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US20140073632 TREATING PROTEIN FOLDING DISORDERS WITH SMALL MOLECULE CFTR CORRECTORS  
Novel CFTR corrector compounds that are effective in rescuing halide efflux in a cell are provided. Also provided are methods for treating protein folding disorders (e.g., cystic fibrosis). The...
US20110263601 METHODS OF TREATING ULCERATIVE COLITIS  
Methods are disclosed for treating ulcerative colitis and related diseases and disorders, which comprise inhibiting tryptophan hydroxylase (TPH) in patients in need thereof.
US20150147376 COLOR-STABILIZED IODOPROPYNYL BUTYLCARBAMATE  
Microparticles containing an ultraviolet light absorbing polymer and 3-iodo-2-propynyl butylcarbamate (“IPBC”) resist discoloration by sunlight and other ultraviolet light sources. Methods for...
US20110201602 PROTEIN KINASE MODULATORS AND METHOD OF USE  
The present invention relates to chemical compounds having a general formula I wherein A, B, D, E, G, H1-5 and R1-4 are defined herein, and synthetic intermediates, which are capable of modulating...
US20100317664 METHODS OF AFFECTING GASTROINTESTINAL TRANSIT AND GASTRIC EMPTYING, AND COMPOUNDS USEFUL THEREIN  
Methods and compounds are disclosed for affecting gastrointestinal motility and gastric emptying, which comprise inhibiting tryptophan hydroxylase (TPH) in patients in need thereof
US20140135281 METHODS FOR CONTROLLING VARROA MITES  
The present invention relates to methods and compositions comprising cyromazine for the control of bee mites and for the reduction of bee mite infestations, such as the control and reduction of...
US20120157400 METHODS FOR TREATING KAPOSI SARCOMA  
Methods for treating Kaposi's sarcoma involving the administration of a compound that selectively inhibits pathological production of human VEGF are described. The compound can be administered as...
US20150210652 Substituted Triazines for Malaria Treatment and Chemoprophylaxis  
Disclosed herein are triazine compounds and methods of making and using thereof to treat malaria, provide chemoprophylaxis, and/or treat or inhibit infection by one or more Plasmodium spp.
US20110301108 MATERIALS AND METHODS FOR SENSITIZING MULTIDRUG RESISTANT CELLS  
Disclosed herein are materials and methods for sensitizing multidrug resistant cancer cells that express ABCG2 and related proteins members of a family of ATP-binding transporter superfamily that...
US20120157402 METHODS FOR TREATING BRAIN TUMORS  
Methods for treating brain tumors involving the administration of a compound that selectively inhibits pathological production of human VEGF are described. The compound can be administered as a...
US20130195997 FUNGICIDAL MIXTURES  
The invention relates to a method of controlling fungi and spores and to compositions suitable for this purpose and their use. The compositions according to the invention comprise trifloxystrobin,...
US20140066430 AURORA KINASE MODULATORS AND METHOD OF USE  
The present invention relates to chemical compounds having a general formula I wherein A1, A2, C1, C2, D, L1, L2, Z and R3, R4, R6, R7 and R8 are defined herein, which are capable of modulating...
US20110319418 PROKINETICIN 1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN  
Disclosed are compounds, compositions and methods for treating pain, including inflammatory, visceral, and acute pain. Such compounds are represented by Formula (I) as follows: wherein A1, L1, D,...
US20110319400 PROKINETICIN 1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN  
Disclosed are compounds, compositions and methods for treating pain, including inflammatory, visceral, and acute pain. Such compounds are represented by Formula (I) as follows: wherein A1, L1, D,...
US20130102597 COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS  
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound,...
US20120231090 MOLECULAR BIOMARKER SET FOR EARLY DETECTION OF OVARIAN CANCER  
Embodiments of the present invention concern methods and compositions related to detection of ovarian cancer, including detection of the stage of ovarian cancer, in some cases. In particular, the...
US20140100230 METHODS AND COMPOSITIONS FOR TREATING ANXIETY  
Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
US20110319417 METHODS AND COMPOSITIONS FOR TREATING ANXIETY  
Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
US20140255386 MICRORNA MODULATORS AND METHOD FOR IDENTIFYING AND USING THE SAME  
The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is...
US20120083498 Modulators of Viral Transcription, and Methods and Compositions Therewith  
Processes to treat human immunodeficiency virus (HIV) infection are included.
US20120178707 METHODS FOR TREATING PROSTRATE CONDITIONS  
Methods for treating prostate cancer involving the administration of a compound that selectively inhibits pathological production of human vascular endothelial growth factor (VEGF) are described....
US20150230469 COMPOSITIONS AND METHODS FOR CONTROL OF SAND FLIES AND OTHER BLOOD SUCKING INSECTS  
The invention relates to a new rapid release oral formulation of fipronil or imidacloprid for the effective control of blood-sucking insect populations. Embodiments of the invention relate to...
US20150150878 Methods For Inhibiting Viruses By Targeting Cathepsin-L Cleavage Sites In The Viruses' Glycoproteins  
The disclosure provides methods and compositions useful for inhibiting virus requiring membrane fusion for viral entry, specifically for inhibiting severe acute respiratory syndrome coronavirus...
US20140194429 COMPOSITIONS FOR TREATMENT OF CANCER  
Compounds that are specifically toxic to cancer stem cells are disclosed.
US20150126510 Triazines With Suitable Spacers for Treatment And/Or Prevention of HIV Infections  
The present invention relates to the field of HIV-1 infections, and in particular provides novel compounds containing triazine rings and suitable spacers. The compounds according to this invention...
US20120202763 METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS  
Compounds that selectively inhibit pathological production of human vascular endothelial growth factor (VEGF) and compositions comprising such Compounds are described. Compounds that inhibit viral...
US20140193519 INDIBULIN THERAPY  
The invention provides combination therapy, wherein one or more other therapeutic agents are administered with indibulin or a pharmaceutically acceptable salt thereof and the combination is...
US20150056193 EGFR AND ROS1 KINASE IN CANCER  
The present disclosure provides methods of that include detecting in a biological sample from a patient having or suspected of having cancer the presence of a polypeptide having ROS1 kinase...
US20140288080 THERAPEUTIC METHODS AND AGENTS FOR TREATING MYOTONIC DYSTROPHY  
The invention provides compounds, compositions and methods for treating myotonic dystrophy. The compounds can selectively bind to CUG repeats in RNA, or to CTG repeats in DNA, and inhibit...
US20130261124 THERAPEUTIC METHODS AND AGENTS FOR TREATING MYOTONIC DYSTROPHY  
The invention provides compounds, compositions and methods for treating myotonic dystrophy. The compounds can selectively bind to CUG repeats in RNA, or to CTG repeats in DNA, and inhibit...
US20150238498 COMPOUNDS FOR THE TREATMENT OF PARAMOXYVIRUS VIRAL INFECTIONS  
Disclosed herein are new antiviral compounds, together with pharmaceutical compositions that include one or more antiviral compounds, and methods of synthesizing the same. Also disclosed herein...
US20120202818 UREIDOPHENYL SUBSTITUTED TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS  
The present invention provides Uredophenyl substituted triazine derivatives and provides methods of using these compounds to modulate protein kinases and methods of using these compounds to treat...
US20090041751 Sepsis Prevention Through Adenosine Receptor Modulation  
Methods for treating sepsis or septic shock in a patient comprising administering to said patient a therapeutically effective amount of a composition containing an adenosine A2a receptor antagonist.
US20150126512 Modulators Of TNF-Alpha Signaling  
The present invention provides compounds which are modulators of TNF-α signaling and methods of use thereof for treating a patient having a TNF-α mediated condition. The compounds can be...
US20130310388 Modulators of TNF-Alpha Signaling  
The present invention provides compounds which are modulators of TNF-α signaling and methods of use thereof for treating a patient having a TNF-α mediated condition. The compounds can be...
US20120178697 Compositions and methods for the inhibition of dishevelled proteins  
The Wnt signaling pathways are involved in embryo development as well as in tumorigenesis. Dishevelled (Dvl) tranduces Wnt signals from the receptor Frizzled (Fz) to downstream components in...
US20130090326 Antimicrobial Compounds and Methods of Making and Using the Same  
The present invention relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, and reducing the risk...
US20130096100 DI(ARYLAMINO)ARYL COMPOUND  
The present invention provides a compound which is useful as an inhibitor against the kinase activity of EML4-ALK fusion proteins and mutant EGFR proteins. As a result of extensive and intensive...
US20140343347 METHODS AND RELATED COMPOSITIONS FOR THE TREATMENT OF CANCER  
A method of treatment and/or prevention of cancer comprises administering agents which cause increased intracellular granularity in cancer cells, at least in an amount sufficient to inhibit...
US20150240306 METHODS AND SYSTEMS FOR MONITORING, DIAGNOSING, AND TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE  
A novel set of 98 genes expressed in the respiratory tract epithelium that serve as biomarkers for measuring chronic obstructive pulmonary disease (COPD) activity are provided. Methods of...
US20090306080 VETERINARY FORMULATION  
The present invention relates to a liquid veterinary formulation comprising a stable solution of cyromazine, or a pharmaceutically acceptable salt thereof, in a solvent system which may comprise...
US20120142647 Novel Compounds as Respiratory Stimulants for Treatment of Breathing Control Disorders or Diseases  
The present invention includes compositions that are useful in the treatment of breathing control diseases or disorders in a subject in need thereof. The present invention also includes a method...
US20110071115 PHARMACEUTICALLY USEFUL HETEROCYCLE-SUBSTITUTED LACTAMS  
The invention provides compounds that inhibit CK2 and/or Pim kinases and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders...
US20110183954 TRICYCLIC 2,4-DIAMINO-L,3,5-TRIAZINE DERIVATIVES USEFUL FOR THE TREATMENT OF CANCER AND MYELOPROLIFERATIVE DISORDERS  
The present invention relates to compounds of Formula (I): (I) and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds provide a...
US20150105377 Methods and Compositions for RAF Kinase Mediated Diseases  
The invention discloses methods and compositions for treating or preventing RAF kinase mediated diseases or conditions by administering a compound of Formula 1: or a pharmaceutically acceptable...
US20130252818 AMORPHOUS BIOINORGANIC IONIC LIQUID COMPOSITIONS COMPRISING AGRICULTURAL SUBSTANCES  
An amorphous formulation of a herbicidal or pesticidal substance includes a composition of the formula [A]x[MpClq]y, the composition being an ionic liquid with a melting temperature below 150° C.,...
US20120178758 STYRYL-TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS  
The invention provides Styryl-Triazine derivatives, and further provides methods of using these compounds to modulate protein kinases and to treat protein kinase mediated diseases.
US20150111857 COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT  
Compounds and compositions useful for treating disorders related to KIT and PDFGR are described herein.
US20140323488 DISUBSTITUTED TRIAZINE DIMERS FOR TREATMENT AND/OR PREVENTION OF INFECTIOUS DISEASES  
The present invention relates to novel compounds (I) containing two disubstituted triazine rings covalently linked by an organic linker, thereby creating dimers. These compounds show activity...
US20150057285 BENZYL SUBSTITUTED TRIAZINE DERIVATIVES AND THEIR THERAPEUTICAL APPLICATIONS  
The invention provides triazine compounds and methods of their use to modulate protein kinases and to treat diseases mediated by said protein kinases.