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US20080008682 Modulators of toll-like receptor 7  
The present application provides for a compound of Formula I or II: or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic...
US20070037865 Sirtuin modulating compounds  
Provided herein are novel sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or...
US20150335750 Liquid Formulations of Bendamustine  
Stable liquid formulations of bendamustine, and pharmaceutically acceptable salts thereof, and polar aprotic solvents, are described.
US20150094304 Modulators of ATP-Binding Cassette Transporters  
Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including...
US20140275196 FORMULATIONS OF BENDAMUSTINE  
Methods of treatment using bendamustine formulations designed for small volume intravenous administration are disclosed. The methods conveniently allow shorter administration time without the...
US20140128443 Liquid Formulations Of Bendamustine  
Stable liquid formulations of bendamustine, and pharmaceutically acceptable salts thereof, and polar aprotic solvents, are described.
US20140094496 FORMULATIONS OF BENDAMUSTINE  
Methods of treatment using bendamustine formulations designed for small volume intravenous administration are disclosed. The methods conveniently allow shorter administration time without the...
US20130309196 ANTIVIRAL COMPOUNDS  
The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and...
US20130231344 COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM  
Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of...
US20130041004 Liquid Formulations Of Bendamustine  
Stable liquid formulations of bendamustine, and pharmaceutically acceptable salts thereof, and polar aprotic solvents, are described.
US20120094913 NOVEL PPAR LIGANDS THAT DO NOT CAUSE FLUID RETENTION, EDEMA OR CONGESTIVE HEART FAILURE  
Methods are provided for treating or prophylactically preventing metabolic disorders in humans without causing, promoting, or aggravating fluid retention, peripheral edema, pulmonary edema, or...
US20110190363 LIQUID FORMULATIONS OF BENDAMUSTINE  
Stable liquid formulations of bendamustine, and pharmaceutically acceptable salts thereof, and polar aprotic solvents, are described.
US20100256119 Azole derivatives and fused bicyclic azole derivatives as therapeutic agents  
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, and their use in treating human or animal disorders. The compounds of...
US20100172974 MELT-EXTRUDED ORALLY ADMINISTRABLE OPIOID FORMULATIONS  
Bioavailable sustained release oral opioid analgesic dosage forms, comprising a plurality of multiparticulates produced via melt extrusion techniques are disclosed.
US20100135900 CD37 IMMUNOTHERAPEUTIC COMBINATION THERAPIES AND USES THEREOF  
The present disclosure provides methods for using CD37-specific binding molecules (such as a CD37-specific SMIP or antibody) in combination with mTOR inhibitors (such as rapamycin and derivatives...
US20090264488 NOVEL SOLID FORMS OF BENDAMUSTINE HYDROCHLORIDE  
Novel solid forms of bendamustine hydrochloride are described, as well as methods of their preparation and use.
US20080242712 Identification and uses of novel PPAR ligands that do not cause fluid retention, edema or congestive heart failure  
Methods are provided for treating or prophylactically preventing metabolic disorders in humans without causing, promoting, or aggravating fluid retention, peripheral edema, pulmonary edema, or...
US20080064690 PYRAZOLE-AMIDES AND -SULFONAMIDES  
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-dependent sodium channels. More...
US20080009536 Novel PPAR ligands that do not cause fluid retention, edema or congestive heart failure  
Methods are provided for treating or prophylactically preventing metabolic disorders in humans without causing, promoting, or aggravating fluid retention, peripheral edema, pulmonary edema, or...
US20070202133 BENZIMIDAZOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION  
The present invention is directed to small molecule inhibitors of the IgE response to allergens, which are useful in the treatment of allergy and/or asthma or any diseases where IgE is pathogenic....
US20070032497 Fused-ring compounds and use thereof as drugs  
The present invention provides a fused ring compound of the following formula [I] wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof, and a...
US20060258735 1,3-Bis-(substituted-phenyl)-2-propen-1-ones and their use to treat VCAM-1 mediated disorders  
It has been discovered certain 1,3-bis-(substituted-phenyl)-2-propen-1-ones, including compounds of formula (I) inhibit the expression of VCAM-1, and thus can be used to treat a patient with a...
US20060128777 Cancer treatments  
Methods and compositions for treating cancers characterized by death-resistant cancer cells are described. In general, such methods involve administration of a therapeutically effective amount of...
US20060110450 Bilayer tablet of telmisartan and amlodipine  
A bilayer tablet comprises a first layer formulated for instant release of the angiotensin II receptor antagonist telmisartan from a dissolving tablet matrix and a second layer formulated for...
US20150374671 BENDAMUSTINE PHARMACEUTICAL COMPOSITIONS  
The present invention provides pharmaceutical formulations of lyophilized bendamustine suitable for pharmaceutical use. The present invention further provides methods of producing lyophilized...
US20150353538 COMPOUNDS AND THERAPEUTIC USES THEREOF  
The invention relates to compounds, pharmaceutical compositions and methods useful for treating cancer, systemic or chronic inflammation, rheumatoid arthritis, diabetes, obesity, T-cell mediated...
US20150051258 Novel Solid Forms Of Bendamustine Hydrochloride  
Novel solid forms of bendamustine hydrochloride are described, as well as methods of their preparation and use.
US20140336194 METHOD OF TREATING CONTRAST-INDUCED NEPHROPATHY  
The present invention provides the use of a neutral endopeptidase inhibitor, in the manufacture of a medicament for the treatment, amelioration and/or prevention of contrast-induced nephropathy....
US20140206733 Liquid Formulations Of Bendamustine  
Stable liquid formulations of bendamustine, and pharmaceutically acceptable salts thereof, and polar aprotic solvents, are described.
US20140148490 BENDAMUSTINE PHARMACEUTICAL COMPOSITIONS  
The present invention provides pharmaceutical formulations of lyophilized bendamustine suitable for pharmaceutical use. The present invention further provides methods of producing lyophilized...
US20140080881 Liquid Formulations of Bendamustine  
Stable liquid formulations of bendamustine, and pharmaceutically acceptable salts thereof, and polar aprotic solvents, are described.
US20130309307 Bilayer Pharmaceutical Tablet Comprising Telmisartan and a Diuretic and Preparation Thereof  
The present invention relates to a bilayer pharmaceutical tablet comprising a first layer formulated for immediate release of the angiotensin II receptor antagonist telmisartan from a dissolving...
US20120157505 ORAL FORMULATIONS OF BENDAMUSTINE  
The present invention is directed to oral formulations of bendamustine, and its pharmaceutically acceptable salts, methods of use thereof, and methods of treatment comprising them.
US20120122892 CHEMICAL COMPOUNDS  
This invention relates to novel compounds having the formula (I): and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment for cancer.
US20120015050 METHODS AND MATERIALS FOR ASSESSING LOSS OF HETEROZYGOSITY  
This document provides methods and materials involved in assessing samples (e.g., cancer cells) for the presence of a loss of heterozygosity (LOH) signature. For example, methods and materials for...
US20110263619 PHARMACEUTICAL FORMULATIONS AND USE THEREOF IN THE PREVENTION OF STROKE, DIABETES AND/OR CONGESTIVE HEART FAILURE  
The present invention relates to use of an inhibitor of the renin-angiotensin system (RAS) or a pharmaceutically acceptable derivative thereof, such as ramipril or ramiprilat, in the prevention of...
US20110105573 BENZIMIDAZOLE ACETIC ACIDS EXHIBITING CRTH2 RECEPTOR ANTAGONISM AND USES THEREOF  
The invention relates to benzimidazole acetic acid compounds which function as antagonists of the Chemoattractant Receptor-homologous molecule expressed on T-Helper type 2 cells (CRTH2) receptor....
US20110034441 INDAZOLES AS WNT/B-CATENIN SIGNALING PATHWAY INHIBITORS AND THERAPEUTIC USES THEREOF  
Described herein are methods of treating a disorder or disease in which aberrant Wnt signaling is implicated, with a variety of compounds, including Wnt inhibitor compounds. More particularly, it...
US20090325949 5 HT RECEPTOR MEDIATED NEUROGENESIS  
The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes...
US20080269298 Benzimidazol-1-YL-thiophene compounds for the treatment of cancer  
The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
US20080044482 ORALLY ADMINISTRABLE OPIOID FORMULATIONS HAVING EXTENDED DURATION OF EFFECT  
Sustained release oral solid dosage forms of opioid analgesics are provided as multiparticulate systems which are bioavailable and which provide effective blood levels of the opioid analgesic for...
US20070078121 Enzyme modulators and treatments  
Novel compounds and methods of using those compounds for the treatment of inflammatory conditions, immunological disorders, hyperproliferative diseases, cancer, and diseases characterized by...
US20060247290 DERIVATIVES OF DIOXAN-2-ALKYL CARBAMATES, PREPARATION THEREOF AND APPLICATION THEREOF IN THERAPEUTICS  
A compound corresponding to general formula (I): in which R1 represents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C1-C3)...
US20050192328 Compounds and methods for use thereof in the treatment of viral infections  
Benzimidazole derivatives and salts and prodrugs thereof are disclosed, together with methods for the treatment of cancers or viral infections in warm blooded animals by administration of these...
US20050137242 Betamimetics having a long-lasting activity, processes for preparing them, and their use as medicaments  
A compound of formula 1 wherein: R1 is a group wherein R3 is a benzyl group optionally substituted by a methoxy group; R4 is a hydrogen atom, or R3 and R4 together are a —CO—CH2—O— bridge, the...
US20160083395 ANTIVIRAL COMPOUNDS  
The disclosure is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and...
US20160031858 DICARBOXYLIC ACID BISAMIDE DERIVATIVES, USE THEREOF, PHARMACEUTICAL COMPOSITION BASED THEREON AND METHODS FOR PRODUCING DICARBOXYLIC ACID BISAMIDE DERIVATIVES  
The present invention relates to novel biologically active compounds, in particular dicarboxylic acid bisamide derivatives of general formula I: or pharmaceutically acceptable salts thereof, which...
US20150335588 Oral Dosage Forms of Bendamustine  
In the present invention there is provided an oral pharmaceutical composition, comprising bendamustine or a pharmaceutically acceptable, ester, salt or solvate thereof as an active ingredient, and...
US20150196537 Self-Emulsifying Pharmaceutical Compositions of Hydrophilic Drugs and Preparation Thereof  
The present invention provides an oral self micro-emulsifying pharmaceutical composition of a hydrophilic drug or a pharmaceutically acceptable salt thereof which, in addition to the hydrophilic...
US20150044169 METHODS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION, COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION, AND SCREENING ASSAYS FOR IDENTIFYING COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION  
Briefly described, embodiments of this disclosure include compositions, pharmaceutical compositions, methods of treating a host infected with a virus from the Flaviviridae family of viruses,...