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US20160120878 DERIVATIVES OF BETULIN  
The present invention relates to compounds characterized by having a structure according to the following formula I: or a pharmaceutically acceptable salt thereof. Compounds of the present...
US20150203528 TREATMENT OF PROSTATE CANCER  
Described herein are compounds, methods of making such compounds, pharmaceutical compositions, and medicaments comprising such compounds, and methods of using such compounds to treat androgen...
US20070185068 Use of sex steroid function modulators to treat wounds and fibrotic disorders  
The present application relates to the use of compounds that influence the sex hormone system for the treatment of wounds and/or fibrotic disorders. Preferred compounds for use in such treatments...
US20060233814 Elimination of heterogeneous or mixed cell population in tumors  
Methods of killing or inhibiting tumors comprising of heterogeneous or mixed cell populations is described. The killing or inhibition of tumors is achieved by selectively targeting a unique ligand...
US20060205697 Novel betulin derivatives, preparation thereof and use thereof  
The present invention relates to novel synthetic derivatives of betulin and the use of such derivatives as pharmaceuticals. The present invention is directed to novel compounds of Formula I: or a...
US20160067265 Abiraterone Acetate Formulation  
Pharmaceutical compositions, including unit dosage forms, comprising fine particle abiraterone acetate with or without an antioxidant and or a sequesting agent as well as methods for producing and...
US20150320770 NOVEL COMPOSITIONS AND METHODS FOR TREATING PROSTATE CANCER  
Described herein are compounds, methods of making such compounds, pharmaceutical compositions, and medicaments comprising such compounds, and methods of using such compounds to treat androgen...
US20140079636 TARGETED THERAPEUTICS  
The present invention provides pharmacological compounds including an effector moiety conjugated to an binding moiety that directs the effector moiety to a biological target of interest. Likewise,...
US20100137269 Novel C-17-Heteroaryl Steroidal Cyp17 Inhibitors/Antiandrogens: Synehesis, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity  
Described are steroidal C-17 benzoazoles, pyrimidinoazoles (azabenzoazoles) and diazines. Methods for their synthesis are also described, which include methods having a step of nucleophilic...
US20100047338 Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity  
Described are steroidal C-17 benzoazoles, pyrimidinoazoles (azabenzoazoles) and diazines. Methods for their synthesis are also described, which include methods having a step of nucleophilic...
US20090124554 BUCCAL, POLAR AND NON-POLAR SPRAY OR CAPSULE CONTAINING DRUGS FOR TREATING PAIN  
Buccal aerosol sprays or capsules using polar and non-polar solvent have now been developed which provide biologically active compounds for rapid absorption through the oral mucosa, resulting in...
US20170157148 TREATMENT OF PROSTATE CANCER  
Described herein are compounds, methods of making such compounds, pharmaceutical compositions, and medicaments comprising such compounds, and methods of using such compounds to treat androgen...
US20170129914 Aminosteroids for the Treatment of a PTP1B Associated Disease  
This application is directed to the use of aminosteroid compounds for the selective inhibition of the enzyme PTP1B in a mammal for the treatment of diabetes.
US20140287039 Abiraterone Acetate Formulation  
Pharmaceutical compositions, including unit dosage forms, comprising fine particle abiraterone acetate with or without an antioxidant and or a sequestering agent as well as methods for producing...
US20130101657 ANGIOGENESIS INHIBITORS  
Described herein are methods of inhibiting angiogenesis, and treating or preventing a disease or disorder (or symptoms thereof) associated with angiogenesis, wherein an anti-angiogenesis compound...
US20110171306 METHODS AND PRODUCTS FOR TREATMENT OF DISEASES  
The present invention relates to the treatment of diseases and conditions with an effective amount of a steroid having those formulas given in the specification, or a pharmacologically-acceptable...
US20120178726 NOVEL COMPOUNDS  
The present invention provides compounds of formula (I) wherein n, p, R1, R2, X1, X2, X3, X4, X5, R3a, R3b, R4, R5 and R6 are as defined in the specification, a process for their preparation,...
US20110098631 MEDICAL DEVICES FOR TREATING UROLOGICAL AND UTERINE CONDITIONS  
The present invention relates to implantable or insertable medical devices that treat uterine and urological conditions that cause chronic pelvic pain and other symptoms. In another aspect, the...
US20100048524 Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity  
Described are steroidal C-17 benzoazoles, pyrimidinoazoles (azabenzoazoles) and diazines. Methods for their synthesis are also described, which include methods having a step of nucleophilic...
US20050164991 7-Oxo-DHEA compounds for treating keratinous conditions/afflictions  
7-Oxo-DHEA derivatives, various of which are themselves novel compounds, are well suited for cosmetically/therapeutically treating adverse conditions/afflictions of a keratinous...
US20160229887 NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF  
Described herein are neuroactive steroids of the Formula (I): or a pharmaceutically acceptable salt thereof; wherein -------, R1, R2, R5, A and L are as defined herein. Such compounds are...
US20120077789 METHOD FOR TREATMENT OF DISEASES  
The invention provides a method of inhibiting vascular hyperpermeability in an animal in need thereof. The method comprises administering a vascular-hyperpermeability-inhibiting amount of a...
US20080153789 TOPICAL ADMINISTRATION OF DANAZOL  
Pharmaceutical preparations for topical or local administration of drugs directly to the skin for treatment of disorders of the subcutaneous fatty tissue, in particular in cases of cellulite, are...
US20070281914 Use of a steroid prodrug for the treatment of disease of the posterior segment of the eye  
Use of a composition comprising at least one prodrug of a steroid, preferably of a corticosteroid, for the preparation of an ophthalmic composition intended for the treatment of an ocular...
US20130022593 METHODS OF DIAGNOSING ENDOMETRIOSIS  
The present invention provides biomarkers for the diagnosis and prognosis of endometriosis. Generally, the methods of this invention find use in diagnosing or for providing a prognosis for...
US20130005699 METHODS AND PRODUCTS FOR TREATMENT OF DISEASES  
The invention provides a method of treating a disease or condition mediated by vascular hyperpermeability in an animal. The method comprises administering an amount of a danazol compound effective...
US20120289471 NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX  
The present invention is directed to novel therapeutic compounds comprised of an amino acid bonded to a medicament or drug having a hydroxy, amino, carboxy or acylating derivative thereon. These...
US20120276196 Pharmaceutical Compositions of a Neuroactive Steroid and Methods of Use Thereof  
The present invention relates to pharmaceutical compositions of the neuroactive steroid 3α-hydroxy-3β-methoxymethyl-21-(1′-imidazolyl)-5α-pregnan-20 -one or a pharmaceutically-acceptable salt or...
US20080051380 METHODS AND COMPOSITIONS FOR TREATING CANCER  
Methods and compositions for treating cancer are described herein. More particularly, the methods for treating cancer comprise administering a 17α-hydroxylase/C17,20-lyase inhibitor, such as...
US20050171074 3 ALPHA-HYDROXY-3 BETA-METHOXYMETHYL-SUBSTITUTED STEROIDS AND THE USE THEREOF  
This invention relates to compounds having the Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein: R1 is H or methyl; R2 is 5α- or 5β-H; R3 is an optionally...
US20160068563 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF  
Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I): and pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and...
US20140288036 NOVEL C-17-HETEROARYL STEROIDAL CYP17 INHIBITORS/ANTIANDROGENS, IN VITRO BIOLOGICAL ACTIVITIES, PHARMACOKINETICS AND ANTITUMOR ACTIVITY  
Described are steroidal C-17 benzoazoles, pyrimidinoazoles (azabenzoazoles) and diazines. Methods for their synthesis are also described, which include methods having a step of nucleophilic...
US20140256660 ANTIBIOTIC CONJUGATES LINKED WITH STEROID DRUGS  
The present invention describes novel single drug entities, formed by the linkage of an antibiotic with a steroidal drug via a linker. Upon topical application to the eye, the conjugate would...
US20130137648 DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS  
Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme.
US20110144075 DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS  
Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme.
US20140288037 NOVEL COMPOSITIONS AND METHODS FOR TREATING PROSTATE CANCER  
Described herein are compounds, methods of making such compounds, pharmaceutical compositions, and medicaments comprising such compounds, and methods of using such compounds to treat androgen...
US20080019961 Hedgehog signaling pathway antagonist cancer treatment  
The present invention provides methods and compositions for treating tumorigenic cells (e.g., mammary progenitor cancer cells), with hedgehog signaling pathway antagonists (e.g., Cyclopamine or...
US20070060553 3-Nitrogen-6,7-dioxygen steroids and uses related thereto  
A compound of the formula and pharmaceutically acceptable salts, solvates, stereoisomers and prodrugs thereof, in isolation or in mixture, wherein, independently at each occurrence: R1 and R2 are...
US20160015819 FATTY ACID CONJUGATES OF STATIN AND FXR AGONISTS: COMPOSITIONS AND METHODS OF USE  
The invention relates to fatty acid statin conjugates and fatty acid FXR agonist conjugates; compositions comprising an effective amount of a fatty acid statin conjugate or a fatty acid FXR...
US20090124587 METHODS FOR TREATING CANCER USING 17alpha-HYDROXYLASE/C17,20-LYASE INHIBITORS  
Methods for treating certain cancers in patients, such as mammals, using certain 17α-hydroxylase/C17,20-lyase inhibitors are discussed herein. More particularly, methods for treating cancers...
US20070259842 TRITERPENE QUATERNARY SALTS AS BIOLOGICALLY ACTIVE SURFACTANTS  
The invention provides novel compounds that are quaternary amine derivatives of betulin and other triterpenes. The compounds have antibacterial, antifungal, and surfactant properties.
US20060194769 Small molecules that reduce fungal growth  
The present invention relates to methods for reducing the growth of a fungus with an anti-fungal small molecule. Methods for reducing fungal cell growth in a subject with an anti-fungal small...
US20050059645 Methods for the treatment of male and female sexual dysfunction  
Methods for the treatment of female sexual dysfunction, including treatment of associated postmenopausal symptoms, are provided using very low doses of...
US20140256694 STEROID ANTIBIOTIC CONJUGATES  
The present invention describes steroid antibiotic conjugates. These single drug entities are formed connecting a steroid moiety and two same antibiotics moieties, or a steroid moiety and two...
US20120258939 PHARMACEUTICAL MANUFACTURING PROCESS  
The present invention provides a method for preparing a sterile suspension of a glucocorticosteroid. The glucocorticosteroids used in the invention are preferably antiinflammatory...
US20070059316 Singlet oxygen photosensitizers activated by target binding enhancing the selectivity of targeted pdt agents  
Provided herein are conjugates, kits, articles of manufacture and methods for detection, diagnosis and treatment by photodynamic therapy of certain undesired biological substrate targets,...
US20060003976 Cholesterol/bile acid/bile acid derivative-modified therapeutic drug compounds  
Cholesterol-modified anti-cancer therapeutic drug compounds, bile-acid-modified anti-cancer therapeutic drug compounds, and bile-acid-derivative-modified anti-cancer therapeutic drug compounds;...
US20150051179 NOVEL STEROIDAL CYP17 INHIBITORS/ANTIANDROGENS  
Steroidal C-17 nitrogen-containing heterocycles of Formula I: wherein: the ABCD ring structure is the nucleus of a steroid, or an analog thereof; X is a group capable of coordinating a heme group...
US20090325916 5-ARYL INDAN-1-ONE AND ANALOGS USEFUL AS PROGESTERONE RECEPTOR MODULATORS  
Compounds of formula I or II and pharmaceutical compositions and kits containing these compounds are provided. Also provided are methods of inducing contraception, providing hormone replacement...
US20070259839 TRITERPENE QUATERNARY SALTS AS BIOLOGICALLY ACTIVE SURFACTANTS  
The invention provides novel compounds that are quaternary amine derivatives of betulin and other triterpenes. The compounds have antibacterial, antifungal, and surfactant properties.

Matches 1 - 50 out of 183 1 2 3 4 >