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US20120289551 MINERALOCORTICOID RECEPTOR ANTAGONISTS  
Mineralocorticoid receptor antagonists, of which the following is exemplary.
US20130039967 ORAL DOSAGE FORMS  
The invention relates to specific three layer dosage forms for oral administration of pharmaceutical active substances.
US20150099740 TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS  
A method for treating a patient suffering from disorders and deficits of the central nervous system associated with diabetes, associated with aging and neurodegeneration, comprising attention...
US20110251243 Method and Kit for Assessing a Patient's Genetic Information, Lifestyle and Environment Conditions, and Providing a Tailored Therapeutic Regime  
A method of determining a personalised therapeutic regime, comprising: receiving genetic information relating to a patient; determining genetic criteria relevant to a personalised therapeutic...
US20140107158 METHODS FOR TREATING COGNITIVE DISORDERS  
Disclosed herein are methods of treating a patient suffering a cognitive disorder.
US20120190712 Methods for Treating Cognitive Disorders  
Disclosed herein are methods of treating a patient suffering a cognitive disorder.
US20120128734 Oral Delivery Product  
An oral delivery product comprising a semi-permeable pouch designed for delivery of an active agent in the oral cavity of a subject. The pouch encloses multiple particles, and the particles are...
US20110224723 CYANOACRYLATE TISSUE ADHESIVES  
A tissue adhesive including cyanoacrylate and polyethylene glycol (PEG), wherein the PEG remains a polyether and wherein the tissue adhesive is bioabsorbable. A tissue adhesive including...
US20130224114 Translocator Protein Ligands  
The present invention relates to compounds and methods for imaging translocator protein (18 kDa) (TSPO) expression in a subject. This invention also relates to compounds and methods for the...
US20110044898 TRANSLOCATOR PROTEIN LIGANDS  
The present invention relates to compounds and methods for imaging translocator protein (18 kDa) (TSPO) expression in a subject. This invention also relates to compounds and methods for the...
US20130131028 METHODS FOR TREATMENT OF SLEEP-RELATED BREATHING DISORDERS  
Described herein are methods for modulation of the activity of the carotid body that afford therapeutic benefit for sleep-related breathing disorders and related conditions.
US20140024642 OPHTHALMIC FORMULATION AND METHOD FOR AMELIORATING PRESBYOPIA  
An ophthalmic formulation having an effective amount of a parasympathomimetic agent comprising pilocarpine, or a pharmaceutically acceptable salt thereof, and one or more α1 adrenergic agonists or...
US20130324503 Method of identifying and treating a person having a predisposition to or afflicted with Parkinson disease  
The present invention relates to methods of treatment for Parkinson Disease (PD) in a person by identifying gene variants which may indicate a more favorable response to specific medicaments,...
US20110046116 SEDATIVE FOR USE DURING EYE SURGERY  
A drug for sedating a patient, and especially a smoker, during eye surgery. The drug includes a sedative such as midazolam in a mix with nicotine. The mixture is injected into the patient prior to...
US20070243260 Treatment of Childhood Asthma  
Glycopyrrolate or an analogue thereof is useful for the treatment of childhood asthma.
US20130197023 NEUROPROTECTION BY PHARMACOLOGICAL CHAPERONING OF NICOTINIC ACETYLCHOLINE RECEPTORS  
A method of ameliorating an endoplasmic reticulum (ER) stress response and/or unfolded protein response (UPR) in cells expressing nicotinic acetylcholine receptors (nAChRs) comprises contacting a...
US20150246007 TRANSDERMAL NICOTINE SALT DELIVERY SYSTEM  
A transdermal nicotine salt delivery system to an individual. The system has a high nicotine salt loading to effect therapeutic flux rate. Acrylate polymeric drug reservoir with the high nicotine...
US20140045801 PRAMIPEXOLE TRANSDERMAL DELIVERY FOR SEVERE HEADACHES  
The present invention relates to a method for the treatment and prevention of cluster headaches and migraines using the transdermal administration of pramipexole.
US20140249125 HIGH ENHANCER-LOADING POLYACRYLATE FORMULATION FOR TRANSDERMAL APPLICATIONS  
A polyacrylate formulation suitable for delivery of drug to through a body surface of an individual. By loading the drug and permeation enhancers at a high concentration into a polyacrylate...
US20110256097 Treatment of Conditions that Increase in Severity and/or Occurrence During One or More Phases of the Menstrual Cycle  
Methods are provided for treating a subject for a condition. In accordance with the subject methods, at least a portion of a subject's autonomic nervous system is modulated during at least one...
US20120017924 COATED NICOTINE-CONTAINING CHEWING GUM, MANUFACTURE AND USE THEREOF  
A coated chewing gum product for the delivering of nicotine in any form to a subject by a rapid transmucosal uptake in the oral cavity comprising at least one gum core, nicotine in any form and/or...
US20140356322 Compounds & Methods for the Enhanced Degradation of Targeted Proteins & Other Polypeptides by an E3 Ubiquitin Ligase  
The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins that are...
US20110065748 COMPOSITIONS AND METHODS FOR TREATING DISORDERS OF GASTROINTESTINAL MOTILITY  
Disclosed are methods of treating disorders of gastrointestinal motility by administering to a patient in need of such treatment a compound having the following formula:
US20080132830 Separable solid dosage form administration system  
The invention described herein provides a solid dosage form administration system comprising: an oral solid dosage form containing an active ingredient; and a hand-held applicator; wherein the...
US20120207817 SMALL INTERFERING RNAS AND METHODS FOR PREVENTION, INHIBITION AND/OR TREATMENT OF MALIGNANT PROGRESSION OF BREAST CANCER  
The invention found that overexpression and activation of α9-nAChR are associated with tumorigenesis of breast cancer and create a number of small interfering RNAs to inhibit the expression of...
US20110274740 METHODS OF REDUCING SYMPTOMS IN SUBJECTS USING SINGLE DOSAGE FORMS WITH TAPERING RELEASE RATES  
The present invention is directed to methods of reducing symptoms associated with an abrupt reduction in an endogenous or exogenous chemical in subjects, the methods comprising: (a) administering...
US20120295936 COMPOSITIONS AND METHODS FOR TREATING SEIZURE DISORDERS  
Disclosed are methods of treating a seizure disorder by administering to a patient in need of such treatment a compound having the following formula:
US20110065747 COMPOSITIONS AND METHODS FOR TREATING SEIZURE DISORDERS  
Disclosed are methods of treating a seizure disorder by administering to a patient in need of such treatment a compound having the following formula:
US20110065757 METHODS FOR TREATMENT OF KALLIKREIN-RELATED DISORDERS  
We have identified classes of kallikrein inhibitors as compounds that are useful in the reduction of vascular permeability (e.g., retinal vascular permeability and cerebral vascular permeability)...
US20120244104 NICOTINE CONTAINING FORMULATION  
Disclosed is nicotine containing solid oral transmucosal dosage forms containing a therapeutically effective amount of nicotine polacrilex, citric acid monohydrate, sucrose and liquid glucose. The...
US20080260807 Water-Soluble Films Comprising Nicotine  
A water-soluble film comprising nicotine, wherein said nicotine may be any pharmacologically effective form of nicotine present at one or more locations of the film defined by the application of a...
US20120003158 Biomarkers for Inflammatory Bowel Disease and Methods Using the Same  
The present invention provides various biomarkers of inflammatory bowel disease, including biomarkers for Crohn's disease and biomarkers for Ulcerative colitis. The present invention also provides...
US20110112130 Opioid-Nornicotine Codrugs Combinations for Pain Management  
The present invention relates to the field of pain management, and more particularly to synergistic codrugs comprising an opioid and nornicotine which have been combined to form a single chemical...
US20080070952 Inhibition or Treatment of Dyskinesia  
Prevention or treatment of dyskinesia induced by L-dopa or dopamine agonist can be effected by use of a selective inhibitor of neuronal nitric oxide synthase.
US20140038948 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR  
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
US20110112055 COMPOSITIONS AND METHODS FOR TREATING COLITIS  
Disclosed herein are compositions and methods for treating colitis and other inflammatory bowel diseases, inter alia, indeterminate colitis, Crohn's disease, irritable bowel syndrome and ischemic...
US20130109674 METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING TRIGEMINAL AUTONOMIC CEPHALGIAS, MIGRAINE, AND VASCULAR CONDITIONS  
The present invention relates to, among other things, methods for treating trigeminal cephalgias such as migraine and migraine like headaches and other cerebrovascular conditions associated with...
US20140121213 VOLTAGE-GATED SODIUM CHANNEL BLOCKERS  
In general, the present invention relates to uses of voltage-gated sodium channel blocker compounds, which include corresponding precursors, intermediates, monomers and dimers, corresponding...
US20140255452 METHOD AND APPARATUS FOR DIFFERENTIATING ORAL POUCH PRODUCTS  
A nicotine-containing pharmaceutical product configured for insertion into the mouth of a user of that product is provided. The product can have an outer water-permeable pouch, a...
US20140323423 BIOSYNCHRONOUS TRANSDERMAL DRUG DELIVERY FOR LONGEVITY, ANTI-AGING, FATIGUE MANAGEMENT, OBESITY, WEIGHT LOSS, WEIGHT MANAGEMENT, DELIVERY OF NUTRACEUTICALS, AND THE TREATMENT OF HYPERGLYCEMIA, ALZHEIMER'S DISEASE, SLEEP DISORDERS...  
Systems and methods for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and treating hyperglycemia, Alzheimer's disease, sleep...
US20110288132 Nicotine and Cocoa Powder Compositions  
The present invention relates to a nicotine-containing pharmaceutical composition and methods of using the composition in therapies, such as nicotine replacement therapy.
US20140017286 POUCH CONTAINING NICOTINE IN FREE SALT FORM  
The invention relates to a product for oral delivery of nicotine containing a core comprising a powder of at least one free nicotine salt, at least one pH adjusting agent and at least one filler,...
US20130344079 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING PHENYLKETONURIA (PKU)  
A method of diagnosing Phenylketonuria (PKU) in a subject in need thereof is disclosed. The method comprises detecting phenylalanine fibrils in a tissue of the subject, wherein a presence or level...
US20120022114 Low-dose, non-irritating nicotine nasal composition to reduce the desire to smoke  
A composition for administration to the nasal mucosa of a subject comprises a solution of nicotine or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable solvent. The...
US20110053988 Low-dose, non-irritating nicotine nasal composition to reduce the desire to smoke  
A composition for administration to the nasal mucosa of a subject comprises a solution of nicotine or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable solvent. The...
US20150080381 METHODS OF TREATING ALOPECIA AND ACNE  
Method of treating alopecia and acne with are disclosed. The compounds fall within described by formula I or II:
US20150071972 NICOTINE-CONTAINING PHARMACEUTICAL COMPOSITION  
A composition intended to be employed for therapeutic purposes incorporates a nicotinic compound, a sugar substitute, and a sugar alcohol syrup. Representative forms of nicotine include free base...
US20130078307 NICOTINE-CONTAINING PHARMACEUTICAL COMPOSITION  
A composition intended to be employed for therapeutic purposes incorporates a nicotinic compound, a sugar substitute, and a sugar alcohol syrup. Representative forms of nicotine include free base...
US20130011343 CHEWING GUM HAVING SUSTAINED RELEASE OF NICOTINE  
The present invention relates to a chewing gum having a high Surface Area to Volume ratio (SAV ratio), wherein said chewing gum comprises a water insoluble gum base matrix, a water soluble bulk...
US20100324083 Combinations of Organic Compounds  
The invention provides a pharmaceutical combination comprising: a) compounds that inhibit the binding of the Smac protein to IAPs; andb) a taxane, and a method for treating or preventing a...