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US20120302561 |
Compounds, Formulations, and Methods of Protein Kinase C Inhibition
The invention provides a method of inhibiting atypical protein kinase C (aPKC) comprising contacting an aPKC with a compound having a structure selected from the group consisting of structural... |
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US20140275112 |
Compounds For Stabilizing Ryanodine Receptors From Aberrant Levels Of Calcium Release
Disclosed herein are methods and compositions comprising compounds capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are methods comprising these compounds for treating... |
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US20110251204 |
Modulators of G Protein-Coupled Receptor 88
The present disclosure is generally directed to compounds which can modulate G-protein coupled receptor 88, compositions comprising such compounds, and methods for modulating G-protein coupled... |
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US20150087649 |
TREATING DISORDERS ASSOCIATED WITH ABERRANT ADRENOCORTICAL CELL BEHAVIOR
Methods and agents are provided for treatment of disorders associated with aberrant adrenocortical cell behavior, including (but not limited to) treatment of adrenocortical carcinoma (ACC) and/or... |
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US20140235637 |
COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound,... |
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US20130102597 |
COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound,... |
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US20130267561 |
Substituted 1,3-Dioxanes Useful as PPAR Modulators
Specifically useful stereoisomers of 1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer,... |
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US20110065757 |
METHODS FOR TREATMENT OF KALLIKREIN-RELATED DISORDERS
We have identified classes of kallikrein inhibitors as compounds that are useful in the reduction of vascular permeability (e.g., retinal vascular permeability and cerebral vascular permeability)... |
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US20090258904 |
Epithiolone Analogues
Epothilone analogues include a molecular scaffold which holds at least one segment of epothilone in a predetermined orientation and which rigidities a region between the macrolactone ring and the... |
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US20150065529 |
SYNERGISTIC FUNGICIDAL MEXURES FOR FUNGAL CONTROL IN CEREALS
A fungicidal composition containing a fungicidally effective amount of a compound of Formula I-V and at least one fungicide selected from the group consisting of epoxiconazole, prothioconazole,... |
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US20110082160 |
SYNERGISTIC FUNGICIDAL MIXTURES FOR FUNGAL CONTROL IN CEREALS
A fungicidal composition containing a fungicidally effective amount of a compound of Formula I-V and at least one fungicide selected from the group consisting of epoxiconazole, prothioconazole,... |
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US20140187589 |
FUNGICIDAL COMPOSITIONS FOR CONTROLLING LEAF SPOTS IN SUGAR BEETS
A new method for the control and prevention of sugar beet leaf spot caused by Cercospora beticola (CERCBE) in a sugar beet plant has been discovered. The method involves applying effective amounts... |
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US20140107084 |
ULTRA LOW DOSE DOXEPIN AND METHODS OF USING THE SAME TO TREAT SLEEP DISORDERS
The invention relates to doxepin, pharmaceutically acceptable salts and prodrugs of doxepin; compositions containing the same, and the use of any of the aforementioned for the treatment of sleep... |
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US20150023889 |
FLUORIDE-RESPONSIVE RIBOSWITCHS, FLUORIDE TRANSPORTERS, AND METHODS OF USE
Disclosed are compounds, compositions, and methods relating to fluoride aptamers, fluoride-responsive riboswitches, fluoride-regulated expression constructs, fluoride transporters, nucleic acids... |
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US20140288110 |
PPAR MODULATORS
1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and... |
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US20110178112 |
PPAR Modulators
1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer, inflammation, neurodegenerative disorders and... |
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US20110257130 |
Compositions and Methods for Treatment of Renin-Angiotensin Aldosterone System (RAAS)- Related Disorders
Compounds are provided which can be useful in reducing the activity of an angiotensin-converting enzyme and thus be used to treat or prevent a renin-angiotensin aldosterone system-related... |
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US20090130190 |
Transdermal System for the Delivery of Sufentanil and Its Analogs
Methods and systems for the transdermal delivery of sufentanil and its analogs are described, from patches having a unique pharmacodynamic profile that can be used to treat persistent pain over... |
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US20140187587 |
SYNERGISTIC FUNGICIDAL MIXTURES FOR FUNGAL CONTROL IN CEREALS
A fungicidal composition containing a fungicidally effective amount of (a) the compound of Formula I,... |
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US20140140997 |
Methods of Treating Retroviral Infections in Felines
Provided are methods for treating or reducing the likelihood of developing a retroviral infection in a feline, decreasing retroviral virion entry into a feline cell, decreasing retroviral virion... |
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US20150181871 |
SYNERGISTIC FUNGICIDAL MIXTURES FOR FUNGAL CONTROL IN CEREALS
A fungicidal composition containing a fungicidally effective amount of a compound of Formula I: (3S,6S,7R,8R)-8-benzyl-3-(3-((isobutyryloxy)methoxy)-4-metho
xypicolinamido)-6-methyl-4,9-dioxo-1,5-d... |
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US20150181870 |
SYNERGISTIC FUNGICIDAL MIXTURES FOR FUNGAL CONTROL IN CEREALS
A fungicidal composition containing a fungicidally effective amount of a compound of Formula I: (3S,6S,7R,8R)-8-benzyl-3-(3-((isobutyryloxy)methoxy)-4-metho
xypicolinamido)-6-methyl-4,9-dioxo-1,5-d... |
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US20120196905 |
SYNTHETIC COMPOUNDS AND METHODS TO DECREASE NICOTINE SELF-ADMINISTRATION
Methods and small molecule compounds for smoking and CNS disease harm reduction are provided. One example of a class of compounds that may be used is represented by the compound having the... |
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US20070185147 |
Opioids for the treatment of the restless leg syndrome
The present invention relates to an opioid controlled release oral dosage form comprising at least one opioid for the manufacture of a medicament to treat patients with restless leg syndrome (RLS). |
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US20070270464 |
PRODRUGS OF CURCUMIN ANALOGS
The invention provides sulfur-linked and nitrogen-linked peptidic conjugates of curcumin analogs that can provide increased water solubility and photostability as compared to the corresponding... |
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US20100298345 |
SYNTHETIC COMPOUNDS AND DERIVATIVES AS MODULATORS OF SMOKING OR NICOTINE INGESTION AND LUNG CANCER
Disclosed are nicotine-related compounds that selectively inhibit cytochrome P-450 2A6 (CYP2A6), selectively inhibit cytochrome P-450 2A13 (CYP2A13), and/or selectively modulate a nicotinic... |
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US20120164103 |
Compounds and Methods for the Treatment or Prevention of Flavivirus Infections
Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, Y1, and Z are as defined herein, are useful for treating flaviviridae viral infections. |
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US20110112064 |
Pyridyl Amide T-Type Calcium Channel Antagonists
The present invention is directed to pyridyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in... |
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US20130345233 |
INHIBITORS OF PROTEIN KINASES
Compounds of general Formula (I): wherein R1, R2, R3, Ra, A, B and x are as defined herein are inhibitors of protein kinases in particular members of the cyclin-dependent kinase family and/or the... |
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US20110224225 |
Inhibitors of protein kinases
Compounds of general Formula (I): wherein R1, R2, R3, Ra, A, B and x are as defined herein are inhibitors of protein kinases in particular members of the cyclin-dependent kinase family and/or the... |
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US20090023782 |
INCREASING PLANT VIGOR
Compositions and processes for improving plant vigor are disclosed. |
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US20130296369 |
Cyanoenamines and their use as fungicides
The present invention relates to cyanoenamine derivatives, their process of preparation, intermediate compounds, their use as fungicide active agents, particularly in the form of fungicide... |
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US20150038535 |
Thiophene-carboxamides useful as inhibitors of protein kinases
The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of... |
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US20140323523 |
Positive allosteric modulators of nicotinic acetylcholine receptor
The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The... |
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US20140044806 |
NEW POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR
The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The... |
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US20140010898 |
New positive allosteric modulators of nicotinic acetylcholine receptor
The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The... |
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US20140010897 |
New positive allosteric modulators of nicotinic acetylcholine receptor
The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The... |
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US20130012530 |
New Positive allosteric modulators of nicotinic acetylcholine receptor
The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The... |
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US20140213616 |
PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS
The invention relates to pyridone amide compounds of formula I and I′ or pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels: The invention also provides... |
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US20120108636 |
Allosteric Enhancers of th A1 Adenosine Receptor
The present invention provides compounds of formula (I) wherein W, R1, R5 and R6 have a meaning as defined herein in the specification. The compounds of formula (I) are allosteric enhancers of the... |
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US20130123304 |
PYRIDINE NON-CLASSICAL CANNABINOID COMPOUNDS AND RELATED METHODS OF USE
Disclosed are compounds of the formula I: wherein R1, R2, V, W, X, Y and Z can be as defined herein. The compounds can be used in the treatment of disorders mediated by the cannabinoid receptors. |
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US20120196900 |
PYRIDINE NON-CLASSICAL CANNABINOID COMPOUNDS AND RELATED METHODS OF USE
Disclosed are compounds of the formula I: wherein R1, R2, V, W, X, Y and Z can be as defined herein. The compounds can be used in the treatment of disorders mediated by the cannabinoid receptors. |
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US20130059860 |
NAPHTHALENE CARBOXAMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS
The present invention is directed to naphthalene carboxamide compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in which... |
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US20090275515 |
2-HYDROXY-2-PHENYLTHIOPHENYLPROPIONAMIDES AS ANDROGEN RECEPTOR MODULATORS
Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the... |
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US20090005391 |
Tricyclo Substituted Amides
Compounds of Formula (I) or pharmaceutically acceptable salts thereof, are useful in the prophylactic and therapeutic treatment of hyperglycemia and diabetes. |
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US20120046232 |
COMPOSITIONS AND METHODS FOR REDUCING RELAPSE OF ADDICTIVE BEHAVIOR
Disclosed are methods and compositions comprising mGluR modulators and procysteine drugs. The methods and compositions can be used to treat subjects with prior addiction in order to reduce drug... |
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US20130296373 |
MACROCYCLIC PICOLINAMIDES AS FUNGICIDES
The disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides. |
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US20130296371 |
MACROCYCLIC PICOLINAMIDES AS FUNGICIDES
The disclosure relates to macrocyclic picolinamides of Formula I and their use as fungicides. |
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US20140275179 |
GPR120 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are represented by Formula (I) and Formula... |
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US20140024639 |
Compounds, Compositions, and Methods for Cancer Therapy
Compounds including various oligomers of piperlongumine and/or piperlongumine analogues as well as certain piperlongumine analogues that exhibit improved toxicity to cancer cells are disclosed.... |