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US20150231146 |
METHODS FOR ACUTE AND LONG-TERM TREATMENT OF DRUG ADDICTION
This invention is directed to a method of treating opioid or opioid-like drug addiction, including acute and post-acute withdrawal symptoms, comprising treating an addicted patient with... |
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US20150231145 |
METHODS FOR ACUTE AND LONG-TERM TREATMENT OF DRUG ADDICTION
This invention is directed to a method of treating opioid or opioid-like drug addiction, including acute and post-acute withdrawal symptoms, comprising treating an addicted patient with... |
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US20120035102 |
AZINONE-SUBSTITUTED AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF
Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and... |
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US20110003739 |
AZINONE-SUBSTITUTED AZABICYCLOALKANE-INDOLE AND AZABICYCLOALKANE-PYRROLO-PYRIDINE MCH-1 ANTAGONISTS, METHODS OF MAKING, AND USE THEREOF
Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and... |
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US20050222122 |
Statin therapy for enhancing cognitive maintenance
The present invention relates to a method of treating dementia or a memory disorder comprising administration of a therapeutically effective amount of galantamine (I) and a statin (II). The... |
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US20140221353 |
Methods for Determining the Oncogenic Condition of Cell, Uses Thereof, and Methods for Treating Cancer
The invention relates to methods for detecting the oncogenic condition of cells, including step where the amount of the OCDO compound in said cells is measured, and to the uses thereof. The... |
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US20110059937 |
IL-8 RECEPTOR ANTAGONISTS
This invention relates to novel compounds and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8). |
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US20070110715 |
Treatment of alzheimer's disease
The present invention. The invention relates to the use of interferon-β (IFN-β) for treating and/or preventing Alzheimer's disease (AD), Creutzfeld-Jakob disease (CJD) or... |
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US20110015178 |
Amido-Thiophene Compounds and Their Use
The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain amido-thiophene compounds that, inter alia, inhibit... |
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US20060223790 |
Modulation of Microglial by Nicotinic Medications
A method of treating a subject suffering from a neurodegenerative disease by modulating microglial activation with a therapeutically effective amount of a cholinergic agonist and a cholinesterase... |
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US20060079500 |
Medicament and method for reducing alcohol and/or tobacco consumption
The present invention relates to a medicament for treating addiction craving which is characterized in that the medicament consists of a combination of two administration forms, one of the... |
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US20070232588 |
Anti-parasitic and/or anti-viral and/or anti-microbial compositions
Voacamine and its natural and synthetic derivatives such as 16′-decarbometheoxyvoacamine, N6-demethylvoacamine, voacamidine, tabernamine, ervahamine A, vobasine and coronaridine are useful as... |
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US20070166363 |
Use of cholinesterase inhibitors for treating vascular depression
The invention discloses the use of cholinesterase inhibitors in treating vascular depression. |
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US20060205815 |
Choline esters useful for the treatment of cognitive dysfunctions and enhancement of memory, learning and cognition
The present invention provides compounds of formula I described herein. The present invention also provides a method of treating a cognitive dysfunction in a mammal. The method includes... |
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US20110065683 |
TRISUBSTITUTED PYRAZOLES AS ACETYLCHOLINE RECEPTOR MODULATORS
The present invention relates to 1-alkyl-3-aniline-5-aryl-pyrazole derivatives and pharmaceutically acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing... |
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US20070032460 |
Use of voacamine and related compounds in the treatment of malaria
Voacamine, voacamine isomers, metabolites and derivatives, and related compounds can be used to, in effect, reverse multi-drug resistance in malaria and are non-toxic. The compounds can be used in... |
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US20050182044 |
Combinatorial therapy with an acetylcholinesterase inhibitor and (3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3,-b]indol-5-yl phenylcarbamate
The present invention relates to an improved method of treating, reducing or delaying cognitive impairments associated with the β-amyloid peptide, either in combination with treatment by... |
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US20050277626 |
Methods and compositions for treatment of nicotine dependence and dementias
In accordance with the present invention, it has been unexpectedly found that the administration of an acetylcholinesterase inhibitor in combination with a tricyclic antidepressant having... |
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US20120046271 |
2,5-Methano- and 2,5-Ethano-Tetrahydrobenzazepine Derivatives And Use Thereof To Block Reuptake Of Norepinephrine, Dopamine, and Serotonin
The compounds of the present invention are represented by the following 2,5-methano- and 2,5-ethano-tetrahydrobenzazepine derivatives having formula (I): where the carbon atom designated * is in... |
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US20050267077 |
Method for improving cognitive function by co-administration of a GABAB receptor antagonist and an acetylcholinesterase inhibitor
The present invention provides methods and compositions for improving cognitive function by administering a GABAB receptor antagonist and an acetylcholinesterase inhibitor. |
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US20050191349 |
Galantamine formulations
Galantamine formulations, including sustained-release and fast dissolve formulations, are described. |
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US20060003989 |
Compositions and methods using acetylcholinesterase (ACE) inhibitors to treat central nervous system (CNS) disorders in mammals
Methods and compositions of the invention employ acetylcholinesterase (ACE) inhibitors to prevent and treat diseases and other disorders of the central nervous system (CNS), including Alzheimer's... |
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US20080132486 |
Ligands for Nicotinic Acetylcholine Receptors, and Methods of Making and Using Them
One aspect of the present invention relates to heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. A second aspect of the invention relates to the use of a compound of... |
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US20060229293 |
Compositions for the treatment of hepatitis C and methods for using compositions for the treatment of hepatitis C
The present invention pertains to a composition comprising Ibogaine, an indole alkaloid, its active salts and its principal metabolite noribogaine, a demethylated form of ibogaine, for the... |
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US20060193893 |
Medical devices
The invention relates to medical devices, compositions and methods useful for administrating or delivering a cephalotaxine to a host. The cephalotaxines are useful in treating or preventing an... |
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US20100105658 |
AZA-BRIDGED-RING COMPOUND
[Problems] Provided is a compound which has an antagonistic action on a muscarinic M3 receptor and is useful as an active ingredient of a prophylactic and/or therapeutic agent for an inflammatory... |
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US20080200451 |
Tetrahydroquinolines for Use as Modulators of the Mitotic Motor Protein Eg5
Compounds of the formula (I), in which W, R, R1, R2, R3, R4, R5, R6 and R7 have the meanings indicated in claim 1, can be employed, inter alia, for the treatment of tumours. |
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US20130165426 |
IMIDAZOPYRIDINE, IMIDAZOPYRIMIDINE AND IMIDAZOPYRAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR MODULATORS
Disclosed is a compound of Formula I or a salt thereof, in which X, X1, X2, R1, R2, and R3 are described herein. Also disclosed are pharmaceutical compositions and methods of using the compounds... |
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US20050143350 |
Combination drug therapy to treat obesity
Provided are methods of achieving desirable weight loss in an overweight or obese individual by administering at least one anticholinesterase agent and at least one antidepressant. The invention... |
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US20050063998 |
Oral solution containing galantamine and a sweetening agent
The present invention concerns an oral solution comprising galantamine or a pharmaceutically acceptable addition salt thereof; its use and process of preparing the same. |
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US20090163469 |
Organic Compounds
The present invention relates to compounds of formula I and its salts, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of... |
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US20100227851 |
Method of preventing and/or treating a neurodegenerative disease by administering an extract of Lycoris chejuensis and/or a compound isolated therefrom
Provided are novel use of an extract of Lycoris chejuensis or a compound isolated therefrom for inhibition of β-amyloid production and/or prevention, improvement and/or treatment of a... |
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US20050142193 |
Galantamine formulations
Galantamine formulations substantially free of microcrystalline cellulose, lactose, and/or starch are described. |
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US20070166415 |
Safe medicine for treating and preventing cancer and method of use
The present invention provides a new method for extracting Homoharringtonine (HHT) by culture cells or culture plant tissues. Also, disclosed are methods of obtaining HHT from semi-synthesis and... |
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US20120208796 |
HETEROCYCLIC DERIVATIVES
The present invention relates to a heterocyclic derivative of formula (I) wherein the variables are as defined in the specification or to a pharmaceutically acceptable salt or solvate thereof. The... |
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US20080090808 |
Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction
The present invention provides compositions and methods for preventing, treating or reversing neuronal dysfunction in a mammal resulting from exposure to organophosphate nerve agents,... |
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US20150210681 |
GLUCOSYLCERAMIDE SYNTHASE INHIBITORS
The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with... |
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US20070135406 |
Diazabicyclononene and tetrahydropyridine derivatives with a new side-chain
The invention relates to novel bicyclic derivatives, and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns... |
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US20070135405 |
Novel diazabicyclononene and tetrahydropyridine derivatives with a new polar side-chain
The invention relates to novel bicyclic derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related... |
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US20130266666 |
Combination Therapy with an Antitumor Alkaloid
The present invention relates to the combination of PM01183 with several anticancer drugs, in particular other anticancer drugs selected from antitumor platinum coordination complexes,... |
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US20120071463 |
HYDROXY AND ALKOXY SUBSTITUTED 1H-IMIDAZOQUINOLINES AND METHODS
1H-Imidazo[4,5-c]quinolin-4-amines with a hydroxy, alkoxy, hydroxyalkoxy, or alkoxyalkoxy substituent at the 2-position, pharmaceutical compositions containing these compounds, methods of making... |
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US20090131406 |
CROPWELLLINS AND SYNTHETIC DERIVATIVES THEREOF USED AS MEDICAMENTS
The present invention relates to cripowellins and synthetic derivatives thereof for treating diseases of man and also, in particular, to their use for preparing a medicament for treating cancer or... |
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US20100009968 |
11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS
The use of substituted amides for modulating the activity of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) and the use of these compounds as pharmaceutical compositions, are described. Also a... |
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US20120156219 |
NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF
The compound represented by formulae (I) and (II), the salt thereof, the N-oxide thereof or the solvate thereof, or the prodrug thereof and the pharmaceutical composition comprising thereof have a... |
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US20060223760 |
Compositions and methods for treatment of cancer
The present invention relates to pyrroloquinolinyl-pyrrole-2,5-dione compounds and pyrroloquinolinyl-pyrrolidine-2,5-dione compounds, and methods of preparation of these compounds. The present... |
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US20100197662 |
HETEROCYCLIC COMPOUND HAVING TYPE I 11 BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORY ACTIVITY
Disclosed is a compound useful as a type I 11βhydroxysteroid dehydrogenase inhibitor. A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof,whereinR1 is... |
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US20100249105 |
INDOLE AND INDOLINE DERIVATIVES AND METHODS OF USE THEREOF
The present application relates to indole and indoline derivatives of formula (I), (II), (III), (IV), (V), or (VI) wherein a, R1, R2, R3, R4, R5, U, V, W, X, Y, and Z are as defined in the... |
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US20110160185 |
PYRROLOPYRIMIDINE DERIVATIVES AS JAK3 INHIBITORS
Pyrrolopyrimidine derivatives of Formula (I) that are useful as JAK3 kinase inhibitors. |
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US20100113420 |
PYRROLOPYRIMIDINE DERIVATIVES AS JAK3 INHIBITORS
Pyrrolopyrimidine derivatives of Formula (I) that are useful as JAK3 kinase inhibitors. |
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US20160106725 |
Novel bis-Benzylidine Piperidone Proteasome Inhibitor with Anticancer Activity
We describe a bis-benzylidine piperidone, RA190, which covalently binds to the ubiquitin receptor RPN13 (ADRM1) in the 19S regulatory particle and inhibits proteasome function, triggering rapid... |