Matches 1 - 50 out of 139 1 2 3 >


Match Document Document Title
US20110046136 METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCICATED THEREWITH  
The present invention relates to functional proteins encoded by nucleic acid sequences comprising a nonsense mutation. The present invention also relates to methods for the production of...
US20110152272 Treatment Of Incontinence  
The present invention relates to the use of agonists of 5-HT2C receptors for the treatment of urinary incontinence, preferably mixed incontinence or stress urinary incontinence. The invention also...
US20120225854 COMPOUNDS THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES  
The present invention relates to compounds of Formula I, or pharmaceutically acceptable salts thereof, that interact with glucokinase regulatory protein. In addition, the present invention relates...
US20110212974 METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASE-ASSOCIATED BONE LOSS  
The present invention concerns a method for identifying a compound which inhibits the activation of RAC GTPase by DOCK5 protein comprising the steps of (i) coexpressing the DOCK5 and the RAC...
US20130109698 Small Molecule Inhibitors of Functions of the HIV-1 Matrix Protein  
The present invention includes a method of inhibiting, suppressing or preventing retroviral infection in a subject in need thereof, comprising administering to the subject a pharmaceutical...
US20150183776 DI- AND TRI-HETEROARYL DERIVATIVES AS INHIBITORS OF PROTEIN AGGREGATION  
The present invention relates to certain di- and tri-heteroaryl derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing,...
US20140194402 PYRUVATE KINASE ACTIVATORS FOR USE IN THERAPY  
Described herein are methods for using compounds that activate pyruvate kinase.
US20110183953 SELECTIVE HETEROCYCLIC SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS  
Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such...
US20130231326 SELECTIVE SPHINGOSINE 1 PHOSPHATE RECEPTOR MODULATORS AND METHODS OF CHIRAL SYNTHESIS  
Compounds that selectively modulate the sphingosine 1 phosphate receptor are provided including compounds which modulate subtype 1 of the S1P receptor. Methods of chiral synthesis of such...
US20130053372 5-HT RECEPTOR MODULATORS  
The invention relates to compounds of formula (I), useful for treating disorders mediated by the 5-hydroxytryptamine (serotonin) receptor IB (5-HT1B), e.g. vascular disorders, cancer and CNS...
US20120178713 PHENYL SULPHONAMIDES AS MODULATORS OF ION CHANNELS  
The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the...
US20110059984 HETEROCYCLES USEFUL AS MODULATORS OF ION CHANNELS  
The present invention relates to compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and...
US20130184278 APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES  
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic...
US20130177590 N-HYDROXYAMIDINOHETEROCYCLES AS MODULATORS OF INDOLEAMINE 2,3-DIOXYGENASE  
The present invention is directed to N-hydroxyamidino compounds which are modulators of indoleamine 2,3-dioxygenase (IDO), as well as pharmaceutical compositions thereof and methods of use thereof...
US20150197513 ARYL- AND HETEROARYL-SUBSTITUTED BENZENE DERIVATIVES AS MODULATORS OF PI3-KINASE SIGNALLING PATHWAYS  
The present disclosure relates to certain aryl- or heteroaryl-substituted benzene derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for...
US20130165433 Novel Use  
The present invention is directed to compounds for use in the treatment or prevention of influenza virus infection.
US20110275649 Combination therapy for the prevention of statin induced diabetes  
Novel combinations comprising HMG CoA reductase inhibitors, or statins, with partial fatty acid oxidation inhibitors (pFOXi), and methods for their use, are disclosed. These combinations are...
US20130217687 ARYLSULFONAMIDE CCR3 ANTAGONISTS  
Provided herein are arylsulfonamides that are useful for modulating CCR3 activity, and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing,...
US20080153846 Aminomethyl Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease  
The present invention is directed to aminomethyl compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is...
US20120328691 ANILINOPIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF  
The present invention relates to novel Anilinopiperazine Derivatives of Formula (I), compositions comprising the Anilinopiperazine Derivatives, and methods for using the Anilinopiperazine...
US20080070921 Diamine-Containing, Tetra-Substituted Piperazine Compounds Having Identical 1- and 4-Substituents  
There is provided compounds having the formula of structure I: wherein the groups —C(R8)(CH2)vCH(R9)(CH2)y-Q and —C(R8)(CH2)vCH(R9)(CH2)y-J are the same, and R1a, R1b, R2a, R2b, R8, R9, J, Q, W,...
US20110281885 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN  
A compound of formula: wherein A, Ar, R3, R6, and m are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Cyanoiminopiperazine Compound”), compositions comprising an effective...
US20140235586 COMPOUNDS FOR NONSENSE SUPPRESSION, AND METHODS FOR THEIR USE  
The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or...
US20110160164 COMPOUNDS FOR NONSENSE SUPPRESSION AND METHODS FOR THEIR USE  
The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or...
US20130237548 INJECTABLE EMULSION OF SEDATIVE HYPNOTIC AGENT  
Polymorphs of 7-methyl-5-(3-piperazin-1-ylmethyl-[1,2,4]oxadiazol-5-yl)-2- (4-trifluoromethoxybenzyl)-2,3-dihydroisoindol-1-one mesylate salt, methods of making these polymorphs and uses thereof.
US20060122191 N-(indolethyl-)cycloamine compounds  
N-(indolethyl-)cycloamine compounds of the formula (I): in which R1′, R1″ X, Ar, and n have a meaning indicated in Claim 1, are serotonin reuptake inhibitors (SSRIs) and effectors of the...
US20100010001 NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS  
Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-4-phosphate...
US20140288045 COVALENT INHIBITORS OF KRAS G12C  
Irreversible inhibitors of G12C mutant K-Ras protein are provided. Also disclosed are methods to modulate the activity of G12C mutant K-Ras protein and methods of treatment of disorders mediated...
US20050227994 Decomposition inhibitor for extracellular matrix of cartilage  
It is provided that a pharmaceutical composition inhibiting cartilage extracellular matrix degradation containing a compound of the formula (I): wherein R1 is hydroxy and the like; R2 is...
US20120094981 ANTHELMINTIC AGENTS AND THEIR USE  
This invention is directed to compounds of the formula (I) and salts therefore that are generally useful as anthelmintic agents or as intermediates in processes for making anthelmintic agents....
US20080306088 Metabotropic Glutamate Receptor Oxadiazole Ligands and Their Use as Potentiators 841  
Compounds of Formula I: wherein R1, R2, R3, R4 and Q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods...
US20110118264 PHENYL PIPERAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITION INCLUDING THE SAME AND USE THEREOF  
The present invention relates to novel piperazine derivatives or pharmaceutically acceptable salts thereof, a process for preparing the same, and in particular, a high binding for Serotonin...
US20110269772 AXL KINASE INHIBITORS  
Axl kinase inhibitory compounds are disclosed, as well as compositions and methods of using the same in the treatment of cancer and other conditions mediated by and/or associated with Axl kinase.
US20110263596 2-OXO-3-BENZYLBENZOXAZOL-2-ONE DERIVATIVES AND RELATED COMPOUNDS AS MET KINASE INHIBITORS FOR THE TREATMENT OF TUMOURS  
Described are compounds which inhibit, regulate and/or modulate kinase signal transduction, for example of Met kinase. The compounds are of the formulae A1 to A148 and B1 described herein,...
US20140296245 BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS  
This invention is directed to benzensulfonamide compounds, as stereoisomers, enantiomers, tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates or prodrugs thereof,...
US20080139534 Bisbenzamidines and bisbenzamidoximes for the treatment of human African trypanosomiasis  
Disclosed are bisbenzamidine and bisbenzamidoxime compounds useful for treatment of treatment of trypanosomiasis. The compounds disclosed are useful for treating mammals infected with parasitic...
US20140142112 THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN  
A compound of formula: wherein Ar1, A, R3, X, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a...
US20150080365 HETEROARYL COMPOUNDS WITH CYCLIC BRIDGING UNIT  
This invention relates to certain heteroaryl compounds for use as medicaments, more specifically as medicaments for treating animals. The medicament can be used for the treatment of helminth...
US20140303143 BENZOXAZOLINONE COMPOUNDS WITH SELECTIVE ACTIVITY IN VOLTAGE-GATED SODIUM CHANNELS  
Disclosed are compounds of Formula (A) or a salt thereof, wherein “Het”, Ra, and Rb are defined herein, which have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic...
US20110166155 Substituted Isoindolones and Their Use as Metabotropic Glutamate Receptor Potentiators  
The present invention is directed to compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined for formula I in the description. The invention also relates to...
US20110224187 PYRROLIDINE, PIPERIDINE AND PIPERAZINE DERIVATIVES AND METHODS OF USE THEREOF  
The present invention relates to novel Pyrrolidine, Piperidine and Piperazine Derivatives, pharmaceutical compositions comprising the Pyrrolidine, Piperidine and Piperazine Derivatives and the use...
US20120142700 MICROBIOCIDAL HETEROCYCLES  
The present invention relates to heterocyclic compounds of formula (I) which have microbiocidal activity, in particular fungicidal activity, as well as methods of using the compounds of formula...
US20090048219 ORGANIC NITRIC OXIDE DONOR SALTS OF NONSTEROIDAL ANTIINFLAMMATORY COMPOUNDS, COMPOSITIONS AND METHODS OF USE  
The invention describes novel organic nitric oxide enhancing salts of nonsteroidal antiinflammatory drugs (NSAIDs) and novel compositions comprising at least one organic nitric oxide enhancing...
US20120040933 9-(PIPERAZINYLALKYL) CARBAZOLES AS BAX-MODULATORS  
piperazine compounds for use as pharmaceutically active compounds and in pharmaceutical formulations that are useful for the treatment of disorders associated with apoptosis, including...
US20050203086 Methods of treatment using an EP2 selective receptor agonist  
The present invention relates to methods of treating pulmonary hypertension, facilitating joint fusion, facilitating tendon and ligament repair, reducing the occurrence of secondary fracture,...
US20150210679 SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION  
Disclosed are new small molecules and the uses thereof for inhibiting superoxide dismutase (SOD) expression. Also disclosed are pharmaceutical compositions comprising the small molecule inhibitors...
US20100029625 Therapeutic Agent for Restenosis  
A therapeutic and/or prophylactic agent for restenosis, which comprises a thiadiazoline derivative represented by the general formula (0), or a pharmaceutically acceptable salt thereof: [wherein,...
US20140011810 Compounds that Modulate EGFR Activity and Methods for Treating or Preventing Conditions Therewith  
Provided are compounds and methods for treating or preventing kinase-mediated disorders therewith.
US20110190255 HETEROCYCLIC COMPOUNDS  
Disclosed are compounds of Formula (I) or a stereoisomer or a pharmaceutically acceptable salt thereof, wherein: A is Q is a substituted 5-membered monocyclic heteroaryl group;W is CH2, O, or NH;...
US20100280082 Metabotropic Glutamate Receptor Oxadiazole Ligands and Their Use as Potentiators  
Compounds of Formula (I) wherein R1, R2, R3 R4 and Q are as described in the specification, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing and methods...

Matches 1 - 50 out of 139 1 2 3 >