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US20120289551 |
MINERALOCORTICOID RECEPTOR ANTAGONISTS
Mineralocorticoid receptor antagonists, of which the following is exemplary. |
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US20110034495 |
Method of Modulating Stress-Activated Protein Kinase System
A series of thieno[2,3-b]pyridin-6(7H)-one derivatives, substituted in the 2-position by a carbonyl- or sulfonyl-linked pyrrolidin-1-yl or related moiety, being inhibitors of p38 MAP kinase, are... |
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US20130289020 |
CXCR4 Receptor Antagonists
Disclosed are compounds that are antagonists of the CXCR4 receptor. |
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US20120115911 |
SEED INDEX SYSTEM FOR TREATING AGRICULTURAL SEEDS
Seed index system and methods for treating agricultural seeds with one or more seed care products employing a size-adjusted application rate based on the size of the seeds. Such size-adjusted... |
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US20120114723 |
ONE STEP FIRE ANT CONTROL
The present invention relates to a method for controlling fire ants with a single step application of a combination of a bait and a controlled release treatment composition, and to the novel... |
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US20140228362 |
Method of Treatment or Prophylaxis
The present invention is directed to methods and agents that are useful in the prevention and amelioration of signs and symptoms associated with neuropathic conditions. More particularly, the... |
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US20130065928 |
BIOMARKERS FOR PI3K-DRIVEN CANCER
Disclosed is the discovery that the mTORC2 complex plays a role in the regulation of PKN3 phosphorylation at the turn motif threonine; and the use of the phosphorylation status of the turn motif... |
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US20110230407 |
HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN DEMYELINATING DISEASES AND CENTRAL NERVOUS SYSTEM TRAUMA
Methods are provided for treating and preventing demyelinating diseases including multiple sclerosis, and traumatic injury to the central nervous system including brain trauma and spinal cord... |
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US20150174130 |
COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS
Embodiments of the presently-disclosed subject matter include activators of HssRS that induce endogenous heme biosynthesis by perturbing central metabolism. These molecules are toxic to fermenting... |
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US20150225366 |
Crystalline Polymorphs of the Free Base of 2-Hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde
Disclosed are crystalline free base ansolvate forms of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)me
thoxy)benzaldehyde (or Compound 1), such as the free base Form I, Form II and... |
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US20140163075 |
MODULATION OF THE UBIQUITIN-PROTEASOME SYSTEM (UPS)
The invention relates to the field of 26S proteasome inhibition, activation and modulation and to identify compounds which activate 26S proteasome in live cells and a method of treating autoimmune... |
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US20130045938 |
KINASE MODULATORS FOR THE TREATMENT OF CANCER
A method of treating cancer in which a compound that inhibits the expression, production or release of IL-10 by immune cells is combined with a compound that stimulates the production of IL-12... |
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US20130122090 |
Multiple Unit Tablet Composition
A multiple unit tablet composition comprising an enteric coated multiple unit cores comprising a pharmaceutically active ingredient, wherein plasticizer content of enteric coating is less than... |
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US20120302609 |
Pyrazolines for the Modulation of PKM2
The invention relates to pyrazoline substituted compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from... |
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US20150153343 |
DETECTION SYSTEM FOR THE IDENTIFICATION OF INSECTICIDE RESISTANCE
A rapid, easy, and highly sensitive detection system is herein described for the identification of resistance of animal plant pests to neonicotinoids and pymetrozine. Further, a method for... |
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US20120035221 |
Method of Fungal Pathogen Control in Grass or Turf
Disclosed is a method of controlling fungal organisms in turfgrass with imidacloprid and optionally one or more other fungicides. |
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US20120035220 |
Method of Fungal Pathogen Control in Grass or Turf
Disclosed is a method of controlling fungal organisms in turfgrass with imidacloprid and optionally one or more other fungicides. |
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US20120309791 |
NOVEL COMPOUND FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS
The present invention relates to novel compounds of formula (II) that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as... |
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US20150057315 |
Methods for Treatment of 16P11.2 Microdeletion Syndrome
Subjects that have a 16p11.2 microdeletion syndrome are treated by administering compositions that include mGluR inhibitors, including mGluR antagonists that include mGluR negative allosteric... |
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US20140309262 |
ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES
Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders. |
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US20140271591 |
Compositions and methods for the modulation of hemoglobin (s)
This invention provides pharmaceutical compositions for the allosteric modulation of hemoglobin (S) and methods for their use in treating disorders mediated by hemoglobin (S) and disorders that... |
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US20110195962 |
USE OF MULTI-PHARMACOPHORE COMPOUNDS TO TREAT NASAL DISORDERS
Compositions and methods for treating nasal disorders associated with nasal inflammation using a multipharmacophoric agent (MPA) that can prevent the production and/or release of at least one or... |
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US20110200571 |
Methods for Reducing Nematode Damage to Plants
Methods and compositions for controlling nematode plant damage using seed and/or soil and foliar treatments are disclosed. Seeds, soil, or both are treated with a nematicidal composition followed... |
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US20110118282 |
Soluble Guanylate Cyclase Activators
A compound having the structure useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris,... |
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US20130276352 |
BAIT MATERIALS, PEST MONITORING DEVICES AND OTHER PEST CONTROL DEVICES THAT INCLUDE POLYURETHANE FOAM
A termite bait includes a plurality of cellulosic food material pieces palatable to termites embedded within a water resistant polyurethane foam matrix. Another termite bait includes a plurality... |
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US20140336225 |
KINASE MODULATORS FOR THE TREATMENT OF CANCER
Compounds of the substituted pyrazole class as treatments for cancer are reported. A method of treating cancer in which a compound that inhibits the activity of receptor kinases. Said method is... |
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US20130210863 |
SYNERGISTIC INSECTICIDAL MIXTURES
The present invention relates to synergistic insecticidal mixtures comprising a) a Pyrethroid insecticide (preferably bifenthrin), b) a Neonicotinoid insecticide (preferably imidacloprid) and c) a... |
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US20130102597 |
COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound,... |
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US20130072523 |
ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS
Compounds represented by Formula I: (I) or pharmaceutically acceptable salts thereof, wherein A, B, B′, X, Y, R1, R2, R2′, R3, R3′, R4, R4′, R5′, R5′m, n, or p are as defined herein, are useful... |
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US20150105430 |
METHODS OF TREATING OR PREVENTING NEUROPATHIC PAIN
A method treats or prevents neuropathic pain with a synergistically-enhanced analgesic effect at a dose at which a calcium channel α2δ ligand does not produce any side effects as well as which... |
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US20130005775 |
METHODS OF TREATING ULCERATIVE COLITIS
Methods of treating and managing ulcerative colitis, using imidazole-based compounds that inhibit S1P lyase, are disclosed. |
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US20130130908 |
Agricultural Formulations with Acyl Morpholines and Polar Aprotic Co-Solvents
The present invention provides a formulation comprising a pesticide and/or a plant growth regulator; an acyl morpholine of the formula (I) where R is H, CH3 or C2H5; and a polar aprotic co-solvent... |
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US20110112055 |
COMPOSITIONS AND METHODS FOR TREATING COLITIS
Disclosed herein are compositions and methods for treating colitis and other inflammatory bowel diseases, inter alia, indeterminate colitis, Crohn's disease, irritable bowel syndrome and ischemic... |
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US20130123306 |
Inhibition of Mitogen-activated Protein Kinases in Cardiovascular Disease
The present invention relates to methods for inhibiting subacute thrombosis and/or intimal hyperplasia following an interventional vascular procedure by contacting a blood vessel or a synthetic... |
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US20120208700 |
STABLE AGROCHEMICAL OIL DISPERSIONS
The present disclosure relates to the use of dibenzylidene sorbitol or derivatives of dibenzylidene sorbitol as rheology additives to provide stability to oil dispersion formulations of... |
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US20130095095 |
METHOD FOR TREATING THROMBOTIC DISORDERS USING QUERCETIN-CONTAINING COMPOSITIONS
A method for treating thrombotic disorders using a composition containing quercetin, together with one or more of vitamin B3, vitamin C, and folic acid. Also disclosed is a method of improving the... |
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US20110159065 |
AGRICULTURAL CHEMICAL COMPOSITION AND FRUIT BAG
The present invention provides an agricultural chemical composition containing an agricultural chemical active ingredient A, a sorbitan fatty acid ester and a wax, and a production process... |
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US20090209556 |
SOLUBLE GUANYLATE CYCLASE ACTIVATORS
A compound having the structure useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris,... |
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US20150230469 |
COMPOSITIONS AND METHODS FOR CONTROL OF SAND FLIES AND OTHER BLOOD SUCKING INSECTS
The invention relates to a new rapid release oral formulation of fipronil or imidacloprid for the effective control of blood-sucking insect populations. Embodiments of the invention relate to... |
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US20110301029 |
Composition and Method for Improving Plant Health
The present invention relates to plant-protecting active ingredient mixtures comprising, as active components, a neonicotinoid and one or two fungicides selected from pyraclostrobin and boscalid,... |
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US20120088788 |
SUBSTITUTED IMIDAZOLES AS BOMBESIN RECEPTOR SUBTYPE-3 MODULATORS
Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore... |
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US20140051729 |
COMPOSITIONS AND METHODS FOR TREATING DEGENERATIVE MUSCLE CONDITIONS
Methods and compositions for treating degenerative muscle conditions are disclosed. The compositions disclosed herein include S1P promoting compositions that include an S1P promoting agent.... |
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US20110178040 |
METHOD FOR TREATING FIBROSIS AND CANCER WITH IMIDAZOLIUM AND IMIDAZOLINIUM COMPOUNDS
There is presently provided methods for delivering an anti-fibrotic or anti-cancer agent to a cell. The methods comprise contacting a cell with an effective amount of imidazolium and imidazolinium... |
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US20120245153 |
MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION
Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and use thereof. |
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US20120053150 |
N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INIHIBITORS
The present invention relates to amide compounds, processes for their preparation, pharmaceutical compositions containing these compounds and to their use in the treatment of disorders, conditions... |
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US20120316148 |
Compositions and Methods for Modulating a Kinase
The invention relates to compounds and methods for modulating one or more components of a kinase signaling cascade. |
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US20130123260 |
Methods
The disclosure relates to compounds of formula (I) for use in the treatment or prophylaxis of rhinovirus infection, methods of treating or preventing rhinovirus infection employing said compounds... |
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US20150223452 |
COMPOSITION COMPRISING A PESTICIDAL TERPENE MIXTURE AND A FUNGICIDE
The present invention relates to a composition comprising a) a pesticidal terpene mixture comprising, as pesticidally active chemical compounds α-terpinene, p-cymene and limonene, and b) at least... |
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US20100310563 |
METHODS FOR TREATING INDUCED CELLULAR PROLIFERATIVE DISORDERS
Methods are provided for treating a subject with a cellular proliferative disorder that include administering to the subject a therapeutically effective amount of a JAK2 inhibitor and a... |
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US20140147691 |
WOOD PRESERVATIVE FORMULATION
The present invention relates to a preservative formulation for use in treating wood or other cellulosic materials, said formulation comprising: at least one biocidal metal compound; at least one... |