Matches 1 - 50 out of 217 1 2 3 4 5 >

AcclaimIP-ad

Match Document Document Title
US20050043305 Aryl substituted pyridines, pyrimidines, pyrazines and triazines and the use thereof  
This invention relates aryl substituted pyridines, pyrimidines, pyrazines and triazines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein A1, A2, A3, R1—R4,...
US20120329786 COMPOUNDS AND THERAPEUTIC USES THEREOF  
The invention relates to compounds, pharmaceutical compositions and methods useful for treating cancer, systemic or chronic inflammation, rheumatoid arthritis, diabetes, obesity, T-cell mediated...
US20100190731 METHODS FOR TREATING ACUTE MYOCARDIAL INFARCTIONS AND ASSOCIATED DISORDERS  
The invention relates to methods of treating patients who have suffered an acute myocardial infarction (AMI) with a therapeutic that has anti-fibrotic effects, for example, pirfenidone and analogs...
US20070105858 RETINOIC ACID MIMETIC ANILIDES  
The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X represents O, S...
US20060014743 Methods of preventing bacterial infections with florfenicol-type antibiotics  
The present invention relates to novel florfenicol compounds having the chemical structure: wherein the compounds are useful for the treatment and/or prevention of bacterial infections in a broad...
US20150191454 MODULATORS OF THE PROSTACYCLIN (PGI2) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO  
Cyclohexane derivatives of Formula Ia and pharmaceutical compositions thereof that modulate the activity of the PGI2 receptor. Compounds of the present invention and pharmaceutical compositions...
US20090286809 Preventives or remedies for alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound  
The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general...
US20050192279 Pyridazinones as antagonists of alpha4 integrins  
The present invention relates to certain novel compounds of Formula (I): methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of...
US20140349969 COMPOUNDS AND METHODS FOR TREATING PAIN  
The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies.
US20080090829 SUBSTITUTED HETEROARYL- AND PHENYLSULFAMOYL COMPOUNDS  
The present invention is directed at substituted heteroaryl- and phenylsulfamoyl compounds, pharmaceutical compositions containing such compounds and the use of such compounds as peroxisome...
US20080009498 Phosphodiesterase inhibitors and nitric oxide donors, compositions and methods of use  
The invention provides novel compositions containing at least one phosphodiesterase inhibitor, and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous...
US20070135386 Novel Compounds and Compositions as Cathepsin Inhibitors  
The present invention relates to novel cathepsin S inhibitors, the pharmaceutically acceptable salts and N-oxides thereof, their uses as therapeutic agents and the methods of their making.
US20100273807 Use of PDE III Inhibitors for the Treatment of Asymptomatic (Occult) Heart Failure  
The invention relates to the use of a phosphodiesterase type III (PDE III) inhibitor or Ca2+-sensitizing agent or a pharmaceutically acceptable derivative thereof for the preparation of a...
US20150313215 PESTICIDAL MIXTURES  
Mixtures comprising cis-jasmone and an agrochemical active ingredient are useful in agriculture.
US20130252924 Compounds and Methods for Treating Pain  
The present invention relates to new therapies to treat pain and related diseases, as well as pharmaceutical compounds for use in said therapies.
US20050209232 Pyridazinone ureas as antagonists of alpha4 integrins  
The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating α4 integrin mediated...
US20160108011 Novel Substituted Bicyclic Aromatic Compounds as S-Nitrosoglutathione Reductase Inhibitors  
The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such...
US20110275641 Preventives or remedies for Alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound  
The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general...
US20110275640 Preventives or remedies for alzheimer's disease, or amyloid protein fibril-formation inhibitors, which include a nitrogen-containing heteroaryl compound  
The present invention relates to preventives or remedies for Alzheimer's disease, or to amyloid protein fibril-formation inhibitors, which include as an active ingredient a compound of general...
US20150259327 Chemical Compounds  
The present invention relates to new sulfonamide URAT-1 inhibitor compounds of formula (I) or a pharmaceutically acceptable salt thereof: to compositions containing them, to processes for their...
US20150065517 NEW COMPOUNDS  
The present invention provides organic compounds of the following structure; A-L1-B-C-D-L2-E that are useful for treating or preventing conditions or disorders associated with DGAT1 activity in...
US20090270399 NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS  
This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower...
US20090069332 NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS  
This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower...
US20080119474 NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS  
This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower...
US20070208025 NOVEL PYRIDAZINE DERIVATIVES AND MEDICINES CONTAINING THE SAME AS EFFECTIVE INGREDIENTS  
This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower...
US20070049595 Novel pyridazine derivatives and medicines containing the same as effective ingredients  
This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower...
US20050267113 Novel pyridazine derivatives and medicines containing the same as effective ingredients  
This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower...
US20050065155 Novel pyridazine derivatives and medicines containing the same as effective ingredients  
This invention relates to pyridazine derivatives represented by the formula (1): wherein R1 represents a (substituted) aryl group, R2 represents a phenyl group substituted at 4-position by a lower...
US20100267754 INTEGRIN EXPRESSION INHIBITOR  
The present invention provides an integrin expression inhibitor, and an agent for treating arterial sclerosis, psoriasis, cancer, retinal angiogenesis, diabetic retinopathy or inflammatory...
US20070032496 Compounds for the Treatment of Neurodegeneration and Stroke  
Compounds and related methods for synthesis, and the use of compounds for the treatment of neurodegenerative diseases are disclosed. Compounds are disclosed in connection with PARG and/or PARP...
US20050222123 Cholinesterase inhibitors for treating inflammation  
A method of treating a subject with a cytokine-mediated inflammatory disorder comprising administering to the subject an effective amount of a pharmaceutically acceptable cholinesterase inhibitor,...
US20100144674 PYRIDAZINE DERIVATIVES  
The present invention relates to novel pyridazine derivatives of formula (I) as active ingredients which have microbiocidal activity, in particular fungicidal activity: wherein R1 is hydrogen,...
US20100048579 PYRIDAZINE-, PYRIDINE- AND PYRANE-DERIVATIVES AS GPBAR1 AGONISTS  
A compound of formula (I) wherein the substituents have various meanings, optionally in salt and/or solvate form, and their use as pharmaceuticals.
US20150266861 Glucagon Receptor Modulators  
The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, A1, A2, A3, A4, L, B1, B2, B3 and B4 are as defined herein. The compounds...
US20130052281 NOVEL COMPOUNDS  
The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined in the specification, processes for their preparation,...
US20110152301 Compounds that Inhibit HIV Particle Formation  
The present invention describes novel methods of identifying compounds which inhibit HIV particle formation and Rev-dependent HIV production. The present invention also provides methods and...
US20080269235 PYRIDAZIN-3 (2H) -ONE DERIVATIVES AS PDE4 INHIBITORS  
New pyridazin-3(2H)-one derivatives having the chemical structure of general formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and...
US20050256122 Substituted pyridazinones  
Disclosed are substituted pyridazinones that are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical composition...
US20110293640 Cholinesterase Inhibitors for Treating Inflammation  
A method of treating a subject with a cytokine-mediated inflammatory disorder comprising administering to the subject an effective amount of a pharmaceutically acceptable cholinesterase inhibitor,...
US20090047243 COMBINATIONS FOR THE TREATMENT OF B-CELL PROLIFERATIVE DISORDERS  
The invention features compositions and methods employing combinations of an A2A receptor agonist and a PDE inhibitor for the treatment of a B-cell proliferative disorder, e.g., multiple myeloma.
US20080207621 SOLUBLE EPOXIDE HYDROLASE INHIBITORS  
Disclosed are sulfonamide compounds and compositions that inhibit soluble epoxide hydrolase (sEH), methods for preparing the compounds and compositions, and methods for treating patients with such...
US20150065471 SALTS OF 5-[(1R)-2-(AMINO)-1-HYDROXYETHYL]-8-HYDROXYQUINOLIN-2(1H)-ONE  
The present invention is directed to a pharmaceutically acceptable crystalline addition salt of 5-[(1R)-2-({2-[4-({4-(2,2-difluoro-2-phenylethoxy)phenyl]eth yl}amino)-1-hydroxyethyl]-8-hydroxyquino...
US20160176900 SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS  
Pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.
US20130137683 PLANT DISEASE CONTROLLING COMPOSITION AND USE THEREOF  
A plant disease controlling composition containing a pyridazine compound represented by formula (I): wherein R1 represents a chlorine atom, a bromine atom, a cyano group, or a methyl group, and R2...
US20130137658 PLANT DISEASE CONTROLLING COMPOSITION AND USE THEREOF  
A plant disease controlling composition is provided containing a pyridazine compound represented by formula (I): wherein R1 represents a chlorine atom, a bromine atom, a cyano group or a methyl...
US20130023411 Pesticidal Mixtures Comprising Cyanosulfoximine Compounds  
The invention relates to pesticidal mixtures comprising as active compounds 1) at least one cyanosulfoximine compound I of the formula I wherein R1, R2 and G are defined in the description; and 2)...
US20120157410 COMPOSITIONS AND TREATMENTS USING PYRIDAZINE COMPOUNDS AND CHOLINESTERASE INHIBITORS  
The invention relates to compositions, conjugates and methods comprising pyridazine compounds and cholinesterase inhibitors for modulation of cellular pathways (e.g., signal transduction...
US20100210649 PYRIDAZINONES AND FURAN-CONTAINING COMPOUNDS  
The present invention is directed to pyridazinone compounds of formula (I) and furan compounds of formula (II), pharmaceutical compositions of compounds of formula (I) and (II), kits containing...
US20070037813 Serine Protease Inhibitors  
Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of...
US20070161617 Certain chemical entities, compositions and methods  
Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including...
Matches 1 - 50 out of 217 1 2 3 4 5 >