides methods and compositions for predicting patient responses to cancer treatment using a proliferation gene signature. These methods can comprise measuring in a...
US20130303518 Methods of Inhibiting the Catalytic Activity of a Protein Kinase and of Treating a Protein Kinase Related Disorder  
The invention provides a method of inhibiting the catalytic activity of a protein kinase comprising contacting said protein kinase with a compound of formula (I), or a pharmaceutically acceptable...
US20120121540 Certain Nitrogen Containing Bicyclic Chemical Entities For Treating Viral Infections  
Provided are certain chemical entities, pharmaceutical compositions, and methods of treatment of a member of the flaviviradae family of viruses such as hepacivirus (Hepatitis C or HCV).
US20110152172 Methods of Treating Pulmonary Diseases and Disorders by Modulating Calcium/Calmodulin Dependent Protein Kinase II Activity  
Disclosed are methods of treating or preventing a pulmonary disease or disorder in a subject, the methods comprising administering an effective amount of an compound that inhibits Calmodulin...
US20130263297 METHODS OF TREATING CANCER  
The present invention relates to metastases. More specifically, the invention relates to compositions and methods for the inhibition of metastases of cancer cells, such as prostate cancer cells,...
US20140094499 FORMULATIONS OF (R)-1-(2,2-DIFLUOROBENZO[D] [1,3] DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO-2-(1-HYDROXY-2-METHYLPROPAN-2-YL)-1H-INDOL-5-YL)CYCLOPROPANECARBOXAMIDE  
The present invention relates to formulations of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihyd roxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-in dol-5-yl)cyclopropanecarbo...
US20120015999 FORMULATIONS OF (R)-1-(2,2-DIFLUOROBENZO[D] [1,3] DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO-2-(1-HYDROXY-2-METHYLPROPAN-2-YL)-1H-INDOL-5-YL)CYCLOPROPANECARBOXAMIDE  
The present invention relates to formulations of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihyd roxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-in dol-5-yl)cyclopropanecarbo...
US20120009142 METHODS FOR TREATING HEPATITIS C  
In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one...
US20110082098 NOVOBIOCIN ANALOGUES AND TREATMENT OF POLYCYSTIC KIDNEY DISEASE  
Novobiocin analogues are useful in methods of treating, inhibiting, and/or preventing cyst formation in autosomal dominant polycystic kidney disease (ADPKD) in a subject. The disclosure provides...
US20150057267 Methods and Compositions for Treating Viral Diseases  
The invention provides a method for treating viral infections and coinfections through the use of inhibitory agents that prevent a unique viral structural protein motifs from binding to host...
US20120230958 ONCOLYTIC VACCINIA VIRUS COMBINATION CANCER THERAPY  
Embodiments of the invention are directed methods that include a thymidine kinase deficient vaccinia virus. The methods include evaluating a tumor for reperfusion after treatment with vaccinia...
US20110124700 SYSTEMS AND METHODS OF CANCER STAGING AND TREATMENT  
Methods of assessing the sensitivity of a cancer cell to a tyrosine kinase inhibitor are disclosed. Such methods include assessing the expression of miR-497 and correlating reduced expression with...
US20110262354 CYANINE-CONTAINING COMPOUNDS FOR CANCER IMAGING AND TREATMENT  
This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer...
US20120222142 GUT FLORA-DERIVED EXTRACELLULAR VESICLES, AND METHOD FOR SEARCHING FOR A DISEASE MODEL, VACCINE, AND CANDIDATE DRUG AND FOR DIAGNOSIS USING THE SAME  
The present application relates to a composition including gut flora-derived extracellular vesicles, and to an animal disease model using same. In addition, the present application relates to a...
US20130052205 FLT3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OR THE PREVENTION OF PAIN DISORDERS  
The present invention relates to FLT3 receptor antagonists or inhibitors of FLT3 receptor gene expression for the treatment or the prevention of pain disorders.
US20150259288 5-BROMO-INDIRUBINS  
Disclosed herein are compositions and methods for treating cancer, FLT3-AML, and CML.
US20140037622 HUMAN PAPILLOMA VIRUS AS PREDICTOR OF CANCER PROGNOSIS  
Methods of treating a head and neck cancer are disclosed.
US20140296292 METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR  
Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments...
US20120046242 MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY  
The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant...
US20110200597 SIGNAL PATHWAY ALTERATIONS AND DRUG TARGET ELEVATIONS IN PRIMARY METACHRONOUS METASTATIC COLORECTAL CANCER COMPARED TO NON-METASTATIC DISEASE  
The present invention relates to the identification and diagnostic use of biomarkers in primary colorectal cancer tumors whose activation level are predictive of the likelihood of the onset of...
US20150125389 HALOGENATED COMPOUNDS FOR CANCER IMAGING AND TREATMENT AND METHODS FOR THEIR USE  
Compounds having a structure of Formula I: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R4, R5, X1, X2, X3 and X4 are as defined herein, and wherein...
US20150079111 MECHANISM, DIAGNOSTIC, AND TREATMENTS FOR COMPLICATIONS OF RENAL FAILURE  
Mechanisms for complications of renal failure and processes for treating the same are disclosed. They include contacting a biological fluid (e.g. blood) with a filter body, the filter body having...
US20110158983 COMPOSITIONS AND METHODS FOR MUCOSITIS AND ONCOLOGY THERAPIES  
In alternative embodiments, this invention provides compositions and methods for treating cancer or any condition caused by dysfunctional cells, side effects from treatments for cancer or any...
US20140005181 SMALL MOLECULE ANTAGONISTS OF THE APELIN RECEPTOR FOR THE TREATMENT OF DISEASE  
The present disclosure relates to compounds and methods for treating a disease mediated by apelin.
US20120039888 Methods Of Inhibiting Inflammation-Associated Tissue Damage By Inhibiting Neutrophil Activity  
The present invention relates to compositions and methods for treating inflammation-associated tissue damage, and particularly transfusion-associated, disorders, by inhibiting or reducing...
US20150231209 STIMULATION OF OVARIAN FOLLICLE DEVELOPMENT AND OOCYTE MATURATION  
Methods are provided for stimulating ovarian follicles in a mammal through disruption of the Hippo signaling pathway.
US20120040896 COMPOSITIONS, METHODS AND USES FOR MODULATION OF BRCA 1  
Embodiments of the present invention generally relate to methods, compositions and uses for diagnosis and treatment of cancer. Certain embodiments report methods and compositions for diagnosing...
US20140309263 BIOMARKERS OF THERAPEUTIC RESPONSIVENESS  
The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a...
US20140200226 ANTI-MALARIAL COMPOUNDS FROM MARINE NATURAL PRODUCTS  
Novel compositions and methods for the treatment and prevention of malaria are disclosed herein.
US20130108605 METHOD OF AMELIORATING OXIDATIVE STRESS AND SUPPLEMENTING THE DIET  
A method of supplementing a diet and ameliorating oxidative stress in a mammal includes administering a pharmaceutically effective amount of lipid soluble, hydrophobic active compounds having a...
US20100144821 COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS  
The invention is directed to compounds and methods for treating protein folder disorders. In certain embodiments the invention provides compounds and methods for treating neurodegenerative...
US20140288143 BLADDER CANCER TREATMENT AND METHODS  
Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, bladder cancer treatments include the intravesical...
US20110288472 BLADDER CANCER TREATMENT AND METHODS  
Therapeutic compositions comprising an indoloquinone compound and various bladder cancer treatments and methods are disclosed. More specifically, bladder cancer treatments include the intravesical...
US20120058121 METHODS AND COMPOSITIONS FOR TREATING LUPUS  
The invention relates to compositions and methods for treating lupus. The methods typically comprise the step of administrating one or more compounds selected from isoindigo, indigo, indirubin, or...
US20140155369 PREVENTIVES/REMEDIES FOR STRESS URINARY INCONTINENCE AND METHOD OF SCREENING THE SAME  
An agent for the prophylaxis or treatment of stress urinary incontinence, which contains a substance that activates a serotonin 5-HT2C receptor, an agent for the prophylaxis or treatment of stress...
US20130039979 MEDICATION ON THE BASIS OF 3,3'-DIINDOLYLMETHANE (DIM) WITH HIGH-BIOAVAILABILITY AND ITS USE IN TREATMENT OF HUMAN HYPERPLASTIC AND INFLAMMATORY DISEASES  
The invention relates to medicine and chemico-pharmaceutical industry. A medication for treating human hyperplastic and inflammatory diseases containing 3,3′-diindolylmethane as an active agent...
US20120121536 COMPOSITIONS AND METHODS FOR GLUCOSE TRANSPORT INHIBITION  
Glucose deprivation is an attractive strategy in cancer research and treatment. Cancer cells upregulate glucose uptake and metabolism for maintaining accelerated growth and proliferation rates....