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US20120289551 MINERALOCORTICOID RECEPTOR ANTAGONISTS  
Mineralocorticoid receptor antagonists, of which the following is exemplary.
US20110034495 Method of Modulating Stress-Activated Protein Kinase System  
A series of thieno[2,3-b]pyridin-6(7H)-one derivatives, substituted in the 2-position by a carbonyl- or sulfonyl-linked pyrrolidin-1-yl or related moiety, being inhibitors of p38 MAP kinase, are...
US20130289020 CXCR4 Receptor Antagonists  
Disclosed are compounds that are antagonists of the CXCR4 receptor.
US20120115911 SEED INDEX SYSTEM FOR TREATING AGRICULTURAL SEEDS  
Seed index system and methods for treating agricultural seeds with one or more seed care products employing a size-adjusted application rate based on the size of the seeds. Such size-adjusted...
US20120114723 ONE STEP FIRE ANT CONTROL  
The present invention relates to a method for controlling fire ants with a single step application of a combination of a bait and a controlled release treatment composition, and to the novel...
US20140228362 Method of Treatment or Prophylaxis  
The present invention is directed to methods and agents that are useful in the prevention and amelioration of signs and symptoms associated with neuropathic conditions. More particularly, the...
US20130065928 BIOMARKERS FOR PI3K-DRIVEN CANCER  
Disclosed is the discovery that the mTORC2 complex plays a role in the regulation of PKN3 phosphorylation at the turn motif threonine; and the use of the phosphorylation status of the turn motif...
US20110230407 HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN DEMYELINATING DISEASES AND CENTRAL NERVOUS SYSTEM TRAUMA  
Methods are provided for treating and preventing demyelinating diseases including multiple sclerosis, and traumatic injury to the central nervous system including brain trauma and spinal cord...
US20150174130 COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS  
Embodiments of the presently-disclosed subject matter include activators of HssRS that induce endogenous heme biosynthesis by perturbing central metabolism. These molecules are toxic to fermenting...
US20150225366 Crystalline Polymorphs of the Free Base of 2-Hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde  
Disclosed are crystalline free base ansolvate forms of 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)pyridin-3-yl)me thoxy)benzaldehyde (or Compound 1), such as the free base Form I, Form II and...
US20140163075 MODULATION OF THE UBIQUITIN-PROTEASOME SYSTEM (UPS)  
The invention relates to the field of 26S proteasome inhibition, activation and modulation and to identify compounds which activate 26S proteasome in live cells and a method of treating autoimmune...
US20130045938 KINASE MODULATORS FOR THE TREATMENT OF CANCER  
A method of treating cancer in which a compound that inhibits the expression, production or release of IL-10 by immune cells is combined with a compound that stimulates the production of IL-12...
US20130122090 Multiple Unit Tablet Composition  
A multiple unit tablet composition comprising an enteric coated multiple unit cores comprising a pharmaceutically active ingredient, wherein plasticizer content of enteric coating is less than...
US20120302609 Pyrazolines for the Modulation of PKM2  
The invention relates to pyrazoline substituted compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from...
US20150153343 DETECTION SYSTEM FOR THE IDENTIFICATION OF INSECTICIDE RESISTANCE  
A rapid, easy, and highly sensitive detection system is herein described for the identification of resistance of animal plant pests to neonicotinoids and pymetrozine. Further, a method for...
US20120035221 Method of Fungal Pathogen Control in Grass or Turf  
Disclosed is a method of controlling fungal organisms in turfgrass with imidacloprid and optionally one or more other fungicides.
US20120035220 Method of Fungal Pathogen Control in Grass or Turf  
Disclosed is a method of controlling fungal organisms in turfgrass with imidacloprid and optionally one or more other fungicides.
US20120309791 NOVEL COMPOUND FOR THE TREATMENT OF DISEASES ASSOCIATED WITH AMYLOID OR AMYLOID-LIKE PROTEINS  
The present invention relates to novel compounds of formula (II) that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as...
US20150057315 Methods for Treatment of 16P11.2 Microdeletion Syndrome  
Subjects that have a 16p11.2 microdeletion syndrome are treated by administering compositions that include mGluR inhibitors, including mGluR antagonists that include mGluR negative allosteric...
US20140309262 ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES  
Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders.
US20140271591 Compositions and methods for the modulation of hemoglobin (s)  
This invention provides pharmaceutical compositions for the allosteric modulation of hemoglobin (S) and methods for their use in treating disorders mediated by hemoglobin (S) and disorders that...
US20110195962 USE OF MULTI-PHARMACOPHORE COMPOUNDS TO TREAT NASAL DISORDERS  
Compositions and methods for treating nasal disorders associated with nasal inflammation using a multipharmacophoric agent (MPA) that can prevent the production and/or release of at least one or...
US20110200571 Methods for Reducing Nematode Damage to Plants  
Methods and compositions for controlling nematode plant damage using seed and/or soil and foliar treatments are disclosed. Seeds, soil, or both are treated with a nematicidal composition followed...
US20110118282 Soluble Guanylate Cyclase Activators  
A compound having the structure useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris,...
US20130276352 BAIT MATERIALS, PEST MONITORING DEVICES AND OTHER PEST CONTROL DEVICES THAT INCLUDE POLYURETHANE FOAM  
A termite bait includes a plurality of cellulosic food material pieces palatable to termites embedded within a water resistant polyurethane foam matrix. Another termite bait includes a plurality...
US20140336225 KINASE MODULATORS FOR THE TREATMENT OF CANCER  
Compounds of the substituted pyrazole class as treatments for cancer are reported. A method of treating cancer in which a compound that inhibits the activity of receptor kinases. Said method is...
US20130210863 SYNERGISTIC INSECTICIDAL MIXTURES  
The present invention relates to synergistic insecticidal mixtures comprising a) a Pyrethroid insecticide (preferably bifenthrin), b) a Neonicotinoid insecticide (preferably imidacloprid) and c) a...
US20130102597 COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS  
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound,...
US20130072523 ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS  
Compounds represented by Formula I: (I) or pharmaceutically acceptable salts thereof, wherein A, B, B′, X, Y, R1, R2, R2′, R3, R3′, R4, R4′, R5′, R5′m, n, or p are as defined herein, are useful...
US20150105430 METHODS OF TREATING OR PREVENTING NEUROPATHIC PAIN  
A method treats or prevents neuropathic pain with a synergistically-enhanced analgesic effect at a dose at which a calcium channel α2δ ligand does not produce any side effects as well as which...
US20130005775 METHODS OF TREATING ULCERATIVE COLITIS  
Methods of treating and managing ulcerative colitis, using imidazole-based compounds that inhibit S1P lyase, are disclosed.
US20130130908 Agricultural Formulations with Acyl Morpholines and Polar Aprotic Co-Solvents  
The present invention provides a formulation comprising a pesticide and/or a plant growth regulator; an acyl morpholine of the formula (I) where R is H, CH3 or C2H5; and a polar aprotic co-solvent...
US20110112055 COMPOSITIONS AND METHODS FOR TREATING COLITIS  
Disclosed herein are compositions and methods for treating colitis and other inflammatory bowel diseases, inter alia, indeterminate colitis, Crohn's disease, irritable bowel syndrome and ischemic...
US20130123306 Inhibition of Mitogen-activated Protein Kinases in Cardiovascular Disease  
The present invention relates to methods for inhibiting subacute thrombosis and/or intimal hyperplasia following an interventional vascular procedure by contacting a blood vessel or a synthetic...
US20120208700 STABLE AGROCHEMICAL OIL DISPERSIONS  
The present disclosure relates to the use of dibenzylidene sorbitol or derivatives of dibenzylidene sorbitol as rheology additives to provide stability to oil dispersion formulations of...
US20130095095 METHOD FOR TREATING THROMBOTIC DISORDERS USING QUERCETIN-CONTAINING COMPOSITIONS  
A method for treating thrombotic disorders using a composition containing quercetin, together with one or more of vitamin B3, vitamin C, and folic acid. Also disclosed is a method of improving the...
US20110159065 AGRICULTURAL CHEMICAL COMPOSITION AND FRUIT BAG  
The present invention provides an agricultural chemical composition containing an agricultural chemical active ingredient A, a sorbitan fatty acid ester and a wax, and a production process...
US20090209556 SOLUBLE GUANYLATE CYCLASE ACTIVATORS  
A compound having the structure useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris,...
US20150230469 COMPOSITIONS AND METHODS FOR CONTROL OF SAND FLIES AND OTHER BLOOD SUCKING INSECTS  
The invention relates to a new rapid release oral formulation of fipronil or imidacloprid for the effective control of blood-sucking insect populations. Embodiments of the invention relate to...
US20110301029 Composition and Method for Improving Plant Health  
The present invention relates to plant-protecting active ingredient mixtures comprising, as active components, a neonicotinoid and one or two fungicides selected from pyraclostrobin and boscalid,...
US20120088788 SUBSTITUTED IMIDAZOLES AS BOMBESIN RECEPTOR SUBTYPE-3 MODULATORS  
Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore...
US20140051729 COMPOSITIONS AND METHODS FOR TREATING DEGENERATIVE MUSCLE CONDITIONS  
Methods and compositions for treating degenerative muscle conditions are disclosed. The compositions disclosed herein include S1P promoting compositions that include an S1P promoting agent....
US20110178040 METHOD FOR TREATING FIBROSIS AND CANCER WITH IMIDAZOLIUM AND IMIDAZOLINIUM COMPOUNDS  
There is presently provided methods for delivering an anti-fibrotic or anti-cancer agent to a cell. The methods comprise contacting a cell with an effective amount of imidazolium and imidazolinium...
US20120245153 MGLUR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION  
Compounds useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4) and use thereof.
US20120053150 N-PYRAZOLYL CARBOXAMIDES AS CRAC CHANNEL INIHIBITORS  
The present invention relates to amide compounds, processes for their preparation, pharmaceutical compositions containing these compounds and to their use in the treatment of disorders, conditions...
US20120316148 Compositions and Methods for Modulating a Kinase  
The invention relates to compounds and methods for modulating one or more components of a kinase signaling cascade.
US20130123260 Methods  
The disclosure relates to compounds of formula (I) for use in the treatment or prophylaxis of rhinovirus infection, methods of treating or preventing rhinovirus infection employing said compounds...
US20150223452 COMPOSITION COMPRISING A PESTICIDAL TERPENE MIXTURE AND A FUNGICIDE  
The present invention relates to a composition comprising a) a pesticidal terpene mixture comprising, as pesticidally active chemical compounds α-terpinene, p-cymene and limonene, and b) at least...
US20100310563 METHODS FOR TREATING INDUCED CELLULAR PROLIFERATIVE DISORDERS  
Methods are provided for treating a subject with a cellular proliferative disorder that include administering to the subject a therapeutically effective amount of a JAK2 inhibitor and a...
US20140147691 WOOD PRESERVATIVE FORMULATION  
The present invention relates to a preservative formulation for use in treating wood or other cellulosic materials, said formulation comprising: at least one biocidal metal compound; at least one...