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US20120035216 SMALL VOLUME ORAL TRANSMUCOSAL DOSAGE FORMS CONTAINING SUFENTANIL FOR TREATMENT OF PAIN  
Compositions, systems and methods for administration of small volume sufentanil drug dosage forms via the oral transmucosal route of a subject for treatment of pain.
US20150105424 SMALL VOLUME ORAL TRANSMUCOSAL DOSAGE FORMS CONTAINING SUFENTANIL FOR TREATMENT OF PAIN  
Compositions, systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject for treatment of pain using a device are disclosed.
US20130158074 SMALL VOLUME ORAL TRANSMUCOSAL DOSAGE FORMS CONTAINING SUFENTANIL FOR TREATMENT OF PAIN  
Compositions, methods and systems for administration of small volume sufentanil-containing drug dosage forms to the oral mucosa of a subject are disclosed.
US20150203477 COMPOUNDS AND METHODS FOR ACTIVATING THE APOPTOTIC ARM OF THE UNFOLDED PROTEIN RESPONSE  
N-substituted sulfonylphenyl-5-nitrofuranyl-2-carboxamide derived compounds, which selectively activate the apoptotic, but not the adaptive arm, of the Unfolded Protein Response are provides as is...
US20140107158 METHODS FOR TREATING COGNITIVE DISORDERS  
Disclosed herein are methods of treating a patient suffering a cognitive disorder.
US20120190712 Methods for Treating Cognitive Disorders  
Disclosed herein are methods of treating a patient suffering a cognitive disorder.
US20140350054 SMALL-VOLUME ORAL TRANSMUCOSAL DOSAGE FORMS  
Small-volume oral transmucosal dosage forms or NanoTabs® comprising a predetermined amount of a pharmaceutically active drug are provided. Exemplary applications include use of the NanoTabs® to...
US20130165481 SMALL-VOLUME ORAL TRANSMUCOSAL DOSAGE FORMS  
Small-volume oral transmucosal dosage forms or NanoTabs® comprising a predetermined amount of a pharmaceutically active drug are provided. Exemplary applications include use of the NanoTabs® to...
US20140316333 DISSOLVING SOLID SOLUTION PERFORATOR PATCH FOR MIGRAINE TREATMENT  
A dissolving solid solution perforator (SSP) patch for oral cavity administration may include at least one perforator. The at least one perforator may contain a first drug and be configured to...
US20110046136 METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCICATED THEREWITH  
The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of...
US20110230407 HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN DEMYELINATING DISEASES AND CENTRAL NERVOUS SYSTEM TRAUMA  
Methods are provided for treating and preventing demyelinating diseases including multiple sclerosis, and traumatic injury to the central nervous system including brain trauma and spinal cord...
US20100105735 Small Volume Oral Transmucosal Dosage Forms Containing Sufentanil for Treatment of Pain  
Compositions, methods and systems for administration of small volume sufentanil-containing drug dosage forms to the oral mucosa of a subject are disclosed.
US20110150766 Transdermal patch with fatal overdose protection  
A transdermal patch having a top region containing an antagonist followed by a bottom region containing an agonist, whereby the bottommost end of the bottom region is secured to the skin of the...
US20130131063 Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners  
The invention relates to isoxazolidine containing compounds that bind to bcl proteins and inhibit Bcl function. The compounds may be used for treating and modulating disorders associated with...
US20130245004 ACAMPROSATE FORMULATIONS, METHODS OF USING THE SAME, AND COMBINATIONS COMPRISING THE SAME  
Embodiments disclosed herein generally relate to acamprosate formulations, methods of use of the formulations, to methods of using the formulations in combination with at least one other...
US20140348819 Methods of Treating Cancer  
The present invention provides methods of treating cancer.
US20110195995 Methods of Optimizing Treatment of Estrogen-Receptor Positive Breast Cancers  
Estrogen-receptor positive and progesterone-receptor positive breast cancer treatment can be optimized by determining the level of expression of genes in a breast sample from a human having an...
US20150080349 MODULATION OF BACTERIAL QUORUM SENSING WITH SYNTHETIC LIGANDS  
The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for...
US20110269688 Genetic Alterations Associated with Schizophrenia and Methods of Use Thereof for the Diagnosis and Treatment of the Same  
Compositions and methods for the detection and treatment of schizophrenia are provided.
US20130203814 Association of Rare Recurrent Genetic Variations to Attention-Deficit, Hyperactivity Disorder (ADHD) and Methods of Use Thereof for the Diagnosis and Treatment of the Same  
Compositions and methods for the detection and treatment of ADHD are provided.
US20130287705 METHOD OF TREATING MUCOSAL INFLAMMATION  
A method of treating mucosal inflammation associated with a pathological condition in a mammal is provided. The method comprises the step of inhibiting 5-HT signaling at a target site in order to...
US20150158832 COMPOUNDS AND METHODS OF TREATING CANCER  
Presented herein inter alia are novel compounds and methods of using the same for the treatment of cancers.
US20150094520 METHOD OF INHIBITING C-KIT KINASE  
A method of reducing or inhibiting kinase activity of C-KIT in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or...
US20140005225 METHOD OF INHIBITING C-KIT KINASE  
A method of reducing or inhibiting kinase activity of C-KIT in a cell or a subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or...
US20130156761 Compounds Useful for Inhibiting Metastasis from Cancer and Methods Using Same  
The present invention includes compositions that are useful in preventing or treating metastasis in a subject diagnosed with cancer. The present invention also includes methods of preventing or...
US20150087628 COMPOSITIONS AND METHODS FOR TREATING CANCER  
K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer.
US20140249156 Treatment Of Blood Lipid Abnormalities And Other Conditions  
There is provided a method of treatment of a patient suffering from blood lipid abnormality comprises the administration of a GPR119 agonist.
US20120328580 COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION  
This invention generally provides compounds, pharmaceutical compositions, and methods for their use, which include methods that result in increased expression in an Atoh1 gene (e.g., Hath1) in a...
US20110166196 TREATMENT AND PROPHYLAXIS OF EPILEPSY AND FEBRILE SEIZURES  
Provided are methods for treatment and prophylaxis of convulsive disorders and seizures, such as epilepsy and febrile seizures, by modulating TRPV1 channel activation.
US20140356322 Compounds & Methods for the Enhanced Degradation of Targeted Proteins & Other Polypeptides by an E3 Ubiquitin Ligase  
The present invention relates to bifunctional compounds, which find utility as modulators of targeted ubiquitination, especially inhibitors of a variety of polypeptides and other proteins that are...
US20110111013 TRANSDERMAL THERAPEUTIC SYSTEM FOR ADMINISTRATION OF FENTANYL OR AN ANALOGUE THEREOF  
What is disclosed is a transdermal therapeutic system for administration of an active ingredient through the skin, comprising: (a) a back layer, (b) a reservoir present on the back layer,...
US20110112144 METHODS OF PREPARING SUBSTITUTED HETEROCYCLES  
The present disclosure relates to methods of preparing substituted thiophenes, which are useful for the treatment and prevention of cancers. Also disclosed are substituted thiophenes made by the...
US20140314791 METHODS OF TREATING CANCER  
The present invention provides methods of treating cancer, particularly cancers that are null or have decreased expression or activity of the Lkb1 gene. Also included are methods of identifying...
US20110065748 COMPOSITIONS AND METHODS FOR TREATING DISORDERS OF GASTROINTESTINAL MOTILITY  
Disclosed are methods of treating disorders of gastrointestinal motility by administering to a patient in need of such treatment a compound having the following formula:
US20140371238 COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS  
The invention relates to a compound of Formula I and methods of treating cystic fibrosis comprising the step of administering a therapeutically effective amount of a compound of Formula I or IA to...
US20130096160 ARYLTHIAZOLYL PIPERIDINES AND RELATED COMPOUNDS AS MODULATORS OF SURVIVAL MOTOR NEURON (SMN) PROTEIN PRODUCTION  
Aryl substituted thiazol-2-yl-piperidines and related compounds useful as modulators of survival motor neuron (SMN) protein production are provided herein. Without being bound to any particular...
US20140037622 HUMAN PAPILLOMA VIRUS AS PREDICTOR OF CANCER PROGNOSIS  
Methods of treating a head and neck cancer are disclosed.
US20120208848 GACYCLIDINE FORMULATIONS  
Improved formulations of gacyclidine for direct administration to the inner or middle ear.
US20110136870 GACYCLIDINE FORMULATIONS  
Improved formulations of gacyclidine for direct administration to the inner or middle ear.
US20150080296 Nutritive Fragments, Proteins and Methods  
Nutritive proteins are provided. In some embodiments the nutritive proteins comprise a protein digestibility corrected amino acid score (PDCAAS) that exceeds a benchmark protein. Also provided are...
US20120301430 THIOPHENE ANALOGUES FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS  
Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, and Z are as defined herein, are useful for treating flaviviridae viral infections.
US20080299080 Thiophene analogues for the treatment or prevention of flavivirus infections  
Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R1, X, Y, and Z are as defined herein, are useful for treating flaviviridae viral infections.
US20120295936 COMPOSITIONS AND METHODS FOR TREATING SEIZURE DISORDERS  
Disclosed are methods of treating a seizure disorder by administering to a patient in need of such treatment a compound having the following formula:
US20110065747 COMPOSITIONS AND METHODS FOR TREATING SEIZURE DISORDERS  
Disclosed are methods of treating a seizure disorder by administering to a patient in need of such treatment a compound having the following formula:
US20130267561 Substituted 1,3-Dioxanes Useful as PPAR Modulators  
Specifically useful stereoisomers of 1,3-dioxane derivatives are described and their use in the treatment of a disease or condition dependent on PPAR modulation, such as diabetes, cancer,...
US20120046242 MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY  
The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant...
US20150141397 SUBSTITUTED ANILINES AS CCR(4) ANTAGONISTS  
Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
US20130172315 SUBSTITUTED ANILINES AS CCR(4) ANTAGONISTS  
Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
US20140094462 SONIC HEDGEHOG MODULATORS  
Sonic Hedgehog modulators and methods of use thereof are provided for.
US20130150351 METHODS AND COMPOSITIONS FOR TREATING A SUBJECT FOR CENTRAL NERVOUS SYSTEM (CNS) INJURY  
Methods for treating a central nervous system (CNS) injury in a subject are provided. As of the methods include administering to the subject an effective amount of gamma aminobutyric acid (GABA)...