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US20140213609 PROMOTING AXON RENEGERATION IN THE ADULT CNS THROUGH CONTROL OF PROTEIN TRANSLATION  
Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous...
US20100298348 Method of Decreasing Ubiquitylated Protein Levels  
The present invention provides a method of decreasing the level of ubiquitylated protein in a subject, the method comprising administering a heterocyclic compound disclosed herein or a...
US20130123228 PROMOTING AXON REGENERATION IN THE ADULT CNS THROUGH CONTROL OF PROTEIN TRANSLATION  
Survival of, or axon regeneration in a lesioned mature central nervous system (CNS) neuron is promoted by (a) contacting the neuron with a therapeutically effective amount of an exogenous...
US20110318345 NASAL DELIVERY  
substances and the nasal administration thereof, in particular as one of a liquid, as a suspension or solution, or a powder, to the nasal airway of a subject, in particular the posterior region of...
US20130231311 NOVEL FORMULATIONS FOR TREATMENT OF MIGRAINE  
Systems and methods are described for treating un-met medical needs in migraine and related conditions such as cluster headache. Included are treatments that are both rapid onset and long acting,...
US20110112132 MEANS FOR THE TREATMENT OF ACUTE AND CHRONIC DISORDERS OF CEREBRAL CIRCULATION, INCLUDING INSULT, BASED ON HYDROGENATED PYRIDO (4,3-B) INDOLES (VARIANTS), PHARMACOLOGICAL MEANS BASED THEREON AND METHOD FOR THE USE THEREOF  
A means for the treatment of insult based on hydrogenated pyrido(4,3-b)indoles (variants) of formula (1) or formula (2) a pharmacological means based thereon and a method for the use thereof...
US20140162964 USE IN BRAIN DEGENERATIVE DISEASES  
Disclosed is a new use for sphingosine-1-phosphate (S1P) receptor agonists in the treatment of progressive dementia or brain degenerative diseases.
US20120202801 METHODS FOR TREATING BREAST CANCER  
Methods for treating breast cancer involving the administration of a compound that selectively inhibits pathological production of human vascular endothelial growth factor (VEGF) are described....
US20110280808 Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-Like Proteins  
The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and...
US20110256064 Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-like Proteins  
The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and...
US20130108709 TREATMENT OF MITOCHONDRIA-RELATED DISEASES AND IMPROVEMENT OF AGE-RELATED METABOLIC DEFICITS  
Pharmaceutical compositions and methods for the treatment of subjects, including humans, who have or are at risk for various disease, disorders and conditions, including, mitochondria-associated...
US20140234443 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF  
Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and...
US20130310366 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF  
Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and...
US20120219641 5-HT3 RECEPTOR MODULATORS, METHODS OF MAKING, AND USE THEREOF  
Novel 5-HT3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and...
US20120059013 METHOD OF TREATING EARLY MORNING AKINESIA IN SUBJECTS HAVING PARKINSON'S DISEASE  
The present invention provides a method for treating early morning akinesia, comprising continuous administration to a patient in need of such treatment a therapeutically effective amount of a...
US20130197023 NEUROPROTECTION BY PHARMACOLOGICAL CHAPERONING OF NICOTINIC ACETYLCHOLINE RECEPTORS  
A method of ameliorating an endoplasmic reticulum (ER) stress response and/or unfolded protein response (UPR) in cells expressing nicotinic acetylcholine receptors (nAChRs) comprises contacting a...
US20120157400 METHODS FOR TREATING KAPOSI SARCOMA  
Methods for treating Kaposi's sarcoma involving the administration of a compound that selectively inhibits pathological production of human VEGF are described. The compound can be administered as...
US20120157402 METHODS FOR TREATING BRAIN TUMORS  
Methods for treating brain tumors involving the administration of a compound that selectively inhibits pathological production of human VEGF are described. The compound can be administered as a...
US20150157686 TREATMENTS OF OXIDATIVE STRESS CONDITIONS  
The present invention generally relates to systems and methods for treating certain oxidative stress conditions. In one aspect, compositions and methods of the invention can be used to treat a...
US20140235593 SUBSTITUTED 2-ALKYL-1-OXO-N-PHENYL-3-HETEROARYL-1,2,3,4-TETRAHYDROISOQUINOLINE-4-CARBOXAMIDES FOR ANTIMALARIAL THERAPIES  
In one aspect, the invention relates to novel substituted 2-alkyl-1-oxo-N-phenyl-3-heteroaryl-1,2,3,4-tetrahydroisoqui noline-4-carboxamides; synthetic methods for making the compounds;...
US20120184493 DERMAL FORMULATIONS OF DP2 RECEPTOR ANTAGONISTS  
Described herein are topical formulations for use in the treatment or prevention of dermatological diseases, disorders, or conditions in a mammal. Topical formulations disclosed herein include a...
US20140243348 COMPOSITIONS AND METHODS FOR TREATING HERPES VIRUSES  
Compositions and methods that are useful for the treatment of herpesvirus infection (including herpes simplex virii) are disclosed. Methods for identifying compounds useful for the treatment of...
US20150111919 COMPOSITIONS AND METHODS FOR TREATING MULTIPLE SCLEROSIS  
Described herein are compositions and methods for treating multiple sclerosis. In particular, described herein are compositions that include one or more dimebolins and/or pharmaceutically...
US20110195049 COMPOSITIONS AND METHODS FOR TREATING MULTIPLE SCLEROSIS  
Described herein are compositions and methods for treating multiple sclerosis. In particular, described herein are compositions that include one or more dimebolins and/or pharmaceutically...
US20110269777 METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA USING ANTIPSYCHOTIC COMBINATION THERAPY  
The present invention relates to combination therapies and methods for treating, preventing and/or delaying the onset and/or development of schizophrenia, wherein the combination therapies...
US20120071501 USE OF EXTRACTS OF THE GENUS CIMICIFUGA AS ORGANOSELECTIVE MEDICINES FOR TREATING DISEASES OF THE GENITOURINARY TRACT CAUSED BY SEX HORMONES  
The present invention relates to extracts from Cimicifuga species and particularly from Cimicifuga racemosa, which are suited for producing a ready-formulated drug for the selective treatment...
US20120178707 METHODS FOR TREATING PROSTRATE CONDITIONS  
Methods for treating prostate cancer involving the administration of a compound that selectively inhibits pathological production of human vascular endothelial growth factor (VEGF) are described....
US20140199291 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (PML)  
The invention relates to compositions, methods, and kits for treating subjects infected by or at risk of infection with a DNA virus (e.g., a JC Virus or a BK virus). Aspects of the invention are...
US20130183289 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (PML)  
The invention relates to compositions, methods, and kits for treating subjects infected by or at risk of infection with a DNA virus (e.g., a JC Virus or a BK virus). Aspects of the invention are...
US20140155369 PREVENTIVES/REMEDIES FOR STRESS URINARY INCONTINENCE AND METHOD OF SCREENING THE SAME  
An agent for the prophylaxis or treatment of stress urinary incontinence, which contains a substance that activates a serotonin 5-HT2C receptor, an agent for the prophylaxis or treatment of stress...
US20140127288 LIPOSOME CONTAINING PYRROLOQUINOLINE QUINONE AND SUGAR  
An object of the present invention is to provide a composition that enables extension of the concentration range in which pyrroloquinoline quinone exerts cell growth-promoting function, and an...
US20110178040 METHOD FOR TREATING FIBROSIS AND CANCER WITH IMIDAZOLIUM AND IMIDAZOLINIUM COMPOUNDS  
There is presently provided methods for delivering an anti-fibrotic or anti-cancer agent to a cell. The methods comprise contacting a cell with an effective amount of imidazolium and imidazolinium...
US20130190331 PYRIDO[4,3-B]INDOLES AND METHODS OF USE  
New heterocyclic compounds that may be used to modulate a histamine receptor in an individual are described. Pyrido[4,3-b]indoles are described, as are pharmaceutical compositions comprising the...
US20130190328 PYRIDO[4,3-B]INDOLES AND METHODS OF USE  
New heterocyclic compounds that may be used to modulate a histamine receptor in an individual are described. Pyrido[4,3-b]indoles are described, as are pharmaceutical compositions comprising the...
US20120172377 PYRIDO[4,3-B]INDOLES AND METHODS OF USE  
New heterocyclic compounds that may be used to modulate a histamine receptor in an individual are described. Pyrido[4,3-b]indoles are described, as are pharmaceutical compositions comprising the...
US20120136008 PYRIDO[4,3-B]INDOLES AND METHODS OF USE  
New heterocyclic compounds that may be used to modulate a histamine receptor in an individual are described. Pyrido[4,3-b]indoles are described, as are pharmaceutical compositions comprising the...
US20150133488 COMPOSITIONS AND METHODS FOR TREATING EPILEPSY  
Compositions and methods for treating epilepsy and epileptic syndromes are described herein. The compositions and methods include therapeutically effective amounts of one or more dimebolins, or...
US20110172262 COMPOSITIONS AND METHODS FOR TREATING EPILEPSY  
Compositions and methods for treating epilepsy and epileptic syndromes are described herein. The compositions and methods include therapeutically effective amounts of one or more dimebolins, or...
US20130190323 PYRIDO[3,4-B]INDOLES AND METHODS OF USE  
This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[3,4-b]indoles are described, as are pharmaceutical compositions...
US20130137705 PYRIDO[3,4-B]INDOLES AND METHODS OF USE  
This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[3,4-b]indoles are described, as are pharmaceutical compositions...
US20130131077 PYRIDO[3,4-B]INDOLES AND METHODS OF USE  
This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[3,4-b]indoles are described, as are pharmaceutical-compositions...
US20130123277 PYRIDO[3,4-B]INDOLES AND METHODS OF USE  
This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[3,4-b]indoles are described, as are pharmaceutical compositions...
US20130079352 PYRIDO[3,4-B]INDOLES AND METHODS OF USE  
This disclosure relates to new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Pyrido[3,4-b]indoles are described, as are pharmaceutical compositions...
US20130131099 COMPOUNDS AND METHODS OF TREATING BRAIN DISORDERS  
Nitrated and non-nitrated compounds capable of protecting brain tissue from injury and useful as therapeutic agents to treat neurodegenerative diseases and conditions are disclosed. Methods of...
US20140194429 COMPOSITIONS FOR TREATMENT OF CANCER  
Compounds that are specifically toxic to cancer stem cells are disclosed.
US20110160190 CARBOLINE DERIVATIVES USEFUL IN THE INHIBITION OF ANGIOGENESIS  
In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the...
US20150218180 Heterocyclic compounds and methods for their use  
The present invention relates to heterocyclic compounds useful for antagonising angiotensin II Type 2 (AT2) receptor. More particularly the invention relates to piperidine compounds, compositions...
US20140086918 Methods for Inhibiting Prostate Cancer  
The invention provides methods for reducing growth and/or metastasis of androgen-independent (castration resistant) prostate cancer in a tissue in an animal. In one embodiment the method comprises...
US20130171103 METHODS FOR TREATING VIRAL CONDITIONS  
Compounds that selectively inhibit viral replication or the production of viral RNA or DNA, viral protein or virus induced cytopathic effects and compositions comprising such Compounds are...
US20120202763 METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS  
Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral...