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US20050043305 |
Aryl substituted pyridines, pyrimidines, pyrazines and triazines and the use thereof
This invention relates aryl substituted pyridines, pyrimidines, pyrazines and triazines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A1, A2, A3, R1—R4,... |
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US20120329786 |
COMPOUNDS AND THERAPEUTIC USES THEREOF
The invention relates to compounds, pharmaceutical compositions and methods useful for treating cancer, systemic or chronic inflammation, rheumatoid arthritis, diabetes, obesity, T-cell mediated... |
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US20100190731 |
METHODS FOR TREATING ACUTE MYOCARDIAL INFARCTIONS AND ASSOCIATED DISORDERS
The invention relates to methods of treating patients who have suffered an acute myocardial infarction (AMI) with a therapeutic that has anti-fibrotic effects, for example, pirfenidone and analogs... |
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US20070105858 |
RETINOIC ACID MIMETIC ANILIDES
The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X represents O, S... |
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US20060014743 |
Methods of preventing bacterial infections with florfenicol-type antibiotics
The present invention relates to novel florfenicol compounds having the chemical structure: wherein the compounds are useful for the treatment and/or prevention of bacterial infections in a broad... |
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US20150191454 |
MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
Cyclohexane derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions... |
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US20090286809 |
Preventives or remedies for alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound
The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general... |
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US20050192279 |
Pyridazinones as antagonists of alpha4 integrins
The present invention relates to certain novel compounds of Formula (I): methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of... |
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US20140349969 |
COMPOUNDS AND METHODS FOR TREATING PAIN
The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies. |
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US20080090829 |
SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS
The present invention is directed at substituted heteroaryl- and phenylsulfamoyl compounds, pharmaceutical compositions containing such compounds and the use of such compounds as peroxisome... |
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US20080009498 |
Phosphodiesterase inhibitors and nitric oxide donors, compositions and methods of use
The invention provides novel compositions containing at least one phosphodiesterase inhibitor, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous... |
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US20070135386 |
Novel Compounds and Compositions as Cathepsin Inhibitors
The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making. |
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US20100273807 |
Use of PDE III Inhibitors for the Treatment of Asymptomatic (Occult) Heart Failure
The invention relates to the use of a phosphodiesterase type III (PDE III) inhibitor or Ca2+-sensitizing agent or a pharmaceutically acceptable derivative thereof for the preparation of a... |
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US20150313215 |
PESTICIDAL MIXTURES
Mixtures comprising cis-jasmone and an agrochemical active ingredient are useful in agriculture. |
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US20130252924 |
Compounds and Methods for Treating Pain
The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies. |
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US20050209232 |
Pyridazinone ureas as antagonists of alpha4 integrins
The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating α4 integrin mediated... |
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US20160108011 |
Novel Substituted Bicyclic Aromatic Compounds as S-Nitrosoglutathione Reductase Inhibitors
The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such... |
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US20110275641 |
Preventives or remedies for Alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound
The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general... |
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US20110275640 |
Preventives or remedies for alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound
The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general... |
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US20150259327 |
Chemical Compounds
The present invention relates to new sulfonamide URAT-1 inhibitor compounds of formula (I) or a pharmaceutically acceptable salt thereof: to compositions containing them, to processes for their... |
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US20150065517 |
NEW COMPOUNDS
The present invention provides organic compounds of the following structure; A-L1-B-C-D-L2-E that are useful for treating or preventing conditions or disorders associated with DGAT1 activity in... |
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US20090270399 |
NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS
This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower... |
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US20090069332 |
NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS
This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower... |
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US20080119474 |
NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS
This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower... |
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US20070208025 |
NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS
This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower... |
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US20070049595 |
Novel pyridazine derivatives and medicines containing the same as effective ingredients
This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower... |
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US20050267113 |
Novel pyridazine derivatives and medicines containing the same as effective ingredients
This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower... |
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US20050065155 |
Novel pyridazine derivatives and medicines containing the same as effective ingredients
This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower... |
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US20100267754 |
INTEGRIN EXPRESSION INHIBITOR
The present invention provides an integrin expression inhibitor, and an agent for treating arterial sclerosis, psoriasis, cancer, retinal angiogenesis, diabetic retinopathy or inflammatory... |
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US20070032496 |
Compounds for the Treatment of Neurodegeneration and Stroke
Compounds and related methods for synthesis, and the use of compounds for the treatment of neurodegenerative diseases are disclosed. Compounds are disclosed in connection with PARG and/or PARP... |
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US20050222123 |
Cholinesterase inhibitors for treating inflammation
A method of treating a subject with a cytokine-mediated inflammatory disorder comprising administering to the subject an effective amount of a pharmaceutically acceptable cholinesterase inhibitor,... |
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US20100144674 |
PYRIDAZINE DERIVATIVES
The present invention relates to novel pyridazine derivatives of formula (I) as active ingredients which have microbiocidal activity, in particular fungicidal activity: wherein R1 is hydrogen,... |
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US20100048579 |
PYRIDAZINE-, PYRIDINE- AND PYRANE-DERIVATIVES AS GPBAR1 AGONISTS
A compound of formula (I) wherein the substituents have various meanings, optionally in salt and/or solvate form, and their use as pharmaceuticals. |
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US20150266861 |
Glucagon Receptor Modulators
The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4, L, B1, B2, B3 and B4 are as defined herein. The compounds... |
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US20130052281 |
NOVEL COMPOUNDS
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined in the specification, processes for their preparation,... |
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US20110152301 |
Compounds that Inhibit HIV Particle Formation
The present invention describes novel methods of identifying compounds which inhibit HIV particle formation and Rev-dependent HIV production. The present invention also provides methods and... |
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US20080269235 |
PYRIDAZIN-3 (2H) -ONE DERIVATIVES AS PDE4 INHIBITORS
New pyridazin-3(2H)-one derivatives having the chemical structure of general formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and... |
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US20050256122 |
Substituted pyridazinones
Disclosed are substituted pyridazinones that are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical composition... |
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US20110293640 |
Cholinesterase Inhibitors for Treating Inflammation
A method of treating a subject with a cytokine-mediated inflammatory disorder comprising administering to the subject an effective amount of a pharmaceutically acceptable cholinesterase inhibitor,... |
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US20090047243 |
COMBINATIONS FOR THE TREATMENT OF B-CELL PROLIFERATIVE DISORDERS
The invention features compositions and methods employing combinations of an A2A receptor agonist and a PDE inhibitor for the treatment of a B-cell proliferative disorder, e.g., multiple myeloma. |
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US20080207621 |
SOLUBLE EPOXIDE HYDROLASE INHIBITORS
Disclosed are sulfonamide compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such... |
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US20150065471 |
SALTS OF 5-[(1R)-2-(AMINO)-1-HYDROXYETHYL]-8-HYDROXYQUINOLIN-2(1H)-ONE
The present invention is directed to a pharmaceutically acceptable crystalline addition salt of 5-[(1R)-2-({2-[4-({4-(2,2-difluoro-2-phenylethoxy)phenyl]eth
yl}amino)-1-hydroxyethyl]-8-hydroxyquino... |
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US20160176900 |
SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS
Pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer. |
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US20130137683 |
PLANT DISEASE CONTROLLING COMPOSITION AND USE THEREOF
A plant disease controlling composition containing a pyridazine compound represented by formula (I): wherein R1 represents a chlorine atom, a bromine atom, a cyano group, or a methyl group, and R2... |
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US20130137658 |
PLANT DISEASE CONTROLLING COMPOSITION AND USE THEREOF
A plant disease controlling composition is provided containing a pyridazine compound represented by formula (I): wherein R1 represents a chlorine atom, a bromine atom, a cyano group or a methyl... |
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US20130023411 |
Pesticidal Mixtures Comprising Cyanosulfoximine Compounds
The invention relates to pesticidal mixtures comprising as active compounds 1) at least one cyanosulfoximine compound I of the formula I wherein R1, R2 and G are defined in the description; and 2)... |
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US20120157410 |
COMPOSITIONS AND TREATMENTS USING PYRIDAZINE COMPOUNDS AND CHOLINESTERASE INHIBITORS
The invention relates to compositions, conjugates and methods comprising pyridazine compounds and cholinesterase inhibitors for modulation of cellular pathways (e.g., signal transduction... |
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US20100210649 |
PYRIDAZINONES AND FURAN-CONTAINING COMPOUNDS
The present invention is directed to pyridazinone compounds of formula (I) and furan compounds of formula (II), pharmaceutical compositions of compounds of formula (I) and (II), kits containing... |
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US20070037813 |
Serine Protease Inhibitors
Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of... |
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US20070161617 |
Certain chemical entities, compositions and methods
Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including... |