Matches 1 - 50 out of 145 1 2 3 >


Match Document Document Title
US20110117154 USE OF RIFALAZIL TO TREAT COLONIC DISORDERS  
Methods for treating bacterial infections in the colon, and colonic disorders caused by bacterial infection, using a poorly absorbable form of Rifalazil, are described. Compositions for oral...
US20110104282 New Therapy of Treatment of the Irritable Bowel Syndrome  
The invention provides for new methods for treatment and diagnosis of irritable bowel syndrome (IBS). In particular, there is disclosed the use of a Chlamydia activating agent and one or several...
US20140072536 METHODS OF TREATING MUSCULAR DYSTROPHY  
Disclosed herein are α7β1 integrin modulatory agents and methods of using such to treat conditions associated with decreased α7β1 integrin expression or activity, including muscular dystrophy. In...
US20150139915 METHODS TO DECREASE SUSCEPTIBILITY TO ASTHMATIC BRONCHOCONSTRICTION  
Methods and compositions are described for reducing airway reactivity and the susceptibility to asthmatic bronchoconstriction that involve increasing sphingolipid content in airways and lungs of a...
US20120178747 Compositions and methods for bone formation and remodeling  
The mechanism by which the high bone mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates the canonical Wnt signaling was investigated. The mutation was previously shown to reduce Dkk...
US20100298308 Compositions and methods for bone formation and remodeling  
The mechanism by which the high bone mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates the canonical Wnt signaling was investigated. The mutation was previously shown to reduce Dkk...
US20120129775 ANTIANGIOGENIC SMALL MOLECULES AND METHODS OF USE  
Methods of inhibiting undesired angiogenesis are provided, which methods include administering to a subject a therapeutically effective amount of at least one of the compounds described herein, or...
US20140303144 COMPOUNDS AND METHODS OF TREATING HYPERTENSION  
Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are adrenergic receptor α2B antagonists. The compounds may also bind...
US20130123248 PHARMACOLOGICAL MODULATION OF POSITIVE AMPA RECEPTOR MODULATOR EFFECTS ON NEUROTROPHIN EXPRESSION  
Antagonists of group 1 metabotropic glutamate receptors (mGluR) potentiate the effect of positive AMPA receptor modulators on neurotrophin expression, such as brain-derived neurotrophic factor...
US20110306601 PHARMACOLOGICAL MODULATION OF POSITIVE AMPA RECEPTOR MODULATOR EFFECTS ON NEUROTROPHIN EXPRESSION  
Antagonists of group 1 metabotropic glutamate receptors (mGluR) potentiate the effect of positive AMPA receptor modulators on neurotrophin expression, such as brain-derived neurotrophic factor...
US20140228353 COMPOUNDS AND METHODS OF TREATING DIABETES  
Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are antagonists of the adrenergic receptor α2A. The compounds may...
US20120004219 Method of Inhibition of Respiratory Depression Using Positive Allosteric AMPA Receptor Modulators  
The invention is directed to a method for alleviating respiratory depression in a subject as a result of disease of pharmacological agents such as opiates, opioids or barbiturates. The invention...
US20110014196 Drug Transfer into Living Cells  
The invention relates to compounds comprising a plurality of enzyme substrates suitably linked and further carrying one or more cargo entities. In particular such compounds have the structure...
US20110224201 CGRP RECEPTOR ANTAGONISTS  
Compounds of Formula (I), (wherein variables A1, A2, A3, A4, A5, A6, A7, A8, L, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG, W, Y and Z are as described herein) useful as antagonists of CGRP...
US20080015189 Antimicrobial photoinactivation using chalcogen analogs of benzo(A)phenoxazinium dyes  
Compositions and methods for the use of photoactivatable antimicrobial chalcogen analogs of benzophenoxazinium dyes in the treatment of infections are provided.
US20080009487 Treatment of athersclerotic disease  
The invention features a method of inhibiting the progression of intima-media thickening, or reducing the intima-media thickness (IMT) in arteries in a patient in need thereof by administering to...
US20110245224 FUSED, SPIROCYCLIC HETEROAROMATIC COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS  
The present invention relates to compounds of Formula (I); to pharmaceutically acceptable salts thereof, to methods of using them to treat bacterial infections, and to methods for their preparation.
US20130005720 PHARMACEUTICAL COMPOSITION FOR TREATING CANCER AND APPLICATIONS THEREOF  
This invention relates to a pharmaceutical composition for treating cancer, comprising an effective amount of a compound represented by formula (I): wherein R is —CCOCCOCC— or —CCOCCOCCOCC—; and a...
US20140303155 PHARMACEUTICAL COMPOSITION AND KIT FOR TREATING BACTERIAL INFECTIONS  
The invention relates to pharmacology and medicine, more particularly to novel pharmaceutical compositions and pharmaceutical kits for treating bacterial infections, and to novel method for...
US20120288533 PROTEIN-POLYSACCHARIDE CONJUGATES AND USE FOR ENCAPSULATING NUTRACEUTICALS FOR CLEAR BEVERAGE APPLICATIONS  
The present invention provides protein (or peptide)-polysaccharide (or oligosaccharide) conjugates (PPC) as nanocapsular vehicles for nanoencapsulation of biologically active compounds,...
US20080261962 METHOD OF INHIBITION OF RESPIRATORY DEPRESSION USING POSITIVE ALLOSTERIC AMPA RECEPTOR MODULATORS  
The invention is directed to a method for alleviating respiratory depression in a subject as a result of disease of pharmacological agents such as opiates, opioids or barbiturates. The invention...
US20140050783 METHODS AND COMPOSITIONS FOR SLEEP DISORDERS AND OTHER DISORDERS  
Use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals and pharmaceutical compositions comprising them for the treatment of one or more disorders involving...
US20110071080 METHODS AND COMPOSITIONS FOR SLEEP DISORDERS AND OTHER DISORDERS  
Use of particular substituted heterocycle fused gamma-carboline compounds as pharmaceuticals and pharmaceutical compositions comprising them for the treatment of one or more disorders involving...
US20120040930 TETRACYCLIC TERPENE SERIES COMPOUNDS, METHODS FOR PREPARING SAME, USES THEREOF AS MEDICINES AND PHARMACEUTICAL COMPOUNDS CONTAINING SAME  
The invention concerns a triterpene alkaloid of general formula (I). The invention also concerns a method for making same and use thereof as medicine.
US20120046281 RIFALAZIL COMPOSITIONS AND THERAPEUTIC REGIMENS  
The invention features low-dosage rifalazil compositions and therapeutic regimens which are useful for the treatment of bacterial infections.
US20130210803 FUSED TETRACYCLIC PYRIDO [4,3-B] INDOLE AND PYRIDO [3,4-B] INDOLE DERIVATIVES AND METHODS OF USE  
This disclosure is directed to fused tetracyclic pyrido[4,3-b]indoles and pyrido[3,4-b]indoles. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the...
US20150166572 HALOGENATED BENZOXAZINES AND THEIR USE  
The present invention relates to novel halogenated benzoxazines, methods for their production, their use for the diagnosis of diseases and their use for the production of medicaments for the...
US20140163021 FKBP52-Tau Interaction as a Novel Therapeutical Target for Treating the Neurological Disorders Involving Tau Dysfunction  
Candidate compounds for use in neuro-protection and repair in neurological disorders involving Tau dysfunction (including Alzheimer's disease) are identified from a direct interaction between...
US20120196852 INHIBITORS OF METHIONINE AMINOPEPTIDASES AND METHODS OF TREATING DISORDERS  
The invention is directed towards novel naphthoquinone and naphthothiazole compounds, and methods of treating disorders related to MetAP, including tuberculosis and bacterial infection, using...
US20140256717 MACROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS  
There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or...
US20070248668 Pharmaceutical compositions and uses thereof  
The invention features pharmaceutical compositions including rifalazil, a surfactant, and a lipophilic antioxidant and methods of use thereof.
US20110218195 METHODS AND COMPOSITIONS FOR TREATING BACTERIAL INFECTIONS AND DISEASES ASSOCIATED THEREWITH  
The invention features methods and compostions for treating bacterial infections.
US20120107317 USE OF CYTOPLASMIC C-MYC FOR REGULATING IMMUNE RESPONSES  
The subject invention provides novel uses of cytoplasmic c-Myc for modulation of innate immune responses. The invention is based, at least in part, on the surprising discovery that cytoplasmic...
US20130225558 FUSED TETRACYCLIC PYRIDO [4,3-B] INDOLE AND PYRIDO [3,4-B] INDOLE DERIVATIVES AND METHODS OF USE  
This disclosure is directed to fused tetracyclic pyrido[4,3-b>]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of...
US20140080821 PYRIMIDO-PYRROLO-OXAZINE-DIONE COMPOUND INHIBITORS OF THE CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND USES THEREFOR  
Provided herein are benzopyrimido-pyrrolo-oxazine-dione (BPO) compounds and pyrimido-pyrrolo-quinoxalinedione (PPQ) compounds, and compositions comprising these compounds, that inhibit cystic...
US20090270377 COMBINATION CANCER CHEMOTHERAPY  
Provided is a method for improving treatment of a neoplastic condition by combining a therapeutically effective amount of a polyADP-ribose polymerase inhibitor with a therapeutically effective...
US20140213571 TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES  
The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for...
US20150203513 COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS  
Compounds of formula (I), pharmaceutically acceptable salts thereof, and uses of the compounds of formula (I) for treating bacterial infections are disclosed.
US20140206677 COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS  
Compounds of formula (I), pharmaceutically acceptable salts thereof, and uses of the compounds of formula (I) for treating bacterial infections are disclosed.
US20060276462 Method of treating cognitive decline due to sleep deprivation and stress  
This invention relates to methods of use for AMPA receptor potentiator compounds and pharmaceutical compositions in the prevention and treatment of cognitive impairment as a result of acute or...
US20100069377 TREATMENT OF FEMALE SEXUAL DYSFUNCTION BY COMPOUNDS THAT POSITIVELY MODULATE AMPA-TYPE GLUTAMATE RECEPTORS  
The present invention provides methods of increasing sexual arousal and performance behaviors in female mammals by administration of a therapeutically acceptable amount of a positive modulator of...
US20110306607 HETEROCYCLIC CHROMENE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS  
The invention relates to heterocyclic chromene-spirocyclic piperidine amides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising...
US20060258651 Use of heterocyclic compounds as scce inhibitors  
The present invention relates to heterocyclic inhibitors of stratum corneum chymotryptic enzyme (SCCE). More particularly, the invention relates to the use of compounds with the formula (I) or...
US20080085882 Compositions and Methods for Potentiation of Cancer Agents  
The present invention includes compositions and method to improve the therapeutic index of anti-cancer agents using a novel anti-cancer agent and a modulator or potentiator thereof.
US20100055193 Stable powder formulation containing an anticholinergic agent  
The invention relates to a spray-dried powder formulation comprising particles that contain the following components i) to iii): i) anticholinergic agents, in particular at least one compound of...
US20090215761 QUINOBENZOXAZINE ANALOGS AND METHODS OF USING THEREOF  
The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof;wherein A, U, W, X, Z, B, L, R1, R3, R4...
US20090325946 NOVEL PHENOLIC AND CATECHOLIC AMINES AND PRODRUGS THEREOF  
The present invention relates to novel phenolic and catecholic amines of Formula I, to processes for their preparation, pharmaceutical compositions containing them, to their use in therapy and to...
US20110207711 Therapeutic Compounds  
The present invention relates to pyrazolopyridines and imidazopyridines which are inhibitors of the kinase PDK1 and are thus useful for the treatment of myeloproliferative disorders or cancer. The...
US20140051692 Inhibitors of Human Immunodeficiency Virus Replication  
The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors...
US20080249085 Maytansinoid Analogs as Antitumor Agents  
Ansamycin analogs, including maytansinoid analogs, and their use in treating cell proliferative diseases and conditions, and in particular, for use as antitumor agents.

Matches 1 - 50 out of 145 1 2 3 >