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US20120231015 FRAGILE X MENTAL RETARDATION PROTEIN (FMRP), COMPOSITIONS, AND METHODS RELATED THERETO  
The invention relates to fragile X mental retardation protein (FMKP), compositions, and methods related thereto. In certain embodiments, the invention relates to treating a neurological disorder...
US20110206783 P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN  
The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or...
US20110150766 Transdermal patch with fatal overdose protection  
A transdermal patch having a top region containing an antagonist followed by a bottom region containing an agonist, whereby the bottommost end of the bottom region is secured to the skin of the...
US20130131028 METHODS FOR TREATMENT OF SLEEP-RELATED BREATHING DISORDERS  
Described herein are methods for modulation of the activity of the carotid body that afford therapeutic benefit for sleep-related breathing disorders and related conditions.
US20110256064 Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-like Proteins  
The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and...
US20110098267 TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS  
The invention relates to a topical composition and a method for treating psoriasis. The topical composition comprises one or more compound that inhibits the production of IL-12 and IL-23.
US20060069096 Pyrazolo[3,4-e]benzoxazoles for the treatment of glaucoma  
Pyrazolo[3,4-e]benzoxazoles and analogues thereof for lowering intraocular pressure and treating glaucoma are disclosed.
US20150182532 COMPOSITIONS AND METHODS OF TREATING CELL PROLIFERATION DISORDERS  
The invention relates to compounds and methods for treating cell proliferation disorders.
US20110065705 Compositions and Methods of Treating Cell Proliferation Disorders  
The invention relates to compounds and methods for treating cell proliferation disorders.
US20110281872 COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF CANCER  
The invention relates to compositions and methods for the treatment and prevention of cancer and other cell proliferative disorders.
US20140235637 COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS  
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound,...
US20130102597 COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS  
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound,...
US20120309742 USE OF METABOTROPIC GLUTAMATE RECEPTORS  
The invention concerns the use an mGluR modulator, e.g. an mGluR5 modulator, for the treatment, prevention or delay of progression of cognitive dysfunction.
US20150141397 SUBSTITUTED ANILINES AS CCR(4) ANTAGONISTS  
Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
US20130172315 SUBSTITUTED ANILINES AS CCR(4) ANTAGONISTS  
Aniline compounds are provided which bind to CCR(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.
US20140038948 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR  
Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.
US20110112055 COMPOSITIONS AND METHODS FOR TREATING COLITIS  
Disclosed herein are compositions and methods for treating colitis and other inflammatory bowel diseases, inter alia, indeterminate colitis, Crohn's disease, irritable bowel syndrome and ischemic...
US20120270874 Biaryl Compositions and Methods for Modulating a Kinase Cascade  
The invention relates to compounds and methods for modulating one or more components of a kinase cascade. The invention relates to compounds of the formula I: or a pharmaceutically acceptable salt...
US20110237586 BIARYL COMPOSITIONS AND METHODS FOR MODULATING A KINASE CASCADE  
The invention relates to compounds and methods for modulating one or more components of a kinase cascade. The invention relates to compounds of the formula I: or a pharmaceutically acceptable salt...
US20120214809 Aminoindane Compounds and Use Thereof in Treating Pain  
The present application provides novel aminoindane compounds and methods for preparing and using these compounds. These compounds are useful in treating pain and/or itch in patients by...
US20150099747 Methods and Compositions For Detecting Mutation in the Human EZH2 Gene  
The invention comprises reagents and methods for detecting cancer-associated mutations in the human EZH2 gene. Further, a method of detecting the mutations and a method of treatment are disclosed.
US20140128393 Methods of Treating Cancer  
The present invention relates to methods of treating cancer by administering the EZH2 inhibitor compounds and pharmaceutical compositions to subjects in need thereof. The present invention also...
US20110117055 Methods of Treating Hepatitis C Virus with Oxoacetamide Compounds  
Provided herein are hepatitis C virus entry inhibitor oxoacetamide compounds, pharmaceutical compositions thereof, and methods for their use in treatment or prevention of hepatitis C virus...
US20150232444 THERAPEUTICS TARGETING TRUNCATED ADENOMATOUS POLYPOSIS COLI (APC) PROTEINS  
The described invention provides small molecule anti-cancer compounds that selectively target and inhibit measurable biological activity of truncated APC proteins, an immortalized Human Colonic...
US20140051702 Use of Aminoindane Compounds in Treating Overactive Bladder and Interstitial Cystitis  
The present application provides methods of using the aminoindane compounds of formula (I) or (II) in treating an overactive bladder or interstitial cystitis by administering one or more of the...
US20150080381 METHODS OF TREATING ALOPECIA AND ACNE  
Method of treating alopecia and acne with are disclosed. The compounds fall within described by formula I or II:
US20120238547 2, 3, 6 - TRIAMINO SUBSTITUTED PYRIDINES AS KV7 (KCNQ) CHANNEL MODULATORS  
The present application relates to novel substituted aminopyridine derivatives, to their use in therapy, to pharmaceutical compositions comprising the derivatives, to the use of said derivatives...
US20140213587 Biaryl Compositions and Methods for Modulating a Kinase Cascade  
The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
US20140378430 Heterocyclic Compounds and Methods of Their Use  
The present invention relates to heterocyclic compounds useful for antagonising angiotensin II Type 2 (AT2) receptor. More particularly the invention relates to pyrrolidine and azetidine...
US20120101073 Novel Method For Treating Breathing Disorders or Diseases  
The present invention includes a method of treating a respiratory disease or disorder in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a...
US20140066426 FLUOROMETHYL-SUBSTITUTED PYRROLE CARBOXAMIDES  
The invention relates to pyrrole carboxamides bearing a fluoromethyl-moiety as voltage gated calcium channel blockers, to pharmaceutical compositions containing these compounds and also to these...
US20140323460 Methods for Using Carboxamide, Sulfonamide and Amine Compounds  
Disclosed are uses of carboxamide, sulfonamide and amine compounds for the treatment and amelioration of disorders and conditions related to oxidative stress, mitochondrial dysfunction, free...
US20110245222 Methods for Using Carboxamide, Sulfonamide and Amine Compounds  
Disclosed are uses of carboxamide, sulfonamide and amine compounds for the treatment and amelioration of disorders and conditions related to oxidative stress, mitochondrial dysfunction, free...
US20130053385 METHOD OF COMBATING AND CONTROLLING PESTS  
The use of a compound of formula I wherein the substituents are as defined in claim 1, or compositions containing them in controlling insects, acarines, nematodes or molluscs.
US20120196857 Modulators of Muscarinic Receptors  
The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic...
US20120004226 Modulators of Muscarinic Receptors  
The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic...
US20130017255 Tamper Resistant Dosage Form Comprising an Adsorbent and an Adverse Agent  
Pharmaceutical compositions and dosage forms comprising an adsorbent, and an adverse agent, such as an opioid antagonist. In one embodiment, at least a portion of the adverse agent is on the...
US20140275037 SULFONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES  
Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically...
US20120022027 SULFONYL SEMICARBAZIDES, SEMICARBAZIDES AND UREAS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS FOR TREATING HEMORRHAGIC FEVER VIRUSES, INCLUDING INFECTIONS ASSOCIATED WITH ARENAVIRUSES  
Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain novel semicarbazides, sulfonyl carbazides, ureas and related compounds in therapeutically...
US20140128395 Novel Method  
There is provided inter alia a compound which is an NK-1 receptor antagonist for use in the treatment or prevention of CNV. There is also provided a compound which is an NK-1 antagonist for use in...
US20150045363 Hedgehog Pathway Inhibition for Cartilage Tumor and Metachondromatosis Treatment  
Hedgehog pathway inhibitors, such as small molecules, are used to prevent, slow, block the formation of cartilage tumors as well as exostosis or enchondromas.
US20090318451 MORPHOLINE DOPAMINE AGONISTS FOR THE TREATMENT OF PAIN  
The present invention relates to use of a compound of formula (I), (Ia), or (Ib): wherein A, B, Z, R1 and R2 have the meanings given in the specification, as a medicament for the treatment of a...
US20140155400 METHODS AND COMPOSITIONS FOR TYPING MOLECULAR SUBGROUPS OF MEDULLOBLASTOMA  
Immunohistochemical methods and compositions for the typing of molecular subgroups of medulloblastomas are provided. The methods comprise determining a protein expression profile for a sample...
US20150080364 CARBAMATE COMPOUNDS AND OF MAKING AND USING SAME  
Provided herein are carbamate compounds which may be useful in the treatment of for example, pain, solid tumors and/or obesity.
US20150133297 NEW ANTIFUNGAL COMPOSITIONS  
The present invention relates to new antifungal compositions and their use in the treatment of agricultural products.
US20120220568 Histamine-3 Receptor Antagonists  
This invention is directed to a compound of formula I, wherein R1, R2, R4, R5, R6, R7, R8 and n are as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition...
US20150240306 METHODS AND SYSTEMS FOR MONITORING, DIAGNOSING, AND TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE  
A novel set of 98 genes expressed in the respiratory tract epithelium that serve as biomarkers for measuring chronic obstructive pulmonary disease (COPD) activity are provided. Methods of...
US20100179115 USE OF A GLUCOCORTICOID RECEPTOR II ANTAGONIST TO TREAT DEPRESSION IN PATIENTS TAKING IL-2  
The invention pertains to the discovery that type II glucocorticoid receptor antagonists can be used in methods for reversing or inhibiting the symptoms of depression in patients receiving...
US20110124633 Heterocyclic Compounds, Methods of Making Them and Their Use in Therapy  
In part, the present invention is directed to antibacterial compounds.
US20110112064 Pyridyl Amide T-Type Calcium Channel Antagonists  
The present invention is directed to pyridyl amide compounds which are antagonists of T-type calcium channels, and which are useful in the treatment or prevention of disorders and diseases in...