Matches 1 - 50 out of 202 1 2 3 4 5 >


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US20110256064 Novel Compounds for the Treatment of Diseases Associated with Amyloid or Amyloid-like Proteins  
The present invention relates to novel compounds that can be employed in the treatment of a group of disorders and abnormalities associated with amyloid protein, such as Alzheimer's disease, and...
US20110098267 TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS  
The invention relates to a topical composition and a method for treating psoriasis. The topical composition comprises one or more compound that inhibits the production of IL-12 and IL-23.
US20150030587 HUMAN PAPILLOMA VIRUS AS PREDICTOR OF CANCER PROGNOSIS  
Methods of treating a head and neck cancer are disclosed.
US20140037622 HUMAN PAPILLOMA VIRUS AS PREDICTOR OF CANCER PROGNOSIS  
Methods of treating a head and neck cancer are disclosed.
US20140221366 Substituted Azaheterocycles for the Treatment of Cancer  
The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
US20150231269 DELIVERY OF THERAPEUTIC COMPOUNDS WITH IRON OXIDE NANOPARTICLES  
The present invention relates to the field of drug delivery, in particular the delivery of unmodified cargo molecules (such as doxorubicin and Taxol®) using iron oxide nanoparticles as therapeutic...
US20140314785 COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY  
The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of...
US20120065198 Detection and Treatment of Schizophrenia  
The present invention provides a method for diagnosing schizophrenia, and a schizophrenia diagnostic reagent or device for use in the method. The present invention further provides a therapeutic...
US20110028470 Detection and Treatment of Schizophrenia  
The present invention provides a method for diagnosing schizophrenia, and a schizophrenia diagnostic reagent or device for use in the method. The present invention further provides a therapeutic...
US20120100227 KINASE PROTEIN BINDING INHIBITORS  
The invention relates to protein binding inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating a...
US20150094303 Niacin Mimetics, and Methods of Use Thereof  
Disclosed are heterocyclylalkyl-substituted and heteroaralkyl-substituted pyridines, and pharmaceutically acceptable salts and prodrugs thereof, that are active against a range of mammalian...
US20140018359 Niacin Mimetics, and Methods of Use Thereof  
Disclosed are 6-(morpholinoalkyl)-substituted pyridines, and pharmaceutically acceptable salts and prodrugs thereof, that are active against a range of mammalian therapeutic indications.
US20120077808 Niacin Mimetics, and Methods of Use Thereof  
Disclosed are heterocyclylalkyl-substituted and heteroaralkyl-substituted pyridines, and pharmaceutically acceptable salts and prodrugs thereof, that are active against a range of mammalian...
US20120077807 NIACIN MIMETICS, AND METHODS OF USE THEREOF  
Disclosed are 6-(morpholinoalkyl)-substituted pyridines, and pharmaceutically acceptable salts and prodrugs thereof, that are active against a range of mammalian therapeutic indications.
US20140309221 METHOD OF INHIBITING HAMARTOMA TUMOR CELLS  
Dimorpholinopyrimidines are useful for inhibiting growth or proliferation of hamartoma tumor cells. Because the Dimorpholinopyrimidines inhibit the growth and proliferation of hamartoma tumor...
US20050234030 Modulators of CRTH2, COX-2 and FAAH  
Certain substituted indoles that are modulators of one or more or of CRTH2, COX-2 AND FAAH are described. The compounds are useful for treatment of pain and/or inflammation as well as other disorders.
US20150038481 PYRIMIDINE COMPOUNDS FOR THE TREATMENT OF CANCER  
Described are compounds of Formula I or Formula II: wherein: ring A is a 5- or 6-membered heteroaryl group; dashed lines are optional double bonds; X is N or O; Y is a carbon atom or an S or N...
US20120255502 PACKAGE AND METHOD OF MARKETING  
A method of treatment and a package that is designed to accomplish this. The package provides the pet owner with a pack containing individual doses of topically applied medications pre-packaged...
US20120202806 Novel Pyrimidine- And Triazine-Hepcidine Antagonists  
The present invention relates to new hepcidin antagonists, pharmaceutical compositions containing them and the use thereof as a drug, in particular for the treatment of iron metabolism disorders...
US20150087627 COMBINATION OF KINASE INHIBITORS AND USES THEREOF  
The present invention provides for a method for treating a disease condition associated with PI3-kinase α and/or mTOR in a subject. In another aspect, the invention provides for a method for...
US20130183269 Hepatitis C Virus Inhibitors  
The present disclosure is generally directed to antiviral compounds, and more specifically directed to combinations of compounds which can inhibit the function of the NS5A protein encoded by...
US20150065431 REDUCING CUTANEOUS SCAR FORMATION AND TREATING SKIN CONDITIONS  
The present invention provides methods of reducing cutaneous scar formation by treating a cutaneous wound with a composition comprising a therapeutic agent that is a sodium channel blocker and/or...
US20130121957 Hepatitis C Virus Inhibitors  
The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such...
US20130115193 Hepatitis C Virus Inhibitors  
The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such...
US20110274648 Hepatitis C Virus Inhibitors  
The present disclosure relates to compounds, compositions and methods for the treatment of Hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such...
US20100061960 Amido Anti-Viral Compounds, Compositions, And Methods Of Use  
Disclosed are compounds, stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, their preparation, use, and compositions thereof for treating an infection mediated at least in...
US20140343128 Combination of a phosphoinositide 3-kinase inhibitor and a modulator of the Janus Kinase 2 - Signal Transducer and Activator of Transcription 5 pathway  
The invention relates to a pharmaceutical combination which comprises (a) a phosphoinositide 3-kinase inhibitor compound and (b) a compound which modulates the JAK2-STAT5 pathway for the treatment...
US20130324524 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES  
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods...
US20120045454 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES  
The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods...
US20050059660 Novel combination  
Combinations comprising a) an activator of soluble guanylate cyclase and b) an inhibitor of angiotensin converting enzyme (ACE) are useful for treating hypertension.
US20150258102 THERAPEUTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT AND METHODS OF MAKING AND USING SAME  
The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid and a therapeutic agent...
US20120294930 COMBINATION OF KINASE INHIBITORS AND USES THEREOF  
The present invention provides for a method for treating a disease condition associated with PI3-kinase α and/or mTOR in a subject. In another aspect, the invention provides for a method for...
US20140199236 ANDROGEN RECEPTOR MODULATOR AND USES THEREOF  
Described herein is the androgen receptor modulator of formula (I) in the treatment of prostate cancer in combination with other therapeutic options and in the treatment of diseases or conditions...
US20120264749 MORPHOLINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS  
The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the...
US20090215765 Neuroprotective compounds for treating optic neuropathies  
Neuroprotective compounds for treating optic neuropathies and screening methods for identifying neuroprotective compounds.
US20050137191 Nitrate esters and their use for mitigating cellular damage  
Nitrate esters and methods for mitigating neurodegeneration, affecting neuroprotection, affecting cognition enhancement, and/or preventing or mitigating tissue and/or cellular damage in a subject...
US20150133441 THERAMUTEIN MODULATORS  
This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and...
US20130150358 THERAMUTEIN MODULATORS  
This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and...
US20130053378 TETRA-O-SUBSTITUTED BUTANE-BRIDGE MODIFIED NDGA DERIVATIVES, THEIR SYNTHESIS AND PHARMACEUTICAL USE  
The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (NDGA) compounds and butane bridge modified...
US20120214788 HETEROARYL-SUBSTITUTED PIPERIDINES  
The invention relates to novel heteroaryl-substituted piperidines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing...
US20050009820 Thiochromenones used to combat painful conditions and neurodegenerative diseases  
The invention relates to novel thiochromenones and processes for their preparation, to their use for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis...
US20140296208 KINASE INHIBITORS  
There are provided compounds of formula I, wherein R1A to R1E, R2 to R5, L and X1 to X3 have meanings given in the description, which compounds have antiinflammatory activity (e.g. through...
US20140213583 PI3K Inhibitor for Use in the Treatment of Bone Cancer or for Preventing Metastatic Dissemination Primary Cancer Cells into the Bone  
Provided herein are methods for the treatment of bone cancer and prevention of the metastatic spread of cancer.
US20100267716 METHODS OF TREATING INFLAMMATIONS AND INFECTIONS WITH PYRIDINIUM SALTS  
Compounds of pyridinium salts and methods of their use in medicine, particularly in the prophylaxis and treatment of inflammatory conditions, infectious conditions, as well as immune disorders are...
US20150072980 Substituted 2,3-dihydro-1H-inden-1-one Retinoic acid-related orphan nuclear receptor Antagonists for Treating Multiple Sclerosis  
The present invention is directed to compounds, their synthesis, and their use as antagonists, inverse agonists, modulators and or inhibitors of the Retinoic acid-related orphan nuclear receptor...
US20140051694 Aminooxazole Inhibitors of Cyclin Dependent Kinases  
Oxazole derivatives are described. The inventive compounds are useful as kinase inhibitors, and may be used in the treatment of cancer, such as prostate cancer, lung cancer, breast cancer, colon...
US20130345208 ION CHANNEL MODULATORS AND METHODS OF USE  
In general, the invention relates to novel 4-phenylpyrimidine compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable...
US20090317360 ANTI-VIRAL INHIBITORS AND METHODS OF USE  
Disclosed are compounds and compositions of Formula (I), pharmaceutically acceptable salts and solvates thereof, and their uses for treating viral infections mediated at least in part by a virus...
US20110070197 HEPATITIS C VIRUS INHIBITORS  
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus...
US20110070196 HEPATITIS C VIRUS INHIBITORS  
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit RNA-containing virus, particularly the hepatitis C virus...

Matches 1 - 50 out of 202 1 2 3 4 5 >