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US20110015229 METHOD OF TREATING NEUROPATHIC PAIN  
A method for treating subjects experiencing neuropathic pain is provided. The method involves the application of a solid-forming local anesthetic formulation to a skin surface of the subject...
US20110020450 TITRATABLE DOSAGE TRANSDERMAL DELIVERY SYSTEM  
The present invention relates to a titratable dosage transdermal delivery system for systemic delivery of a therapeutic agent or drug. The system comprises a plurality of patch units that are...
US20150087674 COMPOSITIONS AND METHODS FOR THE TREATMENT OF SEVERE PAIN  
The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical...
US20110288123 FORMULATIONS FOR THE TREATMENT OF ACUTE HERPES ZOSTER PAIN  
The present invention provides compositions and methods that are useful for treatment of pain associated with acute herpes zoster. The aqueous compositions are non-stinging and non-irritating.
US20110086818 METHODS, COMPOSITIONS, AND KITS FOR TREATING PAIN AND PRURITUS  
The invention features methods, compositions, and kits for selective inhibition of pain-and itch sensing neurons (nociceptors and pruriceptors) by drug molecules of small molecule weight, while...
US20110171325 Systems and Methods for Treating Pain Using Brain Stimulation  
The invention comprises systems and methods for treating nociceptive pain including at least one force-regulatable device in mechanical, electrical, or chemical communication with at least one...
US20110150766 Transdermal patch with fatal overdose protection  
A transdermal patch having a top region containing an antagonist followed by a bottom region containing an agonist, whereby the bottommost end of the bottom region is secured to the skin of the...
US20120142649 COMPOSITIONS AND METHODS FOR DELIVERING CLONIDINE AND BUPIVACAINE TO A TARGET TISSUE SITE  
Effective treatments of pain for extended periods of time are provided. Through the administration of an effective amount of immediate release bupivacaine or lidocaine and a sustained release...
US20140315805 LOCALLY RELEASED GROWTH FACTORS TO MEDIATE MOTOR RECOVERY AFTER STROKE  
Methods of improving recovery of a mammal after an ischemic event (e.g., stroke) are provided. In various embodiments the methods involve administering a neural growth factor (e.g., BDNF) into the...
US20150119423 COMPOSITIONS AND METHODS FOR THE TREATMENT OF LOCAL PAIN  
The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical...
US20110039818 Dosage regimen of an S1P receptor agonist  
S1P receptor modulators or agonists are administered following a dosage regimen whereby during the initial days of treatment the daily dosage is lower than the standard daily dosage.
US20140296293 PHARMACEUTICAL COMPOSITIONS COMPRISING A LOCAL ANAESTHETIC SUCH AS BUPIVACAINE FOR LOCAL ADMINISTRATION TO THE MOUTH OR THROAT  
The present invention relates to compositions comprising a lipophilic local anaesthetic, preferably bupivacaine or a pharmaceutically active salt thereof, which are formulated for local...
US20150018390 METHODS AND COMPOSITIONS FOR TREATING POST-OPERATIVE PAIN COMPRISING A LOCAL ANESTHETIC  
The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot...
US20150126556 Treatment of Skin and Mucosal Superficial Wounds Using Adrenergic Receptor Agonists  
The invention generally relates to methods of using adrenergic receptor agonists for the treatment of skin and mucosal superficial wounds. Some of the preferred adrenergic receptor agonists...
US20130149318 PAINTING THE PIA, ARACHNOID, AND SPINAL CORD PARENCHYMA  
A PEG based hydrogel and a procedure for its topical application to the surface of the pia mater of the spinal cord that can be used for intrathecal delivery of diverse drug and biomolecular...
US20120020881 Triaryl-sulphonium compounds, kit and methods for labeling positron emitting isotopes  
This invention relates to novel compounds suitable for labeling by positron emitting isotopes, such as 18F, 11C, 13N and 15O, through appropriate labeling reagents, such as 18F reagents and...
US20150087628 COMPOSITIONS AND METHODS FOR TREATING CANCER  
K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.
US20120088782 LPA RECEPTOR ANTAGONIST  
A compound of the general formula (I): (wherein the symbols are as defined in the description), or a non-toxic salt thereof. This compound engages in LPA receptor bonding and antagonism and hence...
US20120282242 COMPOSITIONS, TARGETS, METHODS AND DEVICES FOR THE THERAPY OF OCULAR AND PERIOCULAR DISORDERS  
Methods for treating ocular and periocular disorders by administration to a human patient of a therapeutically effective amount of a compound that modulates muscle action.
US20130273139 TRANSDERMAL DELIVERY SYSTEMS  
Disclosed are bupivacaine transdermal delivery systems, and related methods.
US20080131527 TOPICAL ANALGESIC COMPOSITION  
This invention concerns a synergistic combination of a topical anesthetic and wound barrier forming agent capable of providing extended analgesia of ‘significant open wounds’ (that being, for...
US20150072971 Methods for Treating Depressive Symptoms  
The present application relates methods for treating a depressive symptom comprising administering an effective amount of a μ opioid receptor agonist or a pharmaceutically acceptable salt thereof...
US20130197035 Surgical Adjuvant Composition and Associated Methods of Use  
Disclosed herein are surgical adjuvant compositions for ameliorating tissue and cellular necrosis and/or apoptosis. In addition, surgical methods are described which include the use of the...
US20090142400 ANALGESIC COATED MEDICAL PRODUCT  
Described are medical products including an analgesic such as lidocaine, bupivicaine, or a mixture thereof. Such medical products can find use in pain relief, particularly after surgery, and can...
US20110014258 GRADIENT COATING FOR BIOMEDICAL APPLICATIONS  
The present invention provides a coating comprising a bioactive material and an antimicrobial agent, wherein the concentration of said antimicrobial agent varies throughout the thickness of the...
US20130109698 Small Molecule Inhibitors of Functions of the HIV-1 Matrix Protein  
The present invention includes a method of inhibiting, suppressing or preventing retroviral infection in a subject in need thereof, comprising administering to the subject a pharmaceutical...
US20100305160 ANESTHETIC METHODS AND COMPOSITIONS  
The present invention relates to compositions and methods use in pain reduction, including but not limited to, peripheral nerve blocks. In particular, the present invention relates to compositions...
US20150126481 ADHESIVE PEEL-FORMING FORMULATIONS FOR DERMAL DELIVERY OF DRUGS AND METHODS OF USING THE SAME  
The present disclosure is drawn to an adhesive peel-forming formulation for dermal delivery of a drug, comprising a drug, a solvent vehicle, and a polymer peel-forming agent. The solvent vehicle...
US20130344132 SUSTAINED-RELEASE LIPOSOMAL ANESTHETIC COMPOSITIONS  
The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the...
US20130189349 SUSTAINED-RELEASE LIPOSOMAL ANESTHETIC COMPOSITIONS  
The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multi vesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the...
US20150126494 NON-RETINOID ANTAGONISTS FOR TREATMENT OF AGE-RELATED MACULAR DEGENERATION AND STARGARDT DISEASE  
A method for treating a disease characterized by excessive lipofuscin accumulation in the retina in mammals afflicted therewith, comprising administering to the mammal an effective amount of a...
US20120108592 PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF SALICYLANILIDES FOR TREATMENT OF HEPATITIS VIRUSES  
A new class of salicylanilides is described. These compounds show strong activity against hepatitis viruses.
US20150148379 Injectable Supersaturated Acetaminophen Solution for Spinal Administration  
The present invention relates to an acetaminophen injectable aqueous solution for use in the treatment or in the prevention of pain by spinal administration, wherein said acetaminophen injectable...
US20150111924 Controlled Delivery System  
The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local...
US20130289069 Controlled Delivery System  
The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local...
US20140105989 Treatment Methods with Low-Dose, Longer-Acting Formulations of Local Anesthetics and Other Agents  
Drug formulations that provide sustained action and/or reduced dosage requirements are provided. In the formulations the drugs (particularly local anesthetics) are associated with reversed cubic...
US20150140133 IN SITU CONTROLLED RELEASE DRUG DELIVERY SYSTEM  
A system is described for long-term controlled release delivery of a drug or a therapeutic agent. According to the invention, one or more drugs or therapeutic agents contained in microspheres are...
US20140329861 Neosaxitoxin Combination Formulations for Prolonged Local Anesthesia  
Since each of the site I sodium channel blockers have a unique activity and cannot be used to extrapolate the same effective dosage for another site I sodium channel blocker, studies were...
US20120059024 DRUG ABUSE DETERRENT, METHODS AND COMPOSITIONS  
The present invention relates generally to the field of pain management. More particularly, the present invention relates to analgesic combinations of an opioid and flupirtine or retigabine which...
US20150224093 Kits and Methods for Treating Post Traumatic Stress Disorder (PTSD) and Hot Flashes  
The present invention is directed to kits and methods for the treatment of a patient suffering from post-traumatic stress disorder (PTSD) and/or hot flashes by an administration of a mixture...
US20150196542 Kits and Methods for Treating Post Traumatic Stress Disorder (PTSD) and Hot Flashes  
The present invention is directed to kits and methods for the treatment of a patient suffering from post-traumatic stress disorder (PTSD) and/or hot flashes by an administration of a mixture...
US20150105425 Kits and Methods for Treating Post Traumatic Stress Disorder (PTSD) and Hot Flashes  
The present invention is directed to kits and methods for the treatment of a patient suffering from post-traumatic stress disorder (PTSD) and/or hot flashes by an administration of a mixture...
US20110046156 TREATMENT OF HEARING AND BALANCE IMPAIRMENTS WITH REDOX-ACTIVE THERAPEUTICS  
Compositions and methods are provided for prophylactic or therapeutic treatment of a mammal for hearing or balance impairments involving neuronal damage, loss, or degeneration, by administration...
US20130195965 METHOD FOR FORMULATING LARGE DIAMETER SYNTHETIC MEMBRANE VESICLES  
The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical...
US20130183373 METHOD FOR FORMULATING LARGE DIAMETER SYNTHETIC MEMBRANE VESICLES  
The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical...
US20130183372 METHOD FOR FORMULATING LARGE DIAMETER SYNTHETIC MEMBRANE VESICLES  
The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical...
US20130177638 METHOD FOR FORMULATING LARGE DIAMETER SYNTHETIC MEMBRANE VESICLES  
The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical...
US20130177637 METHOD FOR FORMULATING LARGE DIAMETER SYNTHETIC MEMBRANE VESICLES  
The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical...
US20130177636 METHOD FOR FORMULATING LARGE DIAMETER SYNTHETIC MEMBRANE VESICLES  
The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical...
US20130177634 METHOD FOR FORMULATING LARGE DIAMETER SYNTHETIC MEMBRANE VESICLES  
The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical...