Matches 1 - 50 out of 193 1 2 3 4 >


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US20150030572 IDENTIFICATION OF MOLECULAR PATHWAYS AND METHODS OF USE THEREOF FOR TREATING RETINAL NEURODEGENERATION AND OTHER NEURODEGENERATIVE DISORDERS  
Drug targets, pathways, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.
US20120114663 METHODS TO TREAT ALLERGIC CONDITIONS  
Disclosed are methods to treat allergic conditions, including pulmonary and non-pulmonary conditions, in a subject by administering a composition that inhibits Pim kinase. Also disclosed are...
US20130018040 Compositions And Methods For Treating Toxoplasmosis, Cryptosporidiosis, And Other Apicomplexan Protozoan Related Diseases  
Compositions and methods for the treatment of toxoplasmosis, caused by the infectious eukaryotic parasite Toxoplasma gondii (T. gondii) and for the treatment of cryptosporidiosis, caused by the...
US20110086797 CONTROL OF SPORE GERMINATION  
Provided are compositions and methods for treating bacterial infections. It is demonstrated herein that bacteria cell wall materials stimulate germination of spores of Gram-positive bacteria, and...
US20150057267 Methods and Compositions for Treating Viral Diseases  
The invention provides a method for treating viral infections and coinfections through the use of inhibitory agents that prevent a unique viral structural protein motifs from binding to host...
US20130310340 METHOD OF TREATING MUSCULAR DEGRADATION  
A method for treating muscular deterioration is disclosed. Also disclosed are embodiments of a compound, and compositions comprising the compound, for inhibiting muscular deterioriation, including...
US20130052205 FLT3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OR THE PREVENTION OF PAIN DISORDERS  
The present invention relates to FLT3 receptor antagonists or inhibitors of FLT3 receptor gene expression for the treatment or the prevention of pain disorders.
US20140314791 METHODS OF TREATING CANCER  
The present invention provides methods of treating cancer, particularly cancers that are null or have decreased expression or activity of the Lkb1 gene. Also included are methods of identifying...
US20150017264 PROCASPASE 3 ACTIVATION BY COMBINATION THERAPY  
The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the...
US20140187510 MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY  
The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant...
US20120046242 MOLECULAR ACTIVATORS OF THE WNT/BETA-CATENIN PATHWAY  
The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/β-catenin signaling by selecting a subject with a condition mediated by aberrant...
US20140037755 Mapkap Kinase-2 as a Specific Target for Blocking Proliferation of P53-Defective Cells  
The present invention relates to compounds and pharmaceutical compositions for treating cellular proliferative disorders, e.g., in patients having one or more p53-deficient cells, screening assays...
US20120129833 CYCLIC KETOENOLS FOR THERAPY  
The invention relates to 5′-biphenyl-substituted cyclic ketoenols for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and...
US20150209308 METHODS TO INHIBIT INTRACELLULAR GROWTH OF BACTERIA AND TO TREAT BACTERIA-MEDIATED DISEASES  
Disclosed is a method of preventing, treating or inhibiting bacterial infections. The method comprises administering at least one of the compounds disclosed herein. Also disclosed are methods of...
US20130261052 INHIBITION OF MEMAPSIN 1 CLEAVAGE IN THE TREATMENT OF DIABETES  
Proteases such as memapsin-1 are import enzymes, playing roles in a variety of diseases including diabetes. The inventors have developed inhibitors of memapsin 1 and methods of use therefore in...
US20130084275 Methods and Compositions for Reducing Interleukin-4 or Interleukin-13 Signaling  
The present invention relates generally to methods and compositions for reducing Interleukin-4 or Interleukin-13 signaling, in particular to treat asthma and atopic dermatitis. The inventors have...
US20100310563 METHODS FOR TREATING INDUCED CELLULAR PROLIFERATIVE DISORDERS  
Methods are provided for treating a subject with a cellular proliferative disorder that include administering to the subject a therapeutically effective amount of a JAK2 inhibitor and a...
US20120316137 Methods and Compositions for Treating Cancer  
The invention features methods, kits, and pharmaceutical compositions for treating cancer using 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-me thylpiperazin-1-yl)-methyl)-3-(trifluoro...
US20110244017 Absorbable Coating For Implantable Device  
The present invention provides an absorbable coating for an implantable device and the methods of making and using the same.
US20140314882 Synergistic Combination Therapy  
Combinations of compounds are provided that produce a synergistic effect when administered.
US20110008468 Uses of chemicals to modulate GSK-3 signaling for treatment of bipolar disorder and other brain disorders  
Aspects of this invention are related, at least in part, to the use of chemical compounds able to inhibit GSK-3 and/or to stabilize β-catenin and formulations thereof. Some aspects of this...
US20140286938 SPIROKETALS  
The present invention relates to spiroketal compounds that are useful in methods of treating or preventing protozoal infections, parasitic infections, bacterial infections, cell proliferative...
US20120202789 COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER  
The present invention relates to the use of specific compounds related to the indolocarbazole K252a, for the preparation of pharmaceutical compositions for the treatment of various forms of cancer.
US20150225355 AZEPANE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS  
Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV...
US20120252784 2,3,4-BENZOTHIADIAZEPINE-2,2-DIOXIDE DERIVATIVES  
Novel 2,3,4-benzothiadiazepines-2,2-dioxides and processes for the preparation thereof are disclosed. The compounds influence the central nervous system and may be used to treat or prevent...
US20130040935 CYCLIC KETO-ENOLS FOR THERAPY  
The invention relates to 5′-biphenyl-substituted cyclic ketoenols for therapeutic purposes, to pharmaceutical compositions and to their use in therapy, in particular for the prophylaxis and...
US20130143866 ANTICANCER COMBINATION TREATMENTS  
Compositions of matter including γ-tocotrienol and SU11274 are disclosed herein. A variety of Met kinase inhibitors may be used in conjunction with tocotrienols in the treatment or prevention of...
US20120114636 LOW MOLECULAR WEIGHT CYCLIN E (LMW-E) AS A BIOMARKER FOR PERSONALIZATION OF CANCER THERAPIES  
Methods are disclosed for predicting a patient response to anti-Her2 therapy or anti-aromatase therapy. In certain embodiments, the methods involve the identification of low molecular weight...
US20130053335 SUPPRESSION OF CANCER GROWTH AND METASTASIS USING NORDIHYDROGUAIARETIC ACID DERIVATIVES WITH 7-HYDROXYSTAUROSPORINE  
Disclosed is a composition comprising a derivative of NDGA and 7-hydroxystaurosporine. The composition can be in a unit dose form or kit. Also disclosed are methods for achieving cytotoxicity,...
US20080260644 CHLORIDE TRANSPORT UPREGULATION FOR THE TREATMENT OF TRAUMATIC BRAIN INJURY  
Compositions and methods are provided for the alleviation of pathology induced by traumatic brain injury.
US20130224255 Treatment Of Diabetic Patients With A Drug Eluting Stent And Adjunctive Therapy  
Embodiments of the present invention include methods for the treatment, prevention, or amelioration of vascular disease in diabetic patients. The methods include both implantation of a stent...
US20100048534 CRYSTALLINE LESTAURTINIB HYDRATES AND CRYSTALLINE LESTAURTINIB HEMIHYDRATE HEMIACETONITRILEATE AND CRYSTALLINE LESTAURTINIB HEMIHYDRATE HEMITETRAHYDROFURANATE  
Crystalline lestaurtinib hydrates and crystalline lestaurtinib hemihydrate hemicetonitrileate and crystalline lestaurtinib hemihydrate hemitetrahydrofuranate, processes to reproducibly make them...
US20110070221 GNAQ MUTATIONS IN MELANOMA  
The present invention provides methods of detecting mutations in a Gnaq gene in a melanocytic neoplasm for diagnostic and prognostic purposes. The invention further provides methods of treating...
US20110052599 Facilitation of Oocyte, Zygote and Pre-Implantation Embryo Maturation  
Compositions and methods are provided for enhancing the survival and promoting the maturation of mammalian oocytes, zygotes and preimplantation embryos. BDNF or BDNF agonists may be administered...
US20120070410 IMIDAZOLOTHIAZOLE COMPOUNDS AND METHODS OF USE THEREOF  
Compounds, compositions and methods are provided for modulating the activity of receptor kinases and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder...
US20120190667 METHOD OF MAKING SOLID DISPERSIONS OF HIGHLY CRYSTALLINE THERAPEUTIC COMPOUNDS  
A process for preparing solid dispersions of highly crystalline compounds. The highly crystalline or thermally labile therapeutic compounds are processed in an extruder in combination with a...
US20120121684 Coating Comprising A Poly(Ethylene Glycol)-Poly(Lactide-Glycolide-Caprolactone) Interpenetrating Network  
Implantable medical devices are disclosed. The devices comprise a coating comprising an interpenetrating network or semi-interpenetrating network. The interpenetrating network or...
US20110130340 METHODS OF IDENTIFYING ANTI-CANCER AGENTS AND USES THEREOF  
The present invention provides methods of identifying and/or detecting anti-cancer agents. The present invention provides methods of identifying and/or detecting compounds that can activate PARP...
US20120039805 Therapeutics And Methods For Treating Neoplastic Diseases Comprising Determining The Level Of Caveolin-1 And/Or Caveolin-2 In A Stromal Cell Sample  
The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate,...
US20100189757 DRUG DEPOT IMPLANT DESIGNS AND METHODS OF IMPLANTATION  
The present invention relates to novel drug depot implant designs for optimal delivery of therapeutic agents to subjects. The invention provides a method for alleviating pain associated with...
US20080096864 Treatment Of Gastrointestinal Stromal Tumors With Imatinib And Midostaurin  
The present invention relates to the use of a combination comprising (a) imatinib or a pharmaceutically acceptable salt thereof and midostaurin or a pharmaceutically acceptable salt thereof for...
US20060154856 NADPH oxidase inhibition pharmacotherapies for Obstructive Sleep Apnea syndrome and its associated morbidities  
The invention relates to compositions and methods for treating Obstructive Sleep Apnea (OSA). Specifically, the invention relates to the use of NADPH Oxigenase inhibitors in compositions and...
US20110136753 GLYCOSYLATED INDOLECARBAZOLES, METHOD FOR OBTAINING SAME AND USES THEREOF  
Glycosylated indolocarbazoles, method for obtaining same and uses thereof. This invention relates to rebeccamycin and staurosporine derivatives obtained by fermentation of recombinant bacterial...
US20100272706 ANTIVIRALS  
This invention provides methods for inhibiting or treating infection by viruses, in particular pox viruses by modulating a kinase, in particular by inhibiting a host cell kinase, involved in...
US20110020362 Adrenergic stimulation mediates hypersensitivity by inducing nerve growth factor expression  
The current invention provides mechanisms by which chronic stress induced hypersensitivity exacerbates the symptoms of irritable bowel syndrome. The invention includes methods of treating...
US20150018294 MODULATORS OF TOUSLED KINASE IN CELLULAR PROCESSES  
The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of...
US20140147415 TREATMENT OF MASTOCYTOSIS WITH MASITINIB  
The present invention relates to the treatment of mastocytosis, and in particular indolent forms of mastocytosis (including smoldering systemic, indolent systemic and cutaneous mastocytosis),...
US20130122064 Ophthalmic Depot Formulations for Periocular or Suconjunctival Administration  
The present invention relates to ophthalmic depot formulations comprising an active agent, e.g. embedded in a pharmacologically acceptable biocompatible polymer or a lipid encapsulating agent,...
US20120269894 Ophthalmic Depot Formulations for Periocular or Suconjunctival Administration  
The present invention relates to ophthalmic depot formulations comprising an active agent, e.g. embedded in a pharmacologically acceptable biocompatible polymer or a lipid encapsulating agent,...
US20140356416 LIPOSOMAL DRUG ENCAPSULATION  
Provided herein are novel methods of making liposomally encapsulated drugs using reverse pH gradients and optimizing internal buffer compositions. Further provided herein are liposome compositions...

Matches 1 - 50 out of 193 1 2 3 4 >