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US20150209353 |
APPLICATION OF 5-HT6 RECEPTOR ANTAGONISTS FOR THE ALLEVIATION OF COGNITIVE DEFICITS OF DOWN SYNDROME
Methods for treating Down syndrome and improving cognitive function of a patient with an intellectual disability are disclosed. 5-hydroxytryptamine sub-receptor six (5-HT6) receptor antagonists... |
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US20130210829 |
APPLICATION OF 5-HT6 RECEPTOR ANTAGONISTS FOR THE ALLEVIATION OF COGNITIVE DEFICITS OF DOWN SYNDROME
Methods for treating Down syndrome and improving cognitive function of a patient with an intellectual disability are disclosed. 5-hydroxytryptamine sub-receptor six (5-HT6) receptor antagonists... |
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US20150224104 |
METHODS FOR THE TREATMENT OF LOCALLY ADVANCED BREAST CANCER
Provided herein are methods of treating, preventing and/or managing locally advanced breast cancer, including inflammatory breast cancer, which comprise administering to a patient one or more... |
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US20110038832 |
METHOD FOR TREATMENT OF MACULAR DEGENERATION USING (+)-2-[1-(3-ETHOXY-4-METHOXYPHENYL)-2-METHYLSULFONYLETHYL]-4-ACETYLAMINOISOINDOLINE-1,3-DIONE
Provided herein are methods of treating macular degeneration, which comprises administering to a patient in need thereof a therapeutically effective amount of... |
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US20120028907 |
METHODS FOR IDENTIFICATION OF TUMOR PHENOTYPE AND TREATMENT
The disclosure relates to methods for identifying a tumor as an E2F-responsive gene over-expressing (ERGO) tumor, methods of determining the likelihood that an ERGO tumor patient will survive to a... |
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US20120178757 |
Method For The Prevention Of Cancer Metastasis
A method is provided for the prevention of cancer metastasis in a patient comprising administering an adrenergic receptor antagonist to a patient in need thereof. The invention also includes an... |
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US20120015906 |
USES OF BORTEZOMIB IN PREDICTING SURVIVAL IN MULTIPLE MYELOMA PATIENTS
The present invention provides a method of predicting outcome of treatment for multiple myeloma based on determining certain cytogenetic anomalies and considering gene expression profiling risks.... |
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US20140309195 |
SMALL MOLECULES THAT PROMOTE SKIN REGENERATION
Provided herein are small molecules for the induction of fibroblast proliferation and increased secretion or production of proteins. The small molecules described herein can be used for the... |
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US20140148485 |
NOVEL FORMULATIONS FOR TREATMENT OF MIGRANE
Systems and methods are described for treating un-met medical needs in migraine and related conditions such as cluster headache. Included are treatments that are both rapid onset and long acting,... |
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US20110039800 |
PROLONGED RELEASE BIOADHESIVE THERAPEUTIC SYSTEMS
The present invention concerns a prolonged release bioadhesive mucosal therapeutic system containing at least one active principle, with an active principle dissolution test of more than 70% over... |
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US20120046315 |
INTERMEDIATE AND ORAL ADMINISTRATIVE FORMATS CONTAINING LENALIDOMIDE
The invention relates to non-crystalline lenalidomide in the form of a storage-stable intermediate, i.e. preferably amorphous lenalidomide together with a surface stabiliser in the form of a... |
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US20110237563 |
FAST DISSOLVING DRUG DELIVERY SYSTEMS
The present invention related to the administration of bioactive agents via oral fast dispersing/dissolving drug delivery systems for treating illnesses of patient with critical buccal condition,... |
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US20130231311 |
NOVEL FORMULATIONS FOR TREATMENT OF MIGRAINE
Systems and methods are described for treating un-met medical needs in migraine and related conditions such as cluster headache. Included are treatments that are both rapid onset and long acting,... |
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US20110118189 |
NOVEL FORMULATIONS FOR TREATMENT OF MIGRAINE
Systems and methods are described for treating un-met medical needs in migraine and related conditions such as cluster headache. Included are treatments that are both rapid onset and long acting,... |
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US20110014205 |
METHODS AND COMPOSITIONS FOR TREATING CHRONIC PELVIC PAIN SYNDROME
The present invention provides methods and compositions for treating chronic pelvic pain syndrome. In particular, the present invention provides methods and compositions for treating chronic... |
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US20140171466 |
PAIN MANAGEMENT IN SICKLE CELL ANEMIA
The present invention relates to a method for the management of pain associated with sickle cell disease. In particular, the method comprises administering to a patient in need of such pain... |
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US20150018389 |
METHOD FOR TREATING PARKINSONS DISEASE AND OTHER NEUROLOGICAL DISEASES
A method for treating a central nervous system or peripheral nervous system dopaminergic deficit state in a mammalian organism in need of such treatment, said method comprising administering to... |
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US20140079813 |
Genes Associated With Post Relapse Survival And Uses Thereof
Provided are methods, systems and kits for predicting post-relapse survival of a cancer patient and for identifying cancer genes predictive of the post-relapse survival of the patient. Values... |
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US20110280808 |
Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins
The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and... |
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US20140221427 |
ISOTOPOLOGUES OF POMALIDOMIDE
Provided herein are pomalidomide, which is enriched with isotopes such as deuterium. Pharmaceutical compositions comprising the isotopes-enriched compounds, and methods of using such compounds are... |
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US20120064004 |
ISOTOPOLOGUES OF THALIDOMIDE
Provided herein are thalidomide, which is enriched with isotopes such as deuterium. Pharmaceutical compositions comprising the isotopes-enriched compounds, and methods of using such compounds are... |
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US20120053159 |
ISOTOPOLOGUES OF LENALIDOMIDE
Provided herein are lenalidomide, which is enriched with isotopes such as deuterium. Pharmaceutical compositions comprising the isotopes-enriched compounds, and methods of using such compounds are... |
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US20130039908 |
PROGNOSTIC MARKERS AND METHODS FOR PROSTATE CANCER
The present invention relates to methods and compositions for the diagnosis, prognosis and treatment of neoplastic disorders. Some embodiments include methods, compositions, and kits for the... |
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US20140187584 |
Substituted 2-(2,6-Dioxopiperidin-3-yl)-phthalimides and -1-Oxoisoindolines and Method of Reducing TNFalpha Levels
Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNFα in a mammal. |
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US20130030021 |
Substituted 2-(2,6-Dioxopiperidin-3-yl)-phthalimides and 1-Oxoisoindolines and Method of Reducing TNFalpha Levels
Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are disclosed. The compounds are useful, for example, in reducing the levels of TNFα in a mammal. |
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US20110152172 |
Methods of Treating Pulmonary Diseases and Disorders by Modulating Calcium/Calmodulin Dependent Protein Kinase II Activity
Disclosed are methods of treating or preventing a pulmonary disease or disorder in a subject, the methods comprising administering an effective amount of an compound that inhibits Calmodulin... |
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US20150087628 |
COMPOSITIONS AND METHODS FOR TREATING CANCER
K-Ras is the most frequently mutated oncogene in human cancer. Disclosed herein are compositions and methods for modulating K-Ras and treating cancer. |
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US20120009142 |
METHODS FOR TREATING HEPATITIS C
In accordance with the present invention, compounds that inhibit viral replication, preferably Hepatitis C Virus (HCV) replication, have been identified, and methods for their use provided. In one... |
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US20120294852 |
ANTAGONISTS OF IL-6 TO RAISE ALBUMIN AND/OR LOWER CRP
The present invention is directed to therapeutic methods using antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat cachexia, fever, weakness and/or fatigue in... |
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US20150259288 |
5-BROMO-INDIRUBINS
Disclosed herein are compositions and methods for treating cancer, FLT3-AML, and CML. |
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US20140274953 |
EX VIVO HUMAN MULTIPLE MYELOMA CANCER NICHE AND ITS USE AS A MODEL FOR PERSONALIZED TREATMENT OF MULTIPLE MYELOMA
The described invention provides an ex vivo dynamic multiple myeloma (MM) cancer niche contained in a microfluidic device. The dynamic MM cancer niche includes (a) a three-dimensional tissue... |
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US20110301198 |
COMPOSITIONS AND METHODS FOR TREATING MYELODYSPLASTIC SYNDROME
This invention generally relates to compositions and methods for treating myelodysplastic syndrome. In one embodiment, this invention relates to methods for treating myelodysplastic syndrome with... |
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US20140296292 |
METHODS AND COMPOSITIONS ASSOCIATED WITH THE GRANULOCYTE COLONY-STIMULATING FACTOR RECEPTOR
Some embodiments include compositions and methods of using or identifying compounds that modulate the activity of the granulocyte colony-stimulating factor receptor (GCFR). Some embodiments... |
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US20130203811 |
THALIDOMIDE AND THALIDOMIDE ANALOGUES FOR THE PREVENTION AND TREATMENT OF SARCOPENIA
The present invention relates to thalidomide and/or thalidomide analogues and methods for using same to maintain or increase muscle mass to prevent and/or treat sarcopenia. The invention also... |
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US20120045519 |
USE OF DEOXYELEPHANTOPIN (DET) AND ANALOGUES THEREOF FOR TREATMENT OF MELANOMA
Methods for treating melanoma in a subject in need thereof are disclosed. The method comprises administering to the subject a composition comprising a therapeutically effective amount of... |
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US20110158983 |
COMPOSITIONS AND METHODS FOR MUCOSITIS AND ONCOLOGY THERAPIES
In alternative embodiments, this invention provides compositions and methods for treating cancer or any condition caused by dysfunctional cells, side effects from treatments for cancer or any... |
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US20130058949 |
ANTAGONISTS OF IL-6 TO PREVENT OR TREAT THROMBOSIS
The present invention is directed to therapeutic methods using IL-6 antagonists such as antibodies and fragments thereof having binding specificity for IL-6 to prevent or treat thrombosis in... |
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US20150174114 |
METHODS FOR THE TREATMENT OF NON-HODGKIN'S LYMPHOMAS USING LENALIDOMIDE, AND GENE AND PROTEIN BIOMARKERS AS A PREDICTOR
Methods of treating or managing specific cancers, including non-Hodgkin's lymphoma, by the administration of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-d
ione are disclosed.... |
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US20110223157 |
METHODS FOR THE TREATMENT OF NON-HODGKIN'S LYMPHOMAS USING LENALIDOMIDE, AND GENE AND PROTEIN BIOMARKERS AS A PREDICTOR
Methods of treating or managing specific cancers, including non-Hodgkin's lymphoma, by the administration of 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-d
ione are disclosed.... |
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US20130209446 |
Copy Number Variant-Dependent Genes As Diagnostic Tools, Predictive Biomarkers And Therapeutic Targets
Provided herein are methods of diagnosing and/or treating malignant or pre-malignant conditions in a subject. Overexpression of copy number variant-dependent genes, e.g., genes encoding a cell... |
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US20110038856 |
METHODS OF TREATING NEOPLASTIC, AUTOIMMUNE AND INFLAMMATORY DISEASES
Methods of treating cancer and autoimmune and inflammatory diseases are provided. |
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US20110172273 |
METHODS OF TREATING MYELODYSPLASTIC SYNDROMES USING LENALIDOMIDE
Methods of treating, preventing and/or managing myelodysplastic syndromes are disclosed. Specific methods encompass the administrations of... |
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US20100310681 |
Modulation of KCNQ Potassium Channel Activity for Treatment of Psychiatric Disorders and the Symptoms Thereof
Disclosed herein are compositions and methods for treating a psychiatric disorder or symptoms thereof in a patient. The compositions comprise a compound that modulates KCNQ (Kv7) potassium channel... |
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US20130101615 |
METHODS FOR PREVENTING OR TREATING A DISEASE OR CONDITION ASSOCIATED WITH MYCOBACTERIUM AVIUM SUBSPECIES PARATUBERCULOSIS
This invention is a method for immunizing, preventing or treating a Mycobacterium avium subspecies paratuberculosis-associated disease or condition by screening subjects for markers indicative of... |
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US20120251496 |
EZATIOSTAT FOR TREATING MULTIPLE MYELOMA
Ezatiostat is useful for inhibiting multiple myeloma cell proliferation and treating multiple myeloma, alone or when added together with another anti-myeloma drug. |
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US20130303530 |
METHODS FOR TREATING CHRONIC PELVIC PAIN SYNDROME WITH ANTIBODIES THAT BINDS MCP-1 OR MIP-1A
The present invention provides methods and compositions for treating chronic pelvic pain syndrome. In particular, the present invention provides methods and compositions for treating chronic... |
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US20130053399 |
METHODS OF ADMINISTERING ANTIHISTAMINES
Methods of using combinations of antihistamines by administering an attenuated dosage amount of a first generation antihistamine for a quick onset concomitantly with a maintenance dosage amount of... |
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US20110178062 |
INDOLE AND BENZOTHIOPHENE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR
Certain substituted indole and benzothiophene compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases. |
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US20110136807 |
Bicyclic compositions and methods for modulating a kinase cascade
The invention relates to compounds and methods for modulating one or more components of a kinase cascade. |
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US20140024641 |
TREATMENT OF ORGANOPHOSPHATE EXPOSURE WITH TRIPTANS
A method of treating exposure to organophosphate agents and preventing morbidity due to such exposure through the administration of a triptan compound to a subject. |