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US20100286150 |
LEVOSIMENDAN FOR USE IN TREATING CHRONIC VALVULAR DISEASE
A method for the treatment of chronic valvular disease (CVD) in animals, particularly dogs, comprising administering to a subject in need thereof an effective amount of levosimendan or a... |
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US20110224128 |
METHODS AND COMPOSITIONS FOR TREATMENT OF MUSCULAR DYSTROPHY
The invention features methods, compositions, and kits useful for the treatment of muscular dystrophy, e.g., Duchenne muscular dystrophy, in a patient. |
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US20140349969 |
COMPOUNDS AND METHODS FOR TREATING PAIN
The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies. |
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US20130252924 |
Compounds and Methods for Treating Pain
The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies. |
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US20080194567 |
Combination Treatment for Enhancing Diuresis
A combination therapy for promoting diuresis in a patient comprises administering levosimendan or its active metabolite or any of their pharmaceutically acceptable salts in conjunction with a... |
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US20110263530 |
Aurora Kinase Modulators and Method of Use
The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R3, R4, R6, R7 and R8 are defined herein, which are capable of modulating... |
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US20110301166 |
METHOD FOR THE PREVENTION OF THROMBOEMBOLIC DISORDERS
A method for the prevention of thrombotic, embolic and/or hemorrhagic disorders, such as cerebral infarction (stroke) or myocardial infarction, by administering levosimendan or its metabolite (II)... |
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US20050255096 |
Combination treatment for acute myocardial infarction
A combination therapy for the treatment of acute myocardial infarction comprises administering a combination of a thrombolytic agent and levosimendan or a pharmaceutically acceptable salt thereof... |
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US20130090307 |
BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS
The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present... |
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US20130085122 |
BACLOFEN AND ACAMPROSATE BASED THERAPY OF NEUROLOGICAL DISORDERS
The present invention relates to combinations and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present... |
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US20120108592 |
PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF SALICYLANILIDES FOR TREATMENT OF HEPATITIS VIRUSES
A new class of salicylanilides is described. These compounds show strong activity against hepatitis viruses. |
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US20150025061 |
GABAA RECEPTOR ANTAGONISTS AFFECTING GANGLION CELL FUNCTION AND VISUAL ACUITY
The present invention is directed to a method of enhancing visual acuity in a subject, comprising intravitreally administering to the subject in need of such enhancement, a therapeutically... |
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US20110263567 |
COMPOUNDS FOR INHIBITING SEMICARBAZIDE-SENSITIVE AMINE OXIDASE (SSAO) / VASCULAR ADHESION PROTEIN-1 (VAP-1) AND USES THEREOF FOR TREATMENT AND PREVENTION OF DISEASES
The present invention relates to compounds of general formula (i) having an oxime moiety or a pharmaceutically acceptable salt, hydrate or solvate thereof and its use for inhibiting... |
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US20130303548 |
INDICATION FOR USE OF NIACIN (NICOTINIC ACID) FOR TREATMENT, PREVENTION AND REVERSAL OF FATTY LIVER DISEASE
Niacin prevents and/or reverses the development of experimental hepatic steatosis, deposition of triglycerides in liver and serum of individuals, deposition of total cholesterol in liver and serum... |
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US20130079328 |
COMPOSITIONS AND METHODS FOR MODULATING THE WNT SIGNALING PATHWAY
The present invention relates to compositions and methods for modulating the Wnt signaling pathway, using compounds having Formula (1) and (3): wherein A, B, Y and Z all represent rings, and R1,... |
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US20110152301 |
Compounds that Inhibit HIV Particle Formation
The present invention describes novel methods of identifying compounds which inhibit HIV particle formation and Rev-dependent HIV production. The present invention also provides methods and... |
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US20140038927 |
COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS
The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present... |
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US20120058992 |
THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF ANGIOGENESIS
The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that... |
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US20120071483 |
THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER DISEASE AND RELATED DISORDERS THROUGH A MODULATION OF CELL STRESS RESPONSE
The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More particularly, the invention relates to combined therapies that... |
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US20130237545 |
PYRIDAZINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING COGNITIVE IMPAIRMENT
This invention relates to pyridazine derivatives, compositions comprising therapeutically effective amounts of those pyridazine derivatives and methods of using those derivatives or compositions... |
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US20070191365 |
3,4,6-Substituted pyridazines for treating neuropathic pain and associated syndromes
The present invention is directed to the use of 3,4,6-substituted pyridazines such as those characterized by structure I for treating conditions such as neuropathic pain among others. |
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US20150191454 |
MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
Cyclohexane derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions... |
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US20110245251 |
MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO
Cyclohexane derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions... |
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US20080146543 |
Angiotensin II receptor antagonist for the prevention or treatment of systemic diseases in cats
The present invention relates to a method of prophylaxis or treatment of systemic diseases in cats, wherein the method comprising administration of a therapeutically effective amount of... |
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US20070299064 |
Pesticidal Heterocyclic Dihaloallyl Compounds
The invention relates to compounds of formula wherein Het, A1, A2, A3, A4, D, W, T, Q, Y, X1, X2, R1, R2, R3, R4, k and m are as defined hereinabove, and, where applicable, to possible E/Z... |
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US20120065165 |
COMPOSITIONS AND METHODS OF TREATING ENDOTHELIAL DISORDERS
Compositions and methods of treating endothelial disorders, including: asthma, erectile dysfunction, pulmonary hypertension, cardiovascular disorders, and other disorders, using a synergistic... |
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US20100317665 |
Anti-Inflammatory And Protein Kinase Inhibitor Compositions And Related Methods For Downregulation Of Detrimental Cellular Responses And Inhibition Of Cell Death
A novel class of pyridazine compositions and related methods of use. |
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US20050070529 |
Use of type 4 phosphodiesterase inhibitors in myocardial diseases
The invention relates to the use of type 4 phosphodiesterase inhibitors to treat myocardial diseases. |
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US20060287318 |
Method for treating glaucoma III B
Provided, among other things, is a method of decreasing intraocular pressure or improving ocular accommodation in an animal, including a human, comprising administering an intraocular pressure... |
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US20140357614 |
Diamino-Pyridine, Pyrimidine, and Pyrazine Modulators of the Histamine H4 Receptor
Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders,... |
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US20110092474 |
Diamino-pyridine, pyrimidine, and pyrazine modulators of the histamine H4 receptor
Diamino-pyridine, pyrimidine and pyridazine compounds which may be used as H4 receptor modulators, and in pharmaceutical compositions and methods for the treatment of disease states, disorders,... |
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US20060063774 |
Phosphodiesterase inhibitor compounds and nitric oxide donors
The invention provides phosphodiesterase inhibitors and/or nitric oxide donors that are useful in treating male impotence, female sexual dysfunction and anal diseases. |
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US20140213598 |
SUBSTITUTED CYANOANILINE COMPOUNDS, PREPARATION AND USE THEREOF
Disclosed is a substituted cyanoaniline compound or a salt thereof, wherein the compound has a structure represented by General Formula I. The compound of General Formula I has broad-spectrum... |
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US20090306081 |
Solid Dosage Formulations of Hydralazine Compounds and Nitric Oxide Donor Compounds
The invention provides solid dosage formulations, methods of making and using the formulations comprising at least one hydralazine compound or a pharmaceutically acceptable salt thereof, and at... |
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US20130029999 |
MYOSIN LIGHT CHAIN KINASE INHIBITOR COMPOUNDS, COMPOSITIONS AND RELATED METHODS OF USE
Pyridazinyl compounds, compositions and related methods of use. |
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US20070191373 |
Heterocyclic compounds for use in the treatment of viral infections
6-substituted-3-substituted-3H-furo[2,3-d]pyrimidin-2-one and 6-substituted-2-substituted-furo[2,3-d]pyrimidine novel compounds are useful in the treatment of viral infection, in particular... |
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US20150224105 |
HETEROCYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEURODEGENERATIVE TAUOPATHIES
The present invention is directed to triazolopyrimidine, phenylpyrimidine, pyridopyridazine, and pyridotriazine compounds which are microtubule-stabilizing compounds and their use in the treatment... |
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US20090137609 |
VITAMIN D-LIKE COMPOUND
The present invention provides a compound represented by the following general formula (I): or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing such a compound,... |
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US20120270836 |
THERAPEUTIC APPROACHES FOR TREATING ALZHEIMER'S DISEASE
The present invention relates to compositions and methods for the treatment of Alzheimer's disease and related disorders. More specifically, the present invention relates to novel combinatorial... |
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US20120028988 |
USE OF PYRIDAZINONE COMPOUND FOR CONTROL OF HARMFUL ARTHROPOD PESTS
Since a pyridazinone compound shown by formula (I) has an activity for controlling arthropod pests, the pyridazinone compound is effective for a use for controlling arthropod pests. |
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US20110065686 |
CHEMICAL COMPOUNDS HAVING ANTIVIRAL ACTIVITY AGAINST DENGUE VIRUS AND OTHER FLAVIVIRUSES
Use of chemical compounds obtained in silico for the preparation of pharmaceutical compositions to attenuate or inhibit Dengue virus infection. Particularly, through the interference or the... |
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US20100190731 |
METHODS FOR TREATING ACUTE MYOCARDIAL INFARCTIONS AND ASSOCIATED DISORDERS
The invention relates to methods of treating patients who have suffered an acute myocardial infarction (AMI) with a therapeutic that has anti-fibrotic effects, for example, pirfenidone and analogs... |
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US20050065154 |
Treatment of migraine accompanied by nausea with a combination of cyclooxygenase-2 selective inhibitors and anti-nausea agents
The present invention is related to the treatment or prevention of migraine accompanied by nausea or vomiting with a combination of a cyclooxygenase-2 selective inhibitor and an anti-nausea agent. |
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US20070219201 |
COMBINATION OF ATOMOXETINE AND A 5HT1A RECEPTOR AGONIST FOR TREATING ADHD AND OTHER DISORDERS
This invention relates to combinations of atomoxetine, and a 5HT1A receptor agonists, kits containing such combinations, pharmaceutical compositions comprising such combinations, and methods of... |
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US20110269715 |
ABNORMAL CANNABIDIOLS AS AGENTS FOR LOWERING INTRAOCULAR PRESSURE
The present invention provides a method of treating glaucoma or ocular hypertension which comprises applying to the eye of a person in need thereof an amount sufficient to treat glaucoma or ocular... |
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US20100077512 |
Pyridazin-4-ylmethyl-sulfonamides used as Fungicides and Against Arthropods
The present invention relates to novel pyridazin-4-ylmethyl-sulfonamide compounds (I) and to their N-oxides, their agriculturally acceptable salts and their veterinarily acceptable salts and also... |
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US20050004124 |
THERAPIES RELATING TO COMBINATIONS OF ALDOSE REDUCTASE INHIBITORS AND CYCLOOXYGENASE-2 INHIBITORS
This invention relates to pharmaceutical compositions and kits comprising pyridazinone compounds and cyclooxygenase-2 inhibitors, therapeutic methods of treatment or prevention of certain... |
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US20070232586 |
Hydrazino-Substituted Heterocyclic Nitrile Compounds and Use Thereof
A compound having an inhibitory activity against cysteine protease, represented by formula (I): (wherein ring X is a heterocyclic group which may contain 1 to 4 hetero atoms selected from an... |
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US20130059848 |
CANNABINOID-2 AGONISTS
The present specification discloses cannabinoid-2 agonists, compositions comprising such cannabinoid-2 agonists, and methods of treating an individual suffering from a disease by administering... |
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US20100004247 |
COMBINATION COMPRISING A MEK INHIBITOR AND AN AURORA KINASE INHIBITOR 188
The present invention relates to a therapeutic combination comprising a MEK inhibitor and an Aurora kinase inhibitor, and to methods for the production of an anti-cancer effect in a patient, which... |