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US20150023950 |
2,6-Diaminopyridine Compounds Suitable for Treating Diseases Associated with Amyloid or Amyloid-Like Proteins or for Treating or Preventing Ocular Diseases or Conditions Associated with a Pathological Abnormality/Change in the Tissue of the Visual System
The present invention relates to 2,6-diaminopyridine compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein and of diseases or... |
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US20140370076 |
TRANSDERMAL DRUG DELIVERY SYSTEM CONTAINING DONEPEZIL
The present invention provides a transdermal drug delivery system comprising donepezil or its pharmaceutically acceptable salt and method of making the same. |
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US20110281912 |
ORAL DISPERSIBLE TABLET
The present invention relates to an oral dispersible tablet comprising at least one filler selected from sugars and sugar alcohols, and microcrystalline cellulose. |
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US20110237563 |
FAST DISSOLVING DRUG DELIVERY SYSTEMS
The present invention related to the administration of bioactive agents via oral fast dispersing/dissolving drug delivery systems for treating illnesses of patient with critical buccal condition,... |
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US20130131028 |
METHODS FOR TREATMENT OF SLEEP-RELATED BREATHING DISORDERS
Described herein are methods for modulation of the activity of the carotid body that afford therapeutic benefit for sleep-related breathing disorders and related conditions. |
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US20110251239 |
COMBINATION THERAPY FOR THE TREATMENT OF DEMENTIA
Provided herein is a combination therapy useful for the treatment of Alzheimer's disease and Alzheimer's disease related dementia. The combination comprises memantine in an immediate or sustained... |
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US20110280808 |
Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins
The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and... |
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US20110218218 |
Formulations Of Indanylamines And The Use Thereof As Local Anesthetics And As Medication For Chronic Pain
Internal-dermal formulations of RS—, S—, or R-2-[2-(N-phenyl-N-2-indanyl)aminoethyl]piperidine causing intradermal accumulation of said piperidine and intended for the treatment of neuropathic... |
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US20110160246 |
Neurodegenerative Protein Aggregation Inhibition Methods and Compounds
Methods and compositions are provided for reducing aggregation of neurodegenerative proteins associated with neurotoxicity or other proteins. The compounds comprise a first domain or targeting... |
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US20120288560 |
Methods for the Treatment of CNS-Related Conditions
The invention provides methods for treating CNS-related conditions with amantadine and donepezil, in which the amantadine is in an extended release form, wherein the extended release amantadine... |
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US20110065749 |
METHOD AND PHARMACEUTICAL COMPOSITION FOR TREATMENT OF MENTAL DISORDERS
A method of treating a mental disorder including administering to a patient in need thereof, an effective amount of a pharmaceutical composition including 1,1-diphenyl-4-piperidine-1-ylbuthan-1-ol... |
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US20050222100 |
Treatment of post-menopausal complaints in breast cancer patients comprising tibolone and a serm
The subject invention provides a use of tibolone and a SERM for the manufacture of a medicine for the treatment of an estrogen-deficiency related complaint and for the prevention of a recurrence... |
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US20140134243 |
Compositions for the Treatment of CNS-Related Conditions
The invention provides methods for treating CNS-related conditions with amantadine and donepezil, in which the amantadine is in an extended release form, wherein the extended release amantadine... |
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US20140121193 |
METHODS FOR TREATING FIBROMYALGIA
The invention provides methods for treating or ameliorating cognitive dysfunction, fatigue, energy, concentration, mood, and pain associated with fibromyalgia using compositions containing... |
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US20110177061 |
METHODS OF TREATING AND PREVENTING NEUROLOGICAL DISORDERS USING DOCOSAHEXAENOIC ACID
The disclosure relates to methods of treating or preventing neurological disorders using docosahexaenoic acid. |
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US20140378440 |
BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS
The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present... |
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US20130090307 |
BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS
The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present... |
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US20130085122 |
BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS
The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present... |
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US20100311726 |
REDUCTION OF BETA-AMYLOID LEVELS BY TREATMENT WITH THE SMALL MOLECULE DIFFERENTIATION-INDUCING FACTOR
The present invention relates to novel uses for a family of small molecules, Differentiation-Inducing Factors (DIFs). It has been discovered that DIFs surprisingly can alter the metabolic... |
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US20140378439 |
MICRORNA BIOMARKERS INDICATIVE OF ALZHEIMER'S DISEASE
The invention provides a method of diagnosing Alzheimer's Disease in a subject, by determining the level of at least one miRNA in a sample derived from the subject, wherein a change in the level... |
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US20120264783 |
METHODS FOR THE TREATMENT OF CNS-RELATED CONDITIONS
The invention provides methods for administering extended release memantine in combination with immediate release donepezil to a subject. Memantine in an extended release form containing 22.5 to... |
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US20120148495 |
METHODS FOR TREATING NICOTINIC ACETYLCHOLINE RECEPTOR ASSOCIATED DISEASES
The present invention provides methods and compositions for treating subjects suffering from a disorder associated with a nicotinic acetylcholine receptor (nAChR), methods for treating a subject... |
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US20120214809 |
Aminoindane Compounds and Use Thereof in Treating Pain
The present application provides novel aminoindane compounds and methods for preparing and using these compounds. These compounds are useful in treating pain and/or itch in patients by... |
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US20150045389 |
COMPOUNDS AND METHODS FOR INHIBITING CIF VIRULENCE FACTOR
The present invention is a screening assay for identifying inhibitors of Pseudomonas aeruginosa CFTR Inhibitory Factor as well as compounds identified by the screening assay for use in... |
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US20150232444 |
THERAPEUTICS TARGETING TRUNCATED ADENOMATOUS POLYPOSIS COLI (APC) PROTEINS
The described invention provides small molecule anti-cancer compounds that selectively target and inhibit measurable biological activity of truncated APC proteins, an immortalized Human Colonic... |
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US20140051702 |
Use of Aminoindane Compounds in Treating Overactive Bladder and Interstitial Cystitis
The present application provides methods of using the aminoindane compounds of formula (I) or (II) in treating an overactive bladder or interstitial cystitis by administering one or more of the... |
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US20110212928 |
METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION
The invention relates to methods and compositions for improving cognitive function by using a combination of a synaptic vesicle protein 2A (SV2A) inhibitor and an acetylcholinesterase inhibitor... |
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US20120283267 |
COMPOSITIONS AND METHODS FOR THE TREATMENT OF GIARDIASIS
Methods of treating exposure to Giardia lamblia and/or giardiasis and methods of antagonizing Giardia lamblia attachment to the intestinal wall of a subject are described herein. |
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US20120129889 |
Non-competitive NMDA receptor antagonists
Disclosed herein are non-competitive NMDA receptor antagonists having chemical structures similar to that of phencyclidine (PCP). These antagonists contain a polycyclic ring structure in place of... |
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US20110189165 |
METHOD OF IDENTIFYING DISEASE RISK FACTORS
Provided herein is a method for identifying a genetic variant that is associated with development of a condition of interest (e.g., Alzheimer's disease), and genetic variants so identified.... |
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US20150025112 |
ORALLY DISINTEGRATING TABLET FORMULATIONS OF DONEPEZIL
The present invention relates to orally disintegrating tablet formulations of donepezil hydrochloride comprising magnesium aluminium silicate, and one or more pharmaceutically acceptable excipient... |
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US20110056863 |
ADHESIVE PREPARATION CONTAINING DONEPEZIL, AND PACKAGE OF THE SAME
[Object] An adhesive preparation containing donepezil is provided in which adhesive layer discoloration over time is inhibited. [Solution] The adhesive preparation containing donepezil has an... |
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US20120045508 |
METHOD AND COMPOSITION FOR ADMINISTERING AN NMDA RECEPTOR ANTAGONIST TO A SUBJECT
The invention provides methods and compositions for administering an NMDA receptor antagonist (e.g., memantine) to a subject. |
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US20120264782 |
COMPOSITIONS FOR THE TREATMENT OF CNS-RELATED CONDITIONS
The invention provides compositions comprising extended release memantine in combination with immediate release donepezil to a subject. Memantine in an extended release form containing 22.5 to 30... |
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US20110269717 |
NEUROGENESIS BY MODULATING ANGIOTENSIN
The instant invention describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The invention includes... |
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US20150051246 |
Treatment of Cognitive Impairment with Combination Therapy
Treatment of varying degrees of cognitive impairment associated with Alzheimer's disease with a combination of a phosphodiesterase 4 inhibitor and an acetylcholinestase inhibitor, including... |
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US20110092464 |
NEUROGENESIS BY MODULATING ANGIOTENSIN
The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The invention includes... |
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US20120010243 |
METHODS FOR TREATING DISORDERS OR DISEASES ASSOCIATED WITH HYPERLIPIDEMIA AND HYPERCHOLESTEROLEMIA WHILE MINIMIZING SIDE EFFECTS
The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an MTP inhibitor to... |
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US20120022070 |
Heat Shock Protein 90 Inhibitors, Methods Of Preparing Same, And Methods For Their Use
Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors are disclosed. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases and... |
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US20120029017 |
PECTIN-CONTAINING JELLY FORMULATION
There is disclosed a technique for making a jelly formulation comprising pectin slide out of a container easily (improving the slidability of the jelly formulation) when taking the formulation out... |
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US20110243998 |
PATCH PREPARATION AND PRODUCTION METHOD THEREOF
The invention provides a patch preparation containing (a) a support and (b) an adhesive layer containing a drug on the surface of the support, wherein a crystal of the drug is formed in the... |
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US20110171302 |
METHOD FOR TREATING NEURODEGENERATIVE DISORDERS WITH ORAL DOSAGE FORMULATION CONTAINING BOTH IMMEDIATE-RELEASE AND SUSTAINED-RELEASE DRUGS
Disclosed herein is a method for treating patient suffering from a disorder related to central nervous system with an oral dosage formulation that contains both sustained-release and... |
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US20120149693 |
THERAPEUTIC COMPOUNDS
The invention relates to protein binding interacting/binding compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for... |
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US20110059905 |
METHODS OF TREATING DISEASE-INDUCED ATAXIA AND NON-ATAXIC IMBALANCE
Methods for treatment of disease-induced ataxia and non-ataxic imbalance are disclosed. The methods involve treating a patient with a compound having nicotinic acetylcholine receptor activity. |
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US20120130147 |
METHODS FOR THE TREATMENT OF TUMORS WITH INDANE COMPOUNDS
Compounds of the formula (I), in which R1, R2, R3, R4, and q have the meanings indicated in Claim 1, can be employed, inter alia, for the treatment of tumours. |
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US20110319386 |
NEUROGENESIS BY MUSCARINIC RECEPTOR MODULATION
The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes... |
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US20130289019 |
METHODS OF TREATING BEHAVIORIAL AND/OR MENTAL DISORDERS
One embodiment of an aspect of the present invention is a method for lessening the symptoms of depression, anxiety, and post-traumatic stress disorder comprising the step of administering a... |
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US20130059003 |
SUSTAINED RELEASE DONEPEZIL FORMULATIONS
Sustained release formulations comprising donepezil, or its pharmaceutically acceptable salts, and methods of preparing the sustained release formulations. |
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US20110064804 |
Methods and Compositions for the Treatment of CNS-Related Conditions
The present invention provides novel methods and compositions for the treatment and prevention of CNS-related conditions. One of the CNS-related conditions treated by the methods and compositions... |
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US20120135971 |
ESTROGEN ANTAGONISTS AS TREATMENTS FOR SCLEROSING DISORDERS
The present invention relates to methods and compositions for treating a subject suffering from a sclerosing disorder, comprising administering, to the subject, an effective amount of an estrogen... |