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US20110195920 BIODEFENSES USING TRIAZOLE-CONTAINING MACROLIDES  
Use of macrolide and ketolide antibiotics for the treatment of acute exposure and diseases caused by biodefense pathogens is described.
US20110009351 SCREENING ASSAY TO IDENTIFY CORRECTORS OF PROTEIN TRAFFICKING DEFECTS  
The present invention relates to a novel assay or screen for identifying compounds with potential therapeutic value for the treatment of protein trafficking diseases such as Cystic Fibrosis (CF)...
US20120065237 METHODS FOR TREATING TRANSTHYRETIN AMYLOID DISEASES  
Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin...
US20110207737 SUBSTITUTED BICYCLIC AMINES FOR THE TREATMENT OF DIABETES  
Described herein are substituted bicyclic amines. In particular, described herein are substituted bicyclic amines that are effective as antagonists of SSTR5 and useful for the treatment, control...
US20120122849 PKM2 MODULATORS FOR USE IN THE TREATMENT OF CANCER  
Compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are pharmaceutical compositions comprising the compounds, and methods of using the compounds in the...
US20150148308 PEST CONTROL COMPOSITION FOR HARMFUL ARTHROPODS, AND PEST CONTROL METHOD FOR HARMFUL ARTHROPODS  
A harmful arthropod control composition comprising a compound represented by the following Formula (1) wherein each symbol represents definitions described in the specification, and one or more...
US20150157607 Compounds that Enhance Atoh1 Expression  
This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a...
US20060069096 Pyrazolo[3,4-e]benzoxazoles for the treatment of glaucoma  
Pyrazolo[3,4-e]benzoxazoles and analogues thereof for lowering intraocular pressure and treating glaucoma are disclosed.
US20110065762 METHODS OF USE OF ANTIVIRAL COMPOUNDS  
The present invention relates, in part, to methods of treatment, prevention, and inhibition of viral disorders. In one aspect, the present invention relates to inhibition of the M2 proton channel...
US20150018388 Treatment of Amyotrophic Lateral Sclerosis  
The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative...
US20150209333 COMPOSITIONS AND METHODS OF TREATING RETINAL DISEASE  
Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin, and, more specifically, for...
US20130102629 ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS  
Compounds represented by formula (I) or pharmaceutically acceptable salts thereof, wherein A, B, B′, X, Y, R1, R2, R2′, R3, R3′, R4, R4′, R5, R5′, m, n, or p are as defined herein, are useful for...
US20130085150 ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS  
Compounds represented by formula I or pharmaceutically acceptable salts thereof, wherein A, B, B′, X, Y, R1, R2, R2′, R3, R3′, R4, R4′, R5, R5′m, n, or p are as defined herein, are useful for...
US20130157997 BENZIMIDAZOLE ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS  
Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein A, B, B′, X, Y, R1, R1′, R2, R2′, R3, R3′, R5, R5′, R6, m, n, or p are as defined herein, are...
US20110195932 Drug Combinations for the Treatment of Duchenne Muscular Dystrophy  
Combinations comprising (or consisting essentially of) one or more compounds of formula (1) with one or more ancillary agents, to processes for preparing the combinations, and to various...
US20140135305 METHODS FOR TREATING SPINAL MUSCULAR ATROPHY  
The present invention provides nucleic acid constructs, methods for identifying and validating compounds that increase the inclusion of exon 7 of SMN2 into mRNA transcribed from the SMN2 gene,...
US20110086833 METHODS FOR TREATING SPINAL MUSCULAR ATROPHY  
The present invention provides nucleic acid constructs, methods for identifying and validating compounds that increase the inclusion of exon 7 of SMN2 into mRNA transcribed from the SMN2 gene,...
US20140080775 MOLECULAR MODULATORS OF THE WNT/BETA-CATENIN PATHWAY  
The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant...
US20110251144 MOLECULAR MODULATORS OF THE WNT/BETA-CATENIN PATHWAY  
The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant...
US20150057320 TRANSTHYRETIN LIGANDS CAPABLE OF INHIBITING RETINOL-DEPENDENT RBP4-TTR INTERACTION FOR TREATMENT OF AGE-RELATED MACULAR DEGENERATION, STARGARDT DISEASE, AND OTHER RETINAL DISEASE CHARACTERIZED BY EXCESSIVE LIPOFUSCIN ACCUMULATION  
A method for treating a disease characterized by excessive lipofuscin accumulation in the retina of a mammal afflicted therewith comprising administering to the mammal an effective amount of a...
US20140100230 METHODS AND COMPOSITIONS FOR TREATING ANXIETY  
Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
US20110319417 METHODS AND COMPOSITIONS FOR TREATING ANXIETY  
Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
US20090275624 INHIBITORS OF CDC PHOSPHATASES  
A subject of the present invention is novel compounds comprising 2 or 3 benzothiazole-4,7-dione- or benzooxazole-4,7-dione-type units, which inhibit the cdc25 phosphatases, in particular cdc25-C...
US20140113012 COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS  
The present invention provides compounds and compositions for the amelioration of arthritis and joint injuries by inducing mesenchymal stem cells into chondrocytes.
US20130150321 Acetaminophen/Ibuprofen Combinations And Method For Their Use  
A pharmaceutical dosage form is provided comprising a non-steroidal anti-inflammatory agent and acetaminophen, and methods for their use. In one embodiment, the dosage form is comprised of...
US20110160223 NMDA Receptor Antagonists for the Treatment of Neuropsychiatric Disorders  
Provided are pharmaceutical compositions and methods of treatment or prophylaxis of certain neuropsychiatric conditions, in particular mood disorders. The compounds are of the general Formula I-V...
US20110081428 Use of thioflavin-like compounds to increase life span and/or health span  
The present invention provides a method of using thioflavin and functionally similar compounds to increase life span and/or health span.
US20110092517 Use of PPAR Delta Ligands for the Treatment or Prevention of Inflammation or Energy Metabolism/Production Related Diseases  
Provided herein are methods for treatment, prevention, or amelioration of one or more symptoms of a disease or condition related to disorders of insulin and/or glucose metabolism, inflammatory...
US20150238467 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY  
This invention relates to pharmaceutical compositions comprising 5-(ethylsulfonyl)-2-(naphthalen-2-yl)benzo[d]oxazole (C1100), to processes for preparing the compositions, and to various...
US20110144043 Stat modulators  
The present invention is directed to methods, kits and compositions for modulating the activity of Stat molecules (e.g., Stat1, Stat3 and Stat5). The compounds of the invention are useful for...
US20110301156 Vanilloid Receptor Ligands, Pharmaceutical Compositions Containing Them, Process For Making Them, and Use Thereof to Treat Pain and Other Conditions  
Vanilloid receptor ligand compounds corresponding to formula I: pharmaceutical compositions containing such compounds, a process for producing such compounds, and methods of using such compounds...
US20120115912 RXR AGONIST COMPOUNDS AND METHODS  
A method of treating a PPARγ and/or RXR related disease or disorder in a subject includes adminstering to the subject an RXR agonist alone or in combination with a PPARγ agonist.
US20120040974 MIF MODULATORS  
The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of MIF expression and treat disorders associated with high or low...
US20150018398 METHODS OF USING ESTROGEN RECEPTOR-BETA LIGANDS AS RADIATION MITIGATORS  
Disclosed herein are methods useful for treating radiation damage in a subject.
US20130303525 KAPPA OPIOID RECEPTOR AGONISTS  
The present invention relates to a series of substituted compounds having the general formula (I), including their stereoisomers and/or their pharmaceutically acceptable salts. (I) Wherein A, m,...
US20120245186 COMBINATION CANCER THERAPY WITH HSP90 INHIBITORY COMPOUNDS  
Disclosed is a method for treating a subject with cancer, comprising administering to the subject an effective amount of paclitaxel or a paclitaxel analogue and an effective amount of a compound...
US20120302601 COMPOSITIONS AND METHODS FOR THE TREATMENT OF MACULAR DEGENERATION  
The present invention is directed to topical ophthalmic compositions of a lipophilic compound and an oligomeric or polymeric carrier wherein the compositions are useful in the treatment and...
US20140113891 Compounds that inhibit human DNA ligases and methods of treating cancer  
Methods for treating cancer using compounds that inhibit human DNA ligases. Methods for using compounds that inhibit human DNA ligases to provide insights into the reaction mechanisms of human DNA...
US20140142117 REVERSE AMIDE COMPOUNDS AS PROTEIN DEACETYLASE INHIBITORS AND METHODS OF USE THEREOF  
The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various...
US20060135574 Novel uses for estrogen beta agonists  
This invention provides methods for treating cognitive diseases or disorders and symptoms thereof with estrogen beta selective agonists.
US20140322278 Modulation of Tissue Transglutaminase Activation in Disease  
Compositions and methods are provided for modulating the physiological activation of tissue transglutaminase (TG2); which methods can include inhibiting the activation of TG2 associated with...
US20120122870 Treatment Of Ischemia-Reperfusion Injury  
Ischemia-reperfusion injury remains a primary cause of morbidity and mortality in individuals who experience disruption of normal blood flow to one or more major organs. For example, there are no...
US20130338092 COMPOUNDS AND METHODS FOR TARGETING LEUKEMIC STEM CELLS  
This invention relates to high-throughput, semi-automated methods for identifying compounds that are effective in targeting leukemia stem cells, as well as compounds identified by those methods...
US20100305120 COMPOUNDS FOR TREATING MUSCULAR DYSTROPHY  
Compounds of formula (I): wherein X, L1, R1, L2, R2, R3, and R4 are as defined herein, are useful in the treatment or prophylaxis of Duchenne muscular dystrophy, Becker muscular dystrophy, or...
US20110086817 ANTI-BACTERIAL AGENTS FROM BENZO[D]HETEROCYCLIC SCAFFOLDS FOR PREVENTION AND TREATMENT OF MULTIDRUG RESISTANT BACTERIA  
Embodiments herein provide compounds and methods of making and using such compounds for prevention and treatment of multidrug resistant bacteria. In particular, embodiments are directed to...
US20110251207 BIARYL-SPIROAMINOOXAZOLINE ANALOGUES AS ALPHA 2C ADRENERGIC RECEPTOR MODULATORS  
In its many embodiments, the present invention provides a novel class of biaryi spiroaminooxazoline analogues as modulators of α2C adrenergic receptor agonists, methods of preparing such...
US20080182872 USE OF ER-BETA SELECTIVE LIGANDS FOR TREATING ACUTE LUNG INJURIES  
The present invention provides a method of treating acute lung injuries, such as acute lung injury induced by peritonitis during sepsis, acute lung injury induced by intravenous bacteremia during...
US20120263675 BIVALENT DIAZO BICYCLIC SMAC  
The invention relates to diazo bicyclic Smac mimetics that are tethered through a covalent linker to give a bivalent species. Bivalent diazo bicyclic Smac mimetics function as inhibitors of...
US20130345222 IDENTIFICATION OF HUMAN T2R RECEPTORS THAT RESPOND TO BITTER COMPOUNDS THAT ELICIT THE BITTER TASTE IN COMPOSITIONS, AND THE USE THEREOF IN ASSAYS TO IDENTIFY COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITIONS AND USE THEREOF  
The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the...
US20140142147 Carbocyanines for G-Quadruplex DNA Stabilization and Telomerase Inhibition  
Cyanines which selectively bind to G-quadruplex DNA complexes, particularly quadruplexes expressed in cancer cells, and methods of making and using thereof are described herein. The cyanine can be...